Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation Termination

Molecular Cell

Volumn 30, Issue 5, 2008, Pages 599-609

  Fan Minogue, Hua ^a   Du, Ming ^a   Pisarev, Andrey V ^b   Kallmeyer, Adam K ^a   Salas Marco, Joe ^a   Keeling, Kim M ^a   Thompson, Sunnie R ^a   Pestova, Tatyana V ^b   Bedwell, David M ^a  

^a University of Alabama at Birmingham   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

PROTEINS

Indexed keywords

HYBRID PROTEIN; PEPTIDE; PROTEIN ERF3; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CODON; CONTROLLED STUDY; EUKARYOTIC CELL; EUPLOTES; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENETIC CODE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE;

AMINO ACID MOTIFS; ANIMALS; CODON, TERMINATOR; EUPLOTES; MODELS, BIOLOGICAL; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PEPTIDE TERMINATION FACTORS; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SUPPRESSION, GENETIC;

EUKARYOTA; EUPLOTES OCTOCARINATUS; SACCHAROMYCES CEREVISIAE;

EID: 44449153482     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.03.020     Document Type: Article

References (30)

1. Alkalaeva E.Z., Pisarev A.V., Frolova L.Y., Kisselev L.L., and Pestova T.V. In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3. Cell 125 (2006) 1125-1136
2. Bertram G., Bell H.A., Ritchie D.W., Fullerton G., and Stansfield I. Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition. RNA 6 (2000) 1236-1247
3. Bonetti B., Fu L., Moon J., and Bedwell D.M. The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences in Saccharomyces cerevisiae. J. Mol. Biol. 251 (1995) 334-345
4. Chavatte L., Seit-Nebi A., Dubovaya V., and Favre A. The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosome. EMBO J. 21 (2002) 5302-5311
5. Eurwilaichitr L., Graves F.M., Stansfield I., and Tuite M.F. The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae. Mol. Microbiol. 32 (1999) 485-496
6. Frolova L.Y., Tsivkovskii R.Y., Sivolobova G.F., Oparina N.Y., Serpinsky O.I., Blinov V.M., Tatkov S.I., and Kisselev L.L. Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis. RNA 5 (1999) 1014-1020
7. Frolova L., Seit-Nebi A., and Kisselev L. Highly conserved NIKS tetrapeptide is functionally essential in eukaryotic translation termination factor eRF1. RNA 8 (2002) 129-136
8. Grentzmann G., Ingram J.A., Kelly P.J., Gesteland R.F., and Atkins J.F. A dual-luciferase reporter system for studying recoding signals. RNA 4 (1998) 479-486
9. Howard M.T., Shirts B.H., Petros L.M., Flanigan K.M., Gesteland R.F., and Atkins J.F. Sequence specificity of aminoglycoside-induced stop codon readthrough: potential implications for treatment of Duchenne muscular dystrophy. Ann. Neurol. 48 (2000) 164-169
10. Inagaki Y., and Doolittle W.F. Class I release factors in ciliates with variant genetic codes. Nucleic Acids Res. 29 (2001) 921-927
11. Inagaki Y., Blouin C., Doolittle W.F., and Roger A.J. Convergence and constraint in eukaryotic release factor 1 (eRF1) domain 1: the evolution of stop codon specificity. Nucleic Acids Res. 30 (2002) 532-544
12. Ito K., Ebihara K., and Nakamura Y. The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast. RNA 4 (1998) 958-972
13. Ito K., Uno M., and Nakamura Y. A tripeptide 'anticodon' deciphers stop codons in messenger RNA. Nature 403 (2000) 680-684
14. Kallmeyer A.K., Keeling K.M., and Bedwell D.M. Eukaryotic release factor 1 phosphorylation by CK2 protein kinase is dynamic but has little effect on the efficiency of translation termination in Saccharomyces cerevisiae. Eukaryot. Cell 5 (2006) 1378-1387
15. Keeling K.M., Lanier J., Du M., Salas-Marco J., Gao L., Kaenjak-Angeletti A., and Bedwell D.M. Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. RNA 10 (2004) 691-703
16. Kim O.T., Yura K., Go N., and Harumoto T. Newly sequenced eRF1s from ciliates: the diversity of stop codon usage and the molecular surfaces that are important for stop codon interactions. Gene 346 (2005) 277-286
17. Kisselev L., Ehrenberg M., and Frolova L. Termination of translation: interplay of mRNA, rRNAs and release factors?. EMBO J. 22 (2003) 175-182
18. Knight R.D., Freeland S.J., and Landweber L.F. The early evolution of the genetic code. Cell 101 (2000) 569-572
19. Lozupone C.A., Knight R.D., and Landweber L.F. The molecular basis of nuclear genetic code change in ciliates. Curr. Biol. 11 (2001) 65-74
20. Muramatsu T., Heckmann K., Kitanaka C., and Kuchino Y. Molecular mechanism of stop codon recognition by eRF1: a wobble hypothesis for peptide anticodons. FEBS Lett. 488 (2001) 105-109
21. Nakamura Y., and Ito K. A tripeptide discriminator for stop codon recognition. FEBS Lett. 514 (2002) 30-33
22. Nakamura Y., Ito K., and Ehrenberg M. Mimicry grasps reality in translation termination. Cell 101 (2000) 349-352
23. Salas-Marco J., and Bedwell D.M. GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination. Mol. Cell. Biol. 24 (2004) 7769-7778
24. Salas-Marco J., and Bedwell D.M. Discrimination between defects in elongation fidelity and termination efficiency provides mechanistic insights into translational readthrough. J. Mol. Biol. 348 (2005) 801-815
25. Salas-Marco J., Fan-Minogue H., Kallmeyer A.K., Klobutcher L.A., Farabaugh P.J., and Bedwell D.M. Distinct paths to stop codon reassignment by the variant-code organisms Tetrahymena and Euplotes. Mol. Cell. Biol. 26 (2006) 438-447
26. Seit-Nebi A., Frolova L., Justesen J., and Kisselev L. Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition. Nucleic Acids Res. 29 (2001) 3982-3987
27. Seit-Nebi A., Frolova L., and Kisselev L. Conversion of omnipotent translation termination factor eRF1 into ciliate-like UGA-only unipotent eRF1. EMBO Rep. 3 (2002) 881-886
28. Song H., Mugnier P., Das A.K., Webb H.M., Evans D.R., Tuite M.F., Hemmings B.A., and Barford D. The crystal structure of human eukaryotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis. Cell 100 (2000) 311-321
29. Tourancheau A.B., Tsao N., Klobutcher L.A., Pearlman R.E., and Adoutte A. Genetic code deviations in the ciliates: evidence for multiple and independent events. EMBO J. 14 (1995) 3262-3267
30. Zavialov A.V., Buckingham R.H., and Ehrenberg M. A posttermination ribosomal complex is the guanine nucleotide exchange factor for peptide release factor RF3. Cell 107 (2001) 115-124