Simulated microgravity activates apoptosis and NF-κB in mice testis

Molecular and Cellular Biochemistry

Volumn 313, Issue 1-2, 2008, Pages 71-78

  Sharma, Chidananda S ^a   Sarkar, Shubhashish ^b   Periyakaruppan, Adaikkappan ^b   Ravichandran, Prabakaran ^a   Sadanandan, Bindu ^b   Ramesh, Vani ^a   Thomas, Renard ^b   Hall, Joseph C ^a   Wilson, Bobby L ^b   Ramesh, Govindarajan T ^a,b  

^a NORFOLK STATE UNIVERSITY   (United States)

^b NASA HEADQUARTERS   (United States)

Author keywords

Apoptosis; Caspase; Microgravity; NF B; Testosterone

Indexed keywords

CASPASE 3; CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TESTOSTERONE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; IMMUNOHISTOCHEMISTRY; MALE; MICROGRAVITY; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN INDUCTION; SIMULATION; TESTIS ATROPHY; TESTIS FUNCTION; TESTIS WEIGHT;

ANIMALS; APOPTOSIS; BODY WEIGHT; CASPASE 3; CASPASE 8; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; ORGAN SIZE; TESTIS; TESTOSTERONE; WEIGHTLESSNESS;

ANIMALIA; MUS;

EID: 44449137869     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-008-9743-3     Document Type: Article

References (45)

1. Tou J, Ronca A, Grindeland R, Wade C (2002) Models to study gravitational biology of mammalian reproduction. Biol Reprod 67:1681-1687
2. Moody S, Gorwill R (2000) Developmental biology research in space: issues and directions in the era of the International Space Station. Dev Biol 228:1-5
3. Gretebeck R, Greenleaf J (1999) Utility of ground-based simulations of weightlessness. In: Lane HW (ed) Nutrition in space flight and weightlessness models. CRC Press, New York, pp 69-96
4. Morey-Holten ER, Globus RK (2002) The hindlimb unloading rodent model: technical aspects. J Appl Physiol 92:1367-1377
5. Amann R, Deaver D, Zirkin B et al (1992) Effects of microgravity or simulated launch on testicular function in rats. J Appl Physiol 73(Suppl):S174-S185
6. Philpott D, Sapp W, Williams C, Stevenson J, Black S, Corbett R (1985) Reduction of the spermatogonial population in rat testis flown on space lab-3. Physiologist 28(Suppl):S211-S212
7. Plakhta-Plakutina G, Serova L, Dreval A, Tarabrin S (1976) Effect of 22 days space flight factors on the state of the sex glands and reproductive capacity of rats. Kosm Biol Aviakosam Med 10:40-47
8. Strollo F (1999) Hormonal changes in humans during space flight. Adv Space Biol Med 7:99-129
9. Serova L, Denisova L, Baikova O (1989) The effect of microgravity on the reproductive function of male rats. Physiologist 32(Suppl):S29-S30
10. Perkins ND (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev 8:49-62
11. Armstrong JW, Kirby-Dobbels K, Chapes SK (1995) The effects of rM-CSF and rIL-6 therapy on immunosuppressed antiorthostatically suspended mice. J Appl Physiol 78:968-975
12. Armstrong JW, Nelson KA, Simske SJ, Luttges MW, Landolo JJ, Chapes SK (1993) Skeletal unloading causes organ specific changes in immune cell responses. J Appl Physiol 75:2734-2739
13. Chapes SK, Mastro AM, Sonnenfeld G, Berry WD (1992) Anti orthostatic suspension as a model for the effects of spaceflight on the immune system. J Leukoc Biol 54:227-235 227-235
14. Rehman J, Christ G, Alyskewycz M, Kerr E, Melman A (2000) Experimental hyper prolactinemia in a rat model: Alteration in centrally mediated neuroerectile mechanisms. Int J Impot Res 12:23-32
15. Stennicke HR, Salvesen GS (1998) Properties of the caspases. Biochim Biphys Acta 1387:17-31
16. Takahashi A, Alnemri ES, Lazebnik YA et al (1996) Cleavage of lamin A by Mch2, but not CPP32: Multiple interleukin 1 beta-converting enzyme related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci 93:8395-8400
17. Stein TP (2002) Space flight and oxidative stress. Nutrition 10:867-871
18. Hadley JA, Hall JC, O'Brien A, Ball R (1992) Effects of a simulated microgravitymodel on cell structure and function in rat testis and epididymis. J Appl Physiol 72:748-759
19. Zhou DX, Qiu SD, Wang ZY, Zhang J (2006) Effect of tail-suspension on the reproduction of adult male rats. Zhonghua Nan Ke Xue 12:326-329
20. Mendis-Handagama SM, Watkins PA, Gelber SJ, Scallen TJ (1998) The effect of chronic luteinizing hormone treatment on adult rat Leydig cells. Tissue Cell 30:64-73
21. Jannini EA, Ulisse S, Piersanti D et al (1993) Early thyroid hormone treatment in rats increases testis size and germ cell number. Endocrinology 132:2726-2728
22. Cooke PS (1991) Thyroid hormones and testis development: A model system for increasing testis growth and sperm production. Ann N Y Acad Sci 637:122-132
23. Francavilla S, D'Abrizio P, Rucci N et al (2000) Fas and Fas ligand expression in fetal and adult human testis with normal or deranged spermatogenesis. J Clin Endocrinol Metab 85:2692-2700
24. Kierzenbaum A (2001) Apoptosis during spermatogenesis: The thrill of being alive. Mol Reprod Dev 58:1-3
25. Scaffidi C, Fulda S, Srinivasan A et al (1998) Two CD 95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1678
26. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
27. Tesaric J, Martinez F, Rienzi L et al (2002) In-vitro effects of FSH and testosterone withdrawal on caspase activation and DNA fragmentation in different cell types of human seminiferous epithelium. Hum Reprod 17:1811-1819
28. Smithwich EB, Young LG (2001) Effects of androgen deprivation on the histology of adult chimpanzee testis. Tissue Cell 33:262-272
29. Blockers TM, Nieschlag E, Kreutz MR, Bergmann M (1994) Localization of follicle stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res 278:595-600
30. Kim JM, Ghosh SR, Weil AC, Zirkin BR (2001) Caspase-3 and caspase activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced testicular testosterone. Endocrinology 142:3801-3816
31. Lee J, Richburg JH, Shipp EB, Meistrich ML, Bockelheide K (1999) The Fas system, a regulator of testicular germ cell apoptosis is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 140:852-858
32. Pentikainen V, Erkkila K, Dunkel L (1999) Fas regulates germ cell apoptosis in the human testis in vitro. Am J Physiol 276:E310-E316
33. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJ (1993) Hormonal control of apoptotic cell death in the testis: Gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7:643-650
34. Troiano L, Fustini MF, Lovato E et al (1994) Apoptosis and spermatogenesis: Evidence from an in vivo model of testosterone withdrawal in the adult rat. Biochem Biophys Res Commun 202:1315-1321
35. Henriksen K, Hakovirta H, Parvinen M (1995) Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: In situ quantification in squash preparations after administration of ethane dimethane sulfonate. Endocrinology 136:3285-3291
36. Yin Y, Stahl BC, DeWolf WC, Morgentaler A (1998) Heat-induced testicular apoptosis occurs independently of hormonal depletion. Apoptosis 3:281-287
37. Blackburn DM, Gray AJ, Lioyd SC, Sheard CM, Foster PMD (1988) Comparison of the effects of the three isomers of dinitrobenzene on the testis in the rat. Toxicol Appl Pharmacol 92:54-64
38. Muguruma M, Yamazaki M, Okamura M, Moto M, Kashida Y, Mitsumori Y (2005) Molecular mechanism on the testicular toxicity of 1,3-dinitrobenzene in Sprague-Dawley rats: Preliminary study. Arch Toxicol 79:729-736
39. Kucharczak J, Simmons MJ, Fan YJ, Gé linas C (2003) To be, or not to be: NFkB is the answer - role of Rel/NF-kB in the regulation of apoptosis. Oncogene 22:8961-8982
40. Rocha S, Campbell KJ, Perkins ND (2003) p53 and Mdm2-independent repression of NF-kB transactivation by the ARF tumor suppressor. Mol Cell 12:15-25
41. Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND (2005) Regulation of NF-kB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24:1157-1169
42. Campbell KJ, Rocha S, Perkins ND (2004) Active repression of antiapoptotic gene expression by ReIA(p65) NF-kB. Mol Cell 13:853-865
43. Papa S, Bubici C, Zazzeroni F et al (2006) The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 13:712-729
44. Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K (2006) Reactive oxygen species mediate crosstalk between NF-kappaB and JNK. Cell Death Differ 13:730-737
45. Vousden KH, Lu X (2002) Live or let die: The cells response to p53. Nat Rev Cancer 2:594-604