메뉴 건너뛰기




Volumn 35, Issue SUPPL 3, 2008, Pages

Pharmacokinetics, Metabolites, and Preclinical Safety of Vinflunine

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; DIETHYLDITHIOCARBAMIC ACID; KETOCONAZOLE; NAVELBINE; VINBLASTINE; VINCA ALKALOID; VINCRISTINE; VINFLUNINE;

EID: 44449134634     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2008.01.007     Document Type: Article
Times cited : (16)

References (35)
  • 1
    • 0030870586 scopus 로고    scopus 로고
    • Vinca alkaloids in superacidic media: A method for creating a new family of antitumor derivatives
    • Fahy J., Duflos A., Ribet J.-P., et al. Vinca alkaloids in superacidic media: A method for creating a new family of antitumor derivatives. J Am Chem Soc 119 (1997) 8576-8577
    • (1997) J Am Chem Soc , vol.119 , pp. 8576-8577
    • Fahy, J.1    Duflos, A.2    Ribet, J.-P.3
  • 2
    • 0022453641 scopus 로고
    • Identification of a distinct class of vinblastine binding sites on microtubules
    • Jordan M.A., Margolis R.L., Himes R.H., and Wilson L. Identification of a distinct class of vinblastine binding sites on microtubules. J Mol Biol 187 (1986) 61-73
    • (1986) J Mol Biol , vol.187 , pp. 61-73
    • Jordan, M.A.1    Margolis, R.L.2    Himes, R.H.3    Wilson, L.4
  • 4
    • 0029020164 scopus 로고
    • Binding of vinblastine to phosphocellulose-purified and αβ-class III tubulin: The role of nucleotides and β-tubulin isotypes
    • Lobert S., Frankfurter A., and Correia J.J. Binding of vinblastine to phosphocellulose-purified and αβ-class III tubulin: The role of nucleotides and β-tubulin isotypes. Biochemistry 34 (1995) 8050-8060
    • (1995) Biochemistry , vol.34 , pp. 8050-8060
    • Lobert, S.1    Frankfurter, A.2    Correia, J.J.3
  • 5
    • 0031933672 scopus 로고    scopus 로고
    • The energetics of vinca alkaloid interactions with tubulin isotypes: Implications for drug efficacy and toxicity
    • Lobert S., Frankfurter A., and Correia J.J. The energetics of vinca alkaloid interactions with tubulin isotypes: Implications for drug efficacy and toxicity. Cell Motil Cytoskeleton 39 (1998) 107-121
    • (1998) Cell Motil Cytoskeleton , vol.39 , pp. 107-121
    • Lobert, S.1    Frankfurter, A.2    Correia, J.J.3
  • 6
    • 0031780236 scopus 로고    scopus 로고
    • A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity
    • Lobert S., Ingram J.W., Hill B.T., and Correia J.J. A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity. Mol Pharmacol 53 (1998) 908-915
    • (1998) Mol Pharmacol , vol.53 , pp. 908-915
    • Lobert, S.1    Ingram, J.W.2    Hill, B.T.3    Correia, J.J.4
  • 7
    • 33846570024 scopus 로고    scopus 로고
    • The thermodynamics of vinca alkaloid-induced tubulin spiral formation
    • Lobert S., Ingram J.W., and Correia J.J. The thermodynamics of vinca alkaloid-induced tubulin spiral formation. Biophys Chem 126 (2007) 50-58
    • (2007) Biophys Chem , vol.126 , pp. 50-58
    • Lobert, S.1    Ingram, J.W.2    Correia, J.J.3
  • 8
    • 0034601812 scopus 로고    scopus 로고
    • Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line
    • Lobert S., Fahy J., Hill B.T., Duflos A., Etievant C., and Correia J.J. Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry 39 (2000) 12053-12062
    • (2000) Biochemistry , vol.39 , pp. 12053-12062
    • Lobert, S.1    Fahy, J.2    Hill, B.T.3    Duflos, A.4    Etievant, C.5    Correia, J.J.6
  • 9
    • 0034665163 scopus 로고    scopus 로고
    • Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules
    • Ngan V.K., Bellman K., Panda D., Hill B.T., Jordan M.A., and Wilson L. Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res 60 (2000) 5045-5051
    • (2000) Cancer Res , vol.60 , pp. 5045-5051
    • Ngan, V.K.1    Bellman, K.2    Panda, D.3    Hill, B.T.4    Jordan, M.A.5    Wilson, L.6
  • 10
    • 0038674316 scopus 로고    scopus 로고
    • The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics
    • Okouneva T., Hill B.T., Wilson L., and Jordan M.A. The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol Cancer Ther 2 (2003) 427-436
    • (2003) Mol Cancer Ther , vol.2 , pp. 427-436
    • Okouneva, T.1    Hill, B.T.2    Wilson, L.3    Jordan, M.A.4
  • 11
    • 0032825746 scopus 로고    scopus 로고
    • Vinflunine, a new vinca alkaloid: Cytotoxicity, cellular accumulation and action on the interphasic and mitotic microtubule cytoskeleton of PtK2 cells
    • Jean-Decoster C., Brichese L., Barret J.-M., et al. Vinflunine, a new vinca alkaloid: Cytotoxicity, cellular accumulation and action on the interphasic and mitotic microtubule cytoskeleton of PtK2 cells. Anticancer Drugs 10 (1999) 537-543
    • (1999) Anticancer Drugs , vol.10 , pp. 537-543
    • Jean-Decoster, C.1    Brichese, L.2    Barret, J.-M.3
  • 12
    • 0034960408 scopus 로고    scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine
    • Ngan V.K., Bellman K., Hill B.T., Wilson L., and Jordan M.A. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol 60 (2001) 225-232
    • (2001) Mol Pharmacol , vol.60 , pp. 225-232
    • Ngan, V.K.1    Bellman, K.2    Hill, B.T.3    Wilson, L.4    Jordan, M.A.5
  • 13
    • 0034858240 scopus 로고    scopus 로고
    • Vinflunine, a second generation novel vinca alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers
    • Hill B.T. Vinflunine, a second generation novel vinca alkaloid with a distinctive pharmacological profile, now in clinical development and prospects for future mitotic blockers. Curr Pharm Des 7 (2001) 1199-1212
    • (2001) Curr Pharm Des , vol.7 , pp. 1199-1212
    • Hill, B.T.1
  • 14
    • 0035150786 scopus 로고    scopus 로고
    • Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model
    • Holwell S.E., Hill B.T., and Bibby M.C. Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. Br J Cancer 84 (2001) 290-295
    • (2001) Br J Cancer , vol.84 , pp. 290-295
    • Holwell, S.E.1    Hill, B.T.2    Bibby, M.C.3
  • 15
    • 0033105721 scopus 로고    scopus 로고
    • Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
    • Hill B.T., Fiebig H.-H., Waud W.R., Poupon M.-F., Colpaert F., and Kruczynski A. Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts. Eur J Cancer 35 (1999) 512-520
    • (1999) Eur J Cancer , vol.35 , pp. 512-520
    • Hill, B.T.1    Fiebig, H.-H.2    Waud, W.R.3    Poupon, M.-F.4    Colpaert, F.5    Kruczynski, A.6
  • 17
    • 0034918410 scopus 로고    scopus 로고
    • Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro
    • Etiévant C., Kruczynski A., Barret J.-M., Tait A.S., Kavallaris M., and Hill B.T. Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro. Cancer Chemother Pharmacol 48 (2001) 62-70
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 62-70
    • Etiévant, C.1    Kruczynski, A.2    Barret, J.-M.3    Tait, A.S.4    Kavallaris, M.5    Hill, B.T.6
  • 18
    • 33745208488 scopus 로고    scopus 로고
    • New therapies in the treatment of breast cancer
    • Roy V., and Perez E.A. New therapies in the treatment of breast cancer. Semin Oncol 33 Suppl 9 (2006) S3-S8
    • (2006) Semin Oncol , vol.33 , Issue.SUPPL. 9
    • Roy, V.1    Perez, E.A.2
  • 19
    • 0025935087 scopus 로고
    • Neurologic complications of chemotherapy
    • Macdonald D.R. Neurologic complications of chemotherapy. Neurol Clin 9 (1991) 955-967
    • (1991) Neurol Clin , vol.9 , pp. 955-967
    • Macdonald, D.R.1
  • 20
    • 0036158822 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neuropathy
    • Quasthoff S., and Hartung H.P. Chemotherapy-induced peripheral neuropathy. J Neurol 249 (2002) 9-17
    • (2002) J Neurol , vol.249 , pp. 9-17
    • Quasthoff, S.1    Hartung, H.P.2
  • 22
    • 0020055097 scopus 로고
    • Neurotoxicity of antineoplastic drugs
    • Kaplan R.S., and Wiernik P.H. Neurotoxicity of antineoplastic drugs. Semin Oncol 9 (1982) 103-130
    • (1982) Semin Oncol , vol.9 , pp. 103-130
    • Kaplan, R.S.1    Wiernik, P.H.2
  • 24
    • 0023088913 scopus 로고
    • Studies on the pathogenesis of vincristine-induced neuropathy
    • Sahenk Z., Brady S.T., and Mendell J.R. Studies on the pathogenesis of vincristine-induced neuropathy. Muscle Nerve 10 (1987) 80-84
    • (1987) Muscle Nerve , vol.10 , pp. 80-84
    • Sahenk, Z.1    Brady, S.T.2    Mendell, J.R.3
  • 25
    • 0035971541 scopus 로고    scopus 로고
    • An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models
    • Ogawa T., Mimura Y., Isowa K., et al. An antimicrotubule agent, TZT-1027, does not induce neuropathologic alterations which are detected after administration of vincristine or paclitaxel in animal models. Toxicol Lett 121 (2001) 97-106
    • (2001) Toxicol Lett , vol.121 , pp. 97-106
    • Ogawa, T.1    Mimura, Y.2    Isowa, K.3
  • 26
    • 0037819331 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours
    • Bennouna J., Fumoleau P., Armand J.-P., et al. Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours. Ann Oncol 14 (2003) 630-637
    • (2003) Ann Oncol , vol.14 , pp. 630-637
    • Bennouna, J.1    Fumoleau, P.2    Armand, J.-P.3
  • 27
    • 33646681175 scopus 로고    scopus 로고
    • Phase I study of vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks
    • Johnson P., Geldart T., Fumoleau P., Pinel M.-C., Nguyen L., and Judson I. Phase I study of vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks. Invest New Drugs 24 (2006) 223-231
    • (2006) Invest New Drugs , vol.24 , pp. 223-231
    • Johnson, P.1    Geldart, T.2    Fumoleau, P.3    Pinel, M.-C.4    Nguyen, L.5    Judson, I.6
  • 28
    • 27144495909 scopus 로고    scopus 로고
    • Phase I study of i.v. vinflunine given on a weekly schedule in previously untreated patients with advanced solid tumours
    • [Abstract 887]
    • Vermoken J.B., Stupp R., Nguyen L., et al. Phase I study of i.v. vinflunine given on a weekly schedule in previously untreated patients with advanced solid tumours. [Abstract 887]. Proc Am Soc Clin Oncol 22 (2003) 221
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 221
    • Vermoken, J.B.1    Stupp, R.2    Nguyen, L.3
  • 30
    • 3943056793 scopus 로고    scopus 로고
    • Vinflunine metabolism and disposition in cancer patients
    • [Abstract 495]
    • Focan C.N.J., Van Heugen J.-C., Kreutz F., et al. Vinflunine metabolism and disposition in cancer patients. [Abstract 495]. Proc Am Soc Clin Oncol 21 (2002) 124a
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Focan, C.N.J.1    Van Heugen, J.-C.2    Kreutz, F.3
  • 31
    • 33845978361 scopus 로고    scopus 로고
    • CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes
    • Zhao X.-P., Zhong J., Liu X.-Q., and Wang G.-J. CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes. Acta Pharmacol Sin 28 (2007) 118-124
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 118-124
    • Zhao, X.-P.1    Zhong, J.2    Liu, X.-Q.3    Wang, G.-J.4
  • 32
    • 44449150579 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) dose-adjusted study of IV vinflunine (VFL) in cancer patients with liver dysfunction (LD): Pharmacokinetic results
    • [Abstract 2423]
    • Paule B., Saliba F., Gil-Delgado M., et al. Phase I and pharmacokinetic (PK) dose-adjusted study of IV vinflunine (VFL) in cancer patients with liver dysfunction (LD): Pharmacokinetic results. [Abstract 2423]. J Clin Oncol 15 18S (2007) 102s
    • (2007) J Clin Oncol , vol.15 , Issue.18 S
    • Paule, B.1    Saliba, F.2    Gil-Delgado, M.3
  • 33
    • 38849175715 scopus 로고    scopus 로고
    • Phase III study of vinflunine versus docetaxel in patients with advanced non-small cell lung cancer previously treated with a platinum containing regimen
    • (abstr 7511)
    • Krzakowski M., Douillard J.Y., Jassem J., et al. Phase III study of vinflunine versus docetaxel in patients with advanced non-small cell lung cancer previously treated with a platinum containing regimen. J Clin Oncol 25 18S (2007) 387 (abstr 7511)
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 387
    • Krzakowski, M.1    Douillard, J.Y.2    Jassem, J.3
  • 34
    • 41549152173 scopus 로고    scopus 로고
    • Vinflunine: a new microtubule inhibitor agent
    • Bennouna J., Delord J.P., Campone M., et al. Vinflunine: a new microtubule inhibitor agent. Clin Cancer Res 14 6 (2008) 1625-1632
    • (2008) Clin Cancer Res , vol.14 , Issue.6 , pp. 1625-1632
    • Bennouna, J.1    Delord, J.P.2    Campone, M.3
  • 35
    • 36048996561 scopus 로고    scopus 로고
    • Phase II study of vinflunine in malignant pleural mesothelioma
    • Talbot D.C., Margery J., Dabouis G., et al. Phase II study of vinflunine in malignant pleural mesothelioma. J Clin Oncol 25 30 (2007) 4751-4756
    • (2007) J Clin Oncol , vol.25 , Issue.30 , pp. 4751-4756
    • Talbot, D.C.1    Margery, J.2    Dabouis, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.