Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-RP132L show the different intracellular location in vitro

Biomedical Research

Volumn 29, Issue 2, 2008, Pages 61-69

  Shimomura Kuroki, Junko ^a   Ubaidus, Sobhan ^b   Freitas, Paulo H L ^b   Li, Minqi ^b   Ishida, Yoko ^b   Saito, Naoaki ^b   Oda, Kimimitsu ^b   Shimooka, Shohachi ^a   Amizuka, Norio ^b  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP; MUTANT PROTEIN; PARATHYROID HORMONE RECEPTOR; RECEPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL SURFACE; CELLULAR DISTRIBUTION; CHONDRODYSPLASIA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; HORMONE TRANSPORT; IMMUNOREACTIVITY; IN VITRO STUDY; MOLECULAR WEIGHT; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; OSTEOBLAST; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT; WILD TYPE;

3T3 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; CYCLIC AMP; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SPACE; LEUCINE; MICE; OSTEOCHONDRODYSPLASIAS; PARATHYROID HORMONE; PROLINE; PROTEIN TRANSPORT; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

RATTUS;

EID: 44449134176     PISSN: 03886107     EISSN: 1880313X     Source Type: Journal    
DOI: 10.2220/biomedres.29.61     Document Type: Article

References (29)

1. Aarts M, Davidson D, Corluka A, Petroulakis E, Guo J, Bringhurst F, Galipeau J and Henderson J (2001) PTHrP promotes quiescence and survival of serum deprived chondrocytes by inhibiting rRNA synthesis. J Biol Chem 276, 37934-37943.
2. Amizuka N, Warshawsky H, Henderson JE, Goltzman D and Karaplis AC (1994) Parathyroid hormone-related peptide (PTHrP)-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J Cell Biol 126, 1611-1623.
3. Amizuka N, Karaplis AC, Henderson JE, Warshawsky H, Lipman ML, Matsuki Y, Ejiri S, Tanaka M, Izumi N, Ozawa H and Goltzman D (1995) Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development. Dev Biol 175, 166-176.
4. Amizuka N, Henderson JE, Hoshi K, Warshawsky H, Ozawa H, Goltzman D and Karaplis AC (1996) Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion. Endocrinology 137, 5055-5067.
5. Amizuka N, Lee HS, Kwan MY, Arazani A, Warshawsky H, Hendy GN, Ozawa H, White JH and Goltzman D (1997) Cell-specific expression of parathyroid hormone (PTH)/PTH-related peptide receptor gene in kidney from kidney specific and ubiquitous promoters. Endocrinology 138, 469-481.
6. Bernier SM and Goltzman D (1993) Regulation of expression of the chondrocytic phenotype in a skeletal cell line (CFK2) in vitro. J Bone Miner Res 8, 475-484.
7. Duchatelet S, Ostergaard E, Cortes D, Lemainque A and Julier C (2005) Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Hum Mol Genet 14, 1-5.
8. Hodsman AB, Fraher LJ, Watson PH, Ostbye T, Stitt LW, Adachi JD, Taves DH and Drost D (1997) A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 82, 620-628.
9. Hoogendam J, Farih-Sips H, Vynaendts LC, Lowik CW, Wit JM and Karperien M (2007) Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing Blomstrand osteochondrodysplasia types I and II. J Clin Endocrinol Metab 92, 1088-1095.
10. Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, Juppner H, Andrulis IL, Wunder JS and Alman BA (2002) A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat Genet 30, 306-310.
11. Ikegame M, Ishibashi O, Yoshizawa T, Shimomura J, Komori T, Ozawa H and Kawashina H (2001) Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture. J Bone Miner Res 16, 24-32.
12. Ishida Y, Komaru K, Ito M, Amaya Y, Kohno S and Oda K (2003) Tissue-nonspecific alkaline phosphatase with an Asp289-Val mutation fails to reach the cell surface and undergoes proteasome-mediated degradation. J Biochem (Tokyo) 134, 63-70.
13. Ito M, Amizuka N, Ozawa H and Oda K (2002) Retention at the cis-Golgi and delayed degradation of tissue-non-specific alkaline phosphatase with an Asn153-Asp substitution, a cause of perinatal hypophosphatasia. Biochem J 361, 473-480.
14. Jobert AS, Zhang P, Couvineau A, Bonaventure J, Roume J, Le Merrer M and Silve C (1998) Absence of functional receptor for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J Clin Invest 102, 34-40.
15. Jüppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, Kolakowski LF Jr, Hock J, Potts JT Jr, Kronenberg HM and Segre GV (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254, 1024-1026.
16. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM and Mulligan RC (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 8, 277-289.
17. Karaplis AC, He B, Nguyen MT, Young ID, Semeraro D, Ozawa H and Amizuka N (1998) Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia. Endocrinology 139, 5255-5258.
18. Kaufman RJ, Scheuner D, Schroder M, Shen X, Lee K, Liu CY and Arnold SM (2002) The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol 3, 411-421.
19. Lanske B, Karaplis AC, Lee K, Luz A, Vortkamp A. Pirro A, Karperien M, Defize LHK, Ho C, Mulligan RC. Abou-Samra AB, Juppner H, Segre GV and Kronenberg HM (1996) PTH/PTHrP receptor in early development and Indian Hedgehog-regulated bone growth. Science 273, 663-666.
20. Miao D, He B, Karaplis AC and Goltzman D (2002) Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109, 1173-1182.
21. Suda N, Gillespie MT, Traianedes K, Zhou H, Ho PWM, Hards DK, Allan EH, Martin TJ and Moseley JM (1996) Expression of parathyroid hormone-related protein in cells of osteoblast lineage. J Cell Physiol 166, 94-104.
22. Suzuki H, Amizuka N, Oda K, Li M, Yoshie H, Ohshuna H, Noda M and Maeda T (2005) Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. Arch Histol Cytol 68, 371-381.
23. Schipani E, Kruse K and Juppner H (1995) A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. Science 268, 98-100.
24. Schipani E, Langman CB, Parfift AM, Jensen GS, Kikuchi S, Koch SW, Cole WG and Juppner H (1996) Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. N Engl J Med 335, 708-714.
25. Thomas BE, Wittelsberger A, Woznica I, Hsieh MY, Monaghan P, Lee BK and Rosenblatt M (2007) Cysteine at position 217 in the intracellular loop 1 plays a critical role in human PTH receptor type 1 membrane translocation and function. J Bone Miner Res 22, 609-616.
26. Trombetta ES and Parodi AJ (2003) Quality control and protein folding in the secretory pathway. Annu Rev Cell Dev Biol 19, 649-676.
27. Yasuda T, Banville D, Rabbani SA, Hendy GN and Goltzman D (1989) Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol 3, 518-525.
28. Zhang P, Jobert AS, Couvineau A and Silve C (1999) A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J Clin Endocrinol Metab 83, 3365-3368.
29. Zhang K and Kaufman RJ (2004) Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279, 25935-25938.