Identification and early characterization of genetically modified NGF-producing neural stem cells grafted into the injured adult rat brain

Neurological Research

Volumn 30, Issue 3, 2008, Pages 244-250

  Pagani, Lucia ^a   Cenciarelli, Carlo ^b   Casalbore, Patrizia ^a   Budoni, Manuela ^b   Sposato, Valentina ^a   Aloe, Luigi ^a  

^a CNR   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Cell transplantation; NGF receptors; Paraquat; rhNGF producing NSC; Striatum

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN TYROSINE KINASE A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CULTURE MEDIUM; GENETIC ENGINEERING; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LENTIVIRINAE; MOUSE; NERVE CELL; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; CELL COUNT; CELLS, CULTURED; CORPUS STRIATUM; CULTURE MEDIA, CONDITIONED; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEURITES; NEURONS; RATS; RECEPTOR, TRKA; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSDUCTION, GENETIC;

EID: 44449122807     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/016164107X230667     Document Type: Article

References (25)

1. Lowell S, Benchoua A, Heavey B, et al. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol 2006; 4: 805-818
2. Kosaka N, Kodama M, Sasaki H, et al. FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation. FASEB J 2006; 20: 1484-1485
3. Ye P, D'Ercole AL. Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system. J Neurosci Res 2006; 83: 1-6
4. Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle 2005; 4: 1753-1757
5. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 2005; 310: 68-71
6. Levi-Montalcini R. The nerve growth factor 35 years later. Science 1987; 237: 1154-1162
7. Pyle AD, Lock LF, Donovan PJ. Neurotrophins mediate human embryonic stem cell survival. Nat Biotechnol 2006; 24: 344-350
8. Lorigados-Pedre L, Bergado-Rosado J. [Nerve growth factor in neurodegeneration and neurorestorative therapy]. Rev Neurol 2004; 38: 957-971
9. Kim DH, Gutin PH, Noble LJ, et al. Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. Neuroreport 1996; 7: 2221-2225
10. Tuszynski MH, Thal L, Pay M, et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005; 11: 551-555
11. Calzà L, Fernandez M, Giuliani A, et al. Stem cells and nervous tissue repair: From in vitro to in vivo. Prog Brain Res 2004; 146: 75-91
12. Bjorklund A, Dunnett SB, Brundin P, et al. Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol 2003; 2: 437-445
13. Lu P, Jones LL, Snyder EY, et al. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003; 181: 115-129
14. Philips MF, Mattiasson G, Wieloch T, et al. Neuroprotective and behavioral efficacy of nerve growth factor-transfected hippocampal progenitor cell transplants after experimental traumatic brain injury. J Neurosurg 2001; 94: 765-774
15. Temple S, Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Curr Opin Neurobiol 1999; 9: 135-141
16. Triaca V, Tirassa P, Aloe L. Presence of nerve growth factor and TrkA expression in the SVZ of EAE rats: Evidence for a possible functional significance. Exp Neurol 2005; 191: 53-64
17. Ossowska K, Wardas J, Smialowska M, et al. A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: An animal model of preclinical stages of Parkinson's disease? Eur J Neurosci 2005; 22: 1294-1304
18. Li XK, Guo AC, Zuo PP. Survival and differentiation of transplanted neural stem cells in mice brain with MPTP-induced Parkinson's disease. Acta Pharmacol Sin 2003; 24: 1192-1198
19. Cenciarelli C, Budoni M, Mercanti D, et al. In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system. Neurol Res 2006; 28: 488-492
20. Gascon E, Vutskits L, Zhang H, et al. Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro. Eur J Neurosci 2005; 21: 69-80
21. Tirassa P, Triaca V, Amendola T, et al. EGF and NGF injected into the brain of old mice enhance BDNF and ChAT in proliferating subventricular zone. J Neurosci Res 2003; 72: 557-564
22. Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000; 33: 199-227
23. Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 2001; 24: 1217-1281
24. Mufson EJ. The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease. J Neuropathol Exp Neurol 2005; 64: 263-272
25. Triaca V, Aloe L. Neuronal markers expression of NGF-primed bone marrow cells (BMCs) transplanted in the brain of 6-hydroxydopamine and ibotenic acid lesioned littermate mice. Neurosci Lett 2005; 384: 82-86