Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury

American Journal of Respiratory and Critical Care Medicine

Volumn 177, Issue 11, 2008, Pages 1215-1222

  Checkley, William ^a,c   Brower, Roy ^a   Korpak, Anna ^b   Thompson, B Taylor ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acute lung injury; Clinician practices; Mechanical ventilation

Indexed keywords

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROGNOSIS; TIDAL VOLUME; AIRWAY RESISTANCE; CLINICAL PRACTICE; COHORT ANALYSIS; METHODOLOGY; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY; RISK; STATISTICAL MODEL; STATISTICS;

AIRWAY RESISTANCE; CLINICAL TRIALS AS TOPIC; COHORT STUDIES; HOSPITAL MORTALITY; HUMANS; LOGISTIC MODELS; ODDS RATIO; PHYSICIAN'S PRACTICE PATTERNS; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RETROSPECTIVE STUDIES; TIDAL VOLUME;

EID: 44449110603     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200709-1424OC     Document Type: Article

References (39)

1. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. Incidence and outcomes of acute lung injury. N Engl J Med 2005;353:1685-1693.
2. The ARDS Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the ARDS. N Engl J Med 2000;342:1301-1308.
3. Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C. Metaanalysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. Am J Respir Crit Care Med 2002;166:1510-1514.
4. Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD. Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med 2004;32:1289-1293.
5. Kalhan R, Mikkelsen M, Dedhiya P, Christie J, Gaughan C, Lanken PN, Finkel B, Gallop R, Fuchs BD. Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med 2006;34:300-306.
6. Weinert CR, Gross CR, Marinelli WA. Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals. Am J Respir Crit Care Med 2003;167:1304-1309.
7. Young MP, Manning HL, Wilson DL, Mette SA, Riker RR, Leiter JC, Liu SK, Bates JT, Parsons PE. Ventilation of patients with acute lung injury and acute respiratory distress syndrome: has new evidence changed clinical practice? Crit Care Med 2004;32:1260-1265.
8. Thompson BT, Hayden D, Matthay MA, Brower R, Parsons PE. Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS. Chest 2001;120:1622-1627.
9. The ARDS Network. Ketoconazole for early treatment of acute lung injury and ARDS: a randomized controlled trial. JAMA 2000;283:1995-2002.
10. The ARDS Network. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and ARDS. Crit Care Med 2002;30:1-6.
11. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the ARDS. N Engl J Med 2004;351:327-336.
12. Wheeler AP, Bernard GR, Thompson BT, Schoenfeld D, Wiedemann HP, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med 2006;354:2213-2224.
13. Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B, Connors AF Jr, Hite RD, Harabin AL; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006;354:2564-2575.
14. Checkley W, Brower RG, Korpak A, Thompson BT. Effects of early management of mechanical ventilation (MV) on hospital mortality in patients with acute lung injury. Am J Respir Crit Care Med 2007;175:A245.
15. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, Thompson BT, Ancukiewicz M; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006;354:1671-1684.
16. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-824.
17. Berry G, Armitage P. Statistical methods in medical research, 3rd ed. London: Blackwell Publishing; 1994. p. 403.
18. Zar J. Biostatistical analysis, 2nd ed. Englewood Cliffs, NJ: Prentice Hall; 1985. pp. 145, 315.
19. Hastie T, Tibshirani RJ. Generalized additive models. London: Chapman & Hall; 1995. p. 95.
20. Agresti A. Categorical data analysis, 2nd ed. Hoboken, NJ: John Wiley & Sons; 2002. pp. 168, 175, 219.
21. Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998;338:347-354.
22. Villar J, Kacmarek RM, Perez-Mendez L, Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 2006;34:1311-1318.
23. Kallet RH, Jasmer RM, Pittet JF, Tang JF, Campbell AR, Dicker R, Hemphill C, Luce JM. Clinical implementation of the ARDS Network protocol is associated with reduced hospital mortality compared with historical controls. Crit Care Med 2005;33:925-929.
24. Jardin F, Fellahi JL, Beauchet A, Vieillard-Baron A, Loubieres Y, Page B. Improved prognosis of acute respiratory distress syndrome 15 years on. Intensive Care Med 1999;25:936-941.
25. Hickling KG, Walsh J, Henderson S, Jackson R. Low mortality rate in adult respiratory distress syndrome using low-volume, pressurelimited ventilation with permissive hypercapnia: a prospective study. Crit Care Med 1994;22:1568-1578.
26. Webb HH, Tierney DF. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures: protection by positive end-expiratory pressure. Am Rev Respir Dis 1974;110:556-565.
27. Parker JC, Hernandez LA, Longenecker GL, Peevy K, Johnson W. Lung edema caused by high peak inspiratory pressures in dogs: role of increased microvascular filtration pressure and permeability. Am Rev Respir Dis 1990;142:321-328.
28. Dreyfuss D, Basset G, Soler P, Saumon G. Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 1985;132:880-884.
29. Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M. Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation: an experimental study. Am Rev Respir Dis 1987;135:312-315.
30. Stuber F, Wrigge H, Schroeder S, Wetegrove S, Zinserling J, Hoeft A, Putensen C. Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury. Intensive Care Med 2002;28:834-841.
31. Villar J, Perez-Mendez L, Aguirre-Jaime A, Kacmarek RM. Why are physicians so skeptical about positive randomized controlled clinical trials in critical care medicine? Intensive Care Med 2005;31:196-204.
32. Ferguson ND, Frutos-Vivar F, Esteban A, Anzueto A, Alia I, Brower RG, Stewart TE, Apezteguia C, Gonzalez M, Soto L, et al.; Mechanical Ventilation International Study Group. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med 2005;33:21-30.
33. Deans KJ, Minneci PC, Suffredini AF, Danner RL, Hoffman WD, Ciu X, Klein HG, Schechter AN, Banks SM, Eichacker PQ, et al. Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols. Crit Care Med 2007;35:1509-1516.
34. Brower R, Thompson BT; ARDS Network Investigators. Tidal volumes in acute respiratory distress syndrome: one size does not fit all. Crit Care Med 2006;34:263-264.
35. Suter P, Fairley HB, Isenberg MD. Effect of tidal volume and positive end-expiratory pressure on compliance during mechanical ventilation. Chest 1978;73:158-162.
36. Berwick DM. Disseminating innovations in health care. JAMA 2003;289:1969-1975.
37. West JB. The physiological challenges of the 1952 Copenhagen poliomyelitis epidemic and a renaissance in clinical respiratory physiology. J Appl Physiol 2005;99:424-432.
38. Tobin MJ. Culmination of an era in research on the acute respiratory distress syndrome. N Engl J Med 2000;342:1360-1361.
39. Slutsky AS. Mechanical ventilation. American College of Chest Physicians' Consensus Conference. Chest 1993;104:1833-1859.