Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s

Planta Medica

Volumn 70, Issue 8, 2004, Pages 753-757

  Sang, Kyu Lee ^a   Nam, Hee Kim ^a   Lee, Jaeick ^b   Dong, Hyun Kim ^b   Eung, Seok Lee ^a   Choi, Han Gon ^a   Hyeun, Wook Chang ^a   Jahng, Yurngdong ^a   Tae, Cheon Jeong ^a  

^a Yeungnam University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Cytochrome P450s; Evodia rutaecarpa; Induction; Liver microsomes; Metabolism; Metabolites; Rutaceae; Rutaecarpine

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 2E1; EVODIA ROTAECARPA EXTRACT; PHENOBARBITAL; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RUTAECARPINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; PROTEIN FUNCTION; RAT; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ALKALOIDS; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; EVODIA; FRUIT; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RUTACEAE;

EID: 4444364510     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827207     Document Type: Article

References (15)

1. Chiou WF, Liao JP, Chen CF. Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa. J Nat Prod 1996; 59: 374-8
2. Moon TC, Murakami M, Kudo I, Son KH, Kang SS, Chang HW. A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflamm Res 1999; 48: 621-5
3. Woo HG, Lee CH, Noh MS, Lee JJ, Jung YS, Baik EJ, Moon CH, Lee SH. Rutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages. Planta Med 2001; 67: 505-9
4. Lee SH, Kim SI, Park JG, Lee ES, Jahng Y. A simple synthesis of rutaecarpine. Heterocycles 2001; 55: 1555-9
5. Guengerich FP. Role of cytochrome P450 enzymes in drug-drug interactions. Adv Phamacol 1997; 43: 7-35
6. Ueng YF, Wang JJ, Lin LC, Park SS, Chen CF. Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa. Life Sci 2001; 70: 207-17
7. Ueng YF, Ko HC, Chen CF, Wang JJ, Chen KT. Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice. Life Sci 2002; 71: 1267-77
8. Ueng YF, Jan WC, Lin LC, Chen TL, Guengerich FP, Chen CF. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metab Dispos 2002; 30: 349-53
9. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75
10. Kim HJ, Chun YJ, Park JD, Kim SI, Roh JK, Jeong TC. Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by red ginseng saponin through cytochrome P450 inhibition. Planta Medica 1997; 63: 415-8
11. Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995; 217: 966-71
12. Jeong TC, Gu HK, Chun YJ, Yun CH, Han SS, Roh JK. Effects of β-ionone on the expression of cytochrome P450 s and NADPH-cytochrome P450 reductase in Sprague Dawley rats. Chem-Biol Interact 1998; 114: 97-107
13. Ko HC, Tsai TH, Chou CJ, Hsu SY, Li SY, Chen CF. High-performance liquid chromatographic determination of rutaecarpine in rat plasma: application to a pharmacokinetic study. J Chromatogr B 1994; 655: 27-31
14. Lee SK, Lee J, Lee ES, Jahng Y, Kim DH, Jeong TC. Characterization of in vitro metabolites of rutaecarpine in rat liver microsomes using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2004; 18: 1073-80
15. Wrighton SA, Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 1992; 22: 1-21