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Volumn 4, Issue 4, 2004, Pages 511-522

Pemetrexed: A novel antifolate agent enters clinical practice

Author keywords

Antifolate; Mesothelioma; Non small cell lung cancer; Pemetrexed; Solid tumors

Indexed keywords

ANTIEMETIC AGENT; CARBOPLATIN; CISPLATIN; CYANOCOBALAMIN; DEXAMETHASONE; DOCETAXEL; DOXORUBICIN; FLUOROURACIL; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; GEMCITABINE; LOMETREXOL; METHOTREXATE; NAVELBINE; OXALIPLATIN; PACLITAXEL; PEMETREXED; RALTITREXED;

EID: 4444351115     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.4.4.511     Document Type: Review
Times cited : (17)

References (65)
  • 1
    • 0031852056 scopus 로고    scopus 로고
    • Multiple folate enzyme inhibition: M7echanism of a novel pyrrolopyrimidine-based antifolate LY-231514 (MTA)
    • Shih C, Habeck LL, Mendelsohn LG, Chen VJ, Schultz RM. Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY-231514 (MTA). Adv. Enzyme Regul. 38, 135-152 (1998).
    • (1998) Adv. Enzyme Regul. , vol.38 , pp. 135-152
    • Shih, C.1    Habeck, L.L.2    Mendelsohn, L.G.3    Chen, V.J.4    Schultz, R.M.5
  • 2
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang NJ, Rusthoven JJ, Symanowski J et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol. 21, 2636-2644 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 3
    • 2442661845 scopus 로고    scopus 로고
    • Randomized Phase III trial of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy
    • Hanna NH, Shepherd FA, Fossella JR et al. Randomized Phase III trial of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy. J. Clin. Oncol. 22, 1589-1597 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1589-1597
    • Hanna, N.H.1    Shepherd, F.A.2    Fossella, J.R.3
  • 4
    • 0026494947 scopus 로고
    • A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-D] pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
    • Taylor EC, Kuhnt D, Shih C et al. A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-D] pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J. Med. Chem. 35, 4450-4454 (1992).
    • (1992) J. Med. Chem. , vol.35 , pp. 4450-4454
    • Taylor, E.C.1    Kuhnt, D.2    Shih, C.3
  • 5
    • 0032914341 scopus 로고    scopus 로고
    • Biological activity of the multitargeted antifolate, MTA (LY-231514), in human cell lines with different resistance mechanisms to antifolate drugs
    • Schultz RM, Chen VJ, Bewley JR, Roberts EF, Shih C, Dempsey JA. Biological activity of the multitargeted antifolate, MTA (LY-231514), in human cell lines with different resistance mechanisms to antifolate drugs. Semin. Oncol. 26, 68-73 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 68-73
    • Schultz, R.M.1    Chen, V.J.2    Bewley, J.R.3    Roberts, E.F.4    Shih, C.5    Dempsey, J.A.6
  • 6
    • 0032964902 scopus 로고    scopus 로고
    • Cellular pharmacology of MTA: A correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
    • Chen VJ, Bewley JR, Andis SL et al. Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Semin. Oncol. 26, 48-54 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 48-54
    • Chen, V.J.1    Bewley, J.R.2    Andis, S.L.3
  • 7
    • 0030891198 scopus 로고    scopus 로고
    • LY-231514, a pyrrolo[2,3-D] pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C, Chen VJ, Gossett LS et al. LY-231514, a pyrrolo[2,3-D] pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 57, 1116-1123 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 8
    • 0002454641 scopus 로고    scopus 로고
    • Preclinical pharmacology studies and the clinical development of a novel multitargeted antifolate, MTA (LY-231514)
    • Jackman AL (Ed.), Humana Press, NJ, USA
    • Shih C, Thornton D. Preclinical pharmacology studies and the clinical development of a novel multitargeted antifolate, MTA (LY-231514). In: Antifolate Drugs in Cancer Therapy. Jackman AL (Ed.), Humana Press, NJ, USA, 183-201 (1999).
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 183-201
    • Shih, C.1    Thornton, D.2
  • 9
    • 0032898580 scopus 로고
    • Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY-231514
    • Schultz RM, Patel VF, Worzalla JF. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY-231514. Anticancer Res. 19, 437-443 (1991).
    • (1991) Anticancer Res. , vol.19 , pp. 437-443
    • Schultz, R.M.1    Patel, V.F.2    Worzalla, J.F.3
  • 10
    • 0032994840 scopus 로고    scopus 로고
    • Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines
    • van Triest B, Pinedo HM, van Hensbergen Y et al. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines. Clin. Cancer Res. 5, 643-654 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 643-654
    • van Triest, B.1    Pinedo, H.M.2    van Hensbergen, Y.3
  • 11
    • 0032936786 scopus 로고    scopus 로고
    • Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates
    • Sierra EE, Goldman ID. Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin. Oncol. 26, 11-23 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 11-23
    • Sierra, E.E.1    Goldman, I.D.2
  • 12
    • 85047688457 scopus 로고    scopus 로고
    • Pemetrexed (Alimta): A novel multitargeted antifolate agent
    • Adjei AA. Pemetrexed (Alimta): a novel multitargeted antifolate agent. Expert Rev. Anticancer Ther. 3, 145-156 (2003).
    • (2003) Expert Rev. Anticancer Ther. , vol.3 , pp. 145-156
    • Adjei, A.A.1
  • 15
    • 0023699993 scopus 로고    scopus 로고
    • Formation and retention and biological activity of N10-propargyl-4-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro
    • Sikora E, Jackman AL, Newell DR, Calvert AH. Formation and retention and biological activity of N10-propargyl-4-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro. Biochem. Pharmacol. 37, 4047-4054 (1998).
    • (1998) Biochem. Pharmacol. , vol.37 , pp. 4047-4054
    • Sikora, E.1    Jackman, A.L.2    Newell, D.R.3    Calvert, A.H.4
  • 16
    • 0032833775 scopus 로고    scopus 로고
    • Glutamyl hydrolase and the multitargeted antifolate LY-231514
    • Rhee MS, Ryan TJ, Galivan J. Glutamyl hydrolase and the multitargeted antifolate LY-231514. Cancer Chemother. Pharmacol. 44, 427-432 (1999).
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 427-432
    • Rhee, M.S.1    Ryan, T.J.2    Galivan, J.3
  • 17
    • 0032943329 scopus 로고    scopus 로고
    • Glutamyl hydrolase: Properties and pharmacologic impact
    • Galivan J, Ryan T, Rhee M, Yao R, Chave K. Glutamyl hydrolase: properties and pharmacologic impact. Semin. Oncol. 26, 33-37 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 33-37
    • Galivan, J.1    Ryan, T.2    Rhee, M.3    Yao, R.4    Chave, K.5
  • 18
    • 0033817515 scopus 로고    scopus 로고
    • The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate
    • Zhao R, Babani S, Gao F, Liu L, Goldman ID. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate. Clin. Cancer Res. 6, 3687-3695 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3687-3695
    • Zhao, R.1    Babani, S.2    Gao, F.3    Liu, L.4    Goldman, I.D.5
  • 19
    • 18244378306 scopus 로고    scopus 로고
    • Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis
    • Mauritz R, Peters GJ, Priest DG et al. Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochem. Pharmacol. 63, 105-115 (2002).
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 105-115
    • Mauritz, R.1    Peters, G.J.2    Priest, D.G.3
  • 20
    • 0028849683 scopus 로고
    • Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY-231514, using the modified continual reassessment method for dose escalation
    • Rinaldi DA. Burris HA, Dorr FA et al. Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY-231514, using the modified continual reassessment method for dose escalation. J. Clin. Oncol. 13, 2842-2850 (1995).
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2842-2850
    • Rinaldi, D.A.1    Burris, H.A.2    Dorr, F.A.3
  • 21
    • 15644372742 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of LY-231514, the multitargeted antifolate
    • McDonald AC, Vasey PA, Adams L et al. A Phase I and pharmacokinetic study of LY-231514, the multitargeted antifolate. Clin. Cancer Res. 4, 605-610 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , pp. 605-610
    • McDonald, A.C.1    Vasey, P.A.2    Adams, L.3
  • 22
    • 0032859301 scopus 로고    scopus 로고
    • A Phase I evaluation of multitargeted antifolate (MTA, LY-231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation
    • Rinaldi DA, Kuhn JG, Burris HA et al. A Phase I evaluation of multitargeted antifolate (MTA, LY-231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. Cancer Chemother. Pharmacol. 44, 372-380 (1999).
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 372-380
    • Rinaldi, D.A.1    Kuhn, J.G.2    Burris, H.A.3
  • 23
    • 17644404490 scopus 로고    scopus 로고
    • Phase I study of pemetrexed (LY-231514) with vitamin supplementation in patients with locally advanced or metastatic cancer
    • (Abstract 532)
    • Hammond LA, Forero M, Beeram B et al. Phase I study of pemetrexed (LY-231514) with vitamin supplementation in patients with locally advanced or metastatic cancer. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 532).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Hammond, L.A.1    Forero, M.2    Beeram, B.3
  • 24
    • 17644405547 scopus 로고    scopus 로고
    • A Phase I dose-finding study of pemetrexed with folic acid (FA) and vitamin B12 in Japanese patients with solid tumors
    • (Abstract 632)
    • Nakagawa K, Kudoh S, Matsui S et al. A Phase I dose-finding study of pemetrexed with folic acid (FA) and vitamin B12 in Japanese patients with solid tumors. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 632).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Nakagawa, K.1    Kudoh, S.2    Matsui, S.3
  • 26
    • 0003292350 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of pemetrexed disodium (LY-231514, MTA, Alimta) in patients (pts) with impaired renal function
    • (Abstract 368)
    • Takimoto C, Baker S, Sweeney CJ et al. Phase I and pharmacokinetic study of pemetrexed disodium (LY-231514, MTA, Alimta) in patients (pts) with impaired renal function. Proc. Am. Soc. Clin. Oncol. (2001) (Abstract 368).
    • (2001) Proc. Am. Soc. Clin. Oncol.
    • Takimoto, C.1    Baker, S.2    Sweeney, C.J.3
  • 27
    • 0032964203 scopus 로고    scopus 로고
    • MTA (LY-231514) in combination treatment regimens using human tumor xenografts and the EMT-6 murine mammary carcinoma
    • Teicher BA, Alvarez E, Liu P et al. MTA (LY-231514) in combination treatment regimens using human tumor xenografts and the EMT-6 murine mammary carcinoma. Semin. Oncol. 26, 55-62 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 55-62
    • Teicher, B.A.1    Alvarez, E.2    Liu, P.3
  • 28
    • 0033993714 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors
    • Adjei AA, Erlichman C, Sloan JA et al. Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors. J. Clin. Oncol. 18, 1748-1757 (2000).
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1748-1757
    • Adjei, A.A.1    Erlichman, C.2    Sloan, J.A.3
  • 29
    • 0033179374 scopus 로고    scopus 로고
    • Cell cycle modulation by a multitargeted antifolate, LY-231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma
    • Tonkinson JL, Worzalla JF, Teng CH, Mendelsohn LG. Cell cycle modulation by a multitargeted antifolate, LY-231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma. Cancer Res. 59, 3671-3676 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3671-3676
    • Tonkinson, J.L.1    Worzalla, J.F.2    Teng, C.H.3    Mendelsohn, L.G.4
  • 30
    • 0032964125 scopus 로고    scopus 로고
    • Preliminary results of a Phase I study with MTA (LY-231514) in combination with cisplatin in patients with solid tumors
    • Thodtmann R, Depenbrock H, Blatter J, Johnson RD, van Oosterom A, Hanauske AR. Preliminary results of a Phase I study with MTA (LY-231514) in combination with cisplatin in patients with solid tumors. Semin. Oncol. 26, 89-93 (1999).
    • (1999) Semin. Oncol. , vol.26 , pp. 89-93
    • Thodtmann, R.1    Depenbrock, H.2    Blatter, J.3    Johnson, R.D.4    van Oosterom, A.5    Hanauske, A.R.6
  • 31
    • 20244374653 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma
    • Hughes A, Calvert P, Azzabi A et al. Phase I clinical and pharmacokinetic study of pemetrexed and carboplatin in patients with malignant pleural mesothelioma. J. Clin. Oncol. 20, 3533-3544 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3533-3544
    • Hughes, A.1    Calvert, P.2    Azzabi, A.3
  • 32
    • 0003205742 scopus 로고    scopus 로고
    • Pemetrexed/oxaliplatin combination: Results of a Phase I study in metastatic solid tumors
    • (Abstract 427)
    • Misset JL, Gamelin E, Campone M et al. Pemetrexed/oxaliplatin combination: results of a Phase I study in metastatic solid tumors. Proc. Am. Soc. Clin. Oncol. (2002) (Abstract 427).
    • (2002) Proc. Am. Soc. Clin. Oncol.
    • Misset, J.L.1    Gamelin, E.2    Campone, M.3
  • 33
    • 0003347578 scopus 로고    scopus 로고
    • Phase I trial of pemetrexed (Alimta™) and vinorelbine in patients (pts) with advanced cancer
    • (Abstract 2102)
    • Millward M, Clarke S, Beale P et al. Phase I trial of pemetrexed (Alimta™) and vinorelbine in patients (pts) with advanced cancer. Proc. Am Soc. Clin. Oncol. (2001) (Abstract 2102).
    • (2001) Proc. Am Soc. Clin. Oncol.
    • Millward, M.1    Clarke, S.2    Beale, P.3
  • 35
    • 4444360108 scopus 로고    scopus 로고
    • An ongoing study of pemetrexed plus chest radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancers
    • (Abstract 515P)
    • Vokes EE, George CM, Szeto L et al. An ongoing study of pemetrexed plus chest radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancers. Lung Cancer (2002) (Abstract 515P).
    • (2002) Lung Cancer
    • Vokes, E.E.1    George, C.M.2    Szeto, L.3
  • 36
    • 0034861227 scopus 로고    scopus 로고
    • Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumors
    • Hanauske AR, Chen V, Paoletti P, Niyikiza, C. Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist 6, 363-373 (2001).
    • (2001) Oncologist , vol.6 , pp. 363-373
    • Hanauske, A.R.1    Chen, V.2    Paoletti, P.3    Niyikiza, C.4
  • 37
    • 0029883293 scopus 로고    scopus 로고
    • Augmentation of the therapeutic activity of lometrexol - (6-R)5,10-dideazatetrahydrofolate - By oral folic acid
    • Alati T, Worzalla JF, Shih C et al. Augmentation of the therapeutic activity of lometrexol - (6-R)5,10-dideazatetrahydrofolate - by oral folic acid. Cancer Res. 56, 2331-2335 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 2331-2335
    • Alati, T.1    Worzalla, J.F.2    Shih, C.3
  • 38
    • 0033966061 scopus 로고    scopus 로고
    • Weekly lometrexol with daily oral folic acid is appropriate for Phase II evaluation
    • Roberts JD, Poplin EA, Tombes MB et al. Weekly lometrexol with daily oral folic acid is appropriate for Phase II evaluation. Cancer Chemother. Pharmacol. 45, 103-110 (2000).
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 103-110
    • Roberts, J.D.1    Poplin, E.A.2    Tombes, M.B.3
  • 39
    • 0029808129 scopus 로고    scopus 로고
    • A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid
    • Laohavinij S, Wedge SR, Lind MJ et al. A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid. Invest. New Drugs 14, 325-335 (1996).
    • (1996) Invest. New Drugs , vol.14 , pp. 325-335
    • Laohavinij, S.1    Wedge, S.R.2    Lind, M.J.3
  • 40
    • 0031730802 scopus 로고    scopus 로고
    • Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY-231514
    • Worzalla JF, Shih C, Schultz RM. Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY-231514. Anticancer Res. 18, 3235-3239 (1998).
    • (1998) Anticancer Res. , vol.18 , pp. 3235-3239
    • Worzalla, J.F.1    Shih, C.2    Schultz, R.M.3
  • 41
    • 0036562507 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
    • Niyikiza C, Baker SD, Seitz DE et al. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol. Cancer Ther. 1, 545-552 (2002).
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 545-552
    • Niyikiza, C.1    Baker, S.D.2    Seitz, D.E.3
  • 42
    • 0028223165 scopus 로고
    • Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies
    • Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am. J. Med. 96, 239-246 (1994).
    • (1994) Am. J. Med. , vol.96 , pp. 239-246
    • Savage, D.G.1    Lindenbaum, J.2    Stabler, S.P.3    Allen, R.H.4
  • 43
    • 0027160548 scopus 로고
    • Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency
    • Stabler SP, Lindenbaum J, Savage DG, Allen RH. Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood 81, 3404-3413 (1993).
    • (1993) Blood , vol.81 , pp. 3404-3413
    • Stabler, S.P.1    Lindenbaum, J.2    Savage, D.G.3    Allen, R.H.4
  • 44
    • 0003340561 scopus 로고    scopus 로고
    • Vitamin B12 and folate reduce toxicity of Alimta (pemetrexed disodium, LY-231514, MTA) a novel antifolate/antimetabolite
    • (Abstract 300)
    • Bunn P, Paoletti P, Niyikiza C et al. Vitamin B12 and folate reduce toxicity of Alimta (pemetrexed disodium, LY-231514, MTA) a novel antifolate/antimetabolite. Proc. Am. Soc. Clin. Oncol. (2001) (Abstract 300).
    • (2001) Proc. Am. Soc. Clin. Oncol.
    • Bunn, P.1    Paoletti, P.2    Niyikiza, C.3
  • 45
    • 0032908148 scopus 로고    scopus 로고
    • Multitargeted antifolate LY-231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: A Phase II study
    • National Cancer Institute of Canada Clinical Trials Group
    • Rusthoven JJ, Eisenhauer E, Butts C et al. Multitargeted antifolate LY-231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: a Phase II study. National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 17, 1194 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1194
    • Rusthoven, J.J.1    Eisenhauer, E.2    Butts, C.3
  • 48
    • 0037842139 scopus 로고    scopus 로고
    • Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
    • Scagliotti GV, Shin DM, Kindler HL et al. Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J. Clin. Oncol. 21, 1556-1561 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1556-1561
    • Scagliotti, G.V.1    Shin, D.M.2    Kindler, H.L.3
  • 49
    • 0035985288 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed disodium (Alimta, LY-231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer
    • Clarke SJ, Abratt P, Goedhals L, Boyer MJ, Millward MJ, Ackland SP. Phase II trial of pemetrexed disodium (Alimta, LY-231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer. Ann. Oncol. 13, 737-741 (2002).
    • (2002) Ann. Oncol. , vol.13 , pp. 737-741
    • Clarke, S.J.1    Abratt, P.2    Goedhals, L.3    Boyer, M.J.4    Millward, M.J.5    Ackland, S.P.6
  • 50
    • 0037352426 scopus 로고    scopus 로고
    • Alimta (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: A Phase II study
    • Smit EF, Mattson K, von Pawel J, Manegold C, Clarke S, Postmus PE. Alimta (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a Phase II study. Ann Oncol. 14, 455-460 (2003).
    • (2003) Ann. Oncol. , vol.14 , pp. 455-460
    • Smit, E.F.1    Mattson, K.2    von Pawel, J.3    Manegold, C.4    Clarke, S.5    Postmus, P.E.6
  • 51
    • 0042010018 scopus 로고    scopus 로고
    • Second-line chemotherapy for non-small cell lung cancer
    • Shepherd FA. Second-line chemotherapy for non-small cell lung cancer. Expert Rev. Anticancer Ther. 3, 435-442 (2003).
    • (2003) Expert Rev. Anticancer Ther. , vol.3 , pp. 435-442
    • Shepherd, F.A.1
  • 52
    • 0034029995 scopus 로고    scopus 로고
    • Front-line treatment of advanced non-small-cell lung cancer with MTA (LY-231514, pemetrexed disodium, Alimta) and cisplatin: A multicenter Phase II trial
    • Manegold C, Gatzemeier U, von Pawel J et al. Front-line treatment of advanced non-small-cell lung cancer with MTA (LY-231514, pemetrexed disodium, Alimta) and cisplatin: a multicenter Phase II trial. Ann. Oncol. 11, 435-440 (2000).
    • (2000) Ann. Oncol. , vol.11 , pp. 435-440
    • Manegold, C.1    Gatzemeier, U.2    von Pawel, J.3
  • 53
    • 0035423962 scopus 로고    scopus 로고
    • Phase II study of pemetrexed disodium, a multitargeted antifolate and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma: A study of the National Cancer Institute of Canada Clinical Trials Group
    • Shepherd FA, Dancey J, Arnold A et al. Phase II study of pemetrexed disodium, a multitargeted antifolate and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group. Cancer 92, 595-600 (2001).
    • (2001) Cancer , vol.92 , pp. 595-600
    • Shepherd, F.A.1    Dancey, J.2    Arnold, A.3
  • 54
    • 0041296381 scopus 로고    scopus 로고
    • Phase II randomized study of pemetrexed plus carboplatin or oxaliplatin, as front-line chemotherapy in patients with locally advanced or metastatic non-small cell lung cancer
    • (Abstract 2513)
    • Scagliotti G, Kortsik C, Castellano D et al. Phase II randomized study of pemetrexed plus carboplatin or oxaliplatin, as front-line chemotherapy in patients with locally advanced or metastatic non-small cell lung cancer. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 2513).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Scagliotti, G.1    Kortsik, C.2    Castellano, D.3
  • 55
    • 1242325913 scopus 로고    scopus 로고
    • Alimta plus carboplatin in patients (pts) with advanced non-small-cell lung cancer (NSCLC): A Phase II trial
    • (Abstract 2580)
    • Zinner R, Obasaju FV, Fossella VA et al. Alimta plus carboplatin in patients (pts) with advanced non-small-cell lung cancer (NSCLC): a Phase II trial. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 2580).
    • (2003) Proc. Am. Soc. Clin. Oncol.
    • Zinner, R.1    Obasaju, F.V.2    Fossella, V.A.3
  • 56
    • 0034218999 scopus 로고    scopus 로고
    • Gemcitabine/Alimta in locally advanced or metastatic non-small-cell lung cancer
    • Ettinger DS. Gemcitabine/Alimta in locally advanced or metastatic non-small-cell lung cancer. Oncology (Huntingt) 14, 49-52 (2000).
    • (2000) Oncology (Huntingt) , vol.14 , pp. 49-52
    • Ettinger, D.S.1
  • 57
    • 0042009726 scopus 로고    scopus 로고
    • Phase II study of pemetrexed in breast cancer patients pretreated with anthracyclines
    • Martin M, Spielmann M, Namer M et al. Phase II study of pemetrexed in breast cancer patients pretreated with anthracyclines. Ann. Oncol. 14, 1246-1252 (2003).
    • (2003) Ann. Oncol. , vol.14 , pp. 1246-1252
    • Martin, M.1    Spielmann, M.2    Namer, M.3
  • 58
    • 0034949445 scopus 로고    scopus 로고
    • A Phase II study of pemetrexed disodium (LY-231514) in patients with locally recurrent or metastatic breast cancer
    • Miles DW, Smith IE, Coleman RE, Calvert AH, Lind MJ. A Phase II study of pemetrexed disodium (LY-231514) in patients with locally recurrent or metastatic breast cancer. Eur. J. Cancer 37, 1366-1371 (2001).
    • (2001) Eur. J. Cancer , vol.37 , pp. 1366-1371
    • Miles, D.W.1    Smith, I.E.2    Coleman, R.E.3    Calvert, A.H.4    Lind, M.J.5
  • 59
    • 0034655141 scopus 로고    scopus 로고
    • Activity of multitargeted antifolate (pemetrexed disodium, LY-231514) in patients with advanced colorectal carcinoma: Results from a Phase II study
    • John W, Picus J, Blanke CD et al. Activity of multitargeted antifolate (pemetrexed disodium, LY-231514) in patients with advanced colorectal carcinoma: results from a Phase II study. Cancer 88, 1807-1813 (2000).
    • (2000) Cancer , vol.88 , pp. 1807-1813
    • John, W.1    Picus, J.2    Blanke, C.D.3
  • 60
    • 0032693973 scopus 로고    scopus 로고
    • Phase II study of first-line LY-231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: An NCIC Clinical Trials Group study
    • Cripps C, Burnell M, Jolivet J et al. Phase II study of first-line LY-231514 (multi-targeted antifolate) in patients with locally advanced or metastatic colorectal cancer: an NCIC Clinical Trials Group study. Ann. Oncol. 10, 1175-1179 (1999).
    • (1999) Ann. Oncol. , vol.10 , pp. 1175-1179
    • Cripps, C.1    Burnell, M.2    Jolivet, J.3
  • 62
    • 0033981350 scopus 로고    scopus 로고
    • Phase II study of the multitargeted antifolate LY-231514 (Alimta, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer
    • Miller KD, Picus J, Blanke C et al. Phase II study of the multitargeted antifolate LY-231514 (Alimta, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer. Ann. Oncol. 11, 101-103 (2000).
    • (2000) Ann. Oncol. , vol.11 , pp. 101-103
    • Miller, K.D.1    Picus, J.2    Blanke, C.3
  • 63
    • 0035446433 scopus 로고    scopus 로고
    • Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck
    • Pivot X, Raymond E, Laguerre B et al. Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck. Br. J. Cancer 85, 649-655 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 649-655
    • Pivot, X.1    Raymond, E.2    Laguerre, B.3
  • 64
    • 0344851699 scopus 로고    scopus 로고
    • A Phase II trial of pemetrexed in patients with metastatic renal cancer
    • Thodtmann R, Sauter T, Weinknecht S et al. A Phase II trial of pemetrexed in patients with metastatic renal cancer. Invest. New Drugs 21, 353-358 (2003).
    • (2003) Invest. New Drugs , vol.21 , pp. 353-358
    • Thodtmann, R.1    Sauter, T.2    Weinknecht, S.3
  • 65
    • 0036987105 scopus 로고    scopus 로고
    • Pemetrexed in gastric cancer: Clinical experience and future perspectives
    • Celio L, Buzzoni R, Longarini R, Marchiano A, Bajetta E. Pemetrexed in gastric cancer: clinical experience and future perspectives. Semin. Oncol. 29, 63-68 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 63-68
    • Celio, L.1    Buzzoni, R.2    Longarini, R.3    Marchiano, A.4    Bajetta, E.5


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