Successful desensitization to fixed drug eruption: The presence of CD25+CD4+ T cells in the epidermis of fixed drug eruption lesions may be involved in the induction of desensitization

Dermatology

Volumn 209, Issue 1, 2004, Pages 29-32

  Teraki, Yuichi ^a   Shiohara, Tetsuo ^a  

^a KYORIN UNIVERSITY   (Japan)

Author keywords

Allopurinol; CD25+CD4+ T cells; Desensitization; Fixed drug eruption; Intraepidermal T cells

Indexed keywords

ALLOPURINOL; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; CASE REPORT; CELL POPULATION; DESENSITIZATION; DRUG ERUPTION; EPIDERMIS; FLOW CYTOMETRY; HUMAN; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INDUCTION; T LYMPHOCYTE;

ADULT; ALLOPURINOL; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; DESENSITIZATION, IMMUNOLOGIC; DRUG ERUPTIONS; FLOW CYTOMETRY; HUMANS; MALE;

EID: 4444350479     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000078583     Document Type: Article

References (19)

1. Korkij W, Soltani K: Fixed drug eruption: A brief review. Arch Dermatol 1984;120:520-524.
2. Meyrier A: Desensitisation in a patient with chronic renal disease and severe allergy to allopurinol. Br Med J 1976;ii:458.
3. Webster E, Panush RS: Allopurinol hypersensitivity in a patient with severe, chronic, tophaceous gout. Arthritis Rheum 1985;28:707-709.
4. Fam AG, Dunne SM, Iazzetta J, Paton TW: Efficacy and safety of desensitization to allopurinol following cutaneous reactions. Arthritis Rheum 2001;44:231-238.
5. Audiacana M, Echechipia S, Fernandez E, Urrutia I: Desensitization in a case of fixed drug eruption from allopurinol (abstract). Clin Exp Allergy 1990;20(suppl 1):121.
6. Garces M, Alonso L, Perez R, et al: Successful oral desensitization in a patient with fixed drug eruption from allopurinol (abstract). Allergy 1995;50(suppl 26):213.
7. Umpierrez A, Cuesta-Herranz J, De Las Heras M, Lluch-Bernal M, Figueredo E, Sastre J: Successful desensitization of a fixed drug eruption caused by allopurinol. J Allergy Clin Immunol 1998;101:286-287.
8. Kelso JM, Keating RM: Successful desensitization for treatment of a fixed drug eruption to allopurinol. J Allergy Clin Immunol 1996;97:1171-1172.
9. Hindsen M, Christensen OB, Gruic V, Lofberg H: Fixed drug eruption: An immunohistochemical investigation of the acute and healing phase. Br J Dermatol 1987;116:351-360.
10. Teraki Y, Moriya N, Shiohara T: Drug-induced expression of intercellular adhesion molecule-1 on lesional keratinocytes in fixed drug eruption. Am J Pathol 1994;145:550-560.
11. Teraki Y, Shiohara T: IFN-γ-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. J Allergy Clin Immunol 2003;112:609-615.
12. Read S, Powrie F: CD4+ regulatory T cells. Curr Opin Immunol 2001;13:644-649.
13. McHugh RS, Shevach EM: The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002;110:693-702.
14. Dubois B, Chapat L, Goubier A, Papiernik M, Nicolas JF, Kaiserlian D: Innate CD4+CD25+ regulatory T cells are required for oral tolerance and control CD8+ T cells mediating skin inflammation. Blood 2003;102:3295-3301.
15. Kursar M, Bonhagen K, Fensterle J, Kohler A, Hurwitz R, Kamradt T, et al: Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J Exp Med 2002;196:1585-1592.
16. Murakami M, Sakamoto A, Bender J, Kappler J, Marrack P: CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc Natl Acad Sci USA 2002;99:8832-8837.
17. Piccirillo CA, Shevach EM: Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 2001;167:1137-1140.
18. Kingsley CI, Karim M, Bushell AR, Wood KJ: CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002;168:1080-1086.
19. Nakamura K, Kitani A, Strober W: Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194:629-644.