Cellular anomalies underlying retinoid-induced phocomelia

Reproductive Toxicology

Volumn 19, Issue 1, 2004, Pages 103-110

  Zhou, Jian ^a   Kochhar, Devendra M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apoptosis; Chondrogenesis; Limb development; Phocomelia; Proliferation; Retinoid

Indexed keywords

RETINOIC ACID; RETINOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS; FORELIMB; LIMB BUD; LIMB DEVELOPMENT; LONG BONE; MESENCHYME; MOUSE; NONHUMAN; PHOCOMELIA; PREGNANCY; PRENATAL EXPOSURE; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CHONDROGENESIS; DISEASE MODELS, ANIMAL; ECTROMELIA; FEMALE; FORELIMB; LIMB BUD; MALE; MESODERM; MICE; MICE, INBRED STRAINS; PREGNANCY; TERATOGENS; TRETINOIN;

EID: 4444305190     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.06.012     Document Type: Article

References (42)

1. D.M. Kochhar Teratogenic activity of retinoic acid Acta Pathol. Microbiol. Scand. 70 3 1967 398 404
2. D.M. Kochhar Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid Teratology 7 3 1973 289 298
3. J.A. Geelen, and Hypervitaminosis A induced teratogenesis CRC Crit. Rev. Toxicol. 6 4 1979 351 375
4. L.A. Davis, and T.W. Sadler Effects of Vitamin A on endocardial cushion development in the mouse heart Teratology 24 2 1981 139 148
5. D.R. Newall, and J.R. Edwards The effect of vitamin A on fusion of mouse palates. II. retinyl palmitate, retinol, and retinoic acid in vitro Teratology 23 1 1981 125 130
6. E. Ruberte, P. Dolle, P. Chambon, and G. Morriss-Kay Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos Development 111 1 1991 45 60
7. P. Kastner, M. Mark, and P. Chambon Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83 6 1995 859 869
8. D.A. Frenz, W. Liu, V. Galinovic-Schwartz, and T.R. Van De Water Retinoic acid-induced embryopathy of the mouse inner ear Teratology 53 5 1996 292 303
9. G.B. Mulder, N. Manley, and L. Maggio-Price Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1 Teratology 58 6 1998 263 275
10. R.E. Shenefelt Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment Teratology 5 1 1972 103 118
11. J.H. Hersh, D.E. Danhauer, M.E. Hand, and B. Weisskopf Retinoic acid embryopathy: timing of exposure and effects on fetal development J. Am. Med. Assoc. 254 7 1985 909 910
12. M.N. Runner Epigenetically regulated genomic expressions for shortened stature and cleft palate are regionally specific in the 11-day mouse embryo J. Craniofac. Genet. Dev. Biol. Suppl. 2 1986 137 168
13. M.A. Satre, and D.M. Kochhar Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb-buds associated with limb dysmorphogenesis Dev. Biol. 133 2 1989 529 536
14. Y.M. Lee, N. Osumi-Yamashita, Y. Ninomiya, C.K. Moon, U. Eriksson, and K. Eto Retinoic acid stage-dependently alters the migration pattern and identity of hindbrain neural crest cells Development 121 3 1995 825 837
15. J.H. Grant, L. Maggio-Price, J. Reutebuch, and M.L. Cunningham Retinoic acid exposure of the mouse on embryonic day 9 selectively spares derivatives of the frontonasal neural crest J. Craniofac. Genet. Dev. Biol. 17 1 1997 1 8
16. T.E. Kwasigroch, and D.M. Kochhar Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme J. Embryol. Exp. Morphol. 59 1980 325 339
17. A.J. Alles, and K.K. Sulik Retinoic-acid-induced limb-reduction defects: perturbation of zones of programmed cell death as a pathogenetic mechanism Teratology 40 2 1989 163 171
18. T.M. Underhill, A.V. Sampaio, and A.D. Weston Retinoid signalling and skeletal development Novartis Found. Symp. 232 2001 171 185 (discussion 85-88)
19. L. Niswander, C. Tickle, A. Vogel, I. Booth, and G.R. Martin FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb Cell 75 3 1993 579 587
20. R.T. Ballock, A. Heydemann, L.M. Wakefield, K.C. Flanders, A.B. Roberts, and M.B. Sporn Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta J. Cell. Physiol. 159 2 1994 340 346
21. P.H. Francis-West, K.E. Robertson, D.A. Ede, C. Rodriguez, J.C. Izpisua-Belmonte, and B. Houston Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning Dev. Dyn. 203 2 1995 187 197
22. K. Patel, R. Nittenberg, D. D'Souza, C. Irving, D. Burt, and D.G. Wilkinson Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds Development 122 4 1996 1147 1155
23. G.R. Han, D.F. Dohi, H.Y. Lee, R. Rajah, G.L. Walsh, and W.K. Hong All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway J. Biol. Chem. 272 21 1997 13711 13716
24. N. Mercader, E. Leonardo, M.E. Piedra, A.C. Martinez, M.A. Ros, and M. Torres FGF signals control proximodistal vertebrate limb development through regulation of Meis genes Development 127 18 2000 3961 3970
25. P. Qin, R. Cimildoro, D.M. Kochhar, K.J. Soprano, and D.R. Soprano PBX, MEIS, IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects Teratology 66 5 2002 224 234
26. T.F. Linsenmayer, and D.M. Kochhar In vitro cartilage formation: effects of 6-diazo-5-oxo-l-norleucine (DON) on glycosaminoglycan and collagen synthesis Dev. Biol. 69 2 1979 517 528
27. A. Franzen, D. Heinegard, and M. Solursh Evidence for sequential appearance of cartilage matrix proteins in developing mouse limbs and in cultures of mouse mesenchymal cells Differentiation 36 3 1987 199 210
28. F. Mallein-Gerin, R.A. Kosher, W.B. Upholt, and M.L. Tanzer Temporal spatial analysis of cartilage proteoglycan core protein gene expression during limb development by in situ hybridization Dev. Biol. 126 2 1988 337 345
29. E.J. Lammer, D.T. Chen, R.M. Hoar, N.D. Agnish, P.J. Benke, and J.T. Braun Retinoic acid embryopathy N. Engl. J. Med. 313 14 1985 837 841
30. C.W. Ragsdale Jr., and J.P. Brockes Retinoids and their targets in vertebrate development Curr. Opin. Cell Biol. 3 6 1991 928 934
31. L. Gillis Thalidomide babies: management of limb defects Br. Med. J. 5305 1962 647 651
32. W. Lenz, and K. Knapp Thalidomide embryopathy Arch. Environ. Health 5 1962 100 105
33. R.W. Smithells Defects and disabilities of thalidomide children Br. Med. J. 1 5848 1973 269 272
34. C.J. Tabin A developmental model for thalidomide defects Nature 396 6709 1998 322 323
35. D. Summerbell, and J.H. Lewis Time, place and positional value in the chick limb-bud J. Embryol. Exp. Morphol. 33 3 1975 621 643
36. J.F. Fallon, A. Lopez, M.A. Ros, M.P. Savage, B.B. Olwin, and B.K. Simandl FGF-2: apical ectodermal ridge growth signal for chick limb development Science 264 5155 1994 104 107
37. T.D. Stephens Proposed mechanisms of action in thalidomide embryopathy Teratology 38 3 1988 229 239
38. X. Sun, F.V. Mariani, and G.R. Martin Functions of FGF signalling from the apical ectodermal ridge in limb development Nature 418 6897 2002 501 508
39. Kochhar DM. Cellular basis of congenital limb deformity induced in mice by Vitamin A. In: The National Foundation-March of Dimes, Birth Defects Original Article Series. NY: Alan R. Liss, 1977. p. 111-54.
40. H. Jiang, and D.M. Kochhar Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud Teratology 46 4 1992 333 340
41. H. Jiang, D.R. Soprano, S.W. Li, K.J. Soprano, J.D. Penner, and M. Gyda 3rd Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors Int. J. Dev. Biol. 39 4 1995 617 627
42. A.D. Weston, L.M. Hoffman, and T.M. Underhill Revisiting the role of retinoid signaling in skeletal development Birth Defects Res. Part C Embryo Today 69 2 2003 156 173