Prolonged treatment with low-dose intravenous pulse cyclophosphamide may reduce rate of relapse in ANCA-associated vasculitis

Nephron - Clinical Practice

Volumn 97, Issue 4, 2004, Pages

  Dhaygude, Ajay ^a   Griffith, Megan ^a   Cairns, Thomas ^a   McLean, Adam ^a   Palmer, Andrew ^a   Taube, David ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

ANCA associated vasculitis; Continuous cyclophosphamide; Pulse cyclophosphamide

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN; INFLIXIMAB; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTROPHIL CYTOPLASMIC ANTIBODY; PREDNISOLONE;

ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; CLINICAL ARTICLE; DEATH; DRUG EFFICACY; DRUG PULSE THERAPY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; INFECTION; INFECTION RATE; LONG TERM CARE; MALE; NEUTROPENIA; PLASMAPHERESIS; PRIORITY JOURNAL; RECURRENCE RISK; RELAPSE; REMISSION; RENOVASCULAR DISEASE; RETROSPECTIVE STUDY; SEPSIS; TREATMENT OUTCOME;

ADULT; AGED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOIMMUNE DISEASES; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULONEPHRITIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOSUPPRESSIVE AGENTS; INFUSIONS, INTRAVENOUS; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PLASMA EXCHANGE; POLYARTERITIS NODOSA; PREDNISOLONE; RECURRENCE; REMISSION INDUCTION; RENAL DIALYSIS; RETROSPECTIVE STUDIES; WEGENER GRANULOMATOSIS;

EID: 4444301225     PISSN: 16602110     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079175     Document Type: Article

References (22)

1. Hewins P, Tervaert JW, Savage CO, Kallenberg CG: Is Wegener's granulomatosis an autoimmune disease? Curr Opin Rheumatol 2000;12:3-10.
2. Fauci AS, Katz P, Haynes BF, Wolff SM: Cyclophosphamide therapy of severe systemic necrotizing vasculitis. N Engl J Med 1979;301:235-238.
3. Fauci AS, Haynes BF, Katz P, Wolff SM: Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 1983;98:76-85.
4. Andrassy K: Therapeutic modalities in patients with generalized Wegener's granulomatosis (WG) and related diseases. APMIS 1990;19(suppl):47.
5. Hoffman GS, Kerr GS, Leavitt RY, et al: Wegener's granulomatosis: An analysis of 158 patients. Ann Intern Med 1992;116:488-498.
6. Gaskin G, Pusey CD: Systemic Vasculitis (ch); in AM Davison (ed): Oxford Textbook of Clinical Nephrology, ed 2. Oxford, Oxford University Press, 1998, pp 877-910.
7. Bansal VK, Beto JA: Treatment of lupus nephritis: A meta-analysis of clinical trials. Am J Kidney Dis 1997 29:193-199.
8. de Groot K, Adu D, Savage CO: The value of pulse cyclophosphamide in ANCA-associated vasculitis: Meta-analysis and critical review. Nephrol Dial Transplant 2001;16:2018-2027.
9. Rasmussen N, Wiik A: Indirect immunofluorescence examination for IgG-ANCA in sera. 1st International Workshop on ANCA. APMIS 1989;6(suppl):16-20.
10. Jennette JC, Falk RJ, Andrassy K, et al: Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994;37:187-192.
11. De' Oliviera J, Gaskin G, Dash A, Rees AJ, Pusey CD: Relationship between disease activity and anti-neutrophil cytoplasmic antibody concentration in long-term management of systemic vasculitis. Am J Kidney Dis 1995;25:380-389.
12. Nachman P, Hogan S, Jennette J, Falk R: Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996;7:33-39.
13. Adu D, Pall A, Luqmani RA: Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis. QJM 1997;90:401-409.
14. Haubitz M, Schellong S, Gobel U, et al: Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement: A prospective, randomized study. Arthritis Rheum 1998;41:1835-1844.
15. Guillevin L, Cordier JF, Lhote F, et al: A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis. Arthritis Rheum 1997;40:2187-2198.
16. Gaskin G, Jayne DR and the European vasculitis study group: Adjunctive plasma exchange is superior to methylprednisolone in acute renal failure due to antinuclear cytoplasm associated glomerulonephritis. Renal Association, Autumn Meeting, London, Oct 2002, p 8.
17. Jayne D, Rasmussen N, Andrassy K, et al, for the European Vasculitis Study Group: A randomised trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic antibodies. N Engl J Med 2003;349:36-44.
18. Jayne DR, Chapel H, Adu D, et al: Intravenous immunoglobulin for ANCA-associated systemic vasculitis with persistent disease activity. QJM 2000;93:433-439.
19. Nowack R, Gobel U, Klooker P, Hergesell O, Andrassy K, van der Woude: Mycophenolate mofetil for maintenance therapy of Wegener's granulomatosis and microscopic polyangiitis: A pilot study in 11 patients with renal involvement. J Am Soc Nephrol 1999;10:1965-1971.
20. Tyndall A, Fassas A, Passweg J, Ruiz de Elvira C, Attal M, Brooks P, et al: Autologous haematopoietic stem cell transplants for autoimmune disease-feasibility and transplant-related mortality. Autoimmune Disease and Lymphoma Working Parties of the European Group for Blood and Marrow Transplantation, the European League Against Rheumatism and the International Stem Cell Project for Autoimmune Disease. Bone Marrow Transplant 1999;24:729-734.
21. Stone JH, Uhlfelder ML, Hellmann DB, Crook S, Bedocs NM, Hoffman GS: Etanercept combined with conventional treatment in Wegener's granulomatosis: A six-month open-label trial to evaluate safety. Arthritis Rheum 2001;44:1149-1154.
22. Booth AD, Jefferson HJ, Ayliffe W, Andrews PA, Jayne DR: Safety and efficacy of TNFalpha blockade in relapsing vasculitis. Ann Rheum Dis 2002;61:559.