Evidence for a size-sensing mechanism in animal cells

Nature Cell Biology

Volumn 6, Issue 9, 2004, Pages 899-905

  Dolznig, Helmut ^a,b,c   Grebien, Florian ^b   Sauer, Thomas ^b   Beug, Hartmut ^a   Müllner, Ernst W ^b  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b MAX F PERUTZ LABORATORIES   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; GROWTH FACTOR; ONCOPROTEIN; PROTEIN INHIBITOR; STEM CELL FACTOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SIZE; CELL VOLUME; CENTRIFUGATION; CHICKEN; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ERYTHROBLAST; FIBROBLAST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; CELL PHYSIOLOGY; CELL SIZE; CHICKENS; ERYTHROBLASTS; G1 PHASE; HUMANS; KINETICS; MICE; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; S PHASE; TIME FACTORS;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

EID: 4444297122     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1166     Document Type: Article

References (23)

1. Mitchison, J. M. Growth during the cell cycle. Int. Rev. Cytol. 226, 165-258 (2003).
2. Saucedo, L. J. & Edgar, B. A. Why size matters: altering cell size. Curr. Opin. Genet. Dev. 12, 565-571 (2002).
3. Conlon, I. J., Raff, M. Differences in the way a mammalian cell and yeast cells coordinate cell growth and cell-cycle progression. J. Biol. 2, 7 (2003).
4. Conlon, I. J., Dunn, G. A., Mudge, A. W. & Raff, M. C. Extracellular control of cell size. Nature Cell Biol. 3, 918-921 (2001).
5. Steinlein, P., Deiner, E., Leutz, A. & Beug, H. Recombinant murine erythropoetin receptor expressed in avian erythroid progenitors mediates terminal erythroid differentiation in vitro. Growth Factors 10, 1-16 (1994).
6. Fry, D. W. et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265, 1093-1095 (1994).
7. Mikulits, W. et al. Dynamics of cell cycle regulators: artifact-free analysis by recultivation of cells synchronized by centrifugal elutriation. DNA Cell Biol. 16, 849-859 (1997).
8. Jorgensen, P., Nishikawa, J. L., Breitkreutz, B. J. & Tyers, M. Systematic identification of pathways that couple cell growth and division in yeast. Science 297, 395-400 (2002).
9. Zhang, J. et al. Genomic scale mutant hunt identifies cell size homeostasis genes in S. cerevisiae. Curr. Biol. 12, 1992-2001 (2002).
10. Neufeld, T. P., de la Cruz, A, F., Johnston, L. A. & Edgar, B. A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193 (1998).
11. Montagne, J. et al. Drosophila S6 kinase: a regulator of cell size. Science 285, 2126-2129 (1999).
12. Lawlor, M. A. et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21, 3728-3738 (2002).
13. s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17, 6649-6659 (1998).
14. Rupes, I. Checking cell size in yeast. Trends Genet. 18, 479-485 (2002).
15. Stocker, H. & Hafen, E. Genetic control of cell size. Curr. Opin. Genet. Dev. 10, 529-535 (2000).
16. Conlon, I. & Raff, M. Size control in animal development. Cell 96, 235-244 (1999).
17. Fantes, P. & Nurse, P. Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division. Exp. Cell Res. 107, 377-386 (1977).
18. Johnston, G. C., Pringle, J. R. & Hartwell, L. H. Coordination of growth with cell division in the yeast Saccharomyces cerevistae. Exp. Cell Res. 105, 79-98 (1977).
19. Killander, D. & Zetterberg, A. Quantitative cytochemical studies on interphase growth. I. determination of DNA, RNA and mass content of age determined mouse fibroblasts in vitro and of intercellular variation in generation time. Exp. Cell Res. 38, 272-284 (1965).
20. Killander, D. & Zetterberg, A. A quantitative cytochemical investigation of the relationship between cell mass and initiation of DNA synthesis in mouse fibroblasts in vitro. Exp. Cell Res. 40, 12-20 (1965).
21. Wessely, O. et al. A novel way to induce erythroid progenitor self renewal: cooperation of c-Kit with the erythropoietin receptor. Biol. Chem. 380, 187-202 (1999).
22. Beug, H. et al. Avian erythropoiesis and erythroleukemia: towards understanding the role of the biomolecules involved. Biochim. Biophys. Acta. 1288, M35-M47 (1996).
23. von Lindern, M. et al. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene 20, 3651-3664 (2001).