Repeated contact with subtoxic soman leads to synaptic vulnerability in hippocampus

Journal of Neuroscience Research

Volumn 77, Issue 5, 2004, Pages 739-746

  Munirathinam, Subramani ^a   Bahr, Ben A ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Excitotoxicity; Hippocampal slice culture; Soman; Spectrin breakdown product; Synaptic decline

Indexed keywords

ACETYLCHOLINE; CHOLINESTERASE INHIBITOR; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; NERVE GAS; NEUROTRANSMITTER; SOMAN; SPECTRIN;

ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN INJURY; BRAIN SLICE; BRAIN TOXICITY; CELL DEATH; CELL LOSS; CONTROLLED STUDY; CONVULSION; DISEASE MARKER; DRUG ACCUMULATION; DRUG EXPOSURE; DRUG MECHANISM; EPILEPTIC DISCHARGE; EXCITOTOXICITY; HIPPOCAMPUS; MEMORY DISORDER; NERVE DEGENERATION; NEUROTOXICOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SEIZURE; SYNAPTIC DEGENERATION; SYNAPTOPATHOGENESIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN DISEASES; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; EXCITATORY AMINO ACID AGONISTS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; NIPECOTIC ACIDS; ORGAN CULTURE TECHNIQUES; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SOMAN; STAINING AND LABELING; SYNAPSES; SYNAPTOPHYSIN; TRIMETHYLTIN COMPOUNDS;

EID: 4444293167     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20209     Document Type: Article

References (45)

1. Bahr BA. 1995. Long-term hippocampal slices: a model system for investigating synaptic mechanisms and pathologic processes. J Neurosci Res 42:294-305.
2. Bahr BA, Abai B, Gall C, Vanderklish PW, Hoffman KB, Lynch G. 1994. Induction of β-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin. Exp Neurol 129:81-94.
3. Bahr BA, Kessler M, Rivera S, Vanderklish PW, Hall RA, Singh Mutneja M, Gall C, Hoffman KB. 1995a. Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices. Hippocampus 5:425-439.
4. Bahr BA, Tiriveedhi S, Park GY, Lynch G. 1995b. Induction of calpain-mediated spectrin fragments by pathogenic treatment in long-term hippocampal slices. J Pharmacol Exp Ther 273:902-908.
5. R antigen (GR53) in brain tissue. Neuroscience 74:707-721.
6. Bahr BA, Bendiske J, Brown QB, Munirathinam S, Caba E, Rudin M, Urwyler S, Sauter A, Rogers G. 2002. Survival signaling and selective neuroprotection through glutamatergic transmission. Exp Neurol 174:37-47.
7. Bendiske J, Caba E, Brown QB, Bahr BA. 2002. Intracellular deposition, microtubule destabilization, and transport failure: an 'early' pathogenic-cascade leading to synaptic decline. J Neuropathol Exp Neurol 61:640-650.
8. Blomgren K, Zhu C, Wang X, Karlsson J-O, Andersson A-L, Bahr BA, Mallard C, Hagberg H. 2001. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia-a mechanism of "pathological apoptosis"? J Biol Chem 276:10191-10198.
9. Brock TO, O'Callaghan JP. 1987. Quantitative changes in the synaptic vesicle proteins synapsin 1 and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci 7:931-942.
10. Carpentier P, Lambrinidis M, Blanchet G. 1991. Early dendritic changes in hippocampal pyramidal neurons (field CA1) of rats subjected to acute soman intoxication: a light microscopic study. Brain Res 541:293-299.
11. Cowan FM, Broomfield CA, Lenz DE, Shih TM. 2001. Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning. J Appl Toxicol 21:293-296.
12. de Groot DM, Bierman EP, Bruijnzeel PL, Carpentier P, Kulig BM, Lallement G, Melchers, BP, Philippens IH, van Huygevoort AH. 2001. Beneficial effects of TCP on soman intoxication in guinea pigs: Seizures, brain damage and learning behaviour. J Appl Toxicol 21:S57-S65.
13. Deshpande SS, Smith, CD, Filbert MG. 1995. Assessment of primary neuronal culture as a model for soman-induced neurotoxicity and effectiveness of memantine as a neuroprotective drug. Arch Toxicol 69:384-390.
14. Feldman RG, White RR, Eriator II. 1993. Trimethyltin encephalopathy. Arch Neurol 50:1320-1324.
15. Filliat P, Baubichon D, Burckhart MF, Pernot-Marino I, Foquin A, Masqueliez C, Perrichon C, Carpentier P, Lallement G. 1999. Memory impairment after soman intoxication in rat: correlation with central neuropathology: improvement with anticholinergic and antiglutamatergic therapeutics. Neurotoxicology 20:535-549.
16. Harry GJ, Goodrum JF, Krigman MR, Morell P. 1985. The use of synapsin 1 as a biochemical marker for neuronal damage by trimethyltin. Brain Res 326:9-18.
17. Ishida N, Akaike M, Tsutsumi S, Kanai H, Masui A, Sadamatsu M, Kuroda Y, Watanabe Y, McEwen BS, Kato N. 1997. Trimethyltin syndrome as a hippocampal degeneration model: temporal changes and neurochemical features of seizure susceptibility and learning impairment. Neuroscience 81:1183-1191.
18. Ishikawa K, Kubo T, Shibanoki S, Matsumoto A, Hata H, Asai S. 1997. Hippocampal degeneration inducing impairment of learning in rats: model of dementia? Behav Brain Res 83:39-44.
19. Kalivas PW, Jackson D, Romanidies A, Wyndham L, Duffy P. 2001. Involvement of pallidothalamic circuitry in working memory. Neuroscience 104:129-136.
20. Kreyberg S, Torvik A, Bjorneboe A, Wiik-Larsen W, Jacobsen, D. (1992). Trimethyltin poisoning: report of a case with postmortem examination. Clin Neuropathol 11:256-259.
21. Lallement G, Carpentier P, Collet A, Pernot-Marino I, Baubichon D, Blanchet G. 1991. Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain Res 563:234-240.
22. Lallement G, Denoyer M, Collet A, Pernot-Marino I, Baubichon D, Monmaur P, Blanchet G. 1992. Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: influence of septal cholinoceptive cells. Neurosci Lett 139:104-107.
23. Lallement G, Delamanche IS, Pernot-Marino I, Baubichon D, Denoyer M, Carpentier P, Blanchet G. 1993. Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with a w3-site ligand. Brain Res 618:227-237.
24. Lemercier G, Carpentier P, Sentenac-Roumanou H, Morelis P. 1983. Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorous compound. Acta Neuropathol 61:123-129.
25. 2+ influx in cultured hippocampal neurons. Neuron 4:105-117.
26. McDonough J Jr, Shih T. 1997. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 21:559-579.
27. Munirathinam S, Bahr BA. 2002. Low-level soman exposure leads to synaptic damage in the hippocampus and potentiates neuronal vulnerability. Toxicol Sci 58(Suppl):1551.
28. Munirathinam S, Rogers G, Bahr BA. 2002. Positive modulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors elicits neuroprotection after trimethyltin exposure in hippocampus. Toxicol Appl Pharmacol 185:111-118.
29. Pavlovsky L, Browne RO, Friedman A. 2003. Pyridostigmine enhances glutamatergic transmission in hippocampal CA1 neurons. Exp Neurol 179:181-187.
30. Pazdernik TL, Cross RS, Giesler M, Samson FE, Nelson SR. 1985. Changes in local cerebral glucose utilization induced by convulsants. Neuroscience 14:823-835.
31. Raval AP, Dave KR, Mochly-Rosen DM, Sick TJ, Perez-Pinzon MA. 2003. εPKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice. J Neuroscience 23:384-391.
32. Raveh L, Weissman BA, Cohen G, Alkalay D, Rabinovitz I, Sonego H, Brandeis R. 2002. Caramiphen and scopolamine prevent soman-induced brain damage and cognitive dysfunction. Neurotoxicology 23:7-17.
33. Raveh L, Brandeis R, Gilat E, Cohen G, Alkalay D, Rabinovitz I, Sonego H, Weissman BA. 2003. Anticholinergic and antiglutamatergic agents protect against soman-induced brain damage and cognitive dysfunction. Toxicol Sci 75:108-116.
34. Schaller B, Graf R. 2002. Cerebral ischemic preconditioning. An experimental phenomenon or a clinical important entity of stroke prevention? J Neurol 249:1503-1511.
35. Sheardown MJ, Nielsen EO, Hansen AJ, Jacobsen P, Honore T. 1990. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247:571-574.
36. Siman R, Noszek JC, Kegerise C. 1989. Calpain 1 activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 9:1579-1590.
37. Somani SM, Romano J. 2001. Chemical warfare agents: Low level toxicity. Boca Raton, FL: CRC Press.
38. Sparenborg S, Brennecke LH, Jaax NK, Brahman DJ. 1992. Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman. Neuropharmacology 31:357-368.
39. Stoppini L, Buchs PA, Muller D. 1991. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37:173-182.
40. Taylor P. 2001. Anticholinesterase agents. In: Hardman JG, Limbird LE, Gilman AG, editors. The pharmacological basis of therapeutics, 10th ed. New York: McGraw Hill, p 175-191.
41. Vanderklish PW, Bahr BA. 2000. The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states. Int J Exp Pathol 81:323-339.
42. Wade JV, Samson FE, Nelson SR, Pazdernik TL. 1987. Changes in extracellular amino acids during soman- and kainic acid-induced seizures. J Neurochem 49:645-650.
43. Wang KK. 2000. Calpain and caspase: can you tell the difference? Trends Neurosci 23:20-26.
44. Wenk GL, Stoehr JD, Mobley SL, Gurney J, Morris RJ. 1996. Age-related decrease in vulnerability to excitatory amino acids in the nucleus basalis. Neurobiol Aging 17:1-7.
45. Wood SJ, Tattersall JE. 2001. An improved brain slice model of nerve agent-induced seizure activity. J Appl Toxicol 21:S83-S86.