Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect

FEBS Letters

Volumn 574, Issue 1-3, 2004, Pages 145-150

  Aizawa, Yoshiyasu ^a,b   Ueda, Kazuo ^a   Wu, Long Mei ^a   Inagaki, Natsuko ^a   Hayashi, Takeharu ^a   Takahashi, Megumi ^a   Ohta, Masaaki ^c   Kawano, Seiko ^a   Hirano, Yuji ^a   Yasunami, Michio ^a   Aizawa, Yoshifusa ^b   Kimura, Akinori ^a   Hiraoka, Masayasu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c Ehime Prefectural Imabari Hospital   (Japan)

Author keywords

cDNA, complementary deoxyribonucleic acid; DNA, deoxyribonucleic acid; ECG, electrocardiogram; LQT1, long QT syndrome type 1; LQTS, long QT syndrome; PCR, polymerase chain reaction; SSCP, single strand conformation polymorphism; WT, wild type

Indexed keywords

PROPRANOLOL;

ADOLESCENT; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CONFOCAL LASER MICROSCOPY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENE REPRESSION; HUMAN; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ADOLESCENT; ANIMALS; BASE SEQUENCE; COS CELLS; DNA PRIMERS; FEMALE; GENES, DOMINANT; HUMANS; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; MICROSCOPY, CONFOCAL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN TRANSPORT;

EID: 4444273929     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.08.018     Document Type: Article

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