An in vitro investigation of the effects of the nerve agent pretreatment pyridostigmine bromide on human peripheral blood T-cell function

International Immunopharmacology

Volumn 4, Issue 12, 2004, Pages 1455-1466

  Telford, Gary ^a   Wilkinson, Lucy J ^b   Hooi, Doreen S W ^a   Worrall, Vivienne ^b   Green, A Christopher ^b   Cook, David L ^b   Pritchard, David I ^a   Griffiths, Gareth D ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Cytokine; Mitogens; Physostigmine; Pyridostigmine; T cell

Indexed keywords

1,5 BIS(4 ALLYLDIMETHYLAMMONIUMPHENYL)PENTAN 3 ONE DIBROMIDE; CD69 ANTIGEN; CHOLINESTERASE INHIBITOR; CYCLOSPORIN A; DEXAMETHASONE; INTERLEUKIN 2; MITOGENIC AGENT; OXOTREMORINE; OXOTREMORINE M; PHYSOSTIGMINE; PYRIDOSTIGMINE; RECEPTOR ANTIBODY; SCOPOLAMINE; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CHOLINESTERASE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ACETYLCHOLINESTERASE; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL PROLIFERATION; CELLS, CULTURED; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CULTURE MEDIA; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MITOGENS; PYRIDOSTIGMINE BROMIDE; T-LYMPHOCYTES;

EID: 4444254891     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.06.009     Document Type: Article

References (48)

1. T.C. Marrs, R.L. Maynard, and F.R. Sidell Organophosphate nerve agents Chemical warfare agentsâ€"toxicology and treatment 1996 John Wiley and Sons Chichester 83 100
2. T.C. Marrs, R.L. Maynard, and F.R. Sidell Treatment and Prophylaxis of organophosphate nerve agent poisoning Chemical warfare agentsâ€" toxicology and treatment 1996 John Wiley and Son Chichester 101 113
3. B.A. Golomb, 1999. A Review of the scientific literature as it pertains to Gulf War illness Volume 2; Pyridostigmine bromide. RAND, MR-1018/2-OSD. In.
4. 2000. Monthly Index of Medical Specialties, Section 5F Mestinon. In p. 153.
5. R.P. Lisak Myasthenia Gravis Curr.Treat.Options.Neurol. 1 1999 239 250
6. L.J. Scott, and K.L. Goa Galantamine: a review of its use in Alzheimer's disease Drugs 60 2000 1095 1122
7. J.J. Sramek, and N.R. Cutler RBC cholinesterase inhibition: a useful surrogate marker for cholinesterase inhibitor activity in Alzheimer disease therapy? Alzheimer Dis. Assoc. Disord. 14 2000 216 227
8. I. Wessler, C.J. Kirkpatrick, and K. Racke The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans Clin. Exp. Pharmacol. Physiol. 26 1999 198 205
9. J.G. Szelenyi, E. Bartha, and S.R. Hollan Acetylcholinesterase activity of lymphocytes: an enzyme characteristic of T-cells Br. J. Haematol. 50 1982 241 245
10. P. Paldi-Haris, J.G. Szelenyi, T.H. Nguyen, and S.R. Hollan Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation Thymus 16 1990 119 122
11. J. Szelenyi, P. Paldi-Haris, and S. Hollan Changes in the cholinergic system of lymphocytes due to mitogenic stimulation Immunol. Lett. 16 1987 49 54
12. T.B. Strom, M.A. Lane, and K. George The parallel, time-dependent, bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation J. Immunol. 127 1981 705 710
13. T. Fujii, S. Tajima, S. Yamada, Y. Watanabe, K.Z. Sato, and M. Matsui Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines Neuroscience Letters 259 1999 71 74
14. K. Kawashima, T. Fujii, Y. Watanabe, and H. Misawa Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes Life Sciences 62 1998 1701 1705
15. T. Fujii, T. Tsuchiya, S. Yamada, K. Fujimoto, T. Suzuki, and T. Kasahara Localization and synthesis of acetylcholine in human leukemic T cell lines J. Neurosci. Res. 44 1996 66 72
16. I. Rinner, P. Felsner, A. Falus, E. Skreiner, T. Kukulansky, and A. Globerson Cholinergic signals to and from the immune system Immunol. Lett. 44 1995 217 220
17. K.Z. Sato, T. Fujii, Y. Watanabe, S. Yamada, T. Ando, and F. Kazuko Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines Neuroscience Letters 266 1999 17 20
18. U. Bany, J. Ryzewski, and W. Maslinski Relative amounts of mRNA encoding four subtypes of muscarinic receptors (m2â€"m5) in human peripheral blood mononuclear cells J. Neuroimmunol. 97 1999 191 195
19. E. Bronzetti, O. Adani, F. Amenta, L. Felici, F. Mannino, and A. Ricci Muscarinic cholinergic receptor subtypes in human peripheral blood lymphocytes Neuroscience Letters 208 1996 211 215
20. S.K. Tayebati, M. Codini, V. Gallai, F. Mannino, L. Parnetti, and A. Ricci Radioligand binding assay of M1â€"M5 muscarinic cholinergic receptor subtypes in human peripheral blood lymphocytes Journal of Neuroimmunology 99 1999 224 229
21. S.K. Tayebati, D. El Assouad, A. Ricci, and F. Amenta Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes J. Neuroimmunol. 132 2002 147 155
22. H. Fujino, Y. Kitamura, T. Yada, T. Uehara, and Y. Nomura Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes Molecular Pharmacology 51 1997 1007 1014
23. K. Kawashima, and T. Fujii xtraneuronal cholinergic system in lymphocytes Pharmacology and Therapeutics 86 2000 29 48
24. E.X. Albuquerque, Y. Aracava, W.M. Cintra, A. Brossi, B. Schonenberger, and S.S. Deshpande Structureâ€"activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptorâ€"ion channel complex Braz. J. Med. Biol. Res. 21 1988 1173 1196
25. K.P. Shaw, Y. Aracava, A. Akaike, J.W. Daly, D.L. Rickett, and E.X. Albuquerque The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor†"ion channel complex Mol. Pharmacol. 28 1985 527 538
26. B. Lockhart, M. Closier, K. Howard, C. Steward, and P. Lestage Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl ben0zilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors Naunyn Schmiedebergs Arch. Pharmacol. 363 2001 429 438
27. J. Wetherell, T. Hall, and S. Passingham Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig Neurotoxicology 23 2002 341 349
28. G.P. Casale, J.L. Vennerstrom, S. Bavari, and T.L. Wang Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbaryl Immunopharmacol. Immunotoxicol. 15 1993 199 215
29. M.C. Fiore, H.A. Anderson, R. Hong, R. Golubjatnikov, J.E. Seiser, and D. Nordstrom Chronic exposure to aldicarb-contaminated groundwater and human immune function Environ. Res. 41 1986 633 645
30. D. Flipo, J. Bernier, D. Girard, K. Krzystyniak, and M. Fournier Combined effects of selected insecticides on humoral immune response in mice Int. J. Immunopharmacol. 14 1992 747 752
31. G.L. Ellman, K.D. Courtney, V.J. Anders, and R.M. Featherstone A new and rapid colourimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88 95
32. H. Matsunaga, T. Suehiro, T. Saita, Y. Nakano, M. Mori, and K. Takata High performance liquid chromatography determination of pyridostigmine in plasma J. Chromatog. 422 1987 353 355
33. O. Yturralde, R.-Y. Lee, L.Z. Benet, L. Fleckenstein, and E.T.L. Lin Ion paired liquid chromatographic method for the analysis of pyridostigmine in plasma J. Liquid Chrom. 10 1987 2231 2246
34. J.Y. Wu, K.J. Munroe, B.H. Gardner, M.S. Wyand, and M.J. Newman Use of particulate forms of protein antigens to increase the sensitivity of antigen-specific proliferation assays J. Immunol. Methods 159 1993 39 45
35. B. Ringdahl Selectivity of partial agonists related to oxotremorine based on differences in muscarinic receptor reserve between the guinea pig ileum and urinary bladder Mol. Pharmacol. 31 1987 351 356
36. T. Fujii, and K. Kawashima Calcium signaling and c-fos gene expression via mg muscarinic acetylcholine receptors in human T- and B-cells Japanese Journal of Pharmacology 84 2000 124 132
37. T. Fujii, and K. Kawashima An independent non-neuronal cholinergic system in lymphocytes Japanese Journal of Pharmacology 85 2001 11 15
38. E.M. Forster, J.A. Barber, F.R. Parker Jr., J.E. Whinnery, R.R. Burton, and P. Boll Effect of pyridostigmine bromide on acceleration tolerance and performance Aviat. Space Environ. Med. 65 1994 110 116
39. C. Morimoto, and S.F. Schlossman The structure and function of CD26 in the T-cell immune response Immunol. Rev. 161 1998 55 70
40. T. Ishii, K. Ohnuma, A. Murakami, N. Takasawa, S. Kobayashi, and N.H. Dang CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO Proc. Natl. Acad. Sci. U. S. A. 98 2001 12138 12143
41. J. Parkin, and B. Cohen An overview of the immune system Lancet 357 2001 1777 1789
42. K.V. Sharma, C. Koenigsberger, S. Brimijoin, and J.W. Bigbee Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth J. Neurosci. Res. 63 2001 165 175
43. G. Johnson, and S.W. Moore The adhesion function on acetylcholinesterase is located at the peripheral anionic site Biochem. Biophys. Res. Commun. 19;258 1999 758 762
44. T. Fujii, Y. Watanabe, T. Inoue, and K. Kawashima Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses Neurochem. Res. 28 2003 423 429
45. M.V. Skok, E.N. Kalashnik, L.N. Koval, V.I. Tsetlin, Y.N. Utkin, and J.P. Changeux Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines Mol. Pharmacol. 64 2003 885 889
46. E. Sato, S. Koyama, Y. Okubo, K. Kubo, and M. Sekiguchi Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity Am. J. Physiol. 274 1998 L970 L979
47. Y.H. Qiu, Y.P. Peng, J.L. Jiang, and J.J. Wang Effect of acetylcholine on in vitro IL-2 production and NK cell cytotoxicity of rats Lymphology 37 2004 31 38
48. P.O. Ogunbiyi, and H.P. Misra Alterations of guinea pig alveolar macrophage oxidative metabolism by nicotine Toxicol. Appl. Pharmacol. 98 1989 25 30