The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome P450 in Fischer rats

Toxicological Sciences

Volumn 81, Issue 1, 2004, Pages 7-13

  Fennell, Timothy R ^a,b   Snyder, Rodney W ^a,b   Parkinson, Carl ^b   Murphy, John ^b   James, R Arden ^b  

^a RTI INTERNATIONAL   (United States)

^b CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

CYP 2E1; Cytochrome P450; Ethylene; Ethylene oxide; Metabolism

Indexed keywords

4 NITROPHENOL; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 ISOENZYME; ETHYLENE; ETHYLENE OXIDE; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EXPOSURE; INHALATION; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; RAT; RAT STRAIN;

ANIMALS; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CHROMATOGRAPHY, GAS; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLENE OXIDE; ETHYLENES; INHALATION EXPOSURE; LIVER; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PROTEINS; RATS; RATS, INBRED F344; STEROID HYDROXYLASES;

EID: 4444247913     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh170     Document Type: Article

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