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Volumn 37, Issue 3, 2004, Pages 767-774

Changes in cyclic nucleotide phosphodiesterase activity and calmodulin concentration in heart muscle of cardiomyopathic hamsters

Author keywords

Calmodulin; Cyclic nucleotide phosphodiesterase; Myopathic hamster

Indexed keywords

CALMODULIN; CALMODULIN INHIBITOR; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIETHYLAMINOETHYL CELLULOSE; ISOENZYME; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III;

EID: 4444243523     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2004.06.013     Document Type: Article
Times cited : (11)

References (54)
  • 1
    • 0001559662 scopus 로고
    • Fractionation and characterization of a cyclic adenosine ribonucleotide formed by tissue particles
    • Sutherland E.W., Roll T.W. Fractionation and characterization of a cyclic adenosine ribonucleotide formed by tissue particles. J Biol Chem. 243:1958;1077-1091
    • (1958) J Biol Chem , vol.243 , pp. 1077-1091
    • Sutherland, E.W.1    Roll, T.W.2
  • 2
    • 0015217764 scopus 로고
    • Cyclic 3′,5′-nucleotide phosphodiesterase. Evidence for and properties of a protein activator
    • Cheung W.Y. Cyclic 3′,5′-nucleotide phosphodiesterase. Evidence for and properties of a protein activator. J Biol Chem. 246:1971;2859-2869
    • (1971) J Biol Chem , vol.246 , pp. 2859-2869
    • Cheung, W.Y.1
  • 5
    • 0031792161 scopus 로고    scopus 로고
    • CAMP-mediated signal transduction and sarcoplasmic reticulum function in heart failure
    • Movsesian M.A. cAMP-mediated signal transduction and sarcoplasmic reticulum function in heart failure. Ann NY Acad Sci. 853:1998;231-239
    • (1998) Ann NY Acad Sci , vol.853 , pp. 231-239
    • Movsesian, M.A.1
  • 6
    • 0014573627 scopus 로고
    • Myocardial adenyl cyclase: Activation by thyroid hormones and evidence for two adenyl cyclase systems
    • Levey G.S., Epstein S.E. Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems. J Clin Invest. 48:1969;1663-1669
    • (1969) J Clin Invest , vol.48 , pp. 1663-1669
    • Levey, G.S.1    Epstein, S.E.2
  • 7
    • 0026684665 scopus 로고
    • Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein
    • Brechler V., Pavoine C., Hanf R., Garbarz E., Fischmeister R., Pecker F. Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein. J Biol Chem. 267:1992;15496-15501
    • (1992) J Biol Chem , vol.267 , pp. 15496-15501
    • Brechler, V.1    Pavoine, C.2    Hanf, R.3    Garbarz, E.4    Fischmeister, R.5    Pecker, F.6
  • 8
    • 0025215525 scopus 로고
    • Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of elective inhibitors
    • Beavo J.A., Reifsenyder D.H. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of elective inhibitors. Trend Pharmacol Science. 11:1990;150-155
    • (1990) Trend Pharmacol Science , vol.11 , pp. 150-155
    • Beavo, J.A.1    Reifsenyder, D.H.2
  • 10
    • 0028136159 scopus 로고
    • Multiple cyclic nucleotide phosphodiesterases
    • Beavo J.A., Conti M., Heaslip R.J. Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol. 46:1994;399-405
    • (1994) Mol Pharmacol , vol.46 , pp. 399-405
    • Beavo, J.A.1    Conti, M.2    Heaslip, R.J.3
  • 11
    • 0029009878 scopus 로고
    • Recent progress in understanding the hormonal regulation of phosphodiesterases
    • Conti M., Nemoz G., Sette C., Vicini E. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr Rev. 16:1995;370-389
    • (1995) Endocr Rev , vol.16 , pp. 370-389
    • Conti, M.1    Nemoz, G.2    Sette, C.3    Vicini, E.4
  • 12
    • 0029146718 scopus 로고
    • Perspectives in biochemistry and biophysics viversity in cyclic nucleotide phosphodiesterase isoenzyme families
    • Manganiello V.C., Murata T., Taira M., Belfrage P., Degerman E. Perspectives in biochemistry and biophysics viversity in cyclic nucleotide phosphodiesterase isoenzyme families. Ar Biochem Biophys. 322:1995;1-13
    • (1995) Ar Biochem Biophys , vol.322 , pp. 1-13
    • Manganiello, V.C.1    Murata, T.2    Taira, M.3    Belfrage, P.4    Degerman, E.5
  • 13
    • 0019321879 scopus 로고
    • Hydrophobic regions function in calmodulin-enzyme(s) interactions
    • Tanaka T., Hidaka H. Hydrophobic regions function in calmodulin-enzyme(s) interactions. J Biol Chem. 225:1980;11078-11080
    • (1980) J Biol Chem , vol.225 , pp. 11078-11080
    • Tanaka, T.1    Hidaka, H.2
  • 14
    • 0023218083 scopus 로고
    • Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility
    • Weishaar R.E., Kobylarz-Singer D.C., Steffen R.P., Kaplan H.R. Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility. Circ Res. 61:1987;539-547
    • (1987) Circ Res , vol.61 , pp. 539-547
    • Weishaar, R.E.1    Kobylarz-Singer, D.C.2    Steffen, R.P.3    Kaplan, H.R.4
  • 15
    • 0025864634 scopus 로고
    • Phosphorylation and characterization of bovine heart calmodulin-dependent phosphodiesterase
    • Sharma R.K. Phosphorylation and characterization of bovine heart calmodulin-dependent phosphodiesterase. Biochemistry. 30:1991;5963-5968
    • (1991) Biochemistry , vol.30 , pp. 5963-5968
    • Sharma, R.K.1
  • 16
    • 0022454622 scopus 로고
    • Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs
    • Harrison S.A., Reifsenyder D.H., Gallis B., Cadd G.G., Beavo J.A. Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Mol Pharmacol. 29:1986;506-514
    • (1986) Mol Pharmacol , vol.29 , pp. 506-514
    • Harrison, S.A.1    Reifsenyder, D.H.2    Gallis, B.3    Cadd, G.G.4    Beavo, J.A.5
  • 17
    • 0031615987 scopus 로고    scopus 로고
    • Downregulation of right ventricular phosphodiesterase PDE-3A mRNA and protein before the development of canine heart failure
    • Smith C.J., He J., Ricketts S.G., Ding J.Z., Moggio R.A., Hintze T.H. Downregulation of right ventricular phosphodiesterase PDE-3A mRNA and protein before the development of canine heart failure. Cell Biochem Biophys. 29:1998;67-88
    • (1998) Cell Biochem Biophys , vol.29 , pp. 67-88
    • Smith, C.J.1    He, J.2    Ricketts, S.G.3    Ding, J.Z.4    Moggio, R.A.5    Hintze, T.H.6
  • 18
    • 0017847012 scopus 로고
    • New cardiotonic agents: A search for digitalis substitute
    • Farah A.E., Alousi A.A. New cardiotonic agents: a search for digitalis substitute. Life Sci. 22:1978;1139-1148
    • (1978) Life Sci , vol.22 , pp. 1139-1148
    • Farah, A.E.1    Alousi, A.A.2
  • 20
    • 0027283557 scopus 로고    scopus 로고
    • Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase
    • Taira M., Hockman S.C., Calvo J.C., Taira M., Belfrage P., Manganiello V.C. Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase. J Biol Chem. 268:1999;18573-18579
    • (1999) J Biol Chem , vol.268 , pp. 18573-18579
    • Taira, M.1    Hockman, S.C.2    Calvo, J.C.3    Taira, M.4    Belfrage, P.5    Manganiello, V.C.6
  • 21
    • 0028949423 scopus 로고
    • Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
    • Reinhardt R.R., Chin E., Zhou J., Taira M., Murata T., Manganiello V.C., et al. Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases. J Clin Invest. 95:1995;1528-1538
    • (1995) J Clin Invest , vol.95 , pp. 1528-1538
    • Reinhardt, R.R.1    Chin, E.2    Zhou, J.3    Taira, M.4    Murata, T.5    Manganiello, V.C.6
  • 22
    • 0030860222 scopus 로고    scopus 로고
    • Species differences in localization of cardiac cAMP-phosphodiesterase activity: A cytochemical study
    • Okruhlicova L., Tribulova N., Styk J., Eckly A., Lugnier C., Slezk J. Species differences in localization of cardiac cAMP-phosphodiesterase activity: a cytochemical study. Mol Cell Biochem. 173:1997;183-188
    • (1997) Mol Cell Biochem , vol.173 , pp. 183-188
    • Okruhlicova, L.1    Tribulova, N.2    Styk, J.3    Eckly, A.4    Lugnier, C.5    Slezk, J.6
  • 23
    • 0030723978 scopus 로고    scopus 로고
    • Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A
    • Smith C.J., Huang R., Sun D., Ricketts S., Hoegler C., Ding J.Z., et al. Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A. Circulation. 96:1997;3116-3123
    • (1997) Circulation , vol.96 , pp. 3116-3123
    • Smith, C.J.1    Huang, R.2    Sun, D.3    Ricketts, S.4    Hoegler, C.5    Ding, J.Z.6
  • 24
    • 0030272632 scopus 로고    scopus 로고
    • Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes
    • Picq M., Dubois M., Grynberg A., Lagarde M., Prigent A.F. Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. J Mol Cell Cardiol. 28:1996;2151-2161
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 2151-2161
    • Picq, M.1    Dubois, M.2    Grynberg, A.3    Lagarde, M.4    Prigent, A.F.5
  • 25
    • 0018370648 scopus 로고
    • Cardiomyopathy of hamster dostrophy
    • Jasmin G., Eu H.Y. Cardiomyopathy of hamster dostrophy. Ann NY Acad Sci. 317:1979;46-58
    • (1979) Ann NY Acad Sci , vol.317 , pp. 46-58
    • Jasmin, G.1    Eu, H.Y.2
  • 26
    • 84984097375 scopus 로고
    • The heart muscle in muscular dystrophy with special reference to involvement of the cardiovascular system in the hereditary myopathy of the hamster
    • Bajusz E., Homburber F., Baker J.R., Opie L.H. The heart muscle in muscular dystrophy with special reference to involvement of the cardiovascular system in the hereditary myopathy of the hamster. Ann NY Acad Sci. 138:1966;213-231
    • (1966) Ann NY Acad Sci , vol.138 , pp. 213-231
    • Bajusz, E.1    Homburber, F.2    Baker, J.R.3    Opie, L.H.4
  • 27
    • 0015275959 scopus 로고
    • Cardiomyopathic Syrian hamster: A possible model of human descase
    • Gertz E.W. Cardiomyopathic Syrian hamster: a possible model of human descase. Prog Exp Tumor Res. 16:1972;242-260
    • (1972) Prog Exp Tumor Res , vol.16 , pp. 242-260
    • Gertz, E.W.1
  • 28
    • 0016646322 scopus 로고
    • Disturbed myocardial calcium metabolism: A possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster
    • Lossnitzer K., Janke J., Hein B., Stauch M., Fleckenstein A. Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster. Recent Adv Stud Card Struct Metab. 6:1975;207-217
    • (1975) Recent Adv Stud Card Struct Metab , vol.6 , pp. 207-217
    • Lossnitzer, K.1    Janke, J.2    Hein, B.3    Stauch, M.4    Fleckenstein, A.5
  • 29
    • 0021123575 scopus 로고
    • Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster
    • Jasmin G., Proschek L. Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster. Can J Physiol Pharmacol. 62:1984;891-898
    • (1984) Can J Physiol Pharmacol , vol.62 , pp. 891-898
    • Jasmin, G.1    Proschek, L.2
  • 30
    • 0017805526 scopus 로고
    • Mitochondrial calcium overloading in cardiomyopathic hamsters
    • Wrogemann K., Nylen E.G. Mitochondrial calcium overloading in cardiomyopathic hamsters. J Mol Cell Cardiol. 10:1978;185-195
    • (1978) J Mol Cell Cardiol , vol.10 , pp. 185-195
    • Wrogemann, K.1    Nylen, E.G.2
  • 33
    • 0018084835 scopus 로고
    • A novel vascular relaxing agent, N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide which affects vascular smooth muscle actomyosin
    • Hidaka H., Asano M., Iwadare S., Matsumoto I., Totsuka T., Aoki N. A novel vascular relaxing agent, N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide which affects vascular smooth muscle actomyosin. J Pharmacol Exp Ther. 207:1978;8-15
    • (1978) J Pharmacol Exp Ther , vol.207 , pp. 8-15
    • Hidaka, H.1    Asano, M.2    Iwadare, S.3    Matsumoto, I.4    Totsuka, T.5    Aoki, N.6
  • 34
    • 0018572098 scopus 로고
    • Cardiotonic activity of amrinone-win 40680 [5-amino-3,4′-bipyridin- 6(1H)-one]
    • Alousi A.A., Farah A.E., Lesher G.Y., Opalka C.J. Jr. Cardiotonic activity of amrinone-win 40680 [5-amino-3,4′-bipyridin-6(1H)-one]. Circ Res. 45:1979;666-677
    • (1979) Circ Res , vol.45 , pp. 666-677
    • Alousi, A.A.1    Farah, A.E.2    Lesher, G.Y.3    Opalka Jr., C.J.4
  • 36
    • 0028956278 scopus 로고
    • Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: Involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase
    • Satake N., Zhou Q., Morikawa M., Inoue M., Shibata S. Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase. J Cardiovasc Pharmacol. 25:1995;489-494
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 489-494
    • Satake, N.1    Zhou, Q.2    Morikawa, M.3    Inoue, M.4    Shibata, S.5
  • 37
    • 0035822683 scopus 로고    scopus 로고
    • Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: The role of protein kinase a and p38 mitogen-activated protein kinase
    • Sanada S., Kitakaze M., Papst P.J., Asanuma H., Node K., Takashima S., et al. Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. Circulation. 104:2001;705-710
    • (2001) Circulation , vol.104 , pp. 705-710
    • Sanada, S.1    Kitakaze, M.2    Papst, P.J.3    Asanuma, H.4    Node, K.5    Takashima, S.6
  • 38
    • 0016096195 scopus 로고
    • A new assay of cyclic nucleotide phosphodiesterase: Its application to human serum
    • Hidaka H., Shibuya M. A new assay of cyclic nucleotide phosphodiesterase: its application to human serum. Biochem Med. 10:1974;301-311
    • (1974) Biochem Med , vol.10 , pp. 301-311
    • Hidaka, H.1    Shibuya, M.2
  • 39
    • 0343374101 scopus 로고
    • N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation
    • Hidaka H., Sasaki Y., Tanaka T., Endo T., Ohno S., Fujii Y., et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc Natl Acad Sci USA. 78:1981;4354-4357
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 4354-4357
    • Hidaka, H.1    Sasaki, Y.2    Tanaka, T.3    Endo, T.4    Ohno, S.5    Fujii, Y.6
  • 42
    • 0019982539 scopus 로고
    • Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts
    • Bristow M.R., Ginsburg R., Minobe W., Cubicciotti R.S., Sageman W.S., Lurie K., et al. Decreased catecholamine sensitivity and β-adrenergic- receptor density in failing human hearts. New Engl Med. 307:1982;205-211
    • (1982) New Engl Med , vol.307 , pp. 205-211
    • Bristow, M.R.1    Ginsburg, R.2    Minobe, W.3    Cubicciotti, R.S.4    Sageman, W.S.5    Lurie, K.6
  • 45
    • 0034846206 scopus 로고    scopus 로고
    • Effects of ACE inhibition and angiotensin II type 1 receptor blockade on cardiac function and G proteins in rats with chronic heart failure
    • Yoshida H., Takahashi M., Tanonaka K., Maki T., Nasa Y., Takeo S. Effects of ACE inhibition and angiotensin II type 1 receptor blockade on cardiac function and G proteins in rats with chronic heart failure. Br J Pharmacol. 134:2001;150-160
    • (2001) Br J Pharmacol , vol.134 , pp. 150-160
    • Yoshida, H.1    Takahashi, M.2    Tanonaka, K.3    Maki, T.4    Nasa, Y.5    Takeo, S.6
  • 46
    • 0031471156 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition and angiotensin II subtype-1 receptor blockade during the progression of left ventricular dysfunction: Differential effects on myocyte contractile processes
    • Spinale F.G., Holzgrefe H.H., Mukherjee R., Webb M.L., Hird R.B., Cavallo M.J., et al. Angiotensin-converting enzyme inhibition and angiotensin II subtype-1 receptor blockade during the progression of left ventricular dysfunction: differential effects on myocyte contractile processes. J Pharmacol Exp Ther. 283:1997;1082-1094
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1082-1094
    • Spinale, F.G.1    Holzgrefe, H.H.2    Mukherjee, R.3    Webb, M.L.4    Hird, R.B.5    Cavallo, M.J.6
  • 48
    • 1942538447 scopus 로고    scopus 로고
    • Electrical and ionic abnormalities in the heart of cardiomyopathic hamsters: In quest of a new paradigm for cardiac failure and lethal arrhythmia
    • Sakamoto A. Electrical and ionic abnormalities in the heart of cardiomyopathic hamsters: in quest of a new paradigm for cardiac failure and lethal arrhythmia. Mol Cell Biochem. 259:2004;183-187
    • (2004) Mol Cell Biochem , vol.259 , pp. 183-187
    • Sakamoto, A.1
  • 49
    • 0028062140 scopus 로고
    • Effect of protein kinase C on cyclic 3′,5′-adenosine monophosphate-dependent phosphodiesterase in hypertrophic cardiomyopathic hamster hearts
    • Lee H.C., Cai J.J., Yu H. Effect of protein kinase C on cyclic 3′,5′-adenosine monophosphate-dependent phosphodiesterase in hypertrophic cardiomyopathic hamster hearts. J Pharmacol Exp Therap. 270:1994;1171-1176
    • (1994) J Pharmacol Exp Therap , vol.270 , pp. 1171-1176
    • Lee, H.C.1    Cai, J.J.2    Yu, H.3
  • 50
    • 0030028155 scopus 로고    scopus 로고
    • Protein kinase C isozyme-specific modulation of cyclic AMP-dependent phosphodiesterase in hypertrophic cardiomyopathic hamster hearts
    • Cai J.J., Lee H.C. Protein kinase C isozyme-specific modulation of cyclic AMP-dependent phosphodiesterase in hypertrophic cardiomyopathic hamster hearts. Mol Pharmacol. 49:1996;81-88
    • (1996) Mol Pharmacol , vol.49 , pp. 81-88
    • Cai, J.J.1    Lee, H.C.2
  • 51
    • 0029786960 scopus 로고    scopus 로고
    • Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts
    • Yu H., Cai J.J., Lee H.C. Cyclic AMP-dependent phosphodiesterase isozyme-specific potentiation by protein kinase C in hypertrophic cardiomyopathic hamster hearts. Mol Pharmacol. 50:1996;549-555
    • (1996) Mol Pharmacol , vol.50 , pp. 549-555
    • Yu, H.1    Cai, J.J.2    Lee, H.C.3
  • 52
    • 0020564488 scopus 로고
    • Calmodulin content and Ca-activated protease activity in dystrophic hamster muscles
    • Klamut H.J., Lin C.H., Strickland K.P. Calmodulin content and Ca-activated protease activity in dystrophic hamster muscles. Muscle Nerve. 6:1983;436-441
    • (1983) Muscle Nerve , vol.6 , pp. 436-441
    • Klamut, H.J.1    Lin, C.H.2    Strickland, K.P.3
  • 53
    • 0021266182 scopus 로고
    • UM-X71 myopathic hamster heart shows altered calcimedin protein levels
    • Moore P.B. UM-X71 myopathic hamster heart shows altered calcimedin protein levels. Biochem Biophys Res Commun. 121:1984;915-921
    • (1984) Biochem Biophys Res Commun , vol.121 , pp. 915-921
    • Moore, P.B.1
  • 54
    • 0027943398 scopus 로고
    • Changes of calmodulin concentration and cyclic 3′,5′- nucleotide phosphodiesterase activities in cardiac muscle of hyper- and hypothyroid rat
    • Mano T., Iwase K., Sawai Y., Oda N., Nishida Y., Mokuno T., et al. Changes of calmodulin concentration and cyclic 3′,5′-nucleotide phosphodiesterase activities in cardiac muscle of hyper- and hypothyroid rat. J Endocrinol. 143:1994;515-520
    • (1994) J Endocrinol , vol.143 , pp. 515-520
    • Mano, T.1    Iwase, K.2    Sawai, Y.3    Oda, N.4    Nishida, Y.5    Mokuno, T.6


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