Effect of triptolide-loaded poly(D, L-lactic acid) nanoparticles on testicle tissue in rats

Chinese Journal of Pharmacology and Toxicology

Volumn 18, Issue 4, 2004, Pages 305-308

  Liu, Ming Xing ^a   Dong, Jing ^a   Yang, Ya Jiang ^a   Yang, Xiang Liang ^a   Xu, Hui Bi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Nanoparticles; Poly(D, L lactic acid); Testis; Triptolide

Indexed keywords

DRUG CARRIER; FRUCTOSE; NANOPARTICLE; POLYLACTIC ACID; TRIPTOLIDE;

ANIMAL TISSUE; ARTICLE; CARBOHYDRATE ANALYSIS; CELL DEATH; CELL DEGENERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GIANT CELL; HISTOPATHOLOGY; MALE; MEASUREMENT; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SECONDARY SPERMATOCYTE; SPERMATID; SPERMATOCYTE; SPERMATOZOON; TESTIS; TESTIS ORGAN INDEX; TISSUE HOMOGENATE;

ANIMALIA;

EID: 4444241496     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Shamon LA, Pezzuto JM, Graves JM, Mehta RR, Wangcharoentrakul S, Sangsuwan R, et al. Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii[J]. Cancer Lett, 1997, 112(1):113-117.
2. Sun X, Zhang SM, Tian CH, Yang L, Wang LM, Li SL. Safety of Tripterygium wilfordii[J]. Chin J New Drugs, 2001, 10(7):539-543.
3. Liu L, Wang ZY, Huang GZ, Liu Y. The influence of triptolide sub-chronic intoxication on kidney and testicle in mice[J]. Acta Univ Med Tongji, 2001, 30(3):214-217.
4. Kawashima Y. Nanoparticulate systems for improved drug delivery[J]. Adv Drug Deliv Rev, 2001, 47(1):1-2.
5. Chang J, Liu HF, Yao KD. Recent advances in medical nanoparticles[J]. Chin J Biomed Eng, 2000, 19(4):423-431.
6. Murakami H, Kobayashi M, Takeuchi H, Kawashima Y. Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method[J]. Int J Pharm, 1999, 187(2):143-152.
7. Gonzales GF, Villena A. Influence of low corrected seminal fructose levels on sperm chromatin stability in semen from men attending an infertility service[J]. Fertil Steril, 1997, 67(4):763-768.
8. Lin YZ, Peng SJ, Chen SH, Liu SP, Zou GL. Effect of triptolide on metabolism of testicular tissue in rats[J]. J Wuhan Univ (Nat Sci Ed), 1999, 45(2):200-202.
9. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices[J]. J Control Release, 2001, 70(1-2):1-20.
10. Hans ML, Lowman AM. Biodegradable nanoparticles for drug delivery and targeting[J]. Curr Opin Solid State Mater Sci, 2002, 6:319-327.
11. Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E. Lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix[J]. J Control Release, 1999, 57(3):259-268.