Age and gender dependent levels of glutathione and glutathione S-transferases in human lymphocytes

Carcinogenesis

Volumn 19, Issue 10, 1998, Pages 1873-1875

  Van Lieshout, Esther M M ^a   Peters, Wilbert H M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOBIMANE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOENZYME; MONOCLONAL ANTIBODY;

AGE; ARTICLE; CYTOSOL; DENSITOMETRY; DENSITY GRADIENT CENTRIFUGATION; FEMALE; GENDER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOCYTE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED;

EID: 0031715236     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.10.1873     Document Type: Article

References (19)

1. Hayes,J.D. and Pulford,D.J. (1995) The glutathione 5-transferase supergene family: regulation of GST and contribution of the isoenzymes to cancer chemoprevention and drug resistance. Crit. Rev. Biochem. Mol. Boil., 31, 445-600.
2. Pemble,S., Schroeder,K.R., Spencer,S.R., Meyer,D.J., Hallier,E., Bolt,H.M., Ketterer,B. and Taylor,J.B. (1994) Human glutathione S-transferase theta (GSTT1) cDNA cloning and the characterization of a genetic polymorphism. Biochem. J., 300, 271-276.
3. Tan,K.L., Webb,G.C, Baker,G.C. and Board,P.G. (1995) Molecular cloning of a cDNA and chromosomal localization of a human theta class glutathione S-transferase gene (GSTT2) to chromosome 22. Genomics, 25, 381-387.
4. MacDonald,C.M., Dow,J. and Moore,M.R. (1977) A possible protective role for sulphydryl compounds in acute alcoholic liver injury. Biochem. Pharmacol., 26, 1529-1531.
5. Staal,F.J., Ela,S.W., Roederer,M., Anderson,M.T. and Herzenberg,L.A. (1992) Glutathione deficiency and human immunodeficiency virus infection. Lancet, 339, 909-912.
6. DiSimplicio,P., Dolara,P. and Lodovici,M. (1984) Blood glutathione as a measure of exposure to toxic compounds. J. Appl. Toxico., 4, 227-229.
7. Peters, W.H.M., Roelofs,H.M.J., Hectors,M.P.C, Nagengast,F.M. and Jansen,J.B.M.J. (1993) Glutathione and glutathione 5-transferases in Barren's epithelium. Br. J. Cancer, 67, 1413-1417.
8. Loguercio,C., Taranto,D., Beneduce,F., Vitale,L.M. and Delle-Cava,M. (1996) Age affects glutathione content and glutathione transferase activity in human gastric mucosa. Ital. J. Gastroenterol., 28, 477-481.
9. Lowry,O.H., Rosenbrough,N.J., Farr,A.L. and Randal,R.J. (1951) Protein measurement with the folin phenol reagent. J. Boil. Chem., 193, 265-275.
10. Peters,W.H.M., Boon,C.E.W., Roelofs,H.M.J., Wobbes,Th., Nagengast,F.M. and Kremers,P.G. (1992) Expression of drug metabolizing enzymes and P-170 glycoprotein in colorectal carcinoma and normal mucosa. Gastroenterology, 103, 448-455.
11. Peters,W.H.M., Kock,L., Nagengast,F.M. and Roelofs,H.M.J. (1990) Immunodetection with a monoclonal antibody of glutathione 5-transferase mu in patients with and without carcinomas. Biochem. Pharmacol., 39, 591-597.
12. Van Ommen,B., Bogaards,J.J.P., Peters,W.H.M., Blaauwboer,B. and Van Bladeren,P.J. (1990) Quantification of human hepatic glutathione S-transferases. Biochem. J., 269, 609-613.
13. Peters,W.H.M., Nagengast,F.M. and Wobbes,Th. (1989) Glutathione S-transferases in normal and cancerous human colon tissue. Carcinogenesis, 10, 2371-2374.
14. Nijhoff, W.A., Groen,G.M. and Peters,W.H.M. (1993) Induction of rat hepatic and intestinal glutathione S-transferases and glutathione by dietary naturally occurring anticarcinogens. Int. J. Oncol., 3, 1131-1139.
15. Ceballos-Picot,J., Trivier,J.M., Nicole,A., Sinet,P.M. and Thevenin,M. (1992) Age-correlated modifications of copper-zinc Superoxide dismutase and glutathione-related enzyme activities in human erythrocytes. Clin. Chem., 38, 66-70.
16. Richie,J.P, Skowronski,L., Abraham,P. and Leutzinger,Y. (1996) Blood glutathione concentrations in a large-scale human study. Clin. Chem., 42, 64-70.
17. Michelet,F., Gueguen,R., Leroy,P., Wellman,M., Nicolas,A. and Siest,G. (1995) Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits. Clin. Chem., 41, 1509-1517.
18. Yang,C.S., Chou,S.T., Liu,L., Tsai,P.J. and Kuo,J.S. (1995) Effect of ageing on human plasma glutathione concentrations as determined by highperformance liquid chromatography with fluorimetric detection. J. Chromatogr. B. Biomed. Appl., 674, 23-30.
19. Lang,C.A., Naryshkin,S., Schneider,D.L., Mills,B.J. and Lindeman,R.D. (1992) Low blood glutathione levels in healthy aging adults. J. Lab. Clin. Med., 120, 720-725.