Dilutional coagulopathy, an underestimated problem?

Transfusion Medicine and Hemotherapy

Volumn 31, Issue 4, 2004, Pages 237-242

  Fries, D ^a,b   Streif, W ^a   Haas, T ^a   Kuhbacher G ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Colloids; Crystalloids; Dilutional coagulopathy; Thrombelastography

Indexed keywords

BLOOD CLOTTING DISORDER; CONFERENCE PAPER; CRYSTALLOID; DISSEMINATED INTRAVASCULAR CLOTTING; FIBRIN POLYMERIZATION; HUMAN; THROMBOELASTOGRAPHY;

EID: 4444224004     PISSN: 16603796     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080408     Document Type: Conference Paper

References (59)

1. Lynn M, Jeroukhimov, Klein Y, Martinowitz U: Updates in the management of severe coagulopathy in trauma patients. Intensive Care Med 2002;28:241-247.
2. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL: Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma 1997;42:716-720.
3. Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B: Predicting life-threatening coagulopathy in massively transfused trauma patient: Hypothermia and acidosis revisited. J Trauma 1997;42:857-862.
4. Gando S, Tedo I, Kubota M: Post-trauma coagulation and fibrinolysis. Crit Care Med 1992;20:594-600.
5. Kapsch DN, Metzler M, Harrington M, Mitchell FL, Silver D: Fibrinolytic response to trauma. Surgery 1984;95:473-478.
6. Gubler KD, Gentilello LM, Hassantash SA, Maier RV: The impact of hypothermia on dilutional coagulopathy. J Trauma 1994;36:847-851.
7. Murray DJ, Pennell BJ, Weinstein SL, Olson JD: Packed red cells in acute blood loss: Dilutional coagulopathy as a cause of surgical bleeding. Anesth Analg 1995;80:336-342.
8. Murray DJ, Olson J, Strauss R, Tinker JH: Coagulation changes during packed red cell replacement of major blood loss. Anesthesiology 1988;69:839-845.
9. Leslie SD, Toy PTCY: Laboratory hemostatic abnormalities in massively transfused patients given red blood cells and crystalloids. Am J Clin Pathol 1991;96:224-232.
10. McLoughlin TM, Fontana JL, Alving B, Mongan PD, Bünger R: Profound normovolemic hemodilution: Hemostatic effects in patients and in a porcine model. Anesth Analg 1996;83:459-465.
11. Ciaverella D, Reed RL, Counts RB, Baron L, Pavlin E, Heimbach DM, Carrico CJ: Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient. Br J Haematol 1987;67:365-368.
12. Gentillelo LM, Pierson DJ: Trauma critical care. Am J Respir Crit Care Med 2001;163:604-607.
13. Spiess BD, Gillies BS, Chandler W, Verrier E: Changes in transfused therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. J Cardiothorac Vasc Anesth 1995;9:168-173.
14. Whitten CW, Greilich PE: Thrombelastography: Past, present and future. Anesthesiology 2000;92:1223-1225.
15. Hartert H: Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klein Wochenschr 1948;577- 583.
16. Mallet SV, Cox DJA: Thrombelastography. Br J Anaesth 1992;69:307-313.
17. Haisch G, Boldt J, Krebs C, Kumle B, Suttner S, Schulz A: The influence of intravascular therapy with a new hydroxyethyl starch preparation (6% HES 130/0.4) on coagulation in patients undergoing major abdominal surgery. Anesth Analg 2001;92:565-571.
18. Calatzis AN, Kling M, Calatzis AL, Mielke L, Hipp R, Stemberger A: Fast and specific coagulation monitoring through modified thrombelastography. Ann Hematol 1996;72(suppl 1):P92.
19. Valeri CR, Cassidy G, Pivacek LE, Ragno G, Lieberthal W, Crowley JP, Khuri SF, Loscalzo J; Anemia induced increase in bleeding time: the implication for treatment of nonsurgical blood loss. Transfusion 2001;41:977-983.
20. Small M, Lowe GD, Cameron E, Forbes CD: Contribution of the haematokrit to the bleeding time. Haemostasis 1983;13:379-384.
21. Blajchman MA, Bordin JO, Bardossy L, Heddle NM: The contribution of the haematocrit to the thrombocytopenic bleeding in experimental animals. Br J Haematol 1994;86:347-350.
22. Santos MT, Valles J, Aznar J, Marcus AJ, Broekman MJ, Safier LB: Prothrombotic effects of erythrocytes on platelet reactivity. Reduction by aspirin. Circulation 1997;95:63-68.
23. Peyrou V, Lormeau JC, Herault JP, Gaich C, Pfliegger AM, Herbert JM: Contribution of erythrocytes to thrombin generation in whole blood. Thromb Haemost 1999;81:400-406.
24. Escolar G, Garrido M, Mazzara R, Castillo R, Ordinas A: Experimental basis for the use of red cell transfusion in the management of anaemic-thrombocytopenic patients. Transfusion 1988;28:406-411.
25. Hiippala ST: Dextran and hydroxyethyl starch interfere with fibrinogen assays. Blood Coagul Fibrinolysis 1995;6:743-746.
26. Gottumukkala VNR, Sharma SK, Philip J: Assessing platelet and fibrinogen contribution to clot strength using modified thrombelastography in pregnant women. Anesth Analg 1999;89:1453-1455.
27. Cochrane Injuries Group Albumin Reviewers: Human albumin administration in critically ill patients. Systemic review of randomised controlled trials. BMJ 1998;317:235-240.
28. Mortier E, Ongenae M, Baerdemaeker LD, Herregods L, Den Blauwen N, Van Aken J, Rolly G: In vitro evaluation of the effect of profound haemodilution with hydroxyethyl starch 6%, modified gelatine 4%, and dextran 40 10% on coagulation profile measured by thrombelastography. Anaesthesia 1997;52:1061-1064.
29. Schierhout G, Roberts I: Fluid resuscitation with colloid or crystalloid solution in critically ill patients: A systemic review of randomized trials. BMJ 1998;316:961-964.
30. Choi P, Yip G, Quinonez LG, Cook DJ: Crystalloids vs. colloids in fluid resuscitation. A systemic review. Crit Care Med 1999;27:200-221.
31. Roberts I, Evans P, Bunn F, Kwan I, Crowhurst E: Is the normalisation of blood pressure in bleeding trauma patients harmful. Lancet 2001;357:385-387.
32. Ruttmann TG, James MFM, Viljoen JF: Haemodilution induces a hypercoagulable state. Br J Anaesth 1996;76:412-414.
33. Karoutsos S, Nathan N, Lahrimi A, Grouille D, Feiss P, Cox DJA: Thrombelastogram reveals hypercoagulability after administration of gelatin solution. Br J Anaesth 1999;82:175-177.
34. Ng KFJ, Lam CCK, Chan LC: In vivo effects of haemodilution with saline on coagulation: A randomized controlled trial. Br J Anaesth 2002;88:475-480.
35. Ruttmann TG, James MFM, Finlayson J: Effects on coagulation of intravenous crystalloid or colloid in patients undergoing peripheral vascular surgery. Br J Anaesth 2002;89:226-230.
36. Innerhofer P, Fries D, Klingler A, Streif W: In vivo effects of haemodilution with saline on coagulation. Br J Anaesth 2002;89:934-939.
37. Fries D, Innerhofer P, Klingler A, Berresheim U, Mittermayr M, Calatzis A, Schobersberger W: The effect of the combined administration of colloids and lactated Ringer's solution on the coagulation system: An in vitro study using thrombelastograph coagulation analysis. Anesth Analg 2002;94:1280-1287.
38. Innerhofer P, Fries D, Margreiter J, Klingler A, Kühbacher G, Wachter B, Oswald E, Salner E, Frischhut B, Schobersberger W: The effect of perioperatively administered colloids and crystalloids on primary hemostasis and clot formation. Anesth Analg 2002;95:858-865.
39. Petroianu GA, Maleck WH, Koettner KP, Liu J, Schmitt A: Effect of in vitro hemodilution with hydroxyethyl starch and dextrans on the activity of plasma clotting factors. Crit Care Med 2003;31:250-254.
40. Mardel SN, Saunders FM, Allen H, Menezes G, Edwards CM, Ollerenshaw L, Baddeley D, Kennedy A, Ibbotson RM: Reduced clot quality of clot formation with gelatin based plasma substitutes. Br J Anaesth 1998;80:204-207.
41. Engvall E, Ruoslahti E, Miller EJ: Affinity of fibronectin to collagens of different genetic types and fibrinogen. J Exp Med 1978;147:1584-1595.
42. Treib J, Baron JF, Grauer MT, Strauss RG: An international view of hydroxyethyl starches. Int Care Med 1999;25:258-268.
43. Vogt NH, Bothner U, Lerch G, Lindner KH, Georgieff M: Large dose administration of 6% hydroxyethyl starch 200/0.5 for total hip arthroplasty: Plasma homeostasis, hemostasis and renal function compared to use of 5% human albumin. Anesth Analg 1996;83:262-268.
44. Entholzer EK, Mielke LL, Calatzis AN, Feyh J, Hipp R, Hargasser SR: Coagulation effects of a recently developed hydroxyethyl starch (HES 130/0.4) compared to hydroxyethyl starches with higher molecular weight. Acta Anaesthesiol Scand 2000;44:1116-1121.
45. Gallandat R, Siemons A, Baus D, van Rooyen-Butijn WT, Haagenaars JA, van Oeveren W, Bepperling F: A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery. Can J Anaesth 2000;47:1207-1215.
46. Menzebach A, Cassens U, Van Aken H, Booke M: Strategies to reduce perioperative blood loss related to non-surgical bleeding. Eur J Anaesthesiol 2003;20:764-770.
47. Mortelsmans YJ, Vermaut GA, Van Aken H: A simple method for calculating component dilution during fluid resuscitation: The Leuven approach. J Clin Anesth 1994;6:279-287.
48. Stainsby D, MacLennan S, Hamilton PJ: Management of massive blood loss: A template guideline: Br J Anaesth 2000;85:487-491.
49. Reed RL 2nd, Ciavgerella D, Heimbach DM, Baron L, Pavlin E, Counts RB, Carrico CJ: Prophylactic platelet administration during massive transfusion. Ann Surg 1986;203:40-48.
50. Hirshberg A, Dugas M, Banez Ei, Scott BG, Wall MJ, Mattox KL: Minimizing dilutional coagulopathy in exsanguinating hemorrhage: A computer simulation. J Trauma 2003;54:454-463.
51. Hiippala ST, Myllylä GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995;81:360-365.
52. Murray DJ, Pennel BJ, Weinstein SL, Olson JD: Packed red cells in acute blood loss: Dilutional coagulopathy as a cause of surgical bleeding. Anesth Analg 1995;80:336-342.
53. Eika C, Havie O, Godal HC: The value of preoperative haemostatic screening. Scand J Haematol 1978;21:349-354.
54. Robbins JA, Rose SD: Partial thromboplastin time as screening test. Ann Intern Med 1979;90:796-797.
55. Lucas CE, Ledgerwood AM: Clinical significance of altered coagulation tests after massive transfusion for trauma. Ann Surg 1981;47:125-130.
56. Singbartl K, Innerhofer P, Radvan J, Westphalen B, Fries D, Stogbauer R, Van Aken H: Hemostasis and hemodilution: A quantitative mathematical guide for clinical practice. Anesth Analg 2003;96:929-935.
57. Vorstand und wissenschaftlicher Beirat der Bundesärztekammer: Leitlinien zur Therapie mit Blutkomponenten und Plasmaderivaten. Köln, Deutscher Ärzteverlag, 2001.
58. Savirez M, Fries D, Klingler A, Schobersberger W, Innerhofer P: The effect of the fibrinogen and factor XIII substitution on dilutional coagulopathy - an in vitro model using thrombelastography (ROTEG). Ann Hematol 2002;81(suppl 1):P76.
59. Fries D, Krismer A, Schobersberger A, Klingler A, Klima G, Wenzel V, Innerhofer P: The effect of fibrinogen on dilutional coagulopathy - a porcine model. Intensive Care Med 2003;29(suppl 1):D527