Updates in the management of severe coagulopathy in trauma patients

Intensive Care Medicine, Supplement

Volumn 28, Issue 2, 2002, Pages S241-S247

  Lynn, Mauricio ^a   Jeroukhimov, Igor ^a   Klein, Yoram ^a   Martinowitz, Uri ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Coagulopathy; Hemorrhage; Hypothermia; Recombinant activated factor VII (rFVIIa)

Indexed keywords

BLOOD CLOTTING FACTOR; RECOMBINANT BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

BLEEDING; BLOOD CLOTTING DISORDER; CORRELATION ANALYSIS; DISEASE COURSE; DRUG EFFICACY; FIBRINOLYSIS; HEMODILUTION; HEMOPHILIA; HEMOSTASIS; HUMAN; HYPOTHERMIA; INJURY; INTENSIVE CARE UNIT; LAPAROTOMY; METABOLIC ACIDOSIS; MORTALITY; NONHUMAN; PATHOGENESIS; PATIENT CARE; PHYSIOLOGY; POSTTRAUMATIC COMPLICATION; PROPHYLAXIS; RESUSCITATION; REVIEW; SURGICAL TECHNIQUE; SURVIVAL; THROMBOCYTE; THROMBOCYTOPENIA; TREATMENT OUTCOME; WOUND INFECTION;

BLOOD LOSS, SURGICAL; FACTOR VII; HEMORRHAGE; HEMOSTASIS; HUMANS; RECOMBINANT PROTEINS; WOUNDS AND INJURIES;

EID: 0036035516     PISSN: 09351701     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (39)

1. MacKenzie EJ, Fowler CJ (2000) Epidemiology. In: Mattox KL, Feliciano DV, Moore EE (eds) Trauma, 4th Edn. McGraw-Hill, New York, pp 21-39
2. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT (1995) Epidemiology of trauma death: A reassessment. J Trauma 38:185-193
3. Hoyt DB, Bulger EM, Knudson MM, Morris J, Ierardi R, Sugerman HJ, Shackford SR, Landercasper J, Winchell RJ, Jurkovich G (1994) Death in the operating room: An analysis of a multi-center experience. J Trauma 37:426-432
4. Rotondo MF, Zonies DH (1997) The damage control sequence and underlying logic. Surg Clin North Am 77:761-777
5. Johnson JW, Gracias VH, Schwab CW, Reilly PM, Kauder DR, Shapiro MB, Dabrowski GP, Rotondo MF (2001) Evolution in damage control for exsanguinating penetrating abdominal injury. J Trauma 51:261-269
6. Moore EE (1996) Staged laparotomy for the hypothermia, acidosis and coagulopathy syndrome. Am J Surg 172:405-410
7. Rotondo MF, Schwab CW, McGonigal MD, Phillips GR 3rd, Fruchterman TM, Kauder DR, Latenser BA, Angood PA (1993) Damage control: An approach to improve survival in exsanguinated penetrating abdominal injury. J Trauma 35:375-382
8. Eddy VA, Morris JA, Cullinane DC (2000) Hypothermia, coagulopathy, acidosis. Surg Clin North Am 80:845-854
9. Hiippala ST, Myllyla GJ, Vahtera EM (1995) Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 81:360-365
10. Goskowicz R (1999) The complication of massive blood transfusion. Anesth Clin North Am 17:959-975
11. Villalobos TJ, Adelson E, Borila TG (1955) Hematologic changes in hypothermic dogs. Proc Soc Exp Biol Med 89:192-196
12. Hessell EA, Schmer G, Dillard DH (1980) Platelet kinetics during deep hypothermia. J Surg Res 28:23-34
13. Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR (1994) Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost 71:633-640
14. Valeri CR, Feingold H, Cassidy G, Ragno G, Khuri S, Altschule MD (1987) Hypothermia-induced reversible platelet dysfunction. Ann Surg 205:175-181
15. Reed RL, Bracey AWJ Jr, Hudson JD, Miller TA, Fischer RP (1990) Hypothermia and blood coagulation: Dissociation between enzyme activity and clotting factor levels. Circ Shock 32:141-152
16. Rohrer MJ, Natale AM (1992) Effect of hypothermia on the coagulation cascade. Crit Care Med 20:1402-1405
17. Gubler KD, Gentilello LM, Hassantash SA, Maier RV (1994) The impact of hypothermia on dilutional coagulopathy. J Trauma 36:847-851
18. Reed RL, Johnson TD, Hudson JD, Fischer RP (1992) The disparity between hypothermic coagulopathy and clotting studies. J Trauma 33:465-470
19. Johnston TD, Chen Y, Reed RL (1994) Functional equivalence of hypothermia to specific clotting factor deficiencies. J Trauma 37:413-417
20. Yoshihara H, Yamamoto T, Mihara H (1985) Changes in coagulation and fibrinolysis occurring in dogs during hypothermia. Thromb Res 37:503-512
21. Yenari MA, PalmerJT, Bracci PM, Steinberg GK (1995) Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent. Thromb Res 77:475-481
22. Gentilello LM, Pierson DJ (2001) Trauma critical care. Am J Respir Crit Care Med 163:604-607
23. Goodnight SH, Kenoyer G, Rapaport SI, Patch MJ, Lee JA, Kurze T (1974) Defibrination after brain tissue destruction: A serious complication of head injury. N Engl J Med 290:1043-1047
24. Rotondo MF, Reilly PM (2000) Bleeding and coagulation complications. In: Mattox KL, Feliciano DV, Moore EE (eds) Trauma, 4th Edn. McGraw-Hill, New York, pp 1274-1275
25. Kincaid EH, Miller PR, Meredith JW, Rahman N, Chang MC (1998) Elevated arterial base deficit in trauma patients: A marker of impaired oxygen utilization. J Am Coll Surg 187:384-392
26. Reed RL II, Ciavarella D, Heimbach DM, Baron L, Pavlin E, Counts RB, Carrico CJ (1986) Prophylactic platelet administration during massive transfusion: A prospective, randomized, double-blind clinical study. Ann Surg 203:40-48
27. Harke H, Rahman S (1980) Haemostatic disorders in massive transfusion. Bibl Haematol 46:179-188
28. Chandler W (1995) The thromboelastograph and the thromboelastograph technique. Semin Thromb Hemost 21 (Suppl 4):1-6
29. Spiess BD (1995) Perioperative coagulation monitoring. In: Spiess BD, Counts RB, Gould SA (eds) Perioperative Transfusion Medicine, 1st Edn. Williams & Wilkins, Baltimore, pp 250-254
30. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL (1997) Usefulness of thromboelastography in assessment of trauma patient coagulation. J Trauma 42:716-720
31. Spiess BD, Gillies BS, Chandler W, Verrier E (1995) Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. J Cardiothorac Vasc Anesth 9:168-173
32. Burch JM, Ortiz VB, Richardson RJ, Martin RR, Mattox KL, Jordan GL Jr (1992) Abbreviated laparotomy and planned reoperation for critically injured patients. Ann Surg 215:476-483
33. Peng RY, Bongard FS (1999) Hypothermia in trauma patients. J Am Coll Surg 188:685-696
34. Kenet G, Walden R, Eldad A, Martinowitz U (1999) Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 354:1879
35. Martinowitz U, Kenet G, Segal E, Luboshitz J, Lubetsky A, Ingerslev J, Lynn M (2001) Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 51:431-439
36. Bernstein DE, Jeffers L, Erhardtsen E, Reddy KR, Glazer S, Squiban P, Bech R, Hedner U, Schiff ER (1997) Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: A preliminary study. Gastroenterology 113:1930-1937
37. Rapaport SI, Rao LVM (1992) Initiation and regulation of tissue factor-dependent blood coagulation. Arterioscler Thromb 12:1111-1121
38. Martinowitz U, Holcomb JB, Pusateri AE (2001) Intravenous rFVII administrated for hemorrhage control in hypothermic coagulopathic swine with grade V liver injury. J Trauma 50:721-729
39. Lynn M, Jeroukhimov I, Jewelewicz D, Popkin C, Johnson EW, Rashid QN, Brown M, Martinowitz U, Cohn SM (2002) Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: A pilot study. J Trauma 52:703-707