CD4-induced down-regulation of T cell adhesion to B cells is associated with localization of phosphatidyl inositol 3-kinase and LFA-1 in distinct membrane domains

European Journal of Immunology

Volumn 34, Issue 8, 2004, Pages 2168-2178

  Trucy, Maÿlis ^a   Barbat, Christiane ^a   Sorice, Maurizio ^b   Fischer, Alain ^a   Mazerolles, Fabienne ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

CD4; LFA 1; Pl3 kinase; Rafts

Indexed keywords

CD4 ANTIGEN; GANGLIOSIDE GM1; GANGLIOSIDE GM3; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P56; ANTIBODY;

ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL MEMBRANE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBODIES; ANTIGENS, CD4; B-LYMPHOCYTES; CELL ADHESION; DOWN-REGULATION; HUMANS; JURKAT CELLS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE MICRODOMAINS; T-LYMPHOCYTES;

EID: 4444219720     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425057     Document Type: Article

References (35)

1. Gahmberg, C. G., Tolvanen, M. and Kotovuori, P., Leukocyte adhesion. Structure and function of human leukocyte beta2-integrins and their cellular ligands. Eur. J. Biochem. 1997. 245: 215-232.
2. Springer, T. A., Adhesion receptors of the immune system. Nature 1990. 346: 425-434.
3. Mazerolles, F., Barbat, C. and Fischer, A., Down-regulation of LFA-1 mediated T cell adhesion induced by the HIV env gp160 requires phosphatidylinositol-3-kinase activity. Eur. J. Immunol. 1997. 27: 2457-2465.
4. + T cell activation. Int. Immunol. 1996a. 8: 267-274.
5. Mazerolles, F., Barbat, C., Hivroz, C. and Fischer, A., Phosphatidylinositol 3-kinase participates in p56lck/CD4 dependent down-regulation of LFA-1 mediated T cell adhesion. J. Immunol. 1996. 157: 4844-4854.
6. Mazerolles, F., Barbat, C., Trucy, M., Kolanus, W. and Fischer, A., Molecular events associated with CD4-mediated down-regulation of LFA-1-dependent adhesion. J. Biol. Chem. 2002. 277: 1276-1283.
7. Stewart, M. and Hogg, N., Regulation of leukocyte integrin function: affinity vs. avidity. J. Cell Biochem. 1996. 61: 554-561.
8. Krauss, K. and Altevogt, P., Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J. Biol. Chem. 1999. 274: 36921-36927.
9. Schade, A. E. and Levine, A. D., Lipid raft heterogeneity in human peripheral blood T lymphoblasts: a mechanism for regulating the initiation of TCR signal transduction. J. Immunol. 2002. 168: 2233-2239.
10. Watanabe, T. and Sendo, F., Physical association of beta2 integrin with GPI-80, a novel glycosylphosphatidylinositol-anchored protein with potential for regulating adhesion and migration. Biochem. Biophys. Res. Commun. 2002. 294: 692-694.
11. Leitinger, B. and Hogg, N., The involvement of lipid rafts in the regulation of integrin function. J. Cell Sci. 2002. 115: 963-972.
12. Montixi, C., Langlet, C., Bernard, A. M., Thimonier, J., Dubois, C., Wurbel, M. A., Chauvin, J. P., Pierres, M. and He, H. T., Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J 1998. 17: 5334-5348.
13. Drevot, P., Langlet, C., Guo, X. J., Bernard, A. M., Colard, O., Chauvin, J. P., Lasserre, R. and He, H. T., TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J. 2002. 21: 1899-1908.
14. Manes, S., Mira, E., Gomez-Mouton, C., Lacalle, R. A., Keller, P., Labrador, J. P. and Martinez, A. C., Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J. 1999. 18: 6211-6220.
15. Whitman, M., Downes, C. P., Keeler, M., Keller, T. and Cantley, L., Type I phosphatidyl kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 1988. 332: 644-646.
16. Kolanus, W., Nagel, W., Schiller, B., Zeitlmann, L., Godar, S., Stockinger, H. and Seed, B., αLβ2 integrin /LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 1996. 86: 233-242.
17. Constantin, G., Majeed, M., Giagulli, C., Piccio, L., Kim, J. Y., Butcher, E. C. and Laudanna, C., Chemokines trigger immediate beta 2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity 2000. 13: 759-769.
18. Kozak, S. L., Heard, J. M. and Kabat, D., Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus. J. Virol. 2002. 76: 1802-1815.
19. Alonso, M. A. and Milian, J., The role of lipid rafts in signalling and membrane trafficking in T lymphocytes. J. Cell Sci. 2001. 114: 3957-3965.
20. Bohuslav, J., Cinek, T. and Horejsi, V., Large, detergent-resistant complexes containing murine antigens Thy-1 and Ly-6 and protein tyrosine kinase p56lck. Eur. J. Immunol. 1993. 23: 825-831.
21. Ilangumaran, S. and Hoessli, D. C., Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem. J. 1998, 335: 433-440.
22. Hammache, D., Yahi, N., Pieroni, G., Ariasi, F., Tamalet, C. and Fantini, J., Sequential interaction of CD4 and HIV-1 gp120 with a reconstituted membrane patch of ganglioside GM3: implications for the role of glycolipids as potential HIV-1 fusion cofactors. Biochem. Biophys. Res. Commun. 1998. 246: 117-122.
23. Kigushi, K., Henning-Chubb, B. C. and Huberman, E., Glycosphingolipid patterns of peripheral blood lymphocytes, monocytes, and granulocytes are cell specific. J. Biol. Chem. 1990. 107: 8-14.
24. Iwabuchi, K., Yamamura, S., Prinetti, A., Handa, K. and Hakomori, S., GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells. J. Biol. Chem 1998. 273: 9130-9138.
25. Garofalo, T., Lenti, L., Longo, A., Misasi R., Mattei, V., Pontieri, G. M., Pavan, A. and Sorice, M., Association of GM3 with Zap-70 induced by T cell activation in plasma membrane microdomains: GM3 as a marker of microdomains in human lymphocytes. J. Biol. Chem. 2002. 277: 11233-11238.
26. Sorice, M., Garofalo, T., Misasi, R., Longo, A., Mikulak, J., Dolo, V., Pontieri, G. M. and Pavan, A., Association between GM3 and CD4-lck complex in human peripheral blood lymphocytes. Glycoconj. J. 2000. 17: 247-257.
27. Brown, D. A. and London, E., Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 2000. 275: 17221-17224.
28. Gomez-Mouton, C., Abad, J. L., Mira, E., Lacalle, R. A., Gallardo, E., Jimenez-Baranda, S., Illa, I., Bernad, A., Manes, S. and Martinez, A. C., Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. Proc. Natl. Acad. Sci. USA 2001. 98: 9642-9647.
29. Mitchell, C. A., Kanca, O. and McIntyre, B. W., Lipid microdomain clustering induces a redistribution of antigen recognition and adhesion molecules on human T lymphocytes. J. Immunol. 2002. 168: 2737-2744.
30. lck tyrosine kinase. J. Immunol. 1994. 152: 5670-5679.
31. Fragoso, R., Ran, D., Zhang, X., Wei-Chih Su, M., Burakoff, S. J. and Jin, Y. J., Lipid raft distribution of CD4 depends on its palmitoylation and association with lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J. Immunol. 2003. 170: 913-921.
32. Harriague, J. and Bismuth, G., Imaging antigen-induced PI3K activation in T cells. Nat. Immunol. 2002. 3: 1090-1096.
33. Costello, P. S., Gallagher, M. and Cantrell, D. A., Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 2002. 3: 1082-1089.
34. Niedergang, F., Dautry-Varsat, A. and Alcover, A., Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors. J. Immunol. 1997. 159: 1703-1710.
35. Mazerolles, F., Lumbroso, C., Lecomte, O., Le Deist, F. and Fischer, A., The role of lymphocyte function-associated antigen-1 (LFA-1) in the adherence of T lymphocytes to B lymphocytes. Eur. J. Immunol. 1988b. 18: 1229-1233.