Phosphatidylinositol 3-Kinase Participates in p56lck/CD4-Dependent Down-Regulation of LFA-1-Mediated T Cell Adhesion

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 4844-4854

  Mazerolles, F ^a,b   Barbat, C ^a   Hivroz, C ^a   Fischer, A ^a  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CD4 ANTIGEN; HLA ANTIGEN CLASS 2; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE LCK; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL LINE; CYTOLOGY; DOWN REGULATION; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANTIGENS, CD4; B-LYMPHOCYTES; BASE SEQUENCE; CELL ADHESION; CELL LINE; DOWN-REGULATION; ENZYME ACTIVATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SRC-FAMILY KINASES; T-LYMPHOCYTES;

EID: 0030457032     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. De Fougerolles, A. R., and T. A. Springer. 1992. Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule-1 on resting lymphocytes. J. Exp. Med. 175:185.
2. Dustin, M. L., and T. A. Springer. 1991. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu. Rev. Immunol. 9:27.
3. Shaw, S., G. Luce, R. Quinones, R. E. Gress, T. A. Springer, and M. E. Sanders. 1986. Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones. Nature 322:262.
4. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425.
5. Dustin, M. L., and T. A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341:619.
6. + T cells. Eur. J. Immunol. 25:2285.
7. Mazerolles, F., F. Amblard, C. Lumbroso, O. Lecomte, P. Van De Moortele, C. Barbat, D. Piatier-Tonneau, C. Auffray, and A. Fischer. 1990. Regulation of T helper-B lymphocyte adhesion through CD4-HLA class II interaction. Eur. J. Immunol. 20:637.
8. Nag, B., H. G. Wada, D. Passmore, B. R. Clartk, S. D. Sharma, and H. McConnell. 1993. Purified β-chain of MHC class II binds to CD4 molecules on transfected HeLa cells. J. Immunol. 150:1358.
9. + T cell activation. Int. Immunol. 8:267.
10. Rudd, C. E., J. M. Trevillyan, J. D. Dasgupta, L. L. Wong, and S. F. Schlossman. 1988. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc. Natl. Acad. Sci. USA 85:5190.
11. Shaw, A. S., K. E. Amrein, K. Hammond, D. F. Stern, B. M. Sefton, and J. K. Rose. 1989. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain. Cell 59:627.
12. lck. Cell 55:301.
13. lck. Nature 338:257.
14. Luo, K., and B. M. Sefton. 1990. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the Lck tyrosine protein kinase at the autophosphorylation cell. Mol. Cell. Biol. 10:5305.
15. lck) that phosphorylates the CD3 complex. Proc. Natl. Acad. Sci. USA 86: 3277.
16. Sleckman, B. P., A. Peterson, J. A. Foran, J. C. Gorga, C. J. Karec, J. L. Strominger, S. J. Burakoff, and J. L. Greestein. 1988. Functional analysis of a cytoplasmic domain-deleted mutant of the CD4 molecule. J. Immunol. 141:49.
17. Veillette, A., J. B. Bolen, and M. A. Bookman. 1989. b. Alterations in tyrosine phosphorylation induced by antibody-mediated crosslinking of the CD4 receptor of T lymphocytes. Mol. Cell. Biol. 9:4441.
18. lck tyrosine kinase. J. Immunol. 152:5670.
19. Merida, I., E. Diez, and G. N. Gaulton. 1991. IL-2 binding activates a tyrosine phosphorylated phosphatidylinositol 3-kinase. J. Immunol. 147:2202.
20. lck SH3 domain binds to PI3-kinase but not PI4-kinase. Mol. Cell. Biol. 13:7708.
21. Cantley, L. C., K. R. Auger, C. L. Carpenter, B. Duckworth, A. Grazioni, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell 64: 231.
22. Coughlin, S. R., J. A. Escobedo, and L. Williams. 1989. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243:1191.
23. Nakanishi, H., K. A. Brewer, and J. H, Exton. 1993. Activation of the ζ isozyme of protein kinase C by phosphatidylinosilol 3,4,5 triphosphate. J. Biol. Chem. 268:13.
24. Remillard, B. R., M. Petrillo, T. B. Maslinski, T. B. Tsudo, B. Strom, L. C. Cantley, and L. Varticovski. 1991. Interleukin-2 receptor regulates activation of phosphatidylinositol-3 kinase. J. Biol. Chem. 266:14167.
25. Ruderman, N. B , R. Kapeller, M. F. White, and L. C. Cantley. 1990. Activation of phosphatidylinositol 3-kinase by insulin. Proc. Natl. Acad. Sci. USA 87:1411.
26. Whitman, M., C. P. Downes, M. Keeler, T. Keller, and L. Cantley. 1988. Type I phosphalidyl kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644.
27. src complexes and PI3 kinase. Cell 65:91.
28. Hu, P., and J. Schlessinger. 1994. Direct association of p110β ptiosphatidylinositol-3-kinase with p85 is mediated by an N-terminal fragment of 110β. Mol. Cell. Biol. 14:2577.
29. Fischer, A., R. Seger, A. Durandy, B. Grospierre, J. L. Virelizier, F. Le Deist, C. Griscelli, E. Fischer, M. Kazatchkine, M. C. Bohler, B. Descamp-Latscha, H. T. Pham, T. A. Springer, D. Olive, and C. Mawas. 1985. Deficiency of the adhesive protein complex lymphocyte function antigen-1, complement receptor type-3, glycoprotein p150,95 in a girl with recurrent bacterial infections. J. Clin. Invest. 76:2385.
30. Mazerolles, F., A. Durandy, D. Piatier-Tonneau, D. Charron, L. Montagnier, C. Auffray, and A. Fischer. 1988. a. Immunosuppressive properties of synthetic peptides derived from CD4 and HLA-DR antigens. Cell 55:497.
31. Cammarota, G., A. Scheirle, B. Takacs, D. M. Doran, R. Knorr, W. Bannwarth, J. Guardiola, and F. Sinigaglia. 1992. Identification of a CD4 binding site on the β2 domain of HLA-DR molecules. Nature 356:799.
32. Arcaro, A., and M. P. Wymann. 1993. Wortmannin is a potent phosphatidylinositol-3 kinase inhibitor: the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses. Biochem. J. 296:297.
33. Vlahos, C., W. F. Matter, K. Y. Hui, and R. F. Brown. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (Ly294002). J. Biol. Chem. 269:5241.
34. Volinia, S., I. Hiles, E. Ormondroyd, D. Nizetic, R. Antonacci, M. Rocci, and M. D. Waterfield. 1994. Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. Genomics 24:472.
35. Cooper, J. A., F. S. Esch, S. S. Taylor, and T. Hunter. 1983. Detection and quantification of phosphotyrosine in proteins. Methods Enzymol. 99:387.
36. Pages, F., M. Ragueneau, R. Rottapel, A. Truneh, J. Nunes, J. Imbert, and D. Olive. 1994. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T cell signalling. Nature 369:327.
37. Rottapel, R., M. Reedijk, D. E. Williams, S. D. Lyman, T. Pawson, and A. Bernstein. 1991. The steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the steel factor. Mol. Cell. Biol. 11:3043.
38. Venkitaraman, A. R., and R. J. Cowling. 1994. Interleukin-7 induces the association of phosphatidylinositol-3 kinase with the a chain of the interleukin-7 receptor. Eur. J. Immunol. 24:2168.
39. Hivroz, C., F. Mazerolles, M. Soula, R. Fagard, S. Graton, S. Meloche, R. P. Sekaly, and A. Fischer. 1993. Human immunodeficiency virus (HIV) glycoprotein 120 and derived peptides activate protein tyrosine kinase in human CD4 T lymphocyte. Eur. J. Immunol. 23:600.
40. lck with CD4 in human T lymphocytes. J. Biol. Chem. 266:11176.
41. Thompson, P. A., J. S. Gutkind, K. C. Robbins, J. A. Ledbetter, and J. B. Bolen. 1992. Identification of distinct populations of PI3-kinase activity following T-cell activation. Oncogene 7:719.
42. Gomez, J., A. Martinez De Aragon, P. Bonay, C. Pitton, A. Garcia, A. Silva, M. Fresno, F. Aliarez, and A. Rebollo. 1995. Physical association and functional relationship between protein kinase C ζ and the actin cytoskeleton. Eur. J. Immunal 25:2673.
43. Higgins, K., J. R. Perez, T. A. Coleman, K. Dorshkind, W. A. McComas, U. M. Sarmiento, C. A. Rosen, and R. Narayanan. 1993. Antisense inhibition of the p65 subunit of NFκB blocks tumorigenicity and causes tumor regression. Proc. Natl. Acad. Sci. USA 90:9901.
44. lck mediates both intermolecular and intramolecular interactions. Proc. Natl. Acad. Sci. USA 90: 10285.
45. lck tyrosine kinase. Eur. J. Immunol. 24:234.
46. Uckun, F. M., G. L. Schieven, I. Dibirdik, M. Chandan-Langhe, L. Tuel-Ahlgreen, and J. A. Ledbetter. 1991. Stimulation of protein tyrosine phosphorylation, phosphoinositides turnover and multiple previously unidentified serine/threonine specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B cell ontogeny. J. Biol. Chem. 266: 17478.
47. 2+ independent costimulatory activity. Eur. J. Immunol. 24:2732.
48. Rameh, L. E., C. S. Chen, and L C. Cantley. 1995. Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI3-kinase association with tyrosine-phosphorylated proteins. Cell 83:821.
49. Akimoto, K., R. Takahashi, S. Moriya, N. Nishioka, J. Takayanagi, K. Kimura, Y. Fukui, S. Osada, K. Mizuno, S. Hirai, A. Kazlauskas, and S. Ohno. 1996. EGF or PDGF receptors activate atypical PKC λ through phosphatidylinositol 3-kinase. EMBO J. 15:788.
50. Boudewijn, M., T. Burgering, and P. J. Coffer. 1995. Protein kinase B (c-akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599.
51. Shibasaki, F., K. Fukami, Y. Fukui, and T. Takenawa. 1994. Phosphatidylinositol 3-kinase binds to α-actinin through p85 subunit. Biochem. J. 302:551.
52. Wyman, M., and A. Arcuro. 1994. Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts. Biochem. J. 298:517.
53. Guinebaull, C., B. Payrastre, C. Racaud-Sultan, H. Mazarguil, M. Breton, G. Mauco, M. Plantavid, and H. Chap. 1995. Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 α with actin filaments and focal adhesion kinase. J. Cell Biol. 129:831.
54. Eberle, M., A. E. Traymor-Kaplan, L. A. Sklar, and J. Novganer. 1990. Is there a relationship between phosphalidylinositol triphosphate and F-actin polymerisation in human neutrophils? J. Biol. Chem. 264:16725.
55. Shimizu, Y., J. L. Mobley, L. D. Finkelstein, and A. Chan. 1995. A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen. J. Cell Biol. 131:1867.
56. Peter, K., and T. E. O'Toole. 1995. Modulation of cell adhesion by changes in αLβ2 (LFA-1,CD11a/CD18) cytoplasmic domain/cytoskeleton interaction. J. Exp. Med. 181:315.
57. Pardi, R., L. Inverardi, C. Rugarli. and J. R. Bender. 1992. Antigen-receptor complex stimulation triggers protein-kinase C dependent CD11a/CD18-cytoskeleton association in T lymphocytes. J. Cell Biol. 116:1211.
58. Stewart, M. P., C. Cabanas, and N. Hogg. 1996. T cell adhesion to intercellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1. J. Immunol. 156:1810.
59. lck. J. Biol. Chem. 269:19435.