Evidence for GABA(A) receptor agonistic properties of ketamine: Convulsive and anesthetic behavioral models in mice

Anesthesia and Analgesia

Volumn 91, Issue 1, 2000, Pages 230-236

  Irifune, Masahiro ^a,b   Sato, Tomoaki ^a   Kamata, Yoshiko ^a   Nishikawa, Takashige ^a   Dohi, Toshihiro ^b   Kawahara, Michio ^b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; FLUMAZENIL; KETAMINE; MUSCIMOL;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; GENERAL ANESTHESIA; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

EID: 0033918547     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200007000-00043     Document Type: Article

References (26)

1. Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature 1994;367:607-14.
2. A receptor/chloride channel complex in anesthesia. Anesthesiology 1993;78:757-76.
3. Kohrs R, Durieux ME. Ketamine: teaching an old drug new tricks. Anesth Analg 1998;87:1186-93.
4. Scholfield CN. Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro. Pflügers Archiv 1980;383:249-55.
5. Gage PW, Robertson B. Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus. Br J Pharmacol 1985;85: 675-81.
6. A receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium. J Pharmacol Exp Ther 1992;263:569-78.
7. Worms P, Depoortere H, Lloyd KG. Neuropharmacological spectrum of muscimol. Life Sci 1979;25:607-14.
8. Moreau J-L, Pieri L, Prud'hon B. Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants. Br J Pharmacol 1989;98:1050-4.
9. Czuczwar SJ, Meldrum BS. Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. Eur J Pharmacol 1982;83:335-8.
10. Litchfield JT Jr, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949;96:99-113.
11. Orlowski M, Reingold DF, Stanley ME. D-and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase. J Neurochem 1977;28:349-53.
12. Chapman AG, Westerberg E, Premachandra M, Meldrum BS. Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. J Neurochem 1984;43:62-70.
13. Horton RW, Chapman AG, Meldrum BS. Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine. J Neurochem 1978;30:1501-4.
14. Boast CA, Pastor G, Gerhardt SC, et al. Behavioral tolerance and sensitization to CGS 19755, a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther 1988;247:556-61.
15. Sivam SP, Nabeshima T, Ho IK. Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: a study with muscimol. J Neurosci Res 1982;7:37-47.
16. Irifune M, Sugimura M, Takarada T, et al. Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline. Br J Anaesth 1999;83:665-7.
17. Veliskova J, Velisek L, Mares P, Rokyta R. Ketamine suppresses both bicuculline-and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. Pharmacol Biochem Behav 1990;37:667-74.
18. Wardley-Smith B, Little HJ, Halsey MJ. Lack of correlation between the anaesthetic and anti-convulsant potencies of althesin, ketamine and methohexitone. Br J Anaesth 1988;60:140-5.
19. Rastogi SK, Ticku MK. Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism. Neuropharmacology 1986;25:175-85.
20. Belelli D, Pistis M, Peters JA, Lambert JJ. General anaesthetic action at transmitter-gated inhibitory amino acid receptors. Trends Pharmacol Sci 1999;20:496-502.
21. A receptor by propofol is independent of the γ subunit. J Pharmacol Exp Ther 1995;274:962-8.
22. Schwieger IM, Szlam F, Hug CC Jr. Absence of agonistic or antagonistic effect of flumazenil (Ro 15-1788) in dogs anesthetized with enflurane, isoflurane, or fentanyl-enflurane. Anesthesiology 1989;70:477-80.
23. Murayama T, Shingu K, Ogawa T, et al. Flumazenil does not antagonize halothane, thiamylal or propofol anaesthesia in rats. Br J Anaesth 1992;69:61-4.
24. Irifune M, Shimizu T, Nomoto M, Fukuda T. Ketamine-induced anesthesia involves the N-methyl-D-aspartate receptor-channel complex in mice. Brain Res 1992;596:1-9.
25. Young AMJ, Bradford HF. N-Methyl-D-aspartate releases γ-aminobutyric acid from rat striatum in vivo: a microdialysis study using a novel preloading method. J Neurochem 1993;60: 487-92.
26. Wakasugi M, Hirota K, Roth SH, Ito Y. The effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro. Anesth Analg 1999;88:676-80.