Multiple copies of AMT2 are prerequisite for the apple pathotype of Alternaria alternata to produce enough AM-toxin for expressing pathogenicity

Journal of General Plant Pathology

Volumn 74, Issue 3, 2008, Pages 222-229

  Harimoto, Yoshiaki ^a   Tanaka, Takayoshi ^a   Kodama, Motoichiro ^b   Yamamoto, Mikihiro ^c   Otani, Hiroshi ^b   Tsuge, Takashi ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

AF toxin; Alternaria alternata; AM toxin; Host specific toxin

Indexed keywords

ALTERNARIA; ALTERNARIA ALTERNATA; FRAGARIA X ANANASSA; MALUS X DOMESTICA;

EID: 44349141339     PISSN: 13452630     EISSN: 1610739X     Source Type: Journal    
DOI: 10.1007/s10327-008-0089-1     Document Type: Article

References (36)

1. Akagi Y, Akamatsu H, Yamamoto M, Tsuge T, Otani H, Kodama M (2005) Characterization of the genomic region, controlling biosynthesis of host-specific AAL-toxins, on the conditionally dispensable chromosome of the tomato pathotype of Alternaria alternata. Fungal Genet Newsl 52:188
2. Akamatsu H, Taga M, Kodama M, Johnson R, Otani H, Kohmoto K (1999) Molecular karyotypes for Alternaria plant pathogens known to produce host-specific toxins. Curr Genet 35:647-656
3. Ahn JH, Walton JD (1996) Chromosomal organization of TOX2, a complex locus controlling host-selective toxin biosynthesis in Cochliobolus carbonum. Plant Cell 8:887-897
4. Covert SF (1998) Supernumerary chromosomes in filamentous fungi. Curr Genet 33:311-319
5. Filajdić N, Sutton TB (1991) Identification and distribution of Alternaria mali on apples in North Carolina and susceptibility of different varieties of apples to Alternaria blotch. Plant Dis 75:1045-1048
6. Harimoto Y, Hatta R, Kodama M, Yamamoto M, Otani H, Tsuge T (2007) Expression profiles of genes encoded by the supernumerary chromosome controlling AM-toxin biosynthesis and pathogenicity in the apple pathotype of Alternaria alternata. Mol Plant Microbe Interact 20:1463-1476
7. Hatta R, Ito K, Hosaki Y, Tanaka T, Tanaka A, Yamamoto M, Akimitsu K, Tsuge T (2002) A conditionally dispensable chromosome controls host-specific pathogenicity in the fungal plant pathogen Alternaria alternata. Genetics 161:59-70
8. Hatta R, Shinjo A, Ruswandi S, Kitani K, Yamamoto M, Akimitsu K, Tsuge T (2006) DNA transposon fossils present on the conditionally dispensable chromosome controlling AF-toxin biosynthesis and pathogenicity of Alternaria alternata. J Gen Plant Pathol 72:210-219
9. Ito K, Tanaka T, Hatta R, Yamamoto M, Akimitsu K, Tsuge T (2004) Dissection of the host range of the fungal plant pathogen Alternaria alternata by modification of secondary metabolism. Mol Microbiol 52:399-411
10. Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM (1997) Comparative anatomy of the aldo-keto reductase superfamily. Biochem J 326:625-636
11. Johnson RD, Johnson L, Itoh Y, Kodama M, Otani H, Kohmoto K (2000) Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity. Mol Plant Microbe Interact 13:742-753
12. Johnson L, Johnson RD, Akamatsu H, Salamiah A, Otani H, Kohmoto K, Kodama M (2001) Spontaneous loss of a conditionally dispensable chromosome from Alternaria alternata apple pathotype leads to loss of toxin production and pathogenicity. Curr Genet 40:65-72
13. Kawamura C, Moriwaki J, Kimura N, Fujita Y, Fuji S, HiranoT, Koizumi S, Tsuge T (1997) The melanin biosynthesis genes of Alternaria alternata can restore pathogenicity of the melanin-deficient mutants of Magnaporthe grisea. Mol Plant Microbe Interact 10:446-453
14. Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism: from biochemistry to genomics. Nat Rev Microbiol 3:937-947
15. Kimura N, Tsuge T (1993) Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata. J Bacteriol 175:4427-4435
16. Kohmoto K, Otani H, Tsuge T (1995) Alternaria alternata pathogens. In: Kohmoto K, Singh US, Singh RP (eds) Pathogenesis and host specificity in plant diseases: histopathological biochemical, genetic and molecular bases, vol. 2. Eukaryotes, Pergamon, Oxford, pp 51-63
17. Kohmoto K, Taniguchi T, Nishimura S (1977) Correlation between the susceptibility of apple cultivars to Alternaria mali and their sensitivity to AM-toxin I. Ann Phytopathol Soc Jpn 43:65-68
18. Maekawa N, Yamamoto M, Nishimura S, Kohmoto K, Kuwata M, Watanabe Y (1984) Studies on host-specific AF-toxins produced by Alternaria alternata strawberry pathotype causing Alternaria black spot of strawberry. 1. Production of host-specific toxins and their biological activity. Ann Phytopathol Soc Jpn 50:600-609
19. Markham JE, Hille J (2001) Host-selective toxins as agents of cell death in plant-fungus interactions. Mol Plant Pathol 2:229-239
20. Masunaka A, Tanaka A, Tsuge T, Peever TL, Timmer LW, Yamamoto H, Yamamoto M, Akimitsu K (2000) Distribution and characterization of AKT homologs in the tangerine pathotype of Alternaria alternata. Phytopathology 90:762-768
21. Masunaka A, Ohtani K, Peever TL, Timmer LW, Tsuge T, Yamamoto M, Yamamoto H, Akimitsu K (2005) An isolate of Alternaria alternata that is pathogenic to both tangerines and rough lemon and produces two host-selective toxins, ACT- and ACR-toxins. Phytopathology 95:241-247
22. Miao VP, Covert SF, VanEtten HD (1991) A fungal gene for antibiotic resistance on a dispensable ("B") chromosome. Science 254:1773-1776
23. Nakatsuka S, Ueda K, Goto T, Yamamoto M, Nishimura S, Kohmoto K (1986) Structure of AF-toxin II, one of the host-specific toxins produced by Alternaria alternata strawberry pathotype. Tetrahedron Lett 27:2753-2756
24. Namiki F, Matsunaga M, Okuda M, Inoue I, Nishi K, Fujita Y, Tsuge T (2001) Mutation of an arginine biosynthesis gene causes reduced pathogenicity in Fusarium oxysporum f. sp. melonis. Mol Plant Microbe Interact 14:580-584
25. Okuno T, Ishita Y, Sawai K, Matsumoto T (1974) Characterization of alternariolide, a host-specific toxin produced by Alternaria mali Roberts. Chem Lett 6:635-638
26. Rotem J (ed) (1994) The genus Alternaria: biology, epidemiology, and pathogenicity. American Phytopathological Society, St Paul
27. Ruswandi SR, Kitani K, Akimitsu K, Tsuge T, Shiraishi T, Yamamoto M (2005) Structural analysis of cosmid clone pcAFT-2 carrying AFT10-1 encoding an acyl-CoA dehydrogenase involved in AF-toxin production in the strawberry pathotype of Alternaria alternata. J Gen Plant Pathol 71:107-116
28. Sambrook J, Russell DW (eds) (2001) Molecular cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor
29. Sanli G, Blaber M (2001) Structural assembly of the active site in an aldo-keto reductase by NADPH cofactor. J Mol Biol 309:1209-1218
30. Sawamura K (1990) Alternaria blotch. In: Jones AL, Aldwinckle H (eds) Compendium of apple and pear diseases. American Phytopathological Society Press, St Paul, pp 24-25
31. Tanaka A, Shiotani H, Yamamoto M, Tsuge T (1999) Insertional mutagenesis and cloning of the genes required for biosynthesis of the host-specific AK-toxin in the Japanese pear pathotype of Alternaria alternata. Mol Plant Microbe Interact 12:691-702
32. Tanaka A, Tsuge T (2000) Structural and functional complexity of the genomic region controlling AK-toxin biosynthesis and pathogenicity in the Japanese pear pathotype of Alternaria alternata. Mol Plant Microbe Interact 13:975-986
33. Thomma BPHJ (2003) Alternaria spp.: from general saprophyte to specific parasite. Mol Plant Pathol 4:225-236
34. Ueno T, Nakashima T, Uemoto M, Fukami H, Lee SN, Izumiya N (1977) Mass spectrometry of Alternaria mali toxins and related cyclodepsipeptides. Bio Mass Spectrom 4:134-142
35. Walton JD (2000) Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: An hypothesis. Fungal Genet Biol 30:167-171
36. Wolpert TJ, Dunkle LD, Ciuffetti LM (2002) Host-selective toxins and avirulence determinants: what's in a name? Annu Rev Phytopathol 40:251-285