Dissection of the host range of the fungal plant pathogen Alternaria alternata by modification of secondary metabolism

Molecular Microbiology

Volumn 52, Issue 2, 2004, Pages 399-411

  Ito, Kaoru ^a   Tanaka, Takayoshi ^a   Hatta, Rieko ^a   Yamamoto, Mikihiro ^b   Akimitsu, Kazuya ^c   Tsuge, Takashi ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AF TOXIN; MYCOTOXIN; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

AFTS1 GENE; ALTERNARIA; ARTICLE; CONTROLLED STUDY; COSMID; CULTIVAR; FUNGUS; GENE; GENE IDENTIFICATION; METABOLISM; MOLECULAR CLONING; NONHUMAN; PATHOTYPE; PEAR; PLANT; PRIORITY JOURNAL; STRAWBERRY;

ALTERNARIA; AMINO ACID SEQUENCE; CHROMOSOMES, FUNGAL; CLONING, MOLECULAR; COSMIDS; FRAGARIA; FRUIT; FUNGAL PROTEINS; GENES, FUNGAL; KARYOTYPING; MALUS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MYCOTOXINS; PLANT DISEASES; PLASMIDS; PYRUS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFORMATION, GENETIC;

ALTERNARIA; ALTERNARIA ALTERNATA; FRAGARIA X ANANASSA; FUNGI; PYRUS COMMUNIS; PYRUS PYRIFOLIA;

EID: 1942468805     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2004.04004.x     Document Type: Article

References (55)

1. Akamatsu, H., Taga, M., Kodama, M., Johnson, R.D., Otani, H., and Kohmoto, K. (1999) Molecular karyotypes for Alternaria plant pathogens known to produce host-specific toxins. Curr Genet 35: 647-656.
2. Altschul, S.F., Madden, T.L., Schäfer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
3. Audhya, T.K., and Russel, D.W. (1973) Production of enniatin A. Can J Microbiol 19: 1051-1054.
4. Brown, D.W., Yu, J.H., Kelkar, H.S., Fernandes, M., Nesbitt, T.C., Keller, N.P., et al. (1996) Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc Natl Acad Sci USA 93: 1418-1422.
5. Covert, S.F. (1998) Supernumerary chromosomes in filamentous fungi. Curr Genet 33: 311-319.
6. Covert, S.F., Enkerli, J., Miao, V.P.W., and VanEtten, H.D. (1996) A gene for maackiain detoxification from a dispensable chromosome of Nectria haematococca. Mol Gen Genet 251: 397-406.
7. Enkerli, J., Bhatt, G., and Covert, S.F. (1997) Nht1, a transposable element cloned from a dispensable chromosome in Nectria haematococca. Mol Plant-Microbe Interact 10: 742-749.
8. Galagan, J.E., Calvo, S.E., Borkovich, K.A., Selker, E.U., Read, N.D., Jaffe, D., et al. (2003) The genome sequence of the filamentous fungus Neurospora crassa. Nature 422: 859-868.
9. Han, Y., Liu, X., Benny, U., Kistler, H.C., and VanEtten, H.D. (2001) Genes determining pathogenicity to pea are clustered on a supernumerary chromosome in the fungal plant pathogen Nectria haematococca. Plant J 25: 305-314.
10. Hatta, R., Ito, K., Hosaki, Y., Tanaka, T., Tanaka, A., Yamamoto, M., et al. (2002) A conditionally dispensable chromosome controls host-specific pathogenicity in the fungal plant pathogen Alternaria alternata. Genetics 161: 59-70.
11. Hayashi, N., Tanabe, K., Tsuge, T., Nishimura, S., Kohmoto, K., and Otani, H. (1990) Determination of host-selective toxin production during spore germination of Alternaria alternata by high-performance liquid chromatography. Phytopathology 80: 1088-1091.
12. He, C.Z., Rusa, A.G., Polawski, A.M., Irwin, J.A.G., and Manners, J.M. (1998) Transfer of a supernumerary chromosome between vegetatively incompatible biotypes of the fungus Colletotrichum gloeosporioides. Genetics 150: 1459-1466.
13. Inoue, I., Namiki, F., and Tsuge, T. (2002) Plant colonization by the vascular wilt fungus Fusarium oxysporum requires FOW1, a gene encoding a mitochondrial protein. Plant Cell 14: 1869-1883.
14. Jez, J.M., Bennett, M.J., Schlegel, B.P., Lewis, M., and Penning, T.M. (1997) Comparative anatomy of the aldo-keto reductase superfamily. Biochem J 326: 625-636.
15. Johnson, L., Johnson, R.D., Akamatsu, H., Salamiah, A., Otani, H., Kohmoto, K., and Kodama, M. (2001) Spontaneous loss of a conditionally dispensable chromosome from Alternaria alternata apple pathotype leads to loss of toxin production and pathogenicity. Curr Genet 40: 65-72.
16. Johnson, R.D., Johnson, L., Itoh, Y., Kodama, M., Otani, H., and Kohmoto, K. (2000) Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity. Mol Plant-Microbe Interact 13: 742-753.
17. Kempken, F., and Kück, U. (1996) restless, an active Ac-like transposon from the fungus Tolypocladium inflatum: structure, expression, and alternative RNA splicing. Mol Cell Biol 16: 6563-6572.
18. Kimura, N., and Tsuge, T. (1993) Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata. J Bacteriol 175: 4427-4435.
19. Kohmoto, K., Itoh, Y., Shimomura, N., Kondoh, Y., Otani, H., Kodama, M., et al. (1993) Isolation and biological activities of two host-specific toxins from the tangerine pathotype of Alternaria alternata. Phytopathology 83: 495-502.
20. Kohmoto, K., Otani, H., and Tsuge, T. (1995) Alternaria alternata pathogens. In Pathogenesis and Host Specificity in Plant Diseases: Histopathological Biochemical, Genetic and Molecular Bases, Vol. II. Eukaryotes. Kohmoto, K., Singh, U.S., and Singh, R.P. (eds). Oxford: Pergamon, pp. 51-63.
21. Lee, C., Görisch, H., Kleinkauf, H., and Zocher, R. (1992) A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum. J Biol Chem 267: 11741-11744.
22. Maekawa, N., Yamamoto, M., Nishimura, S., Kohmoto, K., Kuwata, M., and Watanabe, Y. (1984) Studies on host-specific AF-toxins produced by Alternaria alternata strawberry pathotype causing Alternaria black spot of strawberry. 1. Production of host-specific toxins and their biological activity. Ann Phytopathol Soc Jpn 50: 600-609.
23. Markham, J.E., and Hille, J. (2001) Host-selective toxins as agents of cell death in plant-fungus interactions. Mol Plant Pathol 2: 229-240.
24. Masunaka, A., Tanaka, A., Tsuge, T., Peever, T., Timmer, L.W., Yamamoto, M., et al. (2000) Distribution and characterization of AKT homologs in the tangerine pathotype of Alternaria alternata. Phytopathology 90: 762-768.
25. Miao, V.P.W., Covert, S.F., and VanEtten, H.D. (1991) A fungal gene for antibiotics resistance on a dispensable (B) chromosome. Science 254: 1773-1776.
26. Nakashima, T., Ueno, T., Fukami, H., Taga, T., Masuda, H., Osaki, K., et al. (1985) Isolation and structures of AK-toxin I and II, host-specific phytotoxic metabolites produced by Alternaria alternata Japanese pear pathotype. Agric Biol Chem 49: 807-815.
27. Nakatsuka, S., Ueda, K., Goto, T., Yamamoto, M., Nishimura, S., and Kohmoto, K. (1986) Structure of AF-toxin II, one of the host-specific toxins produced by Alternaria alternata strawberry pathotype. Tetrahedron Lett 27: 2753-2756.
28. Nikolskaya, A.N., Panaccione, D.G., and Walton, J.D. (1995) Identification of peptide synthetase-encoding genes from filamentous fungi producing host-selective phytotoxins or analogs. Gene 165: 207-211.
29. Nishimura, S., and Kohmoto, K. (1983) Host-specific toxins and chemical structures from Alternaria species. Annu Rev Phytopathol 21: 87-116.
30. Ochman, H., Lawrence, J.G., and Groisman, E.A. (2000) Lateral gene transfer and the nature of bacterial innovation. Nature 405: 299-304.
31. Okuda, M., Ikeda, K., Namiki, F., Nishi, K., and Tsuge, T. (1998) Tfo1: an Ac-like transposon from the plant pathogenic fungus Fusarium oxysporum. Mol Gen Genet 258: 599-607.
32. Okuno, T., Ishita, Y., Sawai, K., and Matsumoto, T. (1974) Characterization of alternariolide, a host-specific toxin produced by Alternaria mali Roberts. Chem Lett 1974: 635-638.
33. Otani, H., Nishimura, S., Kohmoto, K., Yano, K., and Seno, T. (1975) Nature of specific susceptibility to Alternaria kikuchiana in Nijisseiki cultivar among Japanese pears (V). Role of host-specific toxin in early step of infection. Ann Phytopathol Soc Jpn 41: 467-476.
34. Païs, M., Das, B.C., and Ferron, P. (1981) Depsipeptides from Metarhizium anisopliae. Phytochemistry 20: 715-723.
35. Peeters, H., Zocher, R., Madry, N., Oelrichs, P.B., Kleinkauf, H., and Kraepelin, G. (1983) Cell-free synthesis of the depsipeptide beauvercin. J Antibiot 36: 1762-1766.
36. Reiser, J., Muheim, A., Hardegger, M., Frank, G., and Fiechter, A. (1994) Aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. Gene cloning, sequence analysis, expression, and purification of the recombinant enzyme. J Biol Chem 269: 28152-28159.
37. Rosewich, U.L., and Kistler, H.C. (2000) Role of horizontal gene transfer in the evolution of fungi. Annu Rev Phytopathol 38: 325-363.
38. Rotem, J. (1994) The Genus Alternaria: Biology, Epidemiology, and Pathogenicity. St Paul, MN: The American Phytopathological Society Press.
39. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
40. Sanli, G., and Blaber, M. (2001) Structural assembly of the active site in an aldo-keto reductase by NADPH cofactor. J Mol Biol 309: 1209-1218.
41. Tanaka, A., and Tsuge, T. (2000) Structural and functional complexity of the genomic region controlling AK-toxin biosynthesis and pathogenicity in the Japanese pear pathotype of Alternaria alternata. Mol Plant-Microbe Interact 13: 975-986.
42. Tanaka, A., and Tsuge, T. (2001) Reporter gene analysis of AKT3-1 and AKT3-2 expression during conidial germination of the Japanese pear pathotype of Alternaria alternata. J Gen Plant Pathol 67: 15-22.
43. Tanaka, A., Shiotani, H., Yamamoto, M., and Tsuge, T. (1999) Insertional mutagenesis and cloning of the genes required for biosynthesis of the host-specific AK-toxin in the Japanese pear pathotype of Alternaria alternata. Mol Plant-Microbe Interact 12: 691-702.
44. Thompson, J.D., Higgins, D.G., and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
45. Tsuge, T., Nishimura, S., and Kobayashi, H. (1990) Efficient integrative transformation of the phytopathogenic fungus Alternaria alternata mediated by the repetitive rDNA sequences. Gene 90: 207-214.
46. Tsuge, T., Tanaka, A., Nishikawa, R., Hatta, R., Ito, K., Masunaka, A., et al. (2001) Molecular genetics of host-specific toxin biosynthesis in Alternaria alternata. In Delivery and Perception of Pathogen Signals in Plants. Keen, N., Mayama, S., Leach, J.L., and Tsuyumu, S. (eds). St Paul, MN: The American Phytopathological Society Press, pp. 87-96.
47. Ueno, T., Nakashima, T., Uemoto, M., Fukami, H., Lee, S.N., and Izumiya, N. (1977) Mass spectrometry of Alternaria mali toxins and related cyclodepsipeptides. Biomed Mass Spectrom 4: 134-142.
48. VanEtten, H.D., Jorgensen, S., Enkerli, J., and Covert, S.F. (1998) Inducing the loss of conditionally dispensable chromosomes in Nectria haematococca during vegetative growth. Curr Genet 33: 299-303.
49. Walton, J.D. (2000) Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: an hypothesis. Fungal Genet Biol 30: 167-171.
50. Wolpert, T.J., Dunkle, L.D., and Ciuffetti, L.M. (2002) Host-selective toxins and avirulence determinants: what's in a name? Annu Rev Phytopathol 40: 251-285.
51. Yamamoto, M., Nishimura, S., Kohmoto, K., and Otani, H. (1984) Studies on host-specific AF-toxins produced by Alternaria alternata strawberry pathotype causing Alternaria black spot of strawberry. (2) Role of toxins in pathogenesis. Ann Phytopathol Soc Jpn 50: 610-619.
52. Yamamoto, M., Nakatsuka, S., Otani, H., Kohmoto, K., and Nishimura, S. (2000) (+)-catechin acts as an infection-inhibiting factor in strawberry leaf. Phytopathology 90: 595-600.
53. Yang, G., Rose, M.S., Turgeon, B.G., and Yoder, O.C. (1996) A polyketide synthase is required for fungal virulence and production of the polyketide T-toxin. Plant Cell 8: 2139-2150.
54. Yoder, O.C. (1980) Toxins in pathogenesis. Annu Rev Phytopathol 18: 103-129.
55. Yoder, O.C. (1998) A mechanistic view of the fungal/plant interaction based on host-specific toxin studies. In Molecular Genetics of Host-Specific Toxins in Plant Disease. Kohmoto, K., and Yoder, O.C. (eds). Dordrecht: Kluwer Academic Publishers, pp. 3-15.