Position and role of the BK channel α subunit s0 helix inferred from disulfide crosslinking

Journal of General Physiology

Volumn 131, Issue 6, 2008, Pages 537-548

  Liu, Guoxia ^a   Zakharov, Sergey I ^a   Yang, Lin ^a   Deng, Shi Xian ^a   Landry, Donald W ^a   Karlin, Arthur ^a   Marx, Steven O ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; DISULFIDE BOND; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CALCIUM; CELL LINE, TRANSFORMED; CONSERVED SEQUENCE; CYSTEINE; DISULFIDES; ELECTROPHYSIOLOGY; ELECTROSTATICS; HELIX-LOOP-HELIX MOTIFS; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44349137529     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200809968     Document Type: Article

References (37)

1. 2+ sensitivity is enhanced by its β1 subunit. J. Gen. Physiol. 126:393-412.
2. Bass, R.B., A.S. Miller, S.L. Gloor, and J.J. Falke. 2007. The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis. Methods Enzymol. 423:1-24.
3. Becker, L., M.E. Nesheim, and M.L. Koschinsky. 2006. Catalysis of covalent Lp(a) assembly: evidence for an extracellular enzyme activity that enhances disulfide bond formation. Biochemistry. 45:9919-9928.
4. Bernstein, G.M., and O.T. Jones. 2007. Kinetics of internalization and degradation of N-type voltage-gated calcium channels: role of the α2/δ subunit. Cell Calcium. 41:27-40.
5. Bose, A.K., M.S. Manhas, D.P. Sahu, and V.R. Hedge. 1984. Stereospecific cyclization of β-hydroxyl aryl amides to β-lactams. Can. J. Chem. 62:2498-2505.
6. Butler, S.L., and J.J. Falke. 1996. Effects of protein stabilizing agents on thermal backbone motions: a disulfide trapping study. Biochemistry. 35:10595-10600.
7. Campos, F.V., B. Chanda, B. Roux, and F. Bezanilla. 2007. Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc. Natl. Acad. Sci. USA. 104:7904-7909.
8. Elliott, D.J., E.J. Neale, Q. Aziz, J.P. Dunham, T.S. Munsey, M. Hunter, and A. Sivaprasadarao. 2004. Molecular mechanism of voltage sensor movements in a potassium channel. EMBO J. 23:4717-4726.
9. Hansen, R.E., H. Ostergaard, and J.R. Winther. 2005. Increasing the reactivity of an artificial dithiol-disulfide pair through modification of the electrostatic milieu. Biochemistry. 44:5899-5906.
10. 2+. J. Gen. Physiol. 114:305-336.
11. Iscla, I., G. Levin, R. Wray, and P. Blount. 2007. Disulfide trapping the mechanosensitive channel MscL into a gating-transition state. Biophys. J. 92:1224-1232.
12. Jansen, M., and M.H. Akabas. 2006. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J. Neurosci. 26:4492-4499.
13. Jiang, X.M., M. Fitzgerald, C.M. Grant, and P.J. Hogg. 1999. Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase. J. Biol. Chem. 274:2416-2423.
14. + channel. Nature. 423:33-41.
15. Jugloff, D.G., R. Khanna, L.C. Schlichter, and O.T. Jones. 2000. Internalization of the Kv1.4 potassium channel is suppressed by clustering interactions with PSD-95. J. Biol. Chem. 275:1357-1364.
16. Karlin, A., C. Wang, J. Li, and Q. Xu. 2004. Transfer in SDS of biotinylated proteins from acrylamide gels to an avidin-coated membrane filter. Biotechniques. 36:1010-1016.
17. + channel. J. Biol. Chem. 270:22434-22439.
18. Kosower, E.M., N.S. Kosower, H. Kenety-Londner, and L. Levy. 1974. Glutathione. IX. New thiol-oxidizing agents: DIP, DIP+1, DIP+2. Biochem. Biophys. Res. Commun. 59:347-351.
19. Koval, O.M., Y. Fan, and B.S. Rothberg. 2007. A role for the S0 transmembrane segment in voltage-dependent gating of BK channels. J. Gen. Physiol. 129:209-220.
20. Laine, M., M.C. Lin, J.P. Bannister, W.R. Silverman, A.F. Mock, B. Roux, and D.M. Papazian. 2003. Atomic proximity between S4 segment and pore domain in Shaker potassium channels. Neuron. 39:467-481.
21. + channel. Science. 309:897-903.
22. Lu, X., A.W. Gross, and H.F. Lodish. 2006. Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J. Biol. Chem. 281:7002-7011.
23. Luo, B.H., T.A. Springer, and J. Takagi. 2004. A specific interface between integrin transmembrane helices and affinity for ligand. PLoS Biol. 2:e153.
24. + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc. Natl. Acad. Sci. USA. 94:14066-14071.
25. Morrow, J.P., S.I. Zakharov, G. Liu, L. Yang, A.J. Sok, and S.O. Marx. 2006. Defining the BK channel domains required for β1-subunit modulation. Proc. Natl. Acad. Sci. USA. 103:5096-5101.
26. 2+-activated potassium channel. Neuron. 42:745-756.
27. Rost, B., R. Casadio, P. Fariselli, and C. Sander. 1995. Transmembrane helices predicted at 95% accuracy. Protein Sci. 4:521-533.
28. + channel, revealed by voltage-clamp fluorometry. Proc. Natl. Acad. Sci. USA. 103:12619-12624.
29. Scholle, A., S. Dugarmaa, T. Zimmer, M. Leonhardt, R. Koopmann, B. Engeland, O. Pongs, and K. Benndorf. 2004. Rate-limiting reactions determining different activation kinetics of Kv1.2 and Kv2.1 channels. J. Membr. Biol. 198:103-112.
30. Schoppa, N.E., K. McCormack, M.A. Tanouye, and F.J. Sigworth. 1992. The size of gating charge in wild-type and mutant Shaker potassium channels. Science. 255:1712-1715.
31. + channel (hslo). Proc. Natl. Acad. Sci. USA. 94:5427-5431.
32. + channels: an additional transmembrane region at the N terminus. Proc. Natl. Acad. Sci. USA. 93:14922-14927.
33. Whitley, P., L. Nilsson, and G. von Heijne. 1993. Three-dimensional model for the membrane domain of Escherichia coli leader peptidase based on disulfide mapping. Biochemistry. 32:8534-8539.
34. Wilkinson, B., and H.F. Gilbert. 2004. Protein disulfide isomerase. Biochim. Biophys. Acta. 1699:35-44.
35. Wolin, C.D., and H.R. Kaback. 2000. Thiol cross-linking of transmembrane domains IV and V in the lactose permease of Escherichia coli. Biochemistry. 39:6130-6135.
36. + channels. Proc. Natl. Acad. Sci. USA. 103:7292-7297.
37. Zakharov, S.I., J.P. Morrow, G. Liu, L. Yang, and S.O. Marx. 2005. Activation of the BK (SLO1) potassium channel by mallotoxin. J. Biol. Chem. 280:30882-30887.