Functional and computational studies of the ligand-associated metal binding site of β3 integrins

Proteins: Structure, Function and Genetics

Volumn 71, Issue 4, 2008, Pages 1779-1791

  Murcia, Marta ^a,b   Jirouskova, Marketa ^c   Li, Jihong ^c   Coller, Barry S ^c   Filizola, Marta ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

IIb 3; V 3; AP5; Binding; Fibrinogen; Molecular dynamics; Platelets; Steered molecular dynamics

Indexed keywords

ALPHA2BBETA 3 INTEGRIN; BETA3 INTEGRIN; ECHISTATIN; EPTIFIBATIDE; FIBRINOGEN; HYBRID PROTEIN; METAL; MONOCLONAL ANTIBODY; MUTANT PROTEIN; PROTEIN ANTIBODY; VITRONECTIN; VITRONECTIN RECEPTOR;

ALLOSTERISM; ARTICLE; BINDING KINETICS; BINDING SITE; CELL ADHESION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; LIGAND BINDING; MATHEMATICAL COMPUTING; METAL BINDING; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; SIMULATION;

ANTIBODIES, MONOCLONAL; BINDING SITES; CELL ADHESION; CELL LINE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; FIBRINOGEN; HUMANS; INTEGRIN BETA3; KIDNEY; LIGANDS; METALS; MODELS, MOLECULAR; MUTATION; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

EID: 44349114473     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21859     Document Type: Article

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