Three novel β-propeller mutations causing Glanzmann thrombasthenia result in production of normally stable pro-αIIb, but variably impaired progression of pro-αIIbβ3 from endoplasmic reticulum to Golgi

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 12, 2005, Pages 2773-2783

  Nelson, E J R ^a   Li, J ^a   Mitchell, W B ^a   Chandy, M ^b   Srivastava, A ^b   Coller, B S ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

IIb 3; propeller mutations; Biogenesis; Glanzmann thrombasthenia

Indexed keywords

ALPHA2 INTEGRIN; BETA3 INTEGRIN; DNA; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA;

ARTICLE; BIOGENESIS; CELLULAR DISTRIBUTION; DNA SEQUENCE; ENDOPLASMIC RETICULUM; GENE EXPRESSION; GENE MUTATION; GENETIC STABILITY; GLANZMANN DISEASE; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; INDIA; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION;

ADULT; CHILD, PRESCHOOL; ENDOPLASMIC RETICULUM; FEMALE; GOLGI APPARATUS; HUMANS; MALE; MOLECULAR STRUCTURE; MUTATION, MISSENSE; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; THROMBASTHENIA;

EID: 29244462341     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01593.x     Document Type: Article

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