Synthesis, anti-HIV-1 integrase, and cytotoxic activities of 4-chloro-N-(4-oxopyrimidin-2-yl)-2-mercaptobenzenesulfonamide derivatives

European Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2008, Pages 1188-1198

  Brzozowski, Zdzisław ^a   Sławiński, Jarosław ^a   Saczewski, Franciszek ^a   Sanchez, Tino ^b   Neamati, Nouri ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

4 Chloro N (3,4 dihydro 4 oxopyrimidin 2 yl) 2 mercaptobenzenesulfonamid e derivatives; Anti HIV activity; Cytotoxic activity; Synthesis

Indexed keywords

2 BENZYLTHIO 4 CHLORO N (1,4 DIHYDRO 1 METHYL 4 OXOQUINAZOLIN 2 YL) 5 METHYLBENZENESULFONAMIDE; 2 BENZYLTHIO 4 CHLORO N (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YL) 5 METHYLBENZENESULFONAMIDE; 2 BENZYLTHIO 4 CHLORO N (3,4 DIHYDRO 4 OXOTHIENO[2,3 E]PYRIMIDIN 2 YL) 5 METHYLBENZENESULFONAMIDE; 2 BENZYLTHIO 4 CHLORO N (3,4 DIHYDRO 4 OXOTHIENO[3,4 E]PYRIMIDIN 2 YL) 5 METHYLBENZENESULFONAMIDE; 2 BENZYLTHIO 4 CHLORO N (7 CHLORO 3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YL) 5 METHYLBENZENESULFONAMIDE; 4 BENZYLTHIO 2 CHLORO 5 (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLAMINOSULFONYL) N (4 METHOXYPHENYL)BENZAMIDE; 4 BENZYLTHIO 2 CHLORO 5 (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLAMINOSULFONYL) N (4 METHYLPHENYL)BENZAMIDE; 4 BENZYLTHIO 2 CHLORO 5 (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLAMINOSULFONYL) N (PHENYL)BENZAMIDE; 4 BENZYLTHIO 2 CHLORO 5 (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLAMINOSULFONYL)BENZAMIDE; 4 BENZYLTHIO 2 CHLORO N (4 CHLOROPHENYL) 5 (3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLAMINOSULFONYL)BENZAMIDE; 4 CHLORO N (3 AMINO 1H 1,2,4 TRIAZOL 5 YL) 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; 4 CHLORO N (3 FURFURYL 3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YL) 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; 4 CHLORO N (3 FURFURYL 3,4 DIHYDRO 4 OXOTHIENO[2,3 E]PYRIMIDIN 2 YL) 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; 4 CHLORO N [3 FURFURYL 3,4 DIHYDRO 4 OXO 6 (3 THIENYL)THIENO[2,3 E]PYRIMIDIN 2 YL] 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; INTEGRASE; INTEGRASE INHIBITOR; N (3 BENZYL 3,4 DIHYDRO 4 OXO 6 PHENYLTHIENO[2,3 E]PYRIMIDIN 2 YL) 4 CHLORO 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; N (3 BENZYL 3,4 DIHYDRO 4 OXOTHIENO[2,3 E]PYRIMIDIN 2 YL) 4 CHLORO 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; N (3 BENZYL 3,4 DIHYDRO 4 OXOTHIENO[3,4 E]PYRIMIDIN 2 YL) 4 CHLORO 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; N [3 BENZYL 6 (4 CHLOROPHENYL) 3,4 DIHYDRO 4 OXOLTHIENO[2,3 E]PYRIMIDIN 2 YL] 4 CHLORO 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; N [3 BENZYL 6 (TERT BUTYL) 3,4 DIHYDRO 4 OXOTHIENO[2,3 E]PYRIMIDIN 2 YL] 4 CHLORO 2 MERCAPTO 5 METHYLBENZENESULFONAMIDE; NSC 661073; SULFONAMIDE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROPHOTOMETRY, INFRARED; SULFONAMIDES;

EID: 44349088988     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.08.013     Document Type: Article

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