Synthesis and anti-HIV-1 activity of a novel series of 1,4,2-benzodithiazine-dioxides

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5298-5302

  Brzozowski, Zdzisław ^a   Saczewski, Franciszek ^a   Neamati, Nouri ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Anti HIV activity; Imidazo 1,2 b 1,4,2 benzodithiazines; Pyrimido 1,2 b 1,4,2 benzodithiazines; Synthesis

Indexed keywords

2 (CHLOROMETHYL) 2,3 DIHYDROIMIDAZO[1,2 B][1,4,2]BENZODITHIAZINE; 2,3 DIHYDROIMIDAZO[1,2 B][1,4,2]BENZODITHIAZINE DERIVATIVE; 4 CHLORO 2,3,4 TRIHYDROPYRIMIDO[1,2 B][1,4,2]BENZODITHIAZINE DERIVATIVE; IMIDAZOLE DERIVATIVE; N (6 CHLORO 1,1 DIOXO 1,4,2 BENZODITHIAZIN 3 YL)AMINOPROPANOL DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRIMIDO[1,2 B][1,4,2]BENZODITHIAZINE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC S-OXIDES; HIV-1; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33748325734     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.089     Document Type: Article

References (17)

1. Scozzafava A., Owa T., Mastrolorenzo A., and Supuran C.T. Curr. Med. Chem. 10 (2003) 925
2. Supuran C.T., Casini A., and Scozzafava A. Med. Res. Rev. 23 (2003) 531
3. Brzozowski Z. Acta Polon. Pharm. Drug Res. 52 (1995) 91
4. Brzozowski Z. Acta Polon. Pharm. Drug Res. 52 (1995) 287
5. Brzozowski Z. Acta Polon. Pharm. Drug Res. 53 (1996) 269
6. Brzozowski Z. Acta Polon. Pharm. Drug Res. 55 (1998) 49
7. Brzozowski Z. Acta Polon. Pharm. Drug Res. 55 (1998) 375
8. Brzozowski Z. Acta Polon. Pharm. Drug Res. 55 (1998) 473
9. Neamati N., Mazunder A., Sunder S., Owen J.H., Schultz R.J., and Pommier Y. Antivir. Chem. Chemother. 8 (1997) 485
10. Kuo Ch.L., Assefa H., Brzozowski Z., Sławiński J., Sa{ogonek}czewski F., Buolamwini J.K., and Neamati N. J. Med. Chem. 47 (2004) 385
11. Brzozowski Z., Sa{ogonek}czewski F., Sanchez T., Kuo Ch.l., Gdaniec M., and Neamati N. Bioorg. Med. Chem. 12 (2004) 3663
12. Brzozowski Z., Sa{ogonek}czewski F., and Neamati N. Bioorg. Med. Chem. 14 (2006) 2985
13. Brzozowski Z., and Sławiński J. Acta Polon. Pharm. 41 (1984) 133
14. Brzozowski Z., Sa{ogonek}czewski F., and Gdaniec M. Bioorg. Med. Chem. 11 (2003) 3673
15. Pomarnacka E., and Brzozowski Z. Acta Polon. Pharm. 43 (1986) 8
16. 3), 3.47 (t, J = 5.1 Hz, 2H, H-2,2), 3.80 (t, J = 5.1 Hz, 2H, H-4,4), 7.50 (s, 1H, H-7), 7.69 (s, 1H, H-10) ppm.
17. Wieslow O.W., Kiser R., Fine D., Bader J., Shoemaker R.H., and Boyd M.R. J. Natl. Cancer Inst. 81 (1989) 577