메뉴 건너뛰기




Volumn 88, Issue 6, 2008, Pages 627-633

Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats

Author keywords

Halofuginone; Heparanase; Hepatic stellate cells; Hydrodynamics based transfection; Rat liver fibrosis; VEGF

Indexed keywords

HALOFUGINONE; HEPARANASE; MESSENGER RNA; THIOACETAMIDE; VASCULOTROPIN; VASCULOTROPIN 165;

EID: 44349088069     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.30     Document Type: Article
Times cited : (22)

References (49)
  • 3
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117:539-548.
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 4
    • 0037192866 scopus 로고    scopus 로고
    • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis
    • Murphy FR, Issa R, Zhou X, et al. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem 2002;277:11069-11076.
    • (2002) J Biol Chem , vol.277 , pp. 11069-11076
    • Murphy, F.R.1    Issa, R.2    Zhou, X.3
  • 5
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538-549.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3
  • 6
    • 2942622398 scopus 로고    scopus 로고
    • Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking
    • Issa R, Zhou X, Constandinou CM, et al. Spontaneous recovery from micronodular cirrhosis: evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004;126:1795-1808.
    • (2004) Gastroenterology , vol.126 , pp. 1795-1808
    • Issa, R.1    Zhou, X.2    Constandinou, C.M.3
  • 7
    • 0025875756 scopus 로고
    • Proteoglycans: Structures and interactions
    • Kjellen L, Lindahl U. Proteoglycans: structures and interactions. Annu Rev Biochem 1991;60:443-475.
    • (1991) Annu Rev Biochem , vol.60 , pp. 443-475
    • Kjellen, L.1    Lindahl, U.2
  • 8
    • 0027292970 scopus 로고
    • Integral membrane heparan sulfate proteoglycans
    • David G. Integral membrane heparan sulfate proteoglycans. FASEB J 1993;7:1023-1030.
    • (1993) FASEB J , vol.7 , pp. 1023-1030
    • David, G.1
  • 9
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 2001;108:341-347.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 12
    • 0033057962 scopus 로고    scopus 로고
    • Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
    • Vlodavsky I, Friedmann Y, Elkin M, et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 1999;5:793-802.
    • (1999) Nat Med , vol.5 , pp. 793-802
    • Vlodavsky, I.1    Friedmann, Y.2    Elkin, M.3
  • 13
    • 0034255845 scopus 로고    scopus 로고
    • Heparanase, a potential regulator of cell-matrix interactions
    • Dempsey LA, Brunn GJ, Platt JL. Heparanase, a potential regulator of cell-matrix interactions. Trends Biochem Sci 2000;25:349-351.
    • (2000) Trends Biochem Sci , vol.25 , pp. 349-351
    • Dempsey, L.A.1    Brunn, G.J.2    Platt, J.L.3
  • 14
    • 33748683743 scopus 로고    scopus 로고
    • Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
    • Ilan N, Elkin M, Vlodavsky I. Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol 2006;38:2018-2039.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 2018-2039
    • Ilan, N.1    Elkin, M.2    Vlodavsky, I.3
  • 15
    • 1942467417 scopus 로고    scopus 로고
    • Heparanase expression during normal liver development and following partial hepatectomy
    • Goldshmidt O, Yeikilis R, Mawasi N, et al. Heparanase expression during normal liver development and following partial hepatectomy. J Pathol 2004;203:594-602.
    • (2004) J Pathol , vol.203 , pp. 594-602
    • Goldshmidt, O.1    Yeikilis, R.2    Mawasi, N.3
  • 16
    • 0027469572 scopus 로고
    • Halofuginone: An inhibitor of collagen type I synthesis
    • Granot I, Halevy O, Hurwitz S, et al. Halofuginone: an inhibitor of collagen type I synthesis. Biochim Biophys Acta 1993;1156:107-112.
    • (1993) Biochim Biophys Acta , vol.1156 , pp. 107-112
    • Granot, I.1    Halevy, O.2    Hurwitz, S.3
  • 17
    • 0032054482 scopus 로고    scopus 로고
    • Halofuginone: A novel antifibrotic therapy
    • Pines M, Nagler A. Halofuginone: a novel antifibrotic therapy. Gen Pharmacol 1998;30:445-450.
    • (1998) Gen Pharmacol , vol.30 , pp. 445-450
    • Pines, M.1    Nagler, A.2
  • 18
    • 33947143078 scopus 로고    scopus 로고
    • Gene expression during chemically induced liver fibrosis: Effect of halofuginone on TGF-beta signaling
    • Gnainsky Y, Kushnirsky Z, Bilu G, et al. Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling. Cell Tissue Res 2007;328:153-166.
    • (2007) Cell Tissue Res , vol.328 , pp. 153-166
    • Gnainsky, Y.1    Kushnirsky, Z.2    Bilu, G.3
  • 19
    • 38849209865 scopus 로고    scopus 로고
    • Targeting TGF-beta signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer effect of halofuginone
    • Pines M. Targeting TGF-beta signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer effect of halofuginone. Exp Opinion Drug Discov 2008;3:1-10.
    • (2008) Exp Opinion Drug Discov , vol.3 , pp. 1-10
    • Pines, M.1
  • 20
    • 0036708283 scopus 로고    scopus 로고
    • Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats
    • Spira G, Mawasi N, Paizi M, et al. Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats. J Hepatol 2002;37:331-339.
    • (2002) J Hepatol , vol.37 , pp. 331-339
    • Spira, G.1    Mawasi, N.2    Paizi, M.3
  • 21
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699.
    • (1995) J Hepatol , vol.22 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 22
    • 0022362862 scopus 로고
    • A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections
    • Lopez-De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 1985;33:737-743.
    • (1985) J Histochem Cytochem , vol.33 , pp. 737-743
    • Lopez-De Leon, A.1    Rojkind, M.2
  • 23
    • 0019880528 scopus 로고
    • A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues
    • Jamall IS, Finelli VN, Que Hee SS. A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues. Anal Biochem 1981;112:70-75.
    • (1981) Anal Biochem , vol.112 , pp. 70-75
    • Jamall, I.S.1    Finelli, V.N.2    Que Hee, S.S.3
  • 24
    • 0034961836 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis
    • Jonsson JR, Clouston AD, Ando Y, et al. Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis. Gastroenterology 2001;121:148-155.
    • (2001) Gastroenterology , vol.121 , pp. 148-155
    • Jonsson, J.R.1    Clouston, A.D.2    Ando, Y.3
  • 25
    • 0026341256 scopus 로고
    • Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6
    • Greenwel P, Schwartz M, Rosas M, et al. Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6. Lab Invest 1991;65:644-653.
    • (1991) Lab Invest , vol.65 , pp. 644-653
    • Greenwel, P.1    Schwartz, M.2    Rosas, M.3
  • 26
    • 0027251069 scopus 로고
    • Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43
    • Greenwel P, Rubin J, Schwartz M, et al. Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Lab Invest 1993;69:210-216.
    • (1993) Lab Invest , vol.69 , pp. 210-216
    • Greenwel, P.1    Rubin, J.2    Schwartz, M.3
  • 27
    • 1642532387 scopus 로고    scopus 로고
    • Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes
    • Gnainsky Y, Spira G, Paizi M, et al. Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes. J Hepatol 2004;40:269-277.
    • (2004) J Hepatol , vol.40 , pp. 269-277
    • Gnainsky, Y.1    Spira, G.2    Paizi, M.3
  • 28
    • 33744956853 scopus 로고    scopus 로고
    • Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
    • Popov Y, Patsenker E, Bauer M, et al. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem 2006;281:15090-15098.
    • (2006) J Biol Chem , vol.281 , pp. 15090-15098
    • Popov, Y.1    Patsenker, E.2    Bauer, M.3
  • 29
    • 33750629632 scopus 로고    scopus 로고
    • Hydrodynamics based transfection in normal and fibrotic rats
    • Yeikilis R, Gal S, Kopeiko N, et al. Hydrodynamics based transfection in normal and fibrotic rats. World J Gastroenterol 2006;12:6149-6155.
    • (2006) World J Gastroenterol , vol.12 , pp. 6149-6155
    • Yeikilis, R.1    Gal, S.2    Kopeiko, N.3
  • 30
    • 32944479184 scopus 로고    scopus 로고
    • Heparanase induces vascular endothelial growth factor expression: Correlation with p38 phosphorylation levels and Src activation
    • Zetser A, Bashenko Y, Edovitsky E, et al. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res 2006;66:1455-1463.
    • (2006) Cancer Res , vol.66 , pp. 1455-1463
    • Zetser, A.1    Bashenko, Y.2    Edovitsky, E.3
  • 32
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • Fausto N. Liver regeneration. J Hepatol 2000;32:19-31.
    • (2000) J Hepatol , vol.32 , pp. 19-31
    • Fausto, N.1
  • 33
    • 0032801286 scopus 로고    scopus 로고
    • Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
    • Li D, Friedman SL. Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J Gastroenterol Hepatol 1999;14:618-633.
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 618-633
    • Li, D.1    Friedman, S.L.2
  • 34
    • 0034100952 scopus 로고    scopus 로고
    • Is liver fibrosis reversible?
    • Benyon RC, Iredale JP. Is liver fibrosis reversible? Gut 2000;46:443-446.
    • (2000) Gut , vol.46 , pp. 443-446
    • Benyon, R.C.1    Iredale, J.P.2
  • 35
    • 0035405778 scopus 로고    scopus 로고
    • Heparanase as mediator of angiogenesis: Mode of action
    • Elkin M, Ilan N, Ishai-Michaeli R, et al. Heparanase as mediator of angiogenesis: mode of action. FASEB J 2001;15:1661-1663.
    • (2001) FASEB J , vol.15 , pp. 1661-1663
    • Elkin, M.1    Ilan, N.2    Ishai-Michaeli, R.3
  • 37
    • 2542494203 scopus 로고    scopus 로고
    • Heparanase induces endothelial cell migration via protein kinase B/Akt activation
    • Gingis-Velitski S, Zetser A, Flugelman MY, et al. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem 2004;279:23536-23541.
    • (2004) J Biol Chem , vol.279 , pp. 23536-23541
    • Gingis-Velitski, S.1    Zetser, A.2    Flugelman, M.Y.3
  • 38
    • 34147094691 scopus 로고    scopus 로고
    • Translocation of heparanase into nucleus results in cell differentiation
    • Nobuhisa T, Naomoto Y, Okawa T, et al. Translocation of heparanase into nucleus results in cell differentiation. Cancer Sci 2007;98:535-540.
    • (2007) Cancer Sci , vol.98 , pp. 535-540
    • Nobuhisa, T.1    Naomoto, Y.2    Okawa, T.3
  • 39
    • 0029858861 scopus 로고    scopus 로고
    • Reduction in pulmonary fibrosis in vivo by halofuginone
    • Nagler A, Firman N, Feferman R, et al. Reduction in pulmonary fibrosis in vivo by halofuginone. Am J Respir Crit Care Med 1996;154:1082-1086.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1082-1086
    • Nagler, A.1    Firman, N.2    Feferman, R.3
  • 40
    • 0037143648 scopus 로고    scopus 로고
    • Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice
    • Su AI, Guidotti LG, Pezacki JP, et al. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci USA 2002;99:11181-11186.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11181-11186
    • Su, A.I.1    Guidotti, L.G.2    Pezacki, J.P.3
  • 41
    • 0033038014 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats
    • Assy N, Spira G, Paizi M, et al. Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats. J Hepatol 1999;30:911-915.
    • (1999) J Hepatol , vol.30 , pp. 911-915
    • Assy, N.1    Spira, G.2    Paizi, M.3
  • 42
    • 0035860182 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiopoietin in liver regeneration
    • Kraizer Y, Mawasi N, Seagal J, et al. Vascular endothelial growth factor and angiopoietin in liver regeneration. Biochem Biophys Res Commun 2001;287:209-215.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 209-215
    • Kraizer, Y.1    Mawasi, N.2    Seagal, J.3
  • 43
    • 33845973033 scopus 로고    scopus 로고
    • Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: Implications for regulation of liver fibrosis
    • Zhou X, Jamil A, Nash A, et al. Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis. J Biol Chem 2006;281:39757-39765.
    • (2006) J Biol Chem , vol.281 , pp. 39757-39765
    • Zhou, X.1    Jamil, A.2    Nash, A.3
  • 44
    • 0036121027 scopus 로고    scopus 로고
    • Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth- factor-beta-mediated Smad3 activation in fibroblasts
    • McGaha TL, Phelps RG, Spiera H, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth- factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol 2002;118:461-470.
    • (2002) J Invest Dermatol , vol.118 , pp. 461-470
    • McGaha, T.L.1    Phelps, R.G.2    Spiera, H.3
  • 45
    • 1542504567 scopus 로고    scopus 로고
    • Portal tract fibrogenesis in the liver
    • Ramadori G, Saile B. Portal tract fibrogenesis in the liver. Lab Invest 2004;84:153-159.
    • (2004) Lab Invest , vol.84 , pp. 153-159
    • Ramadori, G.1    Saile, B.2
  • 46
    • 0027185252 scopus 로고
    • Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat
    • Krull NB, Zimmermann T, Gressner AM. Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat. Hepatology 1993;18:581-589.
    • (1993) Hepatology , vol.18 , pp. 581-589
    • Krull, N.B.1    Zimmermann, T.2    Gressner, A.M.3
  • 47
    • 26044478185 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats
    • Novosyadlyy R, Dargel R, Scharf JG. Expression of insulin-like growth factor-I and insulin-like growth factor binding proteins during thioacetamide-induced liver cirrhosis in rats. Growth Horm IGF Res 2005;15:313-323.
    • (2005) Growth Horm IGF Res , vol.15 , pp. 313-323
    • Novosyadlyy, R.1    Dargel, R.2    Scharf, J.G.3
  • 48
    • 34247587198 scopus 로고    scopus 로고
    • Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations
    • Guyot C, Combe C, Clouzeau-Girard H, Moronvalle-Halley V, Desmoulière A. Specific activation of the different fibrogenic cells in rat cultured liver slices mimicking in vivo situations. Virchows Arch 2007;450:503-512.
    • (2007) Virchows Arch , vol.450 , pp. 503-512
    • Guyot, C.1    Combe, C.2    Clouzeau-Girard, H.3    Moronvalle-Halley, V.4    Desmoulière, A.5
  • 49
    • 0035142629 scopus 로고    scopus 로고
    • Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
    • Bruck R, Genina O, Aeed H, et al. Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 2001;33:379-386.
    • (2001) Hepatology , vol.33 , pp. 379-386
    • Bruck, R.1    Genina, O.2    Aeed, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.