Appropriate prescribing in older people

Reviews in Clinical Gerontology

Volumn 17, Issue 2, 2007, Pages 139-151

  Mukhopadhyay, Indranil ^a   Lally, Frank ^b   Crome, Peter ^b  

^a CITY GENERAL HOSPITAL   (United Kingdom)

^b KEELE UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; CLINICAL PRACTICE; DRUG UTILIZATION; ELDERLY CARE; HUMAN; PATIENT COMPLIANCE; POLYPHARMACY; PRESCRIPTION; REVIEW;

EID: 44349083488     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259808002396     Document Type: Review

References (91)

1. Prescriptions Dispensed in the Community: Statistics for 1996 to 2006, England. Statistical Bulletin IC 2007 11C July 2007. Available from: URL: http://www.ic.nhs.uk/webfiles/publications/PrescDispensed%2096to06/ Bulletin%20220807%20version%20for%202006.pdf
2. Gurwitz JH, Field TS, Avorn J et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med 2000; 109: 87-94.
3. Hanlon JT, Schmader KE, Ruby CM, Weinberger M. Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc 2001; 49: 200-09.
4. Crome P, Pollock K. Age-discrimination in prescribing: accounting for concordance. Rev Clin Gerontol 14; 1-4: 2005.
5. Department of Health. National Service Framework for Older People. Medicines and Older People. London: HMSO; 2001.
6. Parish PA. Drug prescribing-the concern of all. J Roy Soc sProm Health 1973; 93: 213-17.
7. Somel M, Khaitovich P, Bahn S, Paabo S, Lachmann M. Gene-expression becomes heterogeneous with age. Curr Biol 2006; 16: R359-R360.
8. Nelson EA, Dannefer D. Aged heterogeneity: fact or fiction? The fate of diversity in gerontological research. Gerontologist 1992; 32: 17-23.
9. Jackson SHD, Mangoni AA, Batty GM. Optimization of drug prescribing. Br J Clin Pharmacol 2004; 57: 231-36.
10. Barber N. What constitutes good prescribing? BMJ 1995; 310(6984): 923-5.
11. Nascher IL. Geriatrics. NY Med J 1909; 358-59.
12. Anantharaju A, Feller A, Chedid A. The aging liver. Gerontology 2002; 48: 343-53.
13. Zeeh J, Platt D. The aging liver. Gerontology 2002; 48: 121-27.
14. Greenblatt DJ, Harmatz JS, Shapiro L, Engelhardt N, Gouthro TA, Shader RI. Sensitivity to triazolam in the elderly. N Engl J Med 1991; 324: 1691-98.
15. Castleden CM, George CF. The effect of ageing on the hepatic clearance of propranolol. Br J Clin Pharmacol 1979; 7: 49-54.
16. Kaplan C, Pasternack B, Shah H, Gallo G. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975; 80: 227-34.
17. Muhlberg W, Platt D. Age-dependent changes of the kidneys: pharmacological implications. Gerontology 1999; 45: 243-53.
18. Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs. J Am Geriatr Soc 1999; 47: 30-39.
19. Lewis JH, Kilgore ML, Goldman DP et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 2003; 21: 1383-89.
20. Hutchins LF, Unger JM, Crowley JJ, Coltman CA, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061-67.
21. Rich MW, Bosner MS, Chung MK, Shen J, McKenzie JP. Is age an independent predictor of early and late mortality in patients with acute myocardial infarction? Am J Med 1992; 92: 7-13.
22. Lee PY, Alexander KP, Hammill BG, Pasquali SK, Peterson ED. Representation of elderly persons and women in published randomized trials of acute coronary syndromes. JAMA 2001; 286: 708-13.
23. Masoudi FA, Havranek EP, Wolfe P et al. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J 2003; 146: 250-57.
24. Giovanazzi-Bannon S, Rademaker A, Lai G, Benson AB, III. Treatment tolerance of elderly cancer patients entered on to phase II clinical trials: an Illinois Cancer Center study. J Clin Oncol 1994; 12: 2447-52.
25. Thiemann DR, Coresh J, Schulman SP, Gerstenblith G, Oetgen WJ, Powe NR. Lack of benefit for intravenous thrombolysis in patients with myocardial infarction who are older than 75 years. Circulation 2000; 101: 2239-46.
26. Royal Pharmaceutical Society of Great Britain. From Compliance to Concordance - Achieving Partnership in Medicine-taking. London: Royal Pharmaceutical Society of Great Britain; 1987.
27. Royal College of Physicians. National Clinical Sentinel Audit of Evidence-based prescribing for Older People. London: Royal College of Physicians; 2000.
28. Thomson S, Crome P. Appropriate prescribing in older people. Rev Clin Gerontol 2002; 12: 213-20.
29. Burns E., Austin CA., Bax N D S. Elderly patients' understanding of their drug therapy: The effect of cognitive function. Age Ageing 1990; 19: 236-40.
30. Beers MH, Ouslander JG, Fingold SF et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med 1992; 117: 684-89.
31. Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 1991; 151: 1825-32.
32. Chin MH, Wang LC, Jin L et al. Appropriateness of medication selection for older persons in an urban academic emergency department. Acad Emerg Med 1999; 6: 1232-41.
33. Lindley CM, Tully MP, Paramsothy V, Tallis RC. Inappropriate medication is a major cause of adverse drug reactions in elderly patients. Age Ageing 1992; 21: 294-300.
34. Goulding MR. Inappropriate medication prescribing for elderly ambulatory-care patients. Arch Intern Med 2004; 164: 305-12.
35. Stuck AE, Beers MH, Steiner A, Aronow HU, Rubenstein LZ, Beck JC. Inappropriate medication use in community-residing older persons. Arch Intern Med 1994; 154: 2195-200.
36. Zhan C, Sangl J, Bierman AS et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel Survey. JAMA 2001; 286: 2823-29.
37. Giron MS, Wang HX, Bernsten C, Thorslund M, Winblad B, Fastbom J. The appropriateness of drug use in an older non-demented and demented population. J Am Geriatr Soc 2001; 49: 277-83.
38. Montamat SC, Cusack B. Overcoming problems with polypharmacy and drug misuse in the elderly. Clin Geriatr Med 1992; 8: 143-58.
39. Kennerfalk A, Ruigomez A, Wallander MA, Wilhelmsen L, Johansson S. Geriatric drug therapy and healthcare utilization in the United Kingdom. Ann Pharmacother 2002; 36: 797-803.
40. Rollason V, Vogt N. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Drugs Aging 2003; 20: 817-32.
41. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: The Slone Survey. JAMA 2002; 287: 337-44.
42. Naughton C, Bennett K, Feely J. Prevalence of chronic disease in the elderly based on a national pharmacy claims database. Age Ageing 2006; 35: 633-36.
43. Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ 1997; 315: 1096-69.
44. Harris CM, Dajda R. The scale of repeat prescribing. Br J Gen Pract 1996; 46: 649-53.
45. Schwartz RK, Soumerai SB, Avorn J. Physician motivations for non-scientific drug prescribing. Soc Sci Med 1989; 28: 577-82.
46. Zarba A, Storr CL, Wagner FA. Carrying habits into old age: prescription drug use without medical advice by older American adults. J Am Geriatr Soc 2005; 53: 170-71.
47. Nolan L, O'Malley K. Prescribing for the elderly. Part I: Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988; 36: 142-49.
48. Hanlon JT, Schmader KE, Koronkowski MJ et al. Adverse drug-events in high-risk older outpatients. J Am Geriatr Soc 1997; 45: 945-48.
49. Gallagher P, Barry P, O'Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Therap 2007; 32: 113-21.
50. Rochon PA, Gurwitz JH. Prescribing for seniors: neither too much nor too little. JAMA 1999; 282: 113-15.
51. Grymonpre RE, Mitenko PA, Sitar DS, Aoki FY, Montgomery PR. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988; 36: 1092-98.
52. Wei JY. Disorder of the heart. In: Hazzard WR, Beirman EL, Blass JP eds. Principles of Geriatric Medicine and Gerontology, third edition. New York: McGraw-Hill; 1994. 517-32.
53. Soumerai SB, McLaughlin TJ, Spiegelman D, Hertzmark E, Thibault G, Goldman L. Adverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction. JAMA 1997; 277: 115-21.
54. Chin MH, Wang JC, Zhang JX, Lang RM. Utilization and dosing of angiotensin-converting enzyme inhibitors for heart failure. J Gen Intern Med 1997; 12: 563-66.
55. Croft JB, Giles WH, Roegner RH, Anda RF, Casper ML, Livengood JR. Pharmacologic management of heart failure among older adults by office-based physicians in the United States. J Fam Pract 1997; 44: 382-90.
56. Mendelson G, Aronow WS. Underutilization of angiotensin-converting enzyme inhibitors in older patients with Q-wave anterior myocardial infarction in an academic hospital-based geriatrics practice. J Am Geriatr Soc 1998; 46: 751-52.
57. Rudd AG, Lowe D, Hoffman A, Irwin P, Pearson M. Secondary prevention for stroke in the United Kingdom: results from the National Sentinel Audit of Stroke. Age Ageing 2004; 33: 280-86.
58. Mendelson G, Aronow WS. Underutilization of warfarin in older persons with chronic nonvalvular atrial fibrillation at high risk for developing stroke. J Am Geriatr Soc 1998; 46: 1423-34.
59. Unutzer J, Ferrell B, Llin EHB, Marmon T. Pharmacotherapy of pain in depressed older adults. J Am Geriatr Soc 2004; 52: 1916-22.
60. Strothers HS, Rust G, Minor P, Fresh E, Druss B, Satcher D. Disparities in antidepressant treatment in Medicaid elderly diagnosed with depression. J Am Geriatr Soc 2005; 53: 456-61.
61. Andrade SE, Majumdar SR, Chan KA et al. Low frequency of treatment of osteoporosis among postmenopausal women following a fracture. Arch Intern Med 2003; 163: 2052-57.
62. Gurwitz JH. Suboptimal medication use in the elderly. The tip of the iceberg. JAMA 1994; 272: 316-17.
63. Medication for Older People. Report of a working party of the Royal College of Physicians, second edition, 1997.
64. Likierman A. Performance indicators: 20 early lessons from managerial use. Pub Money Manage 1993; 13: 15-22.
65. Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med 1997; 157: 1531-36.
66. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: Results of a US consensus panel of experts. Arch Intern Med 2003; 163: 2716-24.
67. Clopidogrel and modified-release dipyridamole in the prevention of occlusive vascular events. National Institute for Clinical Excellence 2004. Available from: URL: http://www.nice.org.uk/nicemedia/pdf/FAD_Clopdip_Vascular. pdf
68. McLeod PJ, Huang AR, Tamblyn RM, Gayton DC. Defining inappropriate practices in prescribing for elderly people: a national consensus panel. CMAJ 1997; 156: 385-91.
69. Naugler CT, Brymer C, Stolee P, Arcese ZA. Development and validation of an improving prescribing in the elderly tool. Can J Clin Pharmacol 2000; 7: 103-07.
70. Fialova D, Topinkova E, Gambassi G et al. Potentially inappropriate medication use among elderly home-care patients in Europe. JAMA 2005; 293: 1348-58.
71. Barry PJ, O'Keefe N, O'Connor KA, O'Mahony D. Inappropriate prescribing in the elderly: a comparison of the Beers criteria and the improved prescribing in the elderly tool (IPET) in acutely ill elderly hospitalized patients. J Clil Pharm Therap 2006; 31: 617-26.
72. Hanlon JT, Schmader KE, Boult C et al. Use of inappropriate prescription drugs by older people. J Am Geriatr Soc 2002 ; 50: 26-34.
73. Wenger NS, Shekelle PG. Assessing care of vulnerable elders: ACOVE Project Overview. Ann Intern Med 2001; 135(8 Part2): 642-46.
74. Knight EL, Avorn J. Quality indicators for appropriate medication use in vulnerable elders. Ann Intern Med 2001; 135(Part 2): 703-10.
75. Hanlon JT, Schmader KE, Samsa GP et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol 1992; 45: 1045-51.
76. Cantrill JA, Sibbald B, Buetow S. Indicators of the appropriateness of long-term prescribing in general practice in the United Kingdom: consensus development, face and content validity, feasibility, and reliability. Qual Saf Health Care 1998; 7: 130-35.
77. Buetow SA, Sibbald B, Cantrill JA, Halliwell S. Appropriateness in health care: Application to prescribing. Soc Sci Med 1997; 45: 261-71.
78. Oborne CA, Batty GM, Maskrey V, Swift CG, Jackson SH. Development of prescribing indicators for elderly medical inpatients. Br J Clin Pharmacol 1997; 43: 91-97.
79. Grant RL, Batty GM, Aggarwal R et al. National sentinel clinical audit of evidence-based prescribing for older people: methodology and development. J Eval Clin Pract 2002; 8: 189-98.
80. Jefferey S, Ruby C, Twersky J, Hanlon JT. Effect of an interdisciplinary team on suboptimal prescribing in a long-term care facility. Consult Pharm 1999; 14: 1386-91.
81. Barry PJ, Gallagher P, Ryan C, O'Mahony D. START (screening tool to alert doctors to the right treatment) an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing 2007; 36: 632-38.
82. Shrank WH, Polinski JM, Avorn J. Quality indicators for medication-use in vulnerable elders. J Am Geriatr Soc 2007; 55: S373-S382.
83. Versi E, Appell R, Mobley D, Patton W, Saltzstein D. Dry mouth with conventional and controlled-release oxybutynin in urinary incontinence. Obstet Gynecol 2000; 95: 718-21.
84. Peterson AM, Takiya L, Finley R. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm 2003; 60: 657-65.
85. de Vries T, Henning R, Hogerzeil H, Fresle D. Guide to good prescribing . A practical manual. Geneva: World Health Organisation; 2000.
86. Crotty M, Halbert J, Rowett D et al. An outreach geriatric medication advisory service in residential aged care: a randomised controlled trial of case conferencing. Age Ageing 2004; 33: 612-17.
87. Wu JYF, Leung WYS, Chang S et al. Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. BMJ 2006; 333(7567): 522.
88. Monane M, Matthias DM, Nagle BA, Kelly MA. Improving prescribing patterns for the elderly through an online drug utilization review intervention: a system linking the physician, pharmacist, and computer. JAMA 1998; 280: 1249-52.
89. Teich JM, Merchia PR, Schmiz JL, Kuperman GJ, Spurr CD, Bates DW. Effects of computerized physician order entry on prescribing practices. Arch Intern Med 2000; 160: 2741-47.
90. Bates DW, Leape LL, Cullen DJ et al. Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA 1998; 280: 1311-16.
91. Bates DW. Using information technology to reduce rates of medication errors in hospitals. BMJ 2000; 320(7237): 788-91.