Protectant activity of hexarelin or growth hormone against postischemic ventricular dysfunction in hearts from aged rats

Journal of Cardiovascular Pharmacology

Volumn 32, Issue 2, 1998, Pages 260-265

  Rossoni, Giuseppe ^a   De Gennaro Colonna, Vito ^a   Bernareggi, Micaela ^a   Polvani, Gian Luca ^a   Müller, Eugenio Edoardo ^a   Berti, Ferruccio ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Aging; Growth hormone; Hexarelin; Ischemia reperfusion; Rat heart

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; CREATINE KINASE; GROWTH HORMONE; HEXARELIN; MESSENGER RNA; SOMATOMEDIN C;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY VASCULAR RESISTANCE; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE FUNCTION; MALE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; STUNNED HEART MUSCLE; SUBCUTANEOUS DRUG ADMINISTRATION;

6-KETOPROSTAGLANDIN F1 ALPHA; AGING; ANGIOTENSIN II; ANIMALS; GROWTH HORMONE; HEART; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; OLIGOPEPTIDES; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0031875015     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199808000-00013     Document Type: Article

References (39)

1. Lakatta EG, Yin FC. Myocardial aging: functional alterations and related cellular mechanisms. Am J Physiol 1982;242:H927-41.
2. Ji LL, Dillon D, Wu E. Myocardial aging: antioxidant enzyme systems and related biochemical properties. Am J Physiol 1991; 261:R386-92.
3. 1 receptor agonist. Gerontology 1995;50A:B351-7.
4. De Gennaro Colonna V, Rossoni G, et al. Worsening of ischemic damage in hearts from rats with selective growth hormone deficiency. Eur J Pharmacol 1996;314:333-8.
5. De Gennaro Colonna V, Rossoni G, Bernareggi M, Müller EE, Berti F. Cardiac ischemia and impairment of vascular endothelium function in hearts from GH-deficient rats: protection by hexarelin. Eur J Pharmacol 1997;334:201-7.
6. Deghenghi R, Cananzi MM, Torsello A, Battisti C, Müller EE, Locatelli V. GH-releasing activity of hexarelin, a new growth hormone-releasing peptide, in infant and adult rats. Life Sci 1994;54:1321-8.
7. Cella SG, Locatelli V, Poratelli M, et al. Hexarelin, a potent GHRP analogue: interactions with GHRH and clonidine in young and aged dogs. Peptides 1995;16:81-6.
8. Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990;336:285-8.
9. Merola B, Cittadini A, Colao A, et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J Clin Endocrinol Metab 1993;77:1658-61.
10. Sonntag WE, Steger RW, Forman LJ, Meites J. Decreased pulsatile release of growth hormone in old male rats. Endocrinology 1980;107: 1875-9.
11. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. Impaired growth hormone secretion in the adult population. J Clin Invest 1981;67:1361-9.
12. Chomczynski P, Downs TR, Frohman LA. Feedback regulation of growth hormone (GH)-releasing hormone gene expression by GH in rat hypothalamus. Mol Endocrinol 1988;2:236-40.
13. Cella SG, De Gennaro Colonna V, Locatelli V, et al. Somatotropic dysfunction in growth hormone-releasing hormone-deprived neonatal rats: effect of growth hormone replacement therapy. Pediatr Res 1994;36:315-22.
14. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
15. Cella SG, Locatelli V, Broccia ML, et al. Long term changes of somatotropic function induced by deprivation of growth hormone-releasing hormone during the fetal life of the rat. J Endocrinol 1994;140:111-7.
16. Daughaday WH, Mariz IK, Blethen SL. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid ethanol extracted serum. J Clin Endocrinol Metab 1980;51:781-8.
17. Berti F, Rossoni G, Magni F, et al. Nonsteroidal antiinflammatory drugs aggravate acute myocardial ischemia in the perfused rabbit heart: a role for prostacyclin. J Cardiovasc Pharmacol 1988;12: 438-44.
18. Pradelles P, Grassi J, Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal Chem 1985;57:1170-3.
19. Bergmeyer HU, Rich W, Butter H, et al. Standardization of methods for estimation of enzyme activity in biological fluids. Z Klin Chem 1970;8:658-60.
20. Ullman M, Ullman A, Sommerland H, Skottner A, Oldfors A. Effects of growth hormone on muscle regeneration and IGF-I. Acta Physiol Scand 1990,140:521-5.
21. Ferrari R. Metabolic disturbances during myocardial ischemia and reperfusion. Am J Cardiol 1995;76:17-24B.
22. Grilli R, Bresciani E, Torsello A, et al. Tissue-specific expression of GHS-receptor mRNA in the CNS and peripheral organs of the male rats. 79th Annual Meeting of the Endocrine Society, Minneapolis, 1997 (abstract).
23. Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996;273:974-7.
24. 2+ modulation during postischemic reperfusion in rat heart. Am J Physiol 1995;268:H100-11.
25. Tsukube T, McCully JD, Federman M, Krukenkamp IB, Levitsky S. Developmental differences in cytosolic calcium accumulation associated with surgically induced global ischemia: optimization of cardioplegic protection and mechanism of action. J Thorac Cardiovasc Surg 1996;112:175-84.
26. Akita T, Abe T, Kato S, Kodama I, Toyama J. Protective effects of diltiazem and ryanodine against ischemia-reperfusion injury in neonatal rabbit hearts. J Thorac Cardiovasc Surg 1993;106:55-66.
27. 2+-free medium. J Pharmacol Exp Ther 1983;226:258-68.
28. Nayler WG, Elz JS. Reperfusion injury: laboratory artifacts or clinical dilemma? Circulation 1986;74:215-21.
29. Mathews LS, Enberg B, Norstedt G. Regulation of rat growth hormone receptor gene expression. J Biol Chem 1989;17:9905-10.
30. Engelmann GL, Boehm KD, Haskell JF, Khairallah PA, Ilan J. Insulin-like growth factors and neonatal cardiomyocyte development: ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats. Mol Cell Endocrinol 1989;63:1-14.
31. Sklar MM, Kiess W, Thomas CL, Nissley SP. Developmental expression of the tissue insulin-like growth factor II/mannose 6-phosphate receptor in the rat. J Biol Chem 1989;264:16733-8.
32. Isgaard J, Nilsson A, Vikman. K, Isaksson OGP. Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle. J Endocrinol 1989;120:107-12.
33. Flyvbjerg A, Jorgensen KD, Marshall SM, Prskov H. Inhibitory effect of octreotide on growth hormone-induced IGF-I generation and organ growth in hypophysectomized rats. Am J Physiol 1991;260:E568-74.
34. Donath MY, Jenni R, Brunner HP, et al. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 1996;81:4089-94.
35. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci U S A 1995;92:8031-5.
36. Berti F, Rossoni G, Omini C, et al. Defibrotide, an antithrombotic substance which prevents myocardial contracture in ischemic rabbit heart. Eur J Pharmacol 1987;135:375-82.
37. Lefer AM, Lefer DJ. Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol Toxicol 1993;33:71-90.
38. Berti F, Rossoni G, Della Bella D, et al. Nitric oxide and prostacyclin influence coronary vasomotor tone in perfused rabbit heart and modulate endothelin-1 activity. J Cardiovasc Pharmacol 1993;22:321-6.
39. Brock DB, Guralnik JM, Brody JA. Demography and epidemiology of aging in the United States. In: Schneider EL, Rowe JW, eds. Biology of aging. New York: Academic, 1990:3-23.