Insulin-like growth factor I improves aspects of mycophenolate mofetil-impaired anastomotic healing in an experimental model

British Journal of Surgery

Volumn 95, Issue 6, 2008, Pages 793-798

  Inglin, R A ^a   Baumann, G ^a   Wagner, O J ^a   Candinas, D ^a   Egger, B ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; SOMATOMEDIN C; ANTIMETABOLITE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; KI 67 ANTIGEN; MYCOPHENOLIC ACID;

ANASTOMOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; INTESTINE MUCOSA; MORPHOMETRICS; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RAT; SIGMOID; SUTURE; WOUND HEALING; ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WOUND DEHISCENCE;

ANASTOMOSIS, SURGICAL; ANIMALS; ANTIMETABOLITES; BROMODEOXYURIDINE; CELL PROLIFERATION; COLON, SIGMOID; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INSULIN-LIKE GROWTH FACTOR I; INTESTINAL MUCOSA; KI-67 ANTIGEN; MALE; MYCOPHENOLIC ACID; PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; SURGICAL WOUND DEHISCENCE; WOUND HEALING;

EID: 44249083029     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.6053     Document Type: Conference Paper

References (29)

1. Helderman JH, Goral S. Gastrointestinal complications of transplant immunosuppression. J Am Soc Nephrol 2002; 13: 277-287.
2. Polat A, Nayci A, Polat G, Aksoyek S. Dexamethasone down-regulates endothelial expression of intercellular adhesion molecule and impairs the healing of bowel anastomoses. Eur J Surg 2002; 168: 500-506.
3. Petri JB, Schurk S, Gebauer S, Haustein UF. Cyclosporine A delays wound healing and apoptosis and suppresses activin beta-A expression in rats. Eur J Dermatol 1998; 8: 104-113.
4. Schaffer MR, Fuchs N, Proksch B, Bongartz M, Beiter T, Becker HD. Tacrolimus impairs wound healing: a possible role of decreased nitric oxide synthesis. Transplantation 1998; 65: 813-818.
5. van der Vliet JA, Willems MC, de Man BM, Lomme RM, Hendriks T. Everolimus interferes with healing of experimental intestinal anastomoses. Transplantation 2006; 82: 1477-1483.
6. Zeeh J, Inglin R, Baumann G, Dirsch O, Riley NE, Gerken G et al. Mycophenolate mofetil impairs healing of left-sided colon anastomoses. Transplantation 2001; 71: 1429-1435.
7. Behrend M. A review of clinical experience with the novel immunosuppressive drug mycophenolate mofetil in renal transplantation. Clin Nephrol 1996; 45: 336-341.
8. Hebert MF, Ascher NL, Lake JR, Emond J, Nikolai B, Linna TJ et al. Four-year follow-up of mycophenolate mofetil for graft rescue in liver allograft recipients. Transplantation 1999; 67: 707-712.
9. Ducloux D, Ottignon Y, Semhoun-Ducloux S, Labbe S, Saint-Hillier Y, Miguet JP et al. Mycophenolate mofetil-induced villous atrophy. Transplantation 1998; 66: 1115-1116.
10. Sikas N, Imvrios G, Takoudas D, Gakis D, Papanikolaou V. Mycophenolate mofetil impairs the integrity of colonic anastomosis. J SurgRes 2006; 134: 168-172.
11. Olanrewaju H, Patel L, Seidel ER. Trophic action of local intraileal infusion of insulin-like growth factor I: polyamine dependence. Am J Physiol 1992; 263: E282-E286.
12. Vanderhoof JA, McCusker RH, Clark R, Mohammadpour H, Blackwood DJ, Harty RF et al. Truncated and native insulinlike growth factor I enhance mucosal adaptation after jejunoileal resection. Gastroenterology 1992; 102: 1949-1956.
13. Mantzoros I, Kanellos I, Angelopoulos S, Koliakos G, Pramateftakis MG, Kanellos D et al. The effect of insulin-like growth factor I on healing of colonic anastomoses in cortisone-treated rats. Dis Colon Rectum 2006; 49: 1431-1438.
14. Egger B, Inglin R, Zeeh J, Dirsch O, Huang Y, Buchler MW. Insulin-like growth factor I and truncated keratinocyte growth factor accelerate healing of left-sided colonic anastomoses. Br J Surg 2001; 88: 90-98.
15. Schmid C. Insulin-like growth factors. Cell Biol Int 1995; 19: 445-457.
16. Rouyer-Fessard C, Gammeltoft S, Laburthe M. Expression of two types of receptor for insulinlike growth factors in human colonic epithelium. Gastroenterology 1990; 98: 703-707.
17. Gratzner HG. Monoclonal antibody to 5-bromo- and 5-iododesoxyuridine: a new reagent for detection of DNA replication. Science 1982; 218: 474-475.
18. Ohda Y, Hori K, Tomita T, Hida N, Kosaka T, Fukuda Y et al. Effects of hepatocyte growth factor on rat inflammatory bowel disease models. Dig Dis Sci 2005; 50: 914-921.
19. Meier-Kriesche HU, Li S, Gruessner RW, Fung JJ, Bustami RT, Barr ML et al. Immunosuppression: evolution in practice and trends, 1994-2004. Am J Transplant 2006; 6: 1111-1131.
20. Golconda MS, Valente JF, Bejarano P, Gilinsky N, First MR. Mycophenolate mofetil-induced colonic ulceration in renal transplant recipients. Transplant Proc 1999; 31: 272-273.
21. European Mycophenolate Mofetil Cooperative Study Group. Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 1995; 345: 1321-1325.
22. Sun DF, Fujigaki Y, Fujimoto T, Goto T, Yonemura K, Hishida A. Mycophenolate mofetil inhibits regenerative repair in uranyl acetate-induced acute renal failure by reduced interstitial cellular response. Am J Patbol 2002; 161: 217-227.
23. Skottner A, Arrhenius-Nyberg V, Kanje M, Fryklund L. Anabolic and tissue repair functions of recombinant insulin-like growth factor I. Acta Paediatr Scand Suppl 1990; 367: 63-66.
24. Steeb CB, Shoubridge CA, Tivey DR, Read LC. Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats. Am J Physiol 1997; 272: G522-G533.
25. Leeb SN, Vogl D, Falk W, Scholmerich J, Rogler G, Gelbmann CM. Regulation of migration of human colonic myofibroblasts. Growth Factors 2002; 20: 81-91.
26. Yoshizawa T, Watanabe S, Hirose M, Yamamoto J, Osada T, Sato K et al. Effects of growth factors on aspirin-induced inhibition of wound repair in a rabbit gastric epithelial cell model. Aliment Pharmacol Ther 2000; 14(Suppl 1): 176-182.
27. Howarth GS, Cool JC, Bourne AJ, Ballard FJ, Read LC. Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate. Growth Factors 1998; 15: 279-292.
28. Podolsky DK. Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol 1999; 277: G495-G499.
29. Allison AC, Eugui EM. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant 1996; 10: 77-84.