A review of clinical experience with the novel immunosuppressive drug mycophenolate mofetil in renal transplantation

Clinical Nephrology

Volumn 45, Issue 5, 1996, Pages 336-341

  Behrend, M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Mycophenolate mofetil; New immunosuppressive drugs; Prevention of rejection; Renal transplantation; RS61443

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PURINE DERIVATIVE;

ARTICLE; BLOOD TOXICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG EFFICACY; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; LEUKOPENIA; META ANALYSIS; MULTICENTER STUDY; OPPORTUNISTIC INFECTION; ORAL DRUG ADMINISTRATION; PURINE SYNTHESIS; RANDOMIZED CONTROLLED TRIAL;

CLINICAL TRIALS; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IMP DEHYDROGENASE; KIDNEY TRANSPLANTATION; MYCOPHENOLIC ACID; PILOT PROJECTS;

EID: 0029874331     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Allison AC, Eugui EM 1993 Mycophenolate mofetil, an rationally designed immunosuppressive drug. Clin Transplant 7: 96
2. Almond PS, Matas A, Gillingham K, Dunn DL, Pavne WD, Gores P, Gruessner R, Najarian JS 1993 Risk factors for chronic rejection in renal allograft recipients. Transplantation 55: 752
3. Deierhot MH, Sollinger HW, Diethelm AG, Belzer FO, Kauffman RS 1993 One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation. Transplant Proc 25: 693
4. European Mycophenolate Mofetil Cooperative Study Group 1995 Placebo-controlled study of mycophenolate mofetil combined with cyclosporin and corticosteroids for prevention of acute rejection. Lancet 345: 1321
5. Koyama H, Cecka JM 1992 Rejection episodes. In: Terasaki PJ and Cecka JM (eds) Clinical Transplants 1992. UCLA Tissue Typing Laboratoy, Los Angeles, California, p 391
6. Laskow DA, Deierhoi MH, Hudson SL, Orr CL, Curtis JJ, Diethelm AG 1994 The incidence of subsequent acute rejection following the treatment of refractory renal allograft rejection with mycophenolate mofetil (RS61443). Transplantation 57: 640
7. Lindholm A, Ohlman S, Albrechtsen D, Tufveson G, Persson H, Persson NH 1993 The impact of acute rejection episodes on long-term graft function and outcome in 1347 primary renal transplants treated by 3 cyclosporine regimens. Transplantation 56: 307
8. Morris RE, Hoyt G, Eugui EM, Allison AC 1989 RS-61443 is a novel purine synthesis inhibitor that prolongs allograft and xenograft survival and reverses acute rejection [abstract] Meeting of the American College of Surgeons
9. Platz KP, Bechstein WO, Eckhoff DE, Suzuki Y, Sollinger HW 1991 RS-61443 reverses acute rejection in dogs. Surgery 110: 736
10. Solez K, Axelsen RA, Benediktsson H, Burdick JF, Cohen AH, Colvin KB, Croker BP, Droz D, Dunnill MS, Halloran PF, Häyry P, Jennette JC, Keown PA, Marcussen N, Mihatsch MJ, Morozumi K, Myers BD, Nast CC, Olsen S, Racusen LC, Ramos EL, Rosen S, Sachs DH, Salomon DR, Sanfilippo F, Verani R, von Willebrand E, Yamaguchi Y 1993 International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology-Kidney Int 44: 411
11. Sollinger HW, Belzer FO, Deierhoi MH, Diethelm AG, Gonwa TA, Kauffman RS, Klintmalm GB, McDiarmid SV, Roberts J, Rosenthal JT 1993 RS61443: rescue therapy in refractory kidney transplant rejection. Transplant Proc 25: 698
12. Sollinger HW 1994 RS-61443. Plenary Session at the XVth World Congress of the transplantation society, Kyoto, Japan
13. Sollinger HW, Eugui EM, Allison AC 1991 RS61443: mechanism of action, experimental and early clinical results. Clin Transplant 5: 523