Aminopyrazine CB1 receptor inverse agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3376-3381

  Wustrow, David J ^a   Maynard, George D ^a   Yuan, Jun ^a   Zhao, He ^a   Mao, Jianmin ^a   Guo, Qin ^a   Kershaw, Mark ^a   Hammer, Jack ^a   Brodbeck, Robbin M ^a   Near, Kristen E ^a   Zhou, Dan ^a   Beers, David S ^a   Chenard, Bertrand L ^a   Krause, James E ^a   Hutchison, Alan J ^a  

^a NEUROGEN CORPORATION   (United States)

Author keywords

Brain level; Cannabinoid; CB1 inverse agonist; Ex vivo receptor occupancy; Rat obesity model

Indexed keywords

5,6 DIARYL 2 AMINO PYRAZINE DERIVATIVE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CYTOCHROME P450; CYTOCHROME P450 3A4; RIMONABANT;

ANIMAL TISSUE; ARTICLE; BROMINATION; CEREBELLUM; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FOOD INTAKE; HUMAN; IN VITRO STUDY; LIVER MICROSOME; NONHUMAN; RAT; SUZUKI REACTION;

ANIMALS; BLOOD GLUCOSE; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOCHROME P-450 CYP3A; DISEASE MODELS, ANIMAL; FEEDING BEHAVIOR; HUMANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OBESITY; PIPERIDINES; PYRAZINES; PYRAZOLES; RATS; RECEPTOR, CANNABINOID, CB1; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 44149110367     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.022     Document Type: Article

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