-
2
-
-
2142712507
-
A review of systemic re-tinoid therapy for acne and related conditions
-
Kunynetz RA. A review of systemic re-tinoid therapy for acne and related conditions. Skin Therapy Lett 2004 9 : 1 4.
-
(2004)
Skin Therapy Lett
, vol.9
, pp. 1-4
-
-
Kunynetz, R.A.1
-
4
-
-
33644856918
-
The acute and chronic toxic effects of vitamin a
-
Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006 83 : 191 201.
-
(2006)
Am J Clin Nutr
, vol.83
, pp. 191-201
-
-
Penniston, K.L.1
Tanumihardjo, S.A.2
-
5
-
-
0028275432
-
Tera-togenic risk with etretinate and acitre-tin treatment
-
Geiger JM, Baudin M, Saurat JH. Tera-togenic risk with etretinate and acitre-tin treatment. Dermatology 1994 189 : 109 116.
-
(1994)
Dermatology
, vol.189
, pp. 109-116
-
-
Geiger, J.M.1
Baudin, M.2
Saurat, J.H.3
-
6
-
-
84989611379
-
Tissue changes following deprivation of fat-soluble vitamin a
-
Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble vitamin A. J Exp Med 1925 47 : 753 777.
-
(1925)
J Exp Med
, vol.47
, pp. 753-777
-
-
Wolbach, S.B.1
Howe, P.R.2
-
7
-
-
77951315105
-
Therapeutische Versuche bei Psoriasis mit Vitamin A, zugleich ein Beitrag zur A-Hypervita-minose
-
Frey JR, Schoch MA. Therapeutische Versuche bei Psoriasis mit Vitamin A, zugleich ein Beitrag zur A-Hypervita-minose. Dermatologica 1952 104 : 80.
-
(1952)
Dermatologica
, vol.104
, pp. 80
-
-
Frey, J.R.1
Schoch, M.A.2
-
8
-
-
0031848711
-
Pharmacoki-netics of acitretin and etretinate
-
Wiegand UW, Chou RC. Pharmacoki-netics of acitretin and etretinate. J Am Acad Dermatol 1998 39 : S25 S33.
-
(1998)
J Am Acad Dermatol
, vol.39
-
-
Wiegand, U.W.1
Chou, R.C.2
-
9
-
-
0033761677
-
Adapalene: An update on newer comparative studies between the various retinoids
-
Millikan LE. Adapalene: an update on newer comparative studies between the various retinoids. Int J Dermatol 2000 39 : 784 788.
-
(2000)
Int J Dermatol
, vol.39
, pp. 784-788
-
-
Millikan, L.E.1
-
10
-
-
0033868118
-
Tazarotene versus tretinoin or adapalene in the treatment of acne vul-garis
-
Kakita L. Tazarotene versus tretinoin or adapalene in the treatment of acne vul-garis. J Am Acad Dermatol 2000 43 : S51 S54.
-
(2000)
J Am Acad Dermatol
, vol.43
-
-
Kakita, L.1
-
12
-
-
4644340612
-
A phase II multicenter clinical trial of systemic bexarotene in psoriasis
-
Smit JV, Franssen ME, de Jong EM, Lambert J, Roseeuw DI, De Weert J, Yocum RC, Stevens VJ, van De Kerk-hof PC. A phase II multicenter clinical trial of systemic bexarotene in psoriasis. J Am Acad Dermatol 2004 51 : 249 56.
-
(2004)
J Am Acad Dermatol
, vol.51
, pp. 249-56
-
-
Smit, J.V.1
Franssen, M.E.2
De Jong, E.M.3
Lambert, J.4
Roseeuw, D.I.5
De Weert, J.6
Yocum, R.C.7
Stevens, V.J.8
Van De Kerk-Hof, P.C.9
-
13
-
-
0029794132
-
A decade of molecular biology of retinoic acid receptors
-
Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996 10 : 940 954.
-
(1996)
FASEB J
, vol.10
, pp. 940-954
-
-
Chambon, P.1
-
14
-
-
0026570218
-
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
-
Heyman RA, Mangelsdorf DJ, Dyck JA, Stein RB, Eichele G, Evans RM, Thaller C. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 1992 68 : 397 406.
-
(1992)
Cell
, vol.68
, pp. 397-406
-
-
Heyman, R.A.1
Mangelsdorf, D.J.2
Dyck, J.A.3
Stein, R.B.4
Eichele, G.5
Evans, R.M.6
Thaller, C.7
-
15
-
-
0026541640
-
9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
-
Levin AA, Sturzenbecker LJ, Kazmer S, Bosakowski T, Huselton C, Allenby G, Speck J, Kratzeisen C, Rosenberger M, Lovey A, Grippo JF. 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature 1992 355 : 359 361.
-
(1992)
Nature
, vol.355
, pp. 359-361
-
-
Levin, A.A.1
Sturzenbecker, L.J.2
Kazmer, S.3
Bosakowski, T.4
Huselton, C.5
Allenby, G.6
Speck, J.7
Kratzeisen, C.8
Rosenberger, M.9
Lovey, A.10
Grippo, J.F.11
-
16
-
-
0026597950
-
Characterization of three RXR genes that mediate the action of 9-cis-retinoic acid
-
Mangelsdorf DJ, Borgmeyer U, Hey-man RA, Zhou JY, Ong ES, Oro AE, Kakizuka A, Evans RM. Characterization of three RXR genes that mediate the action of 9-cis-retinoic acid. Genes Dev 1992 6 : 329 344.
-
(1992)
Genes Dev
, vol.6
, pp. 329-344
-
-
Mangelsdorf, D.J.1
Borgmeyer, U.2
Hey-Man, R.A.3
Zhou, J.Y.4
Ong, E.S.5
Oro, A.E.6
Kakizuka, A.7
Evans, R.M.8
-
17
-
-
0027459082
-
Retinoic acid receptors and retinoic X receptors: Interactions with endogenous retinoic acids
-
Allenby G, Bocquel M-T, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Cham-bon P, Levin AA. Retinoic acid receptors and retinoic X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 1993 90 : 30 34.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 30-34
-
-
Allenby, G.1
Bocquel, M.-T.2
Saunders, M.3
Kazmer, S.4
Speck, J.5
Rosenberger, M.6
Lovey, A.7
Kastner, P.8
Grippo, J.F.9
Cham-Bon, P.10
Levin, A.A.11
-
18
-
-
0027264697
-
Expression, purification and binding pro-perties of human cellular retinoic acid-binding protein type I and type II
-
Fogh K, Voorhees JJ, Aström A. Expression, purification and binding pro-perties of human cellular retinoic acid-binding protein type I and type II. Arch Biochem Biophys 1993 300 : 751 755.
-
(1993)
Arch Biochem Biophys
, vol.300
, pp. 751-755
-
-
Fogh, K.1
Voorhees, J.J.2
Aström, A.3
-
19
-
-
0034214303
-
Tissue-specific expression of retinoic acid receptor iso-form transcripts in the mouse embryo
-
Mollard R, Viville S, Ward SJ, Decimo D, Chambon P, Dolle P. Tissue-specific expression of retinoic acid receptor iso-form transcripts in the mouse embryo. Mech Dev 2000 94 : 223 232.
-
(2000)
Mech Dev
, vol.94
, pp. 223-232
-
-
Mollard, R.1
Viville, S.2
Ward, S.J.3
Decimo, D.4
Chambon, P.5
Dolle, P.6
-
20
-
-
0027995188
-
Retinoic acid receptors and cellular retinoid binding proteins: Complex interplay in retinoid signaling
-
Giguere V. Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. En-doc Rev 1994 15 : 61 79.
-
(1994)
En-doc Rev
, vol.15
, pp. 61-79
-
-
Giguere, V.1
-
21
-
-
0028109271
-
Immunological identification and functional quantification of retinoic and retinoid X receptor protein in human skin
-
Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egly C, Chambon P, Voorhees JJ. Immunological identification and functional quantification of retinoic and retinoid X receptor protein in human skin. J Biol Chem 1994 269 : 20629 20635.
-
(1994)
J Biol Chem
, vol.269
, pp. 20629-20635
-
-
Fisher, G.J.1
Talwar, H.S.2
Xiao, J.H.3
Datta, S.C.4
Reddy, A.P.5
Gaub, M.P.6
Rochette-Egly, C.7
Chambon, P.8
Voorhees, J.J.9
-
22
-
-
0028796740
-
Endogenous retinoic acid receptor (RAR) - Retinoid X-receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human kera-tinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR hetero-dimers to confer ligand-dependent activation of hRAR beta 2/RARE (DR5)
-
Xiao JH, Durand B, Chambon P, Voor-hees JJ. Endogenous retinoic acid receptor (RAR) - retinoid X-receptor (RXR) heterodimers are the major functional forms regulating retinoid-responsive elements in adult human kera-tinocytes. Binding of ligands to RAR only is sufficient for RAR-RXR hetero-dimers to confer ligand-dependent activation of hRAR beta 2/RARE (DR5). J Biol Chem 1995 270 : 3001 3011.
-
(1995)
J Biol Chem
, vol.270
, pp. 3001-3011
-
-
Xiao, J.H.1
Durand, B.2
Chambon, P.3
Voor-Hees, J.J.4
-
23
-
-
0031833450
-
The nuclear receptor ligand-binding domain: Structure and function
-
Moras D, Gronemeyer H. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol 1998 10 : 384 391.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 384-391
-
-
Moras, D.1
Gronemeyer, H.2
-
24
-
-
0036847229
-
Gene expression regulation by retinoic acid
-
Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002 43 : 1773 1808.
-
(2002)
J Lipid Res
, vol.43
, pp. 1773-1808
-
-
Balmer, J.E.1
Blomhoff, R.2
-
25
-
-
0035976638
-
Nuclear receptors and lipid physiology: Opening the X-files
-
Chawla A, Repa J, Evans RM, Man-gelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science 2001 294 : 1866 1870.
-
(2001)
Science
, vol.294
, pp. 1866-1870
-
-
Chawla, A.1
Repa, J.2
Evans, R.M.3
Man-Gelsdorf, D.J.4
-
26
-
-
0033305547
-
Nuclear receptor coregulators: Cellular and molecular biology
-
McKenna NJ, Lanz RB, O'Malley BW. Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev 1999 20 : 321 344.
-
(1999)
Endocr Rev
, vol.20
, pp. 321-344
-
-
McKenna, N.J.1
Lanz, R.B.2
O'Malley, B.W.3
-
27
-
-
0035962669
-
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription
-
Dilworth FJ, Chambon P. Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription. Oncogene 2001 20 : 3047 3054.
-
(2001)
Oncogene
, vol.20
, pp. 3047-3054
-
-
Dilworth, F.J.1
Chambon, P.2
-
28
-
-
0031715324
-
Nuclear detection of cellular retinoic acid binding proteins I and II with new antibodies
-
Gaub MP, Lutz Y, Ghyselinck NB, Scheuer I, Pfister V, Chambon P, Ro-chette-Egly C. Nuclear detection of cellular retinoic acid binding proteins I and II with new antibodies. J Histo-chem Cytochem 1998 46 : 1103 1111.
-
(1998)
J Histo-chem Cytochem
, vol.46
, pp. 1103-1111
-
-
Gaub, M.P.1
Lutz, Y.2
Ghyselinck, N.B.3
Scheuer, I.4
Pfister, V.5
Chambon, P.6
Ro-Chette-Egly, C.7
-
29
-
-
0028265730
-
Cellular transport and metabolism of vitamin A: Roles of the cellu-lar retinoid-binding proteins
-
Ong DE. Cellular transport and metabolism of vitamin A: roles of the cellu-lar retinoid-binding proteins. Nutr Rev 1994 52 : S24 S31.
-
(1994)
Nutr Rev
, vol.52
-
-
Ong, D.E.1
-
30
-
-
0029846699
-
Structure/function of cytoplasmic vitamin A-binding proteins
-
Li E, Norris AW. Structure/function of cytoplasmic vitamin A-binding proteins. Ann Rev Nutr 1996 16 : 205 234.
-
(1996)
Ann Rev Nutr
, vol.16
, pp. 205-234
-
-
Li, E.1
Norris, A.W.2
-
31
-
-
0034660094
-
Retinoid-binding proteins: Mediators of retinoid action
-
Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J 2000 348 : 481 495.
-
(2000)
Biochem J
, vol.348
, pp. 481-495
-
-
Noy, N.1
-
32
-
-
0028912640
-
Mice deficient in cellular retinoic acid binding protein II (CRABP II) or in both CRABP I and CRABP II are essentially normal
-
Lampron C, Rochette-Egly C, Gorry P, Dolle P, Mark M, Lufkin T, LeMeur M, Chambon P. Mice deficient in cellular retinoic acid binding protein II (CRABP II) or in both CRABP I and CRABP II are essentially normal. Development 1995 121 : 539 548.
-
(1995)
Development
, vol.121
, pp. 539-548
-
-
Lampron, C.1
Rochette-Egly, C.2
Gorry, P.3
Dolle, P.4
Mark, M.5
Lufkin, T.6
Lemeur, M.7
Chambon, P.8
-
33
-
-
0024503034
-
Provitamin a function of ca-rotenoids: The conversion of beta-carotene into vitamin a
-
Olson JA. Provitamin A function of ca-rotenoids: the conversion of beta-carotene into vitamin A. J Nutr 1989 119 : 105 108.
-
(1989)
J Nutr
, vol.119
, pp. 105-108
-
-
Olson, J.A.1
-
34
-
-
0025935588
-
Vitamin a metabolism: New perspectives on absorption, transport, and storage
-
Blomhoff R, Green MH, Green JB, Berg T, Norum KR. Vitamin A metabolism: new perspectives on absorption, transport, and storage. Physiol Rev 1991 71 : 951 90.
-
(1991)
Physiol Rev
, vol.71
, pp. 951-90
-
-
Blomhoff, R.1
Green, M.H.2
Green, J.B.3
Berg, T.4
Norum, K.R.5
-
35
-
-
0023712276
-
Reduction of re-tinaldehyde bound to cellular retinol-binding protein (type II) by microso-mes from rat small intestine
-
Kakkad BP, Ong DE. Reduction of re-tinaldehyde bound to cellular retinol-binding protein (type II) by microso-mes from rat small intestine. J Biol Chem 1988 263 : 12916 12919.
-
(1988)
J Biol Chem
, vol.263
, pp. 12916-12919
-
-
Kakkad, B.P.1
Ong, D.E.2
-
37
-
-
0035014463
-
Mechanisms involved in the intestinal digestion and absorption of dietary vitamin a
-
Harrison EH, Hussain MM. Mechanisms involved in the intestinal digestion and absorption of dietary vitamin A. J Nutr 2001, 131 : 1405 1408.
-
(2001)
J Nutr
, vol.131
, pp. 1405-1408
-
-
Harrison, E.H.1
Hussain, M.M.2
-
38
-
-
0028295677
-
Transport and metabolism of vitamin a
-
Blomhoff R. Transport and metabolism of vitamin A. Nutr Rev 1994 52 : S13 23.
-
(1994)
Nutr Rev
, vol.52
-
-
Blomhoff, R.1
-
39
-
-
0002259767
-
Retinol and reti-noic acid metabolism
-
In. Sporn, M.B., Roberts, A.B., Goodman, D.S. eds. New York: Raven Press
-
Blaner WS, Olson JA. Retinol and reti-noic acid metabolism. In The Reti-noids: Biology, Chemistry, and Medicine, 2nd edn Sporn MB, Roberts AB, Goodman DS. eds New York : Raven Press, 1994 283 318.
-
(1994)
The Reti-noids: Biology, Chemistry, and Medicine, 2nd Edn
, pp. 283-318
-
-
Blaner, W.S.1
Olson, J.A.2
-
40
-
-
0028265730
-
Cellular transport and metabolism of vitamin A: Roles of the cellular retinoid-binding proteins
-
Ong DE. Cellular transport and metabolism of vitamin A: roles of the cellular retinoid-binding proteins. Nutr Rev 1994 52 : S24 S31.
-
(1994)
Nutr Rev
, vol.52
-
-
Ong, D.E.1
-
41
-
-
0002429453
-
Biosynthesis, absorption, metabolism and transport of retinoids
-
In. Nau, H., Blaner, W.S., eds. Berlin: Springer
-
Vogel S, Gamble MV, Blaner WS. Biosynthesis, absorption, metabolism and transport of retinoids. In Retinoids: The Biochemical and Molecular Basis of Vitamin A and Retinoid Action (Nau H, Blaner WS, eds Vol.139. Berlin : Springer-Verlag, 1999 31 96.
-
(1999)
Retinoids: The Biochemical and Molecular Basis of Vitamin a and Retinoid Action
, vol.139
, pp. 31-96
-
-
Vogel, S.1
Gamble, M.V.2
Blaner, W.S.3
-
42
-
-
33846946440
-
A Membrane Receptor for Reti-nol Binding Protein Mediates Cellular Uptake of Vitamin a
-
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H. A Membrane Receptor for Reti-nol Binding Protein Mediates Cellular Uptake of Vitamin A. Science 2007 315 : 820 825.
-
(2007)
Science
, vol.315
, pp. 820-825
-
-
Kawaguchi, R.1
Yu, J.2
Honda, J.3
Hu, J.4
Whitelegge, J.5
Ping, P.6
Wiita, P.7
Bok, D.8
Sun, H.9
-
43
-
-
0032616999
-
Retinoic acid: Its biosynthesis and metabolism
-
Napoli JL. Retinoic acid: its biosynthesis and metabolism. Prog Nucl Acid Res Mol Biol 1999 6 : 139 188.
-
(1999)
Prog Nucl Acid Res Mol Biol
, vol.6
, pp. 139-188
-
-
Napoli, J.L.1
-
44
-
-
0025917013
-
Interactions of reti-nol with binding proteins: Studies with rat cellular retinol-binding protein and with rat retinol-binding protein
-
Noy N, Blaner WS. Interactions of reti-nol with binding proteins: studies with rat cellular retinol-binding protein and with rat retinol-binding protein. Biochemistry 1991 30 : 6380 6386.
-
(1991)
Biochemistry
, vol.30
, pp. 6380-6386
-
-
Noy, N.1
Blaner, W.S.2
-
45
-
-
0029861003
-
M. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase
-
White JA, Guo YD, Baetz K, Beckett-Jones B, Bonasoro J, Hsu KE, Dilworth FJ, Jones G, Petkovich M. M. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. J Biol Chem 1996 271 : 29922 19927.
-
(1996)
J Biol Chem
, vol.271
, pp. 29922-19927
-
-
White, J.A.1
Guo, Y.D.2
Baetz, K.3
Beckett-Jones, B.4
Bonasoro, J.5
Hsu, K.E.6
Dilworth, F.J.7
Jones, G.8
Petkovich, M.9
-
46
-
-
0028321897
-
Microsomal reti-noic acid metabolism. Effects of cellular retinoic acid-binding protein (Type 1) and C18-hydroxylation as an initial step
-
Fiorella PD, Napoli JL. Microsomal reti-noic acid metabolism. Effects of cellular retinoic acid-binding protein (Type 1) and C18-hydroxylation as an initial step. J Biol Chem 1994 269 : 10538 10544.
-
(1994)
J Biol Chem
, vol.269
, pp. 10538-10544
-
-
Fiorella, P.D.1
Napoli, J.L.2
-
47
-
-
0036496591
-
Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
-
Marill J, Capron CC, Idres N, Chabot GG. Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. Biochem Pharmacol 2002 63 : 933 943.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 933-943
-
-
Marill, J.1
Capron, C.C.2
Idres, N.3
Chabot, G.G.4
-
48
-
-
0030746211
-
CDNA cloning of human re-tinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450
-
White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Pet-kovich M. cDNA cloning of human re-tinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem 1997 272 : 18538 18541.
-
(1997)
J Biol Chem
, vol.272
, pp. 18538-18541
-
-
White, J.A.1
Beckett-Jones, B.2
Guo, Y.D.3
Dilworth, F.J.4
Bonasoro, J.5
Jones, G.6
Pet-Kovich, M.7
-
49
-
-
0030810985
-
Cyp26, a novel mammalian cyto-chrome P450, is induced by retinoic acid and defines a new family
-
Ray WJ, Baion G, Yao M, Gottlieb DI. Cyp26, a novel mammalian cyto-chrome P450, is induced by retinoic acid and defines a new family. J Biol Chem 1997 272 : 18702 18708.
-
(1997)
J Biol Chem
, vol.272
, pp. 18702-18708
-
-
Ray, W.J.1
Baion, G.2
Yao, M.3
Gottlieb, D.I.4
-
50
-
-
0033815009
-
Regulation of CYP26 (cytochrome P450RAI) mRNA expression and reti-noic acid metabolism by retinoids and dietary vitamin a in liver of mice and rats
-
Yamamoto Y, Zolfaghari R, Ross C. Regulation of CYP26 (cytochrome P450RAI) mRNA expression and reti-noic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats. FASEB J 2000 14 : 2119 2127.
-
(2000)
FASEB J
, vol.14
, pp. 2119-2127
-
-
Yamamoto, Y.1
Zolfaghari, R.2
Ross, C.3
-
51
-
-
0034612252
-
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
-
White JA, Ramshaw H, Taimi M, Stangle W, Zhang A, Everingham S, Creighton S, Tam SP, Jones G, Petko-vich M. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc Natl Acad Sci USA 2000 97 : 6403 6408.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6403-6408
-
-
White, J.A.1
Ramshaw, H.2
Taimi, M.3
Stangle, W.4
Zhang, A.5
Everingham, S.6
Creighton, S.7
Tam, S.P.8
Jones, G.9
Petko-Vich, M.10
-
52
-
-
0033571688
-
A second CYP26 P450 in humans and zebrafish: CYP26B1
-
Nelson DR. A second CYP26 P450 in humans and zebrafish: CYP26B1. Arch Biochem Biophys 1999 371 : 345 347.
-
(1999)
Arch Biochem Biophys
, vol.371
, pp. 345-347
-
-
Nelson, D.R.1
-
53
-
-
0034886924
-
Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development
-
MacLean G, Abu-Abed S, Dolle P, Ta-hayato A, Chambon P, Petkovich M. Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development. Mech Dev 2001 107 : 195 201.
-
(2001)
Mech Dev
, vol.107
, pp. 195-201
-
-
MacLean, G.1
Abu-Abed, S.2
Dolle, P.3
Ta-Hayato, A.4
Chambon, P.5
Petkovich, M.6
-
55
-
-
33746596549
-
Skin Retinoid Concentrations Are Modulated by CYP26AI Expression Restricted to Basal Keratinocytes in Normal Human Skin and Differentiated 3D Skin Models
-
Heise R, Mey J, Neis MM, Marquardt Y, Joussen S, Ott H, Wiederholt T, Kurschat P, Megahed M, Bickers DR, Merk HF, Baron JM. Skin Retinoid Concentrations Are Modulated by CYP26AI Expression Restricted to Basal Keratinocytes in Normal Human Skin and Differentiated 3D Skin Models. J Invest Dermatol 2006 126 : 2473 2480.
-
(2006)
J Invest Dermatol
, vol.126
, pp. 2473-2480
-
-
Heise, R.1
Mey, J.2
Neis, M.M.3
Marquardt, Y.4
Joussen, S.5
Ott, H.6
Wiederholt, T.7
Kurschat, P.8
Megahed, M.9
Bickers, D.R.10
Merk, H.F.11
Baron, J.M.12
-
56
-
-
0026463579
-
Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro
-
Duell EA, Astrom A, Griffiths CE, Chambon P, Voorhees JJ. Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. J Clin Invest 1992 90 : 1269 1274.
-
(1992)
J Clin Invest
, vol.90
, pp. 1269-1274
-
-
Duell, E.A.1
Astrom, A.2
Griffiths, C.E.3
Chambon, P.4
Voorhees, J.J.5
-
57
-
-
0037454384
-
Cutaneous expression of cytochrome P450 CYP2S1: Individuality in regulation by therapeutic agents for psoriasis and other skin diseases
-
Smith G, Wolf CR, Deeni YY, Dawe RS, Evans AT, Comrie MM, Ferguson J, Ibbotson SH. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. The Lancet 2003 361 : 1336 1343.
-
(2003)
The Lancet
, vol.361
, pp. 1336-1343
-
-
Smith, G.1
Wolf, C.R.2
Deeni, Y.Y.3
Dawe, R.S.4
Evans, A.T.5
Comrie, M.M.6
Ferguson, J.7
Ibbotson, S.H.8
-
59
-
-
0025932026
-
Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes
-
Buck J, Myc A, Garbe G, Cathomas G. Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes. J Cell Biol 1991 115 : 851 859.
-
(1991)
J Cell Biol
, vol.115
, pp. 851-859
-
-
Buck, J.1
Myc, A.2
Garbe, G.3
Cathomas, G.4
-
60
-
-
0030861229
-
Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes
-
Randolph RK, Simon M. Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes. J Lipid Res 1997 38 : 1374 1383.
-
(1997)
J Lipid Res
, vol.38
, pp. 1374-1383
-
-
Randolph, R.K.1
Simon, M.2
-
61
-
-
0013871298
-
Formation and enterohepatic circulation of metabolites of retinol and reti-noic acid in bile duct-cannulated rats
-
Zachman RD, Dunagin PE Jr., Olson JA. Formation and enterohepatic circulation of metabolites of retinol and reti-noic acid in bile duct-cannulated rats. J Lipid Res 1966 7 : 3 9.
-
(1966)
J Lipid Res
, vol.7
, pp. 3-9
-
-
Zachman, R.D.1
Dunagin Jr., P.E.2
Olson, J.A.3
-
62
-
-
0029816269
-
Bioac-tivities of N-(4-hydroxyphenyl) retina-mide and retinoyl beta-glucuronide
-
Formelli F, Barua AB, Olson JA. Bioac-tivities of N-(4-hydroxyphenyl) retina-mide and retinoyl beta-glucuronide. FASEB J 1996 10 : 1014 1024.
-
(1996)
FASEB J
, vol.10
, pp. 1014-1024
-
-
Formelli, F.1
Barua, A.B.2
Olson, J.A.3
-
64
-
-
0023916061
-
Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans- retinoic acid
-
Van Wauwe JP, Coene MC, Goossens J, Van Nijen G, Cools W, Lauwers W. Ketoconazole inhibits the in vitro and in vivo metabolism of all-trans- retinoic acid. J Pharmacol Exp Ther 1988 245 : 718 722.
-
(1988)
J Pharmacol Exp Ther
, vol.245
, pp. 718-722
-
-
Van Wauwe, J.P.1
Coene, M.C.2
Goossens, J.3
Van Nijen, G.4
Cools, W.5
Lauwers, W.6
-
65
-
-
0025089911
-
Effects of cyto-chrome P-450 inhibition on the in vivo metabolism of all-trans-retinoic acid in rats
-
Van Wauwe J, Coene MC, Goossens J, Cools W, Mombaliu J. Effects of cyto-chrome P-450 inhibition on the in vivo metabolism of all-trans-retinoic acid in rats. J Pharmacol Exp Ther 1990 252 : 365 369.
-
(1990)
J Pharmacol Exp Ther
, vol.252
, pp. 365-369
-
-
Van Wauwe, J.1
Coene, M.C.2
Goossens, J.3
Cools, W.4
Mombaliu, J.5
-
66
-
-
0026659954
-
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo
-
Van Wauwe J, Van Nyen G, Coene MC, Stoppie P, Cools W, Goosens J, Borghgraef P, Janssen PA. Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. J Pharmacol Exp Ther 1992 261 : 773 778.
-
(1992)
J Pharmacol Exp Ther
, vol.261
, pp. 773-778
-
-
Van Wauwe, J.1
Van Nyen, G.2
Coene, M.C.3
Stoppie, P.4
Cools, W.5
Goosens, J.6
Borghgraef, P.7
Janssen, P.A.8
-
67
-
-
0030016611
-
Liarozole inhibits human epidermal re-tinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo
-
Kang S, Duell E, Kim K, Voorhees JJ. Liarozole inhibits human epidermal re-tinoic acid 4-hydroxylase activity and differentially augments human skin responses to retinoic acid and retinol in vivo. J Invest Dermatol 1996 107 : 183 187.
-
(1996)
J Invest Dermatol
, vol.107
, pp. 183-187
-
-
Kang, S.1
Duell, E.2
Kim, K.3
Voorhees, J.J.4
-
68
-
-
33344476038
-
Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xeno-grafts in SCID mice
-
Huynh CK, Brodie AM, Njar VC. Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xeno-grafts in SCID mice. Br J Cancer 2006 94 : 513 523.
-
(2006)
Br J Cancer
, vol.94
, pp. 513-523
-
-
Huynh, C.K.1
Brodie, A.M.2
Njar, V.C.3
-
69
-
-
0024154832
-
Cytochrome P450- dependent metabolism of retinoic acid in rat skin microsomes: Inhibition by ke-toconazole
-
Vanden Bossche H, Willemsens G, Janssen PAJ. Cytochrome P450- dependent metabolism of retinoic acid in rat skin microsomes: inhibition by ke-toconazole. Skin Pharmacol 1988 1 : 176 185.
-
(1988)
Skin Pharmacol
, vol.1
, pp. 176-185
-
-
Vanden Bossche, H.1
Willemsens, G.2
Janssen, P.A.J.3
-
70
-
-
0026668041
-
Experimental studies with li-arozole (R75251): An antitumoral agent which inhibits retinoic acid breakdown
-
De Coster R, Wouters W, van Ginckel R, End D, Krekels M, Coene MC, Bo-wden C. Experimental studies with li-arozole (R75251): an antitumoral agent which inhibits retinoic acid breakdown. J Steroid Biochem Mol Biol 1992 43 : 197 201.
-
(1992)
J Steroid Biochem Mol Biol
, vol.43
, pp. 197-201
-
-
De Coster, R.1
Wouters, W.2
Van Ginckel, R.3
End, D.4
Krekels, M.5
Coene, M.C.6
Bo-Wden, C.7
-
72
-
-
19244376476
-
R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents
-
Stoppie P, Borgers M, Borghgraef P, Dil-len L, Goossens J, Sanz G, Szel H, Van Hove C, Van Nyen G, Nobels G, Van-den Bossche H, Venet M, Willemsen G, van Wauwe J. R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents. J Pharmacol Exp Ther 2000 293 : 304 312.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 304-312
-
-
Stoppie, P.1
Borgers, M.2
Borghgraef, P.3
Dil-Len, L.4
Goossens, J.5
Sanz, G.6
Szel, H.7
Van Hove, C.8
Van Nyen, G.9
Nobels, G.10
Van-Den Bossche, H.11
Venet, M.12
Willemsen, G.13
Van Wauwe, J.14
-
73
-
-
44049090517
-
-
Rambazole™ (R115866) Investigational Drug Brochure. version 3.0.; Oct.
-
Rambazole™ (R115866) Investigational Drug Brochure version 3.0.; Oct. 2005. Data on file at Barrier Therapeutics.
-
(2005)
Data on File at Barrier Therapeutics
-
-
-
74
-
-
34250687668
-
Rambazole™, a potent inhibitor of all-trans-retinoic acid metabolism, applied topically to mouse tail skin exerts retinoid mimetic activity
-
(#420).
-
Stoppie P, Van Wauwe J, Wouters L, Borgers M. Rambazole™, a potent inhibitor of all-trans-retinoic acid metabolism, applied topically to mouse tail skin exerts retinoid mimetic activity. J Invest Dermatol 2004 122 : A70 (#420).
-
(2004)
J Invest Dermatol
, vol.122
-
-
Stoppie, P.1
Van Wauwe, J.2
Wouters, L.3
Borgers, M.4
-
75
-
-
44049091448
-
-
Presented at Eur Acad Der-matol & Venereol. Rhodos
-
Cools M, Stoppie P, Cauwenbergh G, Vanhoutte F, Vandeplassche L. Tolerability, safety and pharmacokinetics of single and multiple oral dosages of R115866 (Rambazole™) in healthy volunteers. Presented at Eur Acad Der-matol & Venereol 2006, Rhodos, P035.22.
-
(2006)
Tolerability, Safety and Pharmacokinetics of Single and Multiple Oral Dosages of R115866 (Rambazole™) in Healthy Volunteers
-
-
Cools, M.1
Stoppie, P.2
Cauwenbergh, G.3
Vanhoutte, F.4
Vandeplassche, L.5
-
76
-
-
34548160458
-
Oral R115866 in the treatment of moderate to severe plaque-type psoriasis
-
in press.
-
Verfaille CJ, Thissen CACB, Boven-schen HJ, Mertens J, Steijlen PM, van de Kerkhof PCM. Oral R115866 in the treatment of moderate to severe plaque-type psoriasis. JEADV 2007, in press.
-
(2007)
JEADV
-
-
Verfaille, C.J.1
Cacb, T.2
Boven-Schen, H.J.3
Mertens, J.4
Steijlen, P.M.5
Van De Kerkhof, P.C.M.6
-
77
-
-
0029155801
-
Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: An open study with oral liaro-zole
-
Dockx P, Decree J, Degreef H. Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: an open study with oral liaro-zole. Br J Dermatol 1995 133 : 426 432.
-
(1995)
Br J Dermatol
, vol.133
, pp. 426-432
-
-
Dockx, P.1
Decree, J.2
Degreef, H.3
-
78
-
-
0034524721
-
Treatment of psoriasis with oral liaro-zole: A dose-ranging study
-
Berth-Jones J, Todd G, Hutchinson P, Thestrup-Pedersen K, Vanhoutte FP. Treatment of psoriasis with oral liaro-zole: a dose-ranging study. Br J Derma-tol 2000 143 : 1170 1176.
-
(2000)
Br J Derma-tol
, vol.143
, pp. 1170-1176
-
-
Berth-Jones, J.1
Todd, G.2
Hutchinson, P.3
Thestrup-Pedersen, K.4
Vanhoutte, F.P.5
-
79
-
-
0035788778
-
Oral liarozole in the treatment of palmoplantar pustular psoriasis: A randomized, double-blind, placebo-controlled study
-
Bhushan M, Burden AD, McElhone K, James R, Vanhoutte FP, Griffiths CEM. Oral liarozole in the treatment of palmoplantar pustular psoriasis: a randomized, double-blind, placebo-controlled study. Br J Dermatol 2001 145 : 546 53.
-
(2001)
Br J Dermatol
, vol.145
, pp. 546-53
-
-
Bhushan, M.1
Burden, A.D.2
McElhone, K.3
James, R.4
Vanhoutte, F.P.5
Griffiths, C.E.M.6
-
80
-
-
44049093313
-
Long-term safety of oral liarozole, a new retinoic acid metabolism blocking agent
-
Vandeplassche G, Beger B, Staszak J, Petit L, Blockhuys S. Long-term safety of oral liarozole, a new retinoic acid metabolism blocking agent. J Eur Acad Dermatol Venereol 2005 19 (Suppl. 2 FC13.14.
-
(2005)
J Eur Acad Dermatol Venereol
, vol.19
, Issue.2
-
-
Vandeplassche, G.1
Beger, B.2
Staszak, J.3
Petit, L.4
Blockhuys, S.5
-
81
-
-
44049088349
-
Safety of oral liarozole in subjects with ichthyosis or psoriasis
-
Vandeplassche G, Verfaille CJ, Beger B, Wouters L, Snoeck E, Cauwenbergh G. Safety of oral liarozole in subjects with ichthyosis or psoriasis. J Eur Acad Der-matol Venereol 2004 18 (Suppl. 2 395 396.
-
(2004)
J Eur Acad Der-matol Venereol
, vol.18
, Issue.2
, pp. 395-396
-
-
Vandeplassche, G.1
Verfaille, C.J.2
Beger, B.3
Wouters, L.4
Snoeck, E.5
Cauwenbergh, G.6
-
82
-
-
0031021596
-
Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liaro-zole
-
Lucker GPH, Heremans AMC, Boeg-heim PJ, van de Kerkhof PCM, Steijlen PM. Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liaro-zole. Br J Dermatol 1997 136 : 71 75.
-
(1997)
Br J Dermatol
, vol.136
, pp. 71-75
-
-
Lucker, G.P.H.1
Heremans, A.M.C.2
Boeg-Heim, P.J.3
Van De Kerkhof, P.C.M.4
Steijlen, P.M.5
-
83
-
-
34247346974
-
Oral liarozole vs. acitretin in the treatment of ichthyosis: A phase II/III multicentre, double-blind, randomized, active-controlled study
-
Verfaille CJ, Vanhoutte FP, Blanchet-Bardon C, van Steensel MA, Steijlen PM. Oral liarozole vs. acitretin in the treatment of ichthyosis: a phase II/III multicentre, double-blind, randomized, active-controlled study. Br J Der-matol 2007 156 : 965 973.
-
(2007)
Br J Der-matol
, vol.156
, pp. 965-973
-
-
Verfaille, C.J.1
Vanhoutte, F.P.2
Blanchet-Bardon, C.3
Van Steensel, M.A.4
Steijlen, P.M.5
-
84
-
-
17444387774
-
Topical liarozole in ichthyosis: A double-blind, left-right comparative study followed by a long-term open maintenance study
-
Lucker G, Verfaille CJ, Heremans A, Vanhoutte FP, Boegheim JP, Steijlen PM. Topical liarozole in ichthyosis: a double-blind, left-right comparative study followed by a long-term open maintenance study. Br J Dermatol 2005 152 : 566 569.
-
(2005)
Br J Dermatol
, vol.152
, pp. 566-569
-
-
Lucker, G.1
Verfaille, C.J.2
Heremans, A.3
Vanhoutte, F.P.4
Boegheim, J.P.5
Steijlen, P.M.6
-
85
-
-
0023759875
-
Serum lipids changes during acitretin (etretin) treatment of psoriasis and palmo-plan-tar pustulosis
-
Vahlquist C, Selinus I, Vessby B. Serum lipids changes during acitretin (etretin) treatment of psoriasis and palmo-plan-tar pustulosis. Acta Derm Venereol 1988 6 : 300 305.
-
(1988)
Acta Derm Venereol
, vol.6
, pp. 300-305
-
-
Vahlquist, C.1
Selinus, I.2
Vessby, B.3
-
87
-
-
33645016350
-
Psoriasis is associated with lipid abnormalities at the onset of skin disease
-
Mallbris L, Granath F, Hamsten A, Ståhle M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 2006 54 : 614 620.
-
(2006)
J Am Acad Dermatol
, vol.54
, pp. 614-620
-
-
Mallbris, L.1
Granath, F.2
Hamsten, A.3
Ståhle, M.4
-
88
-
-
33846194225
-
Oral retinoic acid metabolism blocking agent ramba-zole for plaque psoriasis: An immunohi-stochemical study
-
Bovenschen HJ, Otero ME, Langew-outers AM, van Vlijmen-Willems IMJJ, van Rens DWA, Seyger MMB, van de Kerkhof PCM. Oral retinoic acid metabolism blocking agent ramba-zole for plaque psoriasis: an immunohi-stochemical study. Br J Dermatol 2007 156 : 263 270.
-
(2007)
Br J Dermatol
, vol.156
, pp. 263-270
-
-
Bovenschen, H.J.1
Otero, M.E.2
Langew-Outers, A.M.3
Vlijmen-Willems Imjj, V.4
Van Rens, D.W.A.5
Seyger, M.M.B.6
Van De Kerkhof, P.C.M.7
-
89
-
-
34250686775
-
Effect of topical R115866 (Rambazo-le™) gel on the expression of biomar-kers in the skin of healthy volunteers
-
(#240).
-
Cools M, Pavez-Lorie E, Borgers M, Cauwenbergh G, Vandeplassche L, Wouters L, Torma H, Vahlquist A. Effect of topical R115866 (Rambazo-le™) gel on the expression of biomar-kers in the skin of healthy volunteers. J Invest Dermatol 2006 126 : S40 (#240).
-
(2006)
J Invest Dermatol
, vol.126
-
-
Cools, M.1
Pavez-Lorie, E.2
Borgers, M.3
Cauwenbergh, G.4
Vandeplassche, L.5
Wouters, L.6
Torma, H.7
Vahlquist, A.8
-
90
-
-
34250685290
-
Oral R115866 in the treatment of moderate to severe facial acne vulgaris: An exploratory study
-
Verfaille CJ, Coel M, Boersma IH, Mertens J, Borgers M, Roseeuw. Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study. Br J Dermatol 2007 157 : 122 126.
-
(2007)
Br J Dermatol
, vol.157
, pp. 122-126
-
-
Verfaille, C.J.1
Coel, M.2
Boersma, I.H.3
Mertens, J.4
Borgers, M.5
Roseeuw6
|