Global vasomotor dysfunction and accelerated vascular aging in β-thalassemia major

Atherosclerosis

Volumn 198, Issue 2, 2008, Pages 448-457

  Hahalis, George ^a   Kremastinos, Dimitrios T ^b   Terzis, George ^a   Kalogeropoulos, Andreas P ^a   Chrysanthopoulou, Athina ^a   Karakantza, Marina ^a   Kourakli, Alexandra ^a   Adamopoulos, Stamatis ^c   Tselepis, Alexandros D ^d   Grapsas, Nikos ^e   Siablis, Dimitrios ^a   Zoumbos, Nicholas C ^a   Alexopoulos, Dimitrios ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c ONASSIS CARDIAC SURGERY CENTER   (Greece)

^d UNIVERSITY OF IOANNINA   (Greece)

^e UNIVERSITY GENERAL HOSPITAL OF PATRAS   (Greece)

Author keywords

Carotid atherosclerosis; Endothelium; Inflammation; Iron overload; Thalassemia

Indexed keywords

CHOLESTEROL; D DIMER; FERRITIN; FIBRINOGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGE; AGING; APOPTOSIS; ARTERY DILATATION; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROSCLEROSIS; BRACHIAL ARTERY; CAROTID ARTERY; CHELATION THERAPY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ECHOGRAPHY; FEMALE; FERRITIN BLOOD LEVEL; FIBRINOGEN BLOOD LEVEL; HUMAN; INFLAMMATION; MALE; PATHOPHYSIOLOGY; PREDICTOR VARIABLE; PRIORITY JOURNAL; THALASSEMIA MAJOR; VASOMOTOR DISORDER;

ADULT; BETA-THALASSEMIA; BIOLOGICAL MARKERS; BRACHIAL ARTERY; CAROTID ARTERIES; CAROTID ARTERY DISEASES; FEMALE; HUMANS; MALE; TUNICA INTIMA; TUNICA MEDIA; VASODILATION; VASOMOTOR SYSTEM;

EID: 43949122545     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.09.030     Document Type: Article

References (59)

1. Ladis V., Chouliaras G., Berdousi H., Kanavakis E., and Katamis C. Longitudinal study of survival and causes of death in patients with thalassemia major in Greece. Ann NY Acad Sci 1054 (2005) 445-450
2. Hahalis G., Alexopoulos D., Kremastinos D.T., and Zoumbos N.C. Heart failure in β-thalassemia syndromes: a decade of progress. Am J Med 118 (2005) 957-967
3. Borgna-Pignatti C., Cappellini M.D., De Stefano P., et al. Survival and complications in thalassemia. Ann NY Acad Sci 1054 (2005) 40-47
4. Taher A., Isma'eel H., Mehio G., et al. Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thromb Haemost 96 (2006) 488-491
5. Eldor A., and Rachmilewitz E.A. The hypercoagulable state in thalassemia. Blood 99 (2002) 36-43
6. Pratico D., Pasin M., Barry O.P., et al. Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C. Circulation 99 (1999) 3118-3124
7. Balla G., Jacob H.S., Eaton J.W., Belcher J.D., and Vercellotti G.M. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb 11 (1991) 1700-1711
8. Scaccabarozzi A., Arosio P., Weiss G., et al. Relationship between TNF-alpha and iron metabolism in differentiating human monocytic THP-1 cells. Br J Haematol 110 (2000) 978-984
9. Kunsch C., and Medford R.M. Oxidative stress as a regulator of gene expression in the vasculature. Circ Res 85 (1999) 753-766
10. Schechter A.N., and Gladwin M.T. Hemoglobin and the paracrine and endocrine functions of nitric oxide. N Engl J Med 348 (2003) 1483-1485
11. Day S.M., Duquaine D., Mundada L.V., et al. Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis. Circulation 107 (2003) 2601-2606
12. Rooyakkers T.M., Stroes E.S., Kooistra M.P., et al. Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo. Eur J Clin Invest 32 (2002) S9-S16
13. Nitenberg A., Paycha F., Ledoux S., et al. Coronary artery responses to physiological stimuli are improved by deferoxamine but not by l-arginine in non-insulin-dependent diabetic patients with angiographically normal coronary arteries and no other risk factors. Circulation 97 (1998) 736-743
14. Tuomainen T.P., Diczfalusy U., Kaikkonen J., Nyyssonen K., and Salonen J.T. Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. Free Radic Biol Med 35 (2003) 922-928
15. Gaenzer H., Marschang P., Sturm W., et al. Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol 40 (2002) 2189-2194
16. Gillum R.F. Body iron stores and atherosclerosis. Circulation 96 (1997) 3261-3263
17. Brizzi P., Isaja T., D'Agata A., et al. Oxidized LDL antibodies (OLAB) in patients with beta-thalassemia major. Atheroscler Thromb 9 (2002) 139-144
18. Livrea M.A., Tesoriere L., Pintaudi A.M., et al. Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 88 (1996) 3608-3614
19. Aggeli C., Antoniades C., Cosma C., et al. Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major. Int J Cardiol 105 (2005) 80-84
20. Kyriakou D.S., Alexandrakis M.G., Kyriakou E.S., et al. Activated peripheral blood and endothelial cells in thalassemia patients. Ann Hematol 80 (2001) 577-583
21. Tsomi K., Karagiorga-Lagana M., Fragodimitri C., Karabatsos F., and Katsiki V. Arterial elastorrhexis: manifestation of a generalized connective tissue disorder in beta-thalassemia major. Eur J Heamatol 63 (1999) 287-294
22. Aessopos A., Farmakis D., and Loukopoulos D. Elastic tissue abnormalities resembling pseudo-xanthoma elasticum in beta thalassemia and the sickling syndromes. Blood 99 (2002) 30-35
23. Aessopos A., Farmakis D., Karagiorga M., Rombos I., and Loucopoulos D. Pseudoxanthoma elasticum lesions and cardiac complications as contributing factors for strokes in β-thalassemia patients. Stroke 28 (1997) 2421-2424
24. Heitzer T., Schlinzig T., Krohn K., Meinertz T., and Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104 (2001) 2673-2678
25. Mancini G.B., Dahlof B., and Diez J. Surrogate markers for cardiovascular disease. Circulation 109 (2004) IV22-IV30
26. Levenson J., Gariepy J., Salomon J., Denarie N., and Simon A. Association of plasma viscosity and carotid thickening in a French working cohort. Am J Hypertens 12 (2000) 753-875
27. Drueke T., Witko-Sarsat V., Massy Z., et al. Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease. Circulation 106 (2002) 2212-2217
28. Profumo E, Esposito C, Buttari B, et al. Intracellular expression of TNF-α and IL-6 in peripheral mononuclear cells is associated with the outcome of contralateral disease after carotid endarteriectomy. Atherosclerosis 2006;(May 4) [Epub ahead of print].
29. Magyar M.T., Szikszai Z., Balla J., et al. Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers. Stroke 34 (2003) 58-63
30. Virmani R., Ladich E.R., Burke A.P., and Kolodgie F.D. Histopathology of carotid atherosclerotic disease. Neurosurgery 59 (2006) S219-S227
31. Schillinger M., Exner M., Mlekusch W., et al. Inflammation and carotid artery-risk for atherosclerosis study (ICARAS). Circulation 111 (2005) 2203-2209
32. Elkind M.S., Cheng J., Boden-Albala B., et al. Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke 33 (2002) 31-37
33. Skoog T., Dichtl W., Boquist S., et al. Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men. Eur Heart J 23 (2002) 376-383
34. Neri A., Callea V., D'Ascola D.G., and Martino B. Immune status in thalassemia major. Haematologica 71 (1986) 511-516
35. Rougier F., Cornu E., Praloran V., and Denizot Y. IL-6 and IL-8 production by human bone marrow stromal cells. Cytokine 10 (1998) 93-97
36. Lombardi G., Matera R., Minervini M.M., et al. Serum levels of cytokines and soluble antigens in polytransfused patients with beta-thalassemia major: relationship to immune status. Haematologica 79 (1994) 406-412
37. Del Vecchio G.C., Schettini F., Piacente L., et al. Effects of deferiprone on immune status and cytokine pattern in thalassaemia major. Acta Haematol 108 (2002) 144-149
38. Salsaa B., and Zoumbos N.C. A distinct pattern of cytokine production from blood mononuclear cells in multitransfused patients with beta-thalassaemia. Clin Exp Immunol 107 (1997) 589-592
39. Bellocq A., Israel-Biet D., Cadranel J., et al. Reduction of tumour necrosis factor alpha expression and signalling in peripheral blood mononuclear cells from patients with thalassaemia or sickle cell anaemia upon treatment with desferrioxamine. Cytokine 11 (1999) 168-172
40. Archararit N., Chuncharunee S., Pornvoranunt A., et al. Serum C-reactive protein level in postsplenectomized thalassemic patients. J Med Assoc Thai 83 (2000) S63-S69
41. Spiess B.D. Blood transfusion for cardiopulmonary bypass: the need to answer a basic question. J Cardiothorac Vasc Anesth 16 (2002) 535-538
42. Tricot O., Mallat Z., Heymes C., et al. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation 101 (2000) 2450-2453
43. Yuan J., Angelucci E., Lucarelli G., et al. Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia). Blood 82 (1993) 374-377
44. Cheung Y.F., Chan G.C., and Ha S.Y. Arterial stiffness and endothelial function in patients with beta-thalassemia major. Circulation 106 (2002) 2561-2566
45. Adams M.R., Robinson J., McCredie R., et al. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilatation in adults at risk of atherosclerosis. J Am Coll Cardiol 32 (1998) 123-127
46. Nikolaidis L.A., Mathier M.A., Doverspike A., et al. Coronary blood flow responses are impaired independent of NO and endothelial function in conscious dogs with dilated cardiomyopathy. J Card Fail 11 (2005) 313-321
47. Miller Jr. F.J., Gutterman D.D., Rios C.D., et al. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 82 (1998) 1298-1305
48. Herrera B., Desco M.M., Eisenberg G., Garci{dotless}a-Barreno P., and Del Canizo J.F. Role of elastic fibers in cooling-induced relaxation. Cryobiology 44 (2002) 54-61
49. Young J.L., Libby P., and Schönbeck U. Cytokines in the pathogenesis of atherosclerosis. Thromb Haemost 88 (2002) 554-567
50. Nanami M., Ookawara T., Otaki Y., et al. Tumor necrosis factor-α-induced iron sequestration and oxidative stress in human endothelial cells. Arterioscler Thromb Vasc Biol 25 (2005) 2495-2501
51. Boyle J.J., Weissberg P.L., and Bennett M.R. Tumor necrosis factor-alpha promotes macrophage-induced vascular smooth muscle cell apoptosis by direct and autocrine mechanisms. Arterioscler Thromb Vasc Biol 23 (2003) 1553-1558
52. van der Meer I.M., Oei H.H., Hofman A., et al. Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis. Atherosclerosis 189 (2006) 464-469
53. Fridlender Z.G., and Rund D. Myocardial infarction in a patient with beta-thalassemia major: first report. Am J Hematol 75 (2004) 52-55
54. Tanner M.A., Galanello R., Dessi C., et al. A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115 (2007) 1876-1884
55. Chan S.Y., Mancini G.B., Kuramoto L., et al. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 42 (2003) 1037-1043
56. Kalogeropoulos A., Terzis G., Chrysanthopoulou A., et al. Risk for transient ischemic attacks is mainly determined by intima-media thickness and carotid plaque echogenicity. Atherosclerosis 192 (2007) 190-196
57. Eikelboom J.W., Mehta S.R., Anand S.S., et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 116 (2006) 774-782
58. Singh R., and Venketasubramanian N. Reccurent cerebral infarction in beta-thalassemia major. Cerebrovasc Dis 17 (2004) 344-345
59. Kremastinos D.T., Tiniakos G., Theodorakis G.N., Katritsis D.G., and Toutouzas P.K. Myocarditis in β-thalassemia major: a cause of heart failure. Circulation 91 (1995) 66-71