Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5683-5694

  Isakovic, Aleksandra ^a   Jankovic, Teodora ^b   Harhaji, Ljubica ^a   Kostic Rajacic, Sladjana ^c   Nikolic, Zoran ^a   Vajs, Vlatka ^c   Trajkovic, Vladimir ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute for Medicinal Plants Research   (Serbia)

^c Institute for Chemistry   (Serbia)

Author keywords

Apoptosis; Cell cycle; Glioma; Oxidative stress; Xanthone

Indexed keywords

CASPASE; GENTIACAULEIN; GENTIAKOCHIANIN; REACTIVE OXYGEN METABOLITE; XANTHONE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DIHYDROXYLATION; ENZYME ACTIVATION; GENTIAN; GENTIANA KOCHIANA; GLIOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G0 PHASE; G1 PHASE; G2 PHASE; GENTIANA; GLIOMA; HUMANS; MITOCHONDRIAL MEMBRANES; PLANT EXTRACTS; RATS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHONES;

GENTIANA; GENTIANELLA AUSTRIACA; RATTUS;

EID: 43949101696     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.069     Document Type: Article

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