4-Oxoheptanedioic acid: an orthogonal linker for solid-phase synthesis of base-sensitive oligonucleotides

Tetrahedron Letters

Volumn 49, Issue 26, 2008, Pages 4119-4121

  Leisvuori, Anna ^a   Poijärvi Virta, Päivi ^a   Virta, Pasi ^a   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; HYDRAZINE DERIVATIVE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHATE; PIMELIC ACID DERIVATIVE; RESIN;

ARTICLE; BIODEGRADATION; CHEMICAL STRUCTURE; SENSITIVITY ANALYSIS; SOLID PHASE SYNTHESIS; STRUCTURE ANALYSIS;

EID: 43849099707     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.04.131     Document Type: Article

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17. 2O/AcOH/pyridine, 0.0124/1/4, v/v/v). After 1 h mixing (at 25 °C), acetone (0.5 mL) was added and the suspension was mixed for an additional 15 min. After capping of hydrazine, the resin was filtered and washed with water (3 × 0.5 mL). The filtrate was evaporated to dryness, the residue was dissolved in water, and then the product (7-9) mixture was subjected to RP HPLC.