Synthetic polymers as drug-delivery vehicles in medicine

Metal-Based Drugs

Volumn 2008, Issue , 2008, Pages

  Neuse, Eberhard W ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIMETHYLAMINOPYRIDINE; ALPHA,BETA POLYASPARTAMIDE DERIVATIVE; CISPLATIN; DRUG CARRIER; FERROCENE DERIVATIVE; LIGAND; METHACRYLIC ACID DERIVATIVE; N (2 HYDROXYPROPYL)METHACRYLAMIDE DERIVATIVE; OXYGEN; PLATINUM DERIVATIVE; POLYAMIDOAMINE DERIVATIVE; POLYMER; PYRIDINE DERIVATIVE;

ARTICLE; BIOAVAILABILITY; CANCER CHEMOTHERAPY; CELL KILLING; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; MACROMOLECULE; POLYMERIZATION; PRIORITY JOURNAL; SOLUBILITY;

EID: 43849084688     PISSN: 07930291     EISSN: None     Source Type: Journal    
DOI: 10.1155/2008/469531     Document Type: Article

References (69)

1. Juliano R. L., Biological Approaches to the Controlled Delivery of Drugs 1987 507 New York, NY, USA New York Academy of Sciences
2. Sachdeva M. S., Drug targeting systems for cancer chemotherapy Expert Opinion on Investigational Drugs 1998 7 11 1849 1864
3. Duncan R., The dawning era of polymer therapeutics Nature Reviews, Drug Discovery 2003 2 347 360
4. Ringsdorf H., Structure and properties of pharmacologically active polymers Journal of Polymer Science: Polymer Symposia 1975 51 135 153
5. Kopeček J., Smart and genetically engineered biomaterials and drug delivery systems European Journal of Pharmaceutical Sciences 2003 20 1 1 16
6. Pack D. W., Hoffman A. S., Pun S., Stayton P. S., Design and development of polymers for gene delivery Nature Reviews, Drug Discovery 2005 4 7 581 593
7. Duncan R., Kopeček J., Soluble synthetic polymers as potential drug carriers Advances in Polymer Science 1984 57 51 101
8. Hoes C. J. T., Feijen J., Roerdink F. H. D., Kroon A. M., The application of drug-polymer conjugates in chemotherapy Drug Carrier Systems 1989 New York, NY, USA John Wiley & Sons 57 109
9. Matthews S. E., Pouton C. W., Threadgill M. D., Macromolecular systems for chemotherapy and magnetic resonance imaging Advanced Drug Delivery Reviews 1996 18 2 219 267
10. Veronese F. M., Morpurgo M., Bioconjugation in pharmaceutical chemistry II Farmaco 1999 54 8 497 516
11. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K., Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review Journal of Controlled Release 2000 65 1-2 271 284
12. Christie R. J., Grainger D. W., Design strategies to improve soluble macromolecular delivery constructs Advanced Drug Delivery Reviews 2003 55 3 421 437
13. Duncan R., Vicent M. J., Greco F., Nicholson R. I., Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer Endocrine-Related Cancer 2005 12 1 S189 S199
14. Nori A., Kopeček J., Intracellular targeting of polymer-bound drugs for cancer chemotherapy Advanced Drug Delivery Reviews 2005 57 4 609 636
15. Neri P., Antoni G., Benvenuti F., Cocola F., Gazzei G., Synthesis of α, β -poly[(2-hydroxyethyl)-DL-aspartamide], a new plasma expander Journal of Medicinal Chemistry 1973 16 8 893 897
16. Drobnik J., Saudek V., Vlasák J., Kálal J., Polyaspartamide - a potential drug carrier Journal of Polymer Science: Polymer Symposia 1979 66 1 65 74
17. Kálal J., Drobnik J., Kopeček J., Exner J., Water soluble polymers for medicine British Polymer Journal 1978 10 2 111 114
18. Neri P., Antoni G., α, β -poly(2-Hydroxyethyl)-DL-aspartamide Macromolecular Syntheses 1982 8 25 28
19. Machado M. de L., Neuse E. W., Perlwitz A. G., Water-soluble polyamides as potential drug carriers, V. Carboxy-functionalized polyaspartamides and copolyaspartamides Angewandte Makromolekulare Chemie 1992 195 1 35 56
20. Caldwell G., Neuse E. W., Perlwitz A. G., Water soluble polyamides as potential drug carriers. IX. Polyaspartamides grafted with amine-terminated poly(ethylene oxide) chains Journal of Applied Polymer Science 1997 66 5 911 919
21. Pytela J., Saudek V., Drobník J., Rypáček F., Poly(N5 -hydroxyalkylglutamines). IV. Enzymatic degradation of n5 -(2-hydroxyethyl) -L- glutamine homopolymers and copolymers Journal of Controlled Release 1989 10 1 17 25
22. Danusso F., Ferruti P., Synthesis of tertiary amine polymers Polymer 1970 11 2 88 113
23. Ferruti P., Marchisio M. A., Duncan R., Poly(amido-amine)s: biomedical applications Macromolecular Rapid Communications 2002 23 5-6 332 355
24. Caldwell G., Neuse E. W., Stephanou A., Synthesis of water-soluble polyimidoamines for biomedical application. II. Polymers possessing intrachain-type secondary amino groups suitable for side-chain attachment Journal of Applied Polymer Science 1993 50 3 393 401
25. N'Da D. D., Neuse E. W., Polyamidoamines as drug carriers: synthesis of polymers featuring extrachain-type primary amino groups as drug-anchoring sites South African Journal of Chemistry 2006 59 65 70
26. Kopeček J., Bažilová H., Poly[N-(2-hydroxypropyl) methacrylamide] - I. Radical polymerization and copolymerization European Polymer Journal 1973 9 1 7 14
27. Kopeček J., Kopečková P., Minko T., Lu Z.-R., HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action European Journal of Pharmaceutics and Biopharmaceutics 2000 50 1 61 81
28. Jensen K. D., Nori A., Tijerina M., Kopečková P., Kopeček J., Cytoplasmic delivery and nuclear targeting of synthetic macromolecules Journal of Controlled Release 2003 87 1-3 89 105
29. Hovorka O., Etrych T., Šubr V., Strohalm J., Ulbrich K., Říhová B., HPMA based macromolecular therapeutics: internalization, intracellular pathway and cell death depend on the character of covalent bond between the drug and the peptidic spacer and also on spacer composition Journal of Drug Targeting 2006 14 6 391 403
30. Neuse E. W., Caldwell G., cis-diaminedichloroplatinurn(II) complexes reversibly linked into the main chain of water-soluble polyamides Journal of Inorganic and Organometallic Polymers 1997 7 3 163 181
31. Swarts J. C., Neuse E. W., Perlwitz A. G., Stephanou A., Lamprecht G. J., Water-soluble polyamides as potential drug carriers, VI. Synthesis of amine- and carboxyl-functionalized carrier polymers by high-temperature solution polymerization in polyphosphoric acid Angewandte Makromolekulare Chemie 1993 207 1 123 135
32. Dabrowiak J. C., Bradner W. T., Platinum antitumour agents Progress in Medicinal Chemistry 1987 24 129 158
33. Hambley T. W., The influence of structure on the activity and toxicity of Pt anti-cancer drugs Coordination Chemistry Reviews 1997 166 181 223
34. Neuse E. W., Platinum coordination compounds in cancer research and chemotherapy South African Journal of Science 1999 95 11-12 509 516
35. Kostova I., Platinum complexes as anticancer agents Recent Patents on Anti-Cancer Drug Delivery 2006 1 1 1 22
36. Siegmann-Louda D. W., Carraher C. E. Jr., Abd-El-Aziz A. S., Carraher C. E. Jr., Pittman C. U. Jr., Sheats J. E., Zeldin M., Platinum-containing polymers for the treatment of cancer Macromolecules Containing Metal and Metal-Like Elements, Vol. 3, Biomedical Applications 2004 New York, NY, USA John Wiley & Sons 119 191. chapter 7
37. Howell B. A., Walles E. W., cis-dichloro(substituted o -phenylenediamine)-platinum(II) compounds Inorganica Chimica Acta 1988 142 2 185 186
38. Neuse E. W., Patel B. B., Mbonyana C. W. N., cis- diaminedichloroplatinum(II) complexes reversibly bound to water-soluble polyaspartamide carriers for chemotherapeutic applications - I: platinum coordination to preformed, carrier-attached ethylenediamine ligands Journal of Inorganic and Organometallic Polymers 1991 1 2 147 165
39. Neuse E. W., Caldwell G., Perlwitz A. G., cis-diaminedichloroplatinum(II) complexes reversibly bound to water-soluble polyaspartamide carriers for chemotherapeutic applications - II: platinum coordination to ethylenediamine ligands attached to poly(ethylene oxide)-grafted carrier polymers Journal of Inorganic and Organometallic Polymers 1995 5 3 195 207
40. Mbonyana C. W. N., Neuse E. W., Perlwitz A. G., Monoamineplatinum (II) complexes conjugated to water-soluble carrier polymers for chemotherapeutic applications Applied Organometallic Chemistry 1993 7 4 279 288
41. Caldwell G., Neuse E. W., van Rensburg C. E. J., Cytotoxicity of selected water-soluble polymer-cis-diaminedichloroplatinum(II) conjugates against the human HeLa cancer cell line Journal of Inorganic and Organometallic Polymers 1997 7 4 217 231
42. Schechter B., Caldwell G., Meirim M. G., Neuse E. W., Preliminary toxicological studies of selected water-soluble polymer-platinum conjugates Applied Organometallic Chemistry 2000 14 11 701 708
43. Gianasi E., Buckley R. G., Latigo J., Wasil M., Duncan R., HPMA copolymers platinates containing dicarboxylato ligands. Preparation, characterisation and in vitro and in vivo evaluation Journal of Drug Targeting 2002 10 7 549 556
44. Lin X., Zhang Q., Rice J. R., Stewart D. R., Nowotnik D. P., Howell S. B., Improved targeting of platinum chemotherapeutics: the antitumour activity of the HPMA copolymer platinum agent AP5280 in murine tumour models European Journal of Cancer 2004 40 2 291 297
45. Rademaker-Lakhai J. M., Terret C., Howell S. B., A phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors Clinical Cancer Research 2004 10 10 3386 3395
46. Bariyanga J., Synthesis, characterization and biodegradability of poly(ethylene glycol)-bound molecule platinum complex containing ferrocenyl moiety using MALDI time-of-flight mass spectrometry Journal of Bioactive and Compatible Polymers 2002 17 1 37 50
47. Neuse E. W., Mphephu N., Netshifhefhe H. M., Johnson M. T., Synthesis and preliminary in vitro evaluation of polymeric dicarboxylato- and dihydroxylatoplatinum(II) chelates as antiproliferative agents Polymers for Advanced Technologies 2002 13 10-12 884 895
48. Ohya Y., Shirakawa S., Matsumoto M., Ouchi T., Design of poly(ethylene glycol) immobilizing platinum complex through chelate-type coordination bond Polymers for Advanced Technologies 2000 11 8-12 635 641
49. Andrianov A. K., Water-soluble polyphosphazenes for biomedical applications Journal of Inorganic and Organometallic Polymers and Materials 2006 16 4 397 406
50. Sohn Y. S., Jun Y. J., Kim J. I., Tumor selective and biodegradable polyphosphazene-platinum(II) conjugate antitumor agent, and preparation method thereof 2005. US Patent no. 6951953
51. Johnson M. T., Komane L. L., N'Da D. D., Neuse E. W., Polymeric drug carriers functionalized with pairwise arranged hydroxyl and/or carboxyl groups for platinum chelation Journal of Applied Polymer Science 2005 96 1 10 19
52. Chen L., Schechter B., Arnon R., Wilchek M., Tissue selective affinity targeting using the avidin-biotin system Drug Development Research 2000 50 3-4 258 271
53. Rosenblum M., Chemistry of the Iron Group Metallocenes, Part I 1965 New York, NY, USA Wiley-Interscience
54. Neuse E. W., Rosenberg H., Metallocence Polymers 1970 New York, NY, USA Marcel Dekker
55. Neuse E. W., Polymeric organoiron compounds as prodrugs in cancer research Macromolecular Symposia 2001 172 127 138
56. Neuse E. W., Abd-El-Aziz A. S., Carraher C. E. Jr., Pittman C. U. Jr., Sheats J. E., Zeldin M., Polymeric ferrocene conjugates as antiproliferative agents Macromolecules Containing Metal and Metal-Like Elements, Volume 3, Biomedical Applications 2004 New York, NY, USA John Wiley & Sons 89 117. chapter 6
57. Neuse E. W., Macromolecular ferrocene compounds as cancer drug models Journal of Inorganic and Organometallic Polymers 2005 15 1 3 32
58. Neuse E. W., Metallocene Polymers Encyclopedia of Polymer Science Technology 1968 8 667
59. Neuse E. W., Ferrocene Polymers Advances in Macromolecular Chemistry 1968 1 1
60. Neuse E. W., Polymetallocenylenes-recent developments Journal of Macromolecular Science, Part A 1981 A16 1 3 72
61. Neuse E. W., Mbonyana C. W. N., Sheats J., Carraher C., Pittman C., Zeldin M., Currell B., Synthesis of polyaspartamide-bound Ferrocene compounds Inorganic and Metal-Containing Polymeric Materials 1990 New York, NY, USA Plenum Press 139 150
62. Blom N. F., Neuse E. W., Thomas H. G., Electrochemical characterization of some ferrocenylcarboxylic acids Transition Metal Chemistry 1987 12 4 301 306
63. Swarts J. C., Neuse E. W., Lamprecht G. J., Synthesis and characterization of water-soluble polyaspartamide-ferrocene conjugates for biomedical applications Journal of Inorganic and Organometallic Polymers 1994 4 2 143 153
64. Swarts J. C., Swarts D. M., Maree D. M., Neuse E. W., La Madeleine C., van Lier J. E., Polyaspartamides as water-soluble drug carriers. Part 1: antineoplastic activity of ferrocene-containing polyaspartamide conjugates Anticancer Research 2001 21 3B 2033 2037
65. Johnson M. T., Kreft E., N'Da D. D., Neuse E. W., van Rensburg C. E. J., The cytotoxic activity of macromolecular ferrocene conjugates against the Colo 320 DM human colon cancer line Journal of Inorganic and Organometallic Polymers 2003 13 4 255 267
66. N'Da D. D., Neuse E. W., Polyamidoamines as drug carriers: synthesis of polymers featuring extrachain-type primary amino groups as drug-anchoring sites South African Journal of Chemistry 2006 59 65 70
67. Meirim M. G., Neuse E. W., Caldwell G., Water-soluble polymer-ferrocene conjugates based on polyamide carriers containing intrachain-type secondary amine functions as binding sites Journal of Inorganic and Organometallic Polymers 1998 8 4 225 236
68. Neuse E. W., Meirim M. G., N'Da D. D., Caldwell G., Polymer-ferrocene conjugates containing an ester function in the connecting links Journal of Inorganic and Organometallic Polymers 1999 9 4 221 230
69. Schechter B., Caldwell G., Neuse E. W., A preliminary study of the toxicological properties of selected polymer-ferrocene conjugates Journal of Inorganic and Organometallic Polymers 2000 10 4 177 188