Kinetics of cell growth and cyclosporin A production by tolypocladium inflatum when scaling up from shake flask to bioreactor

Journal of Microbiology and Biotechnology

Volumn 18, Issue 1, 2008, Pages 128-134

  El Enshasy, H ^a   Abdel Fattah, Y ^a   Atta, A ^a   Anwar, M ^b   Omar, H ^b   Abou El Magd, S ^b   Abou Zahra, R ^a  

^a Universities and Research centers District   (Egypt)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Antibiotic production; Cyclosporin A; Growth morphology; Tolypocladium inflatum

Indexed keywords

CYCLOSPORIN A; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; BIOREACTOR; CELL GROWTH; CELL KINETICS; CELL STRUCTURE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG MANUFACTURE; FUNGUS; FUNGUS CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INOCULATION; MYCELIAL GROWTH; NONHUMAN; PH; SCALE UP; TOLYPOCLADIUM INFLATUM; ASCOMYCETES; BIOTECHNOLOGY; CULTURE MEDIUM; EVALUATION; GROWTH, DEVELOPMENT AND AGING; INSTRUMENTATION; KINETICS; METABOLISM; METHODOLOGY; MICROBIOLOGICAL EXAMINATION;

TOLYPOCLADIUM INFLATUM;

BIOREACTORS; BIOTECHNOLOGY; CULTURE MEDIA; CYCLOSPORINE; HYDROGEN-ION CONCENTRATION; HYPOCREALES; IMMUNOSUPPRESSIVE AGENTS; KINETICS; MICROBIOLOGICAL TECHNIQUES;

EID: 43749120304     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Agathos, S. N., J. W. Marshall, C. Moraiti, R. Parekh, and C. Madhosingh. 1986. Physiological and genetic factors for process development of cyclosporine fermentations. J. Ind. Microbiol. 1: 39-48.
2. Alfonso, C., L. Cribiero, and F. Reyes. 1989. Penicillin amidohydrolases in fungal autolysis. Microbiol. Immunol. 33: 69-74.
3. Balakrishnan, K. and A. Pandey. 1996. Influence of amino acids on the biosynthesis of cyclosporine A by Tolypocladium inflatum. Appl. Microbiol. Biotechnol. 45: 800-803.
4. Büchs, J. 2001. Introduction to advantages and problems of shaken cultures. J. Biochem. Eng. 7: 91-98.
5. Chun, G.-T. and S. N. Agathos. 1991. Comparative studies of physiological and environmental effects on the production of cyclosporine A in suspended and immobilized cells of Tolypocladium inflatum. Biotechnol. Bioeng. 37: 256-265.
6. Dubois, M., K. Gilles, J. Hamilton, P. Rebers, and F. Smith. 1956. Colorimetric method of determination of sugars and related substances. Anal. Chem. 290: 181-186.
7. El Enshasy, H. 2007. Filamentous fungal cultures - process characteristics, products, and applications, pp. 225-261. In S. T. Yang (ed.), Bioprocessing for Value-added Products from Renewable Resources. Elsevier Press, The Netherlands.
8. Harvey, L. M., B. McNeil, D. R. Berry, and S. White. 1998. Autolysis in batch cultures of Penicillium chrysogenum at varying agitation rates. Enz. Microb. Technol. 22: 446-458.
9. Heydarian, S. M., M. D. Lilly, and A. P. Ison. 1996. The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture. Biotechnol. Lett. 18: 1181-1186.
10. Isaac, C. C., A. Jones, and M. A. Pickard. 1990. Production of cyclosporins by Tolypocladium niveum strains. Antimicrob. Agents Chemother. 34: 121-127.
11. Kreuzig, F. 1984. High speed liquid chromatography with conventional instruments for determination of cyclosporin A, B, C, and D in fermentation broth. J. Chromatogr. 290: 181-186.
12. Lee, J. and S. N. Agathos. 1991. Dynamic of L-valine in relation to the production of cyclosporine A by Tolypocladium inflatum. Appl. Microbiol. Biotechnol. 34: 513-517.
13. Lee, T. H., G.-K. Chun, and Y. K. Chang. 1997. Development of sporulation/immobilization method and its application for the continuous production of cyclosporine A by Tolypocladium inflatum. Biotechnol. Prog. 13: 546-550.
14. Maier, U. and J. Büchs. 2001. Characterisation of the gas-liquid mass transfer in shaking bioreactors. J. Biochem. Eng. 7: 99-106.
15. Martin, J. F. and A. L. Demain. 1980. Control of antibiotic biosynthesis. Microbiol. Rev. 44: 230-251.
16. Mayer, A. F. and W.-D. Deckwer. 1996. Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivations. Appl. Microbiol. Biotechnol. 45: 41-46.
17. McIntyre, M., D. R. Berry, and B. McNeil. 2000. Role of protease in autolysis of Penicillium chlysogenum chemostat cultures in response to nutrient depletion. Appl. Microbiol. Biotechnol. 53: 235-242.
18. Murthy, M. V., E. V. Mohand, and A. K. Sadhukhan. 1999. Cyclosporin-A production by Tolypocladium inflatum using solid state fermentation. Process Biochem. 34: 269-280.
19. Papagianni, M. 2004. Fungal morphology and metabolite production in submerged mycelial processes. Biotechnol. Adv. 22: 189-259.
20. Pritchard, D. I. 2005. Sourcing a chemical succession for cyclosporin from parasites and human pathogens. Drug Discovery Today 10: 688-691.
21. Schreiber, S. L. and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13: 136-142.
22. Sekar, C. and K. Balaraman. 1998. Immobilization of the fungus Tolypocladium sp. for the production of cyclosporin A. Bioprocess Eng. 19: 281-283.
23. Sekar, C. and K. Balaraman. 1998. Optimization studies on the production of cyclosporine A by solid state fermentation. Bioprocess Eng. 18: 293-296.
24. Sowden, J. M. and B. R. Allen. 1992. Cyclosporin in dermatology: A historical overview. Int. J. Dermatol. 31: 520-523.
25. Sugiyama, M., S. Mizuno, Y. Ohta, H. Mochizuki, and O. Nimi. 1990. Kinetic studies of streptomycin uptake implicated in self-resistance in a streptomycin producer. Biotechnol. Lett. 12: 1-6.
26. Szabo, I., A. Penyige, G. Barabas, and J. Barabas. 1990. Effect of aminoglycoside antibiotics on the autolytic enzyme of Streptomyces griseus. Arch. Microbiol. 155: 99-102.
27. Tamura, S., Y. Park, M. Toriyama, and M. Okabe. 1997. Change of mycelial morphology in tylosin production by batch culture of Streptomyces fradiae under various shear conditions. J. Ferment. Bioeng. 83: 523-528.
28. White, S., M. McIntyre, D. Berry, and B. McNeil. 2002. The autolysis of industrial filamentous fungi. Crit. Rev. Biotechnol. 22: 1-14.
29. Wittler, R., H. Baumgartl, D. W. Lubbers, and K. Schügerl. 1986. Investigations of oxygen transfer into Penicillium chrysogenum pellets by microprobe measurement. Biotechnol. Bioeng. 28: 1024-1031.