Additional notes on clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance

Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 2, 2008, Pages 128-133

  Takaai, Mari ^a   Kayano, Yuichiro ^a   Shimizu, Takako ^a   Taguchi, Masato ^a   Hashimoto, Yukiya ^a,b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b NONE   (Japan)

Author keywords

Clinical pharmacokinetic trial; Oral clearance; Sampling design; Simulation; Steady state

Indexed keywords

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RESEARCH; METHODOLOGY; REPEATED DRUG DOSE; SENSITIVITY AND SPECIFICITY; SIMULATION; STATISTICAL ANALYSIS; STEADY STATE; AREA UNDER THE CURVE; HALF LIFE TIME; HUMAN; METABOLIC CLEARANCE RATE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS;

ADMINISTRATION, ORAL; AREA UNDER CURVE; HALF-LIFE; HUMANS; METABOLIC CLEARANCE RATE; PHARMACOKINETICS;

EID: 43749114719     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.23.128     Document Type: Article

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