Simulation for clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 11, 2007, Pages 2159-2162

  Ishida, Kazuya ^a   Kayano, Yuichiro ^a   Taguchi, Masato ^a   Hashimoto, Yukiya ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Clinical pharmacokinetic trial; Oral clearance; Sampling design; Steady state simulation

Indexed keywords

DRUG;

ARTICLE; BLOOD SAMPLING; COMPUTER SIMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; STEADY STATE;

ADMINISTRATION, ORAL; CLINICAL PROTOCOLS; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HUMANS; METABOLIC CLEARANCE RATE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RESEARCH DESIGN;

EID: 36049001303     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.2159     Document Type: Article

References (8)

1. Hashimoto Y., Sheiner L. B., J. Pharmacokinet. Biopharm., 19, 333-353 (1991).
2. Taguchi M., Nozawa T., Mizukami A., Inoue H., Tahara K., Takesono C., Hashimoto Y., Biol. Pharm. Bull., 27, 1642-1648 (2004).
3. Taguchi M., Nozawa T., Igawa A., Inoue H., Takesono C., Tahara K., Hashimoto Y., Biol. Pharm. Bull., 28, 876-871 (2005).
4. Taguchi M., Fujiki A., Iwamoto J., Inoue H., Tahara K., Saigusa K., Horiuchi I., Oshima Y., Hashimoto Y., Biol. Pharm. Bull., 29, 517-521 (2006).
5. Honda M., Ogura Y., Toyoda W., Taguchi M., Nozawa T., Inoue H., Hashimoto Y., Biol. Pharm. Bull., 29, 772-778 (2006).
6. Honda M., Itoh H., Suzuki T., Hashimoto Y., Biol. Pharm. Bull., 29, 2460-2464 (2006).
7. Koue T., Kubo M., Funaki T., Fukuda T., Azuma J., Takaai M., Kayano Y., Hashimoto Y., Biol. Pharm. Bull., 30, 2154-2158 (2007).
8. Sheiner L. B., Beal S. L., J. Pharmacokinet. Biopharm., 11, 303-319 (1983).