Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3

Journal of Antibiotics

Volumn 50, Issue 1, 1997, Pages 82-84

  Nagai, Machiko ^a   Kojima, Fukiko ^a   Naganawa, Hiroshi ^a   Hamada, Masa ^a   Aoyagi, Takaaki ^a,b   Takeuchi, Tomio ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; MICROSOMAL AMINOPEPTIDASE; PHEBESTIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MANUFACTURE; DRUG POTENCY; DRUG STRUCTURE; FERMENTATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

EID: 0031047449     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.82     Document Type: Article

References (16)

1. LOUVARD, D.; S. MAROUX & P. DESNUELLE: Topological studies on the hydrolases bound to the intestinal brush border membrane. Biochim. Biophys. Acta 389: 389-400, 1975
2. FERACCI, H.; S. MAROUX, J. BONICEL & P. DESNUELLE: The aminoacid sequence of the hydrophobia anchor of rabbit intestinal brush border aminopeptidase N. Biochim. Biophys. Acta 684: 133-136, 1982
3. KENNY, A. J.; S. L. STEPHENSON & A. J. TURNER: "Mammalian ectoenzymes" Ed., A. J. KENNY & A. J. TURNER, pp. 169-210, Elsevier, New York, 1987
4. LOOK, A. T.; R. A. ASHMUN, L. H., SHAPIRO & S. C. PEIPER: Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J. Clin. Invest. 83: 1299-1307, 1989
5. GROS, C. G.; B. GIROS & J.-C. SCHWARTZ: Identification of aminopeptidase N as an enkephalin-inactivating enzyme in rat cerebral membranes. Biochemistry 24: 2179-2185, 1985
6. KENNY, A. J.; S. L. STEPHENSON & A. J. TURNER: "Mammalian ectoenzymes" Ed., A. J. KENNY & A. J. TURNER, pp. 211-241, Elsevier, New York, 1987
7. MENRAD, A.; D. SPEICHER, J. WACKER & M. HERLYN: Biochemical and functional characterization of amino-peptidase N expressed by humann melanoma cells. Cancer Res. 53: 1450-1455, 1993
8. SAIKI, I.; H. FUJII, J. YONEDA, F. ABE, M. NAKAJIMA, T. TSURUO & I. AZUMA: Role of amino peptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int. J. Cancer 54: 137-143, 1993
9. FUJII, H.; M. MOTOWO, I. SAIKI, J. YONEDA, I. AZUMA & T. TSURUO: Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin. Exp. metastasis 13: 337-344, 1995
10. INO, K.; S. GOTO, T. OKAMOTO, S. NOMURA, A. NAWA, K. ISOBE, S. MIZUTANI & Y. TOMODA: Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity. Jpn. J. Cancer Res. 85: 927-933, 1994
11. UMEZAWA, H.; T. AOYAGI, T. TANAKA, H. SUDA, A. OKUYAMA, H. NAGANAWA, M. HAMADA & T. TAKEUCHI: Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes. J. Antibiotics 38: 1629-1630, 1985
12. AOYAGI, T.; S. YOSHIDA, Y. NAKAMURA, Y. SHIGIHARA, M. HAMADA & T. TAKEUCHI: Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J. Antibiotics 43: 143-148, 1990
13. AOYAGI, T.; S. YOSHIDA, N. MATSUDA, T. IKEDA, M. HAMADA & T. TAKEUCHI: Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. Taxonomy, production, isolation, physico-chemical properties and biological activities. J. Antibiotics 44: 573-578, 1991
14. UMEZAWA, H.; T. AOYAGI, H. SUDA, M. HAMADA & T. TAKEUCHI: Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J. Antibiotics 29: 97-99, 1976
15. SUDA, H.; T. TAKITA, T. AOYAGI & H. UMEZAWA: The structure of bestatin. J. Antibiotics 29: 100-101, 1976
16. 2, produced by Bacillus cereus BMG302-fT97. II. Structure of fatty acid residue and amino acid sequence. J. Antibiotics 39: 745-754, 1986