Evaluation of cytotoxic, genotoxic and CYP450 enzymatic competition effects of Tanzanian plant extracts traditionally used for treatment of fungal infections

Basic and Clinical Pharmacology and Toxicology

Volumn 102, Issue 6, 2008, Pages 515-526

  Van Den Bout van Den Beukel, Carolien J P ^a   Hamza, Omar J M ^b   Moshi, Mainen J ^b   Matee, Mecky I N ^b   Mikx, Frans ^a   Burger, David M ^a   Koopmans, Peter P ^a   Verweij, Paul E ^a   Schoonen, Willem G E J ^c   Van Der Ven, André J A M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c NV Organon ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACACIA NILOTICA EXTRACT; ACACIA ROBUSTA EXTRACT; AGAURA SALICIFOLIA EXTRACT; ANTIFUNGAL AGENT; CLAUSENA ANISATA EXTRACT; CYPHOSTEMMA HILDEBRANDTIII EXTRACT; CYTOCHROME P450; ELAEODENDRON BUCHANANII EXTRACT; JATROPHA MULTIFIDA EXTRACT; MESSENGER RNA; PREGNANE X RECEPTOR; PTERIDIUM AQUILINUM EXTRACT; SCLEROCARYA BIRREA EXTRACT; SPIROTACHYS AFRICANA EXTRACT; STERCULIA AFRICANA EXTRACT; TURRAEA HOLSTII EXTRACT;

ACACIA NILOTICA; ACACIA ROBUSTA; AGAURA SALICIFOLIA; ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; BRACKEN FERN; CANDIDA; CELL DAMAGE; CELL PROLIFERATION; CLAUSENA ANISATA; CONTROLLED STUDY; CONVULSION; CYPHOSTEMMA HILDEBRANDTIII; CYTOTOXICITY; DOSE RESPONSE; ELAEODENDRON BUCHANANII; GENOTOXICITY; GONORRHEA; HUMAN; HUMAN CELL; JATROPHA MULTIFIDA; MEDICINAL PLANT; MINIMUM INHIBITORY CONCENTRATION; MYCOSIS; NONHUMAN; PLANT LEAF; PLANT ROOT; PLANT STEM; PNEUMONIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; SCLEROCARYA BIRREA; SNAKEBITE; SPIROTACHYS AFRICANA; STERCULIA AFRICANA; TANZANIA; TURRAEA HOLSTII;

ANIMALS; ANTIFUNGAL AGENTS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CYTOCHROME P-450 ENZYME SYSTEM; DNA, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ETHNOPHARMACOLOGY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, BACTERIAL; HELA CELLS; HEPATOCYTES; HUMANS; MEDICINE, AFRICAN TRADITIONAL; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RECEPTORS, STEROID; TANZANIA;

CRICETULUS GRISEUS; JATROPHA MULTIFIDA; SPIROSTACHYS AFRICANA; STERCULIA; TURRAEA HOLSTII;

EID: 43749091717     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2008.00225.x     Document Type: Article

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