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Volumn 8, Issue 5, 2008, Pages 691-704

The role of pegvisomant in the treatment of acromegaly

Author keywords

Acromegaly; Growth hormone receptor; Growth hormone receptor antagonist; Medical treatment; Pegvisomant; Somatostatin analogue

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ANGIOPEPTIN; ANTISENSE OLIGONUCLEOTIDE; ATL 227446; BILIRUBIN; BROMOCRIPTINE; CABERGOLINE; GROWTH HORMONE; LIVER ENZYME; OCTREOTIDE; PEGVISOMANT; QUINAGOLIDE; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE;

EID: 43649103813     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.8.5.691     Document Type: Review
Times cited : (6)

References (99)
  • 2
    • 13044294029 scopus 로고    scopus 로고
    • Liver-derived insulin-like growth factor I (IGF-I) is the principle source of IGF-I in blood but it is not required for postnatal body growth in mice
    • Sjogren K, Liu JL, Blad K, et al. Liver-derived insulin-like growth factor I (IGF-I) is the principle source of IGF-I in blood but it is not required for postnatal body growth in mice. Proc Natl Acad Sci USA 1999;96:7088-92
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7088-7092
    • Sjogren, K.1    Liu, J.L.2    Blad, K.3
  • 3
    • 0029805072 scopus 로고    scopus 로고
    • Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    • Woods KA, Camacho-Hubner C, Savage MO, et al. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 1996;335:1363-7
    • (1996) N Engl J Med , vol.335 , pp. 1363-1367
    • Woods, K.A.1    Camacho-Hubner, C.2    Savage, M.O.3
  • 4
    • 21044454840 scopus 로고    scopus 로고
    • Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation
    • Walenkamp MJE, Karperienm, Pereira AM, et al. Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab 2005;90:2855-64
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2855-2864
    • Walenkamp, M.J.E.1    Karperienm, P.A.M.2
  • 5
    • 0031014027 scopus 로고    scopus 로고
    • A low starting dose of recombinant human growth hormone (GH) in adults with GH deficiency
    • Janssen YJH, Frolich M, Roelfsema F. A low starting dose of recombinant human growth hormone (GH) in adults with GH deficiency. J Clin Endocrinol Metab 1997;82:129-35
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 129-135
    • Janssen, Y.J.H.1    Frolich, M.2    Roelfsema, F.3
  • 6
    • 0028127371 scopus 로고
    • Acromegaly. Clinical and biochemical features in 500 patients
    • Ezzat S, Forster MJ, Berchtold P, et al. Acromegaly. Clinical and biochemical features in 500 patients. Medicine (Baltimore) 1994;73:233-40
    • (1994) Medicine (Baltimore) , vol.73 , pp. 233-240
    • Ezzat, S.1    Forster, M.J.2    Berchtold, P.3
  • 7
    • 0025999498 scopus 로고
    • Growth hormone heterogeneity: Genes, isohormones, variants, and binding proteins
    • Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr Rev 1991;12:424-49
    • (1991) Endocr Rev , vol.12 , pp. 424-449
    • Baumann, G.1
  • 8
    • 0027412707 scopus 로고
    • Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor
    • Sotiropoulos A, Coujon L, Simonin G, et al. Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor. Endocrinology 1993;132:1863-5
    • (1993) Endocrinology , vol.132 , pp. 1863-1865
    • Sotiropoulos, A.1    Coujon, L.2    Simonin, G.3
  • 9
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustinaa, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998;19:717-97
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustinaa1    Veldhuis, J.D.2
  • 10
    • 0035181709 scopus 로고    scopus 로고
    • Altered neuroregulation of GH secretion in viscerally obese premenopausal women
    • Pijl H, Langendonk JG, Burggraaf J, et al. Altered neuroregulation of GH secretion in viscerally obese premenopausal women. J Clin Endocrinol Metab 2001;86:5509-15
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5509-5515
    • Pijl, H.1    Langendonk, J.G.2    Burggraaf, J.3
  • 12
    • 0023886723 scopus 로고
    • Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984
    • Bengtsson BA, Eden S, Ernest I, et al. Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Med Scand 1988;223:327-35
    • (1988) Acta Med Scand , vol.223 , pp. 327-335
    • Bengtsson, B.A.1    Eden, S.2    Ernest, I.3
  • 13
    • 0025409756 scopus 로고
    • Ascertainment and natural history of treated acromegaly in Northern Ireland
    • Ritchie CM, Atkinson AB, Kennedy AL, et al. Ascertainment and natural history of treated acromegaly in Northern Ireland. Ulster Med J 1990;59:55-62
    • (1990) Ulster Med J , vol.59 , pp. 55-62
    • Ritchie, C.M.1    Atkinson, A.B.2    Kennedy, A.L.3
  • 14
    • 7244257406 scopus 로고    scopus 로고
    • Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)
    • Mestron A, Webb SM, Astorga R, et al. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol 2004;151:439-46
    • (2004) Eur J Endocrinol , vol.151 , pp. 439-446
    • Mestron, A.1    Webb, S.M.2    Astorga, R.3
  • 15
    • 1442326975 scopus 로고    scopus 로고
    • Systemic complications of acromegaly: Epidemiology, pathogenesis, and management
    • Colao A, Ferone D, Marzullo P, et al. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 2004;25:102-52
    • (2004) Endocr Rev , vol.25 , pp. 102-152
    • Colao, A.1    Ferone, D.2    Marzullo, P.3
  • 17
    • 0028132941 scopus 로고
    • Characterization of 24-hour growth hormone secretion in acromegaly: Implications for diagnosis and therapy
    • Ho KY, Weisberger AJ. Characterization of 24-hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clin Endocrinol (Oxford) 1994;41:75-83
    • (1994) Clin Endocrinol (Oxford) , vol.41 , pp. 75-83
    • Ho, K.Y.1    Weisberger, A.J.2
  • 18
    • 0028588697 scopus 로고
    • Growth hormone secretion in recently operated acromegalic patients
    • Van Den Berg G, Frolich M, Veldhuis JD, et al. Growth hormone secretion in recently operated acromegalic patients. J Clin Endocrinol Metab 1994;79:1706-15
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1706-1715
    • Van Den Berg, G.1    Frolich, M.2    Veldhuis, J.D.3
  • 19
    • 0030826920 scopus 로고    scopus 로고
    • Van Der Lely AJ, De Herder WW, Janssen JA, et al. Acromegaly: the significance of serum total and free IGF-I and IGF- binding protein-3 in diagnosis. J Endocrinol 1997;155(Suppl 1):S9-13; discussion S15-6:S9-13
    • Van Der Lely AJ, De Herder WW, Janssen JA, et al. Acromegaly: the significance of serum total and free IGF-I and IGF- binding protein-3 in diagnosis. J Endocrinol 1997;155(Suppl 1):S9-13; discussion S15-6:S9-13
  • 20
    • 0028348279 scopus 로고
    • Diagnosis of growth hormone deficiency in adults
    • Hoffman DM, O'Sullivan AJ, Baxter RC, et al. Diagnosis of growth hormone deficiency in adults. Lancet 1994;343:1064-8
    • (1994) Lancet , vol.343 , pp. 1064-1068
    • Hoffman, D.M.1    O'Sullivan, A.J.2    Baxter, R.C.3
  • 21
    • 0031774361 scopus 로고    scopus 로고
    • Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly
    • Swaeringen B, Barker FG, Katznelson L, et al. Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly. J Clin Endocrinol Metab 1998;83:3419-26
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3419-3426
    • Swaeringen, B.1    Barker, F.G.2    Katznelson, L.3
  • 22
    • 2942694305 scopus 로고    scopus 로고
    • Determinants of survival in treated acromegaly in a single center: Predictive value of serial insulin-like growth factor-I measurements
    • Biermasz NR, Dekker FW, Pereira AM, et al. Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor-I measurements. J Clin Endocrinol Metab 2004;89:2789-96
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2789-2796
    • Biermasz, N.R.1    Dekker, F.W.2    Pereira, A.M.3
  • 23
    • 0031936978 scopus 로고    scopus 로고
    • Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery
    • Van Den Berg G, Pincus SM, Frolich M, et al. Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. Eur J Endocrinol 1998;138:164-9
    • (1998) Eur J Endocrinol , vol.138 , pp. 164-169
    • Van Den Berg, G.1    Pincus, S.M.2    Frolich, M.3
  • 24
    • 0031782211 scopus 로고    scopus 로고
    • Long-term endocrinological follow-up evaluation in 115 patients who underwent transsphenoidal surgery for acromegaly
    • Freda PU, Wardlaw SL, Post KD. Long-term endocrinological follow-up evaluation in 115 patients who underwent transsphenoidal surgery for acromegaly. J Neurosurg 1998;89:353-8
    • (1998) J Neurosurg , vol.89 , pp. 353-358
    • Freda, P.U.1    Wardlaw, S.L.2    Post, K.D.3
  • 25
    • 0034489270 scopus 로고    scopus 로고
    • Ten-year follow-up results of transsphenoidal microsurgery in acromegaly
    • Biermasz NR, Van Dulken H, Roelfsema F. Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. J Clin Endocrinol Metab 2000;85:4596-602
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4596-4602
    • Biermasz, N.R.1    Van Dulken, H.2    Roelfsema, F.3
  • 26
    • 0037318764 scopus 로고    scopus 로고
    • Radiotherapy in acromegaly: A protagonist's viewpoint
    • Wass JA. Radiotherapy in acromegaly: a protagonist's viewpoint. Clin Endocrinol (Oxford) 2003;58:128-31
    • (2003) Clin Endocrinol (Oxford) , vol.58 , pp. 128-131
    • Wass, J.A.1
  • 27
    • 0033832946 scopus 로고    scopus 로고
    • Postoperative radiotherapy in acromegaly is effective in reducing GH concentration to safe levels
    • Biermasz NR, Van Dulken H, Roelfsema F. Postoperative radiotherapy in acromegaly is effective in reducing GH concentration to safe levels. Clin Endocrinol (Oxford) 2000;53:321-7
    • (2000) Clin Endocrinol (Oxford) , vol.53 , pp. 321-327
    • Biermasz, N.R.1    Van Dulken, H.2    Roelfsema, F.3
  • 29
    • 0018643801 scopus 로고
    • The influence of bromocriptin on serum levels of growth hormone and other pituitary hormones and its metabolic effects in active acromegaly
    • Roelfsema F, Goslings BM, Frolich M, et al. The influence of bromocriptin on serum levels of growth hormone and other pituitary hormones and its metabolic effects in active acromegaly. Clin Endocrinol (Oxford) 1979;11:235-44
    • (1979) Clin Endocrinol (Oxford) , vol.11 , pp. 235-244
    • Roelfsema, F.1    Goslings, B.M.2    Frolich, M.3
  • 31
    • 0031792509 scopus 로고    scopus 로고
    • Cabergoline in the treatment of acromegaly: A study in 64 patients
    • Abs R, Verhelst J, Maiter D, et al. Cabergoline in the treatment of acromegaly: a study in 64 patients. J Clin Endocrinol Metab 1998;83:374-8
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 374-378
    • Abs, R.1    Verhelst, J.2    Maiter, D.3
  • 32
    • 0043074807 scopus 로고    scopus 로고
    • Current concepts in the biochemical assessment of the patient with acromegaly
    • Freda PU. Current concepts in the biochemical assessment of the patient with acromegaly. Growth Horm IGF Res 2003;13:171-84
    • (2003) Growth Horm IGF Res , vol.13 , pp. 171-184
    • Freda, P.U.1
  • 33
    • 4143066821 scopus 로고    scopus 로고
    • Cabergoline addition to depot somatostatin analogues in resistant acromegalic patients: Efficacy and lack of predictive value of prolactin status
    • Cozzi R, Attanasio R, Lodrini S, et al. Cabergoline addition to depot somatostatin analogues in resistant acromegalic patients: efficacy and lack of predictive value of prolactin status. Clin Endocrinol (Oxford) 2004;61:209-15
    • (2004) Clin Endocrinol (Oxford) , vol.61 , pp. 209-215
    • Cozzi, R.1    Attanasio, R.2    Lodrini, S.3
  • 34
    • 33845986031 scopus 로고    scopus 로고
    • Dopamine agonists and the risk of cardiac-valve regurgitation
    • Schade R, Andersohn F, Suissa S, et al. Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med 2007;356:29-38
    • (2007) N Engl J Med , vol.356 , pp. 29-38
    • Schade, R.1    Andersohn, F.2    Suissa, S.3
  • 35
    • 0037323565 scopus 로고    scopus 로고
    • The pathophysiological consequences of somatostatin receptor internalization and resistance
    • Hofland LJ, Lamberts SWJ. The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr Rev 2003;24:28-47
    • (2003) Endocr Rev , vol.24 , pp. 28-47
    • Hofland, L.J.1    Lamberts, S.W.J.2
  • 36
    • 0026573854 scopus 로고
    • Octreotide inhibits insulin-like growth factor-I hepatic gene expression in hypophysectomized rat: Evidence for a direct and indirect mechanism of action
    • Serri O, Brazeau P, Kachra Z, et al. Octreotide inhibits insulin-like growth factor-I hepatic gene expression in hypophysectomized rat: evidence for a direct and indirect mechanism of action. Endocrinology 1992;130:1816-21
    • (1992) Endocrinology , vol.130 , pp. 1816-1821
    • Serri, O.1    Brazeau, P.2    Kachra, Z.3
  • 37
    • 4043058143 scopus 로고    scopus 로고
    • Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis
    • Murray RD, Kim K, Ren S-G. Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis. J Clin Invest 2004;114:349-56
    • (2004) J Clin Invest , vol.114 , pp. 349-356
    • Murray, R.D.1    Kim, K.2    Ren, S.-G.3
  • 38
    • 0033291744 scopus 로고    scopus 로고
    • Sandostatin LAR Group. Results of a European multicentre study with Sandostatin LAR in acromegalic patients
    • Lancranjan I, Atkinson AB; Sandostatin LAR Group. Results of a European multicentre study with Sandostatin LAR in acromegalic patients. Pituitary 1999;1:105-14
    • (1999) Pituitary , vol.1 , pp. 105-114
    • Lancranjan, I.1    Atkinson, A.B.2
  • 39
    • 10744227971 scopus 로고    scopus 로고
    • Four-year treatment with octreotide-long-acting repeatable in 110 acromegalic patients: Predictive value of short-term results?
    • Cozzi R, Attanasio R, Montini M, et al. Four-year treatment with octreotide-long-acting repeatable in 110 acromegalic patients: predictive value of short-term results? J Clin Endocrinol Metab 2003;88:3090-8
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3090-3098
    • Cozzi, R.1    Attanasio, R.2    Montini, M.3
  • 40
    • 33646022576 scopus 로고    scopus 로고
    • Primary treatment of acromegaly with octreotide LAR: A long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage
    • Cozzi R, Montini M, Attanasio R, et al. Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage. J Clin Endocrinol Metab 2006;91:1397-403
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1397-1403
    • Cozzi, R.1    Montini, M.2    Attanasio, R.3
  • 42
    • 23044466974 scopus 로고    scopus 로고
    • A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly
    • Melmed S, Sternberg R, Cook D, et al. A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. J Clin Endocrinol Metab 2005;90:4405-10
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4405-4410
    • Melmed, S.1    Sternberg, R.2    Cook, D.3
  • 43
    • 19944381531 scopus 로고    scopus 로고
    • Intravenous octreotide test predicts the long term outcome of treatment with octreotide-long-acting repeatable in active acromegaly
    • Biermasz NR, Pereira AM, Smit JW, et al. Intravenous octreotide test predicts the long term outcome of treatment with octreotide-long-acting repeatable in active acromegaly. Growth Horm IGF Res 2005;15:200-6
    • (2005) Growth Horm IGF Res , vol.15 , pp. 200-206
    • Biermasz, N.R.1    Pereira, A.M.2    Smit, J.W.3
  • 44
    • 15044348198 scopus 로고    scopus 로고
    • The value of an acute octreotide suppression test in predicting long-term responses to depot somatostatin analogues in patients with active acromegaly
    • Karavitaki N, Botusan I, Radian S, et al. The value of an acute octreotide suppression test in predicting long-term responses to depot somatostatin analogues in patients with active acromegaly. Clin Endocrinol (Oxford) 2005;62:282-8
    • (2005) Clin Endocrinol (Oxford) , vol.62 , pp. 282-288
    • Karavitaki, N.1    Botusan, I.2    Radian, S.3
  • 45
    • 20444432736 scopus 로고    scopus 로고
    • The nadir growth hormone after an octreotide test dose predicts the long-term efficacy of somatostatin analogue therapy in acromegaly
    • Gilbert JA, Miell JP, Chambers SM, et al. The nadir growth hormone after an octreotide test dose predicts the long-term efficacy of somatostatin analogue therapy in acromegaly. Clin Endocrinol (Oxford)62:742-7
    • Clin Endocrinol (Oxford)62 , pp. 742-747
    • Gilbert, J.A.1    Miell, J.P.2    Chambers, S.M.3
  • 46
    • 33646347639 scopus 로고    scopus 로고
    • A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice
    • Tachas G, Lofthouse S, Wraight, et al. A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in normal mice. J Endocrinol 2006;189:147-54
    • (2006) J Endocrinol , vol.189 , pp. 147-154
    • Tachas, G.1    Lofthouse, S.2    Wraight3
  • 47
    • 0026346040 scopus 로고
    • Crystals of the complex between human growth hormone and the extracellular domain of its receptor
    • Ultsch M, De Vos AM, Kossiakoff AA. Crystals of the complex between human growth hormone and the extracellular domain of its receptor. J Mol Biol 1991;222:865-8
    • (1991) J Mol Biol , vol.222 , pp. 865-868
    • Ultsch, M.1    De Vos, A.M.2    Kossiakoff, A.A.3
  • 48
    • 0027198110 scopus 로고
    • Crystals of growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization
    • Ultsch M, De Vos AM. Crystals of growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization. J Mol Biol 1993;231:1133-6
    • (1993) J Mol Biol , vol.231 , pp. 1133-1136
    • Ultsch, M.1    De Vos, A.M.2
  • 49
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • De Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992;255:306-12
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 50
    • 0028217202 scopus 로고
    • The crystal structure of affinity-matured growth hormone at 2 Å resolution
    • Ultsch MH, Somers W Kossiakoff AA, et al. The crystal structure of affinity-matured growth hormone at 2 Å resolution. J Mol Biol 1994;236:286-99
    • (1994) J Mol Biol , vol.236 , pp. 286-299
    • Ultsch, M.H.1    Somers, W.2    Kossiakoff, A.A.3
  • 51
    • 0025162844 scopus 로고
    • Structural design and molecular evolution of a cytokine receptor superfamily
    • Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990;87:63934-9938
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 63934-69938
    • Bazan, J.F.1
  • 52
    • 26944493862 scopus 로고    scopus 로고
    • Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    • Brown RJ, Adams JJ, Pelekanos RA, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005;12:814-21
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 814-821
    • Brown, R.J.1    Adams, J.J.2    Pelekanos, R.A.3
  • 53
    • 0031622702 scopus 로고    scopus 로고
    • Signaling via JAK tyrosine kinases: Growth hormone receptor as a model system
    • Carter-Su C, Smit LS. Signaling via JAK tyrosine kinases: growth hormone receptor as a model system. Recent Prog Horm Res 1998;53:61-82
    • (1998) Recent Prog Horm Res , vol.53 , pp. 61-82
    • Carter-Su, C.1    Smit, L.S.2
  • 55
    • 0035980108 scopus 로고    scopus 로고
    • Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2
    • Alves Dos Santos CM, Ten Broeke T, Strous GJ. Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2. J Biol Chem 2001;276:32635-41
    • (2001) J Biol Chem , vol.276 , pp. 32635-32641
    • Alves Dos Santos, C.M.1    Ten Broeke, T.2    Strous, G.J.3
  • 56
    • 0036215093 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway regulates the availability of the GH receptor
    • Van Kerkhof P, Smeets M, Strous GJ. The ubiquitin-proteasome pathway regulates the availability of the GH receptor. Endocrinology 2002;143:1243-52
    • (2002) Endocrinology , vol.143 , pp. 1243-1252
    • Van Kerkhof, P.1    Smeets, M.2    Strous, G.J.3
  • 57
    • 3242668973 scopus 로고    scopus 로고
    • Ubiquitin system-dependent regulation of growth hormone receptor signal transduction
    • Strous GJ, Alves Dos Santos C, Gent J, et al. Ubiquitin system-dependent regulation of growth hormone receptor signal transduction. Curr Top Microbiol Immunol 2004;286:81-118
    • (2004) Curr Top Microbiol Immunol , vol.286 , pp. 81-118
    • Strous, G.J.1    Alves Dos Santos, C.2    Gent, J.3
  • 58
    • 0027984986 scopus 로고
    • In vitro and in vivo studies of antagonistic effects of human growth hormone analogs
    • Chen WY, Chen NY, Yun J, et al. In vitro and in vivo studies of antagonistic effects of human growth hormone analogs. J Biol Chem 1994;269:15892-7
    • (1994) J Biol Chem , vol.269 , pp. 15892-15897
    • Chen, W.Y.1    Chen, N.Y.2    Yun, J.3
  • 59
    • 0029989302 scopus 로고    scopus 로고
    • Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization
    • Harding PA, Wang X, Okada S, et al. Growth hormone (GH) and a GH antagonist promote GH receptor dimerization and internalization. J Biol Chem 1996;271:6708-12
    • (1996) J Biol Chem , vol.271 , pp. 6708-6712
    • Harding, P.A.1    Wang, X.2    Okada, S.3
  • 60
    • 0036891721 scopus 로고    scopus 로고
    • Growth hormone receptor antagonist improves insulin resistance in acromegaly
    • Rose DR, Clemmons DR. Growth hormone receptor antagonist improves insulin resistance in acromegaly. Growth Horm IGF Res 2002;12:418-24
    • (2002) Growth Horm IGF Res , vol.12 , pp. 418-424
    • Rose, D.R.1    Clemmons, D.R.2
  • 61
    • 0033591392 scopus 로고    scopus 로고
    • Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling
    • Maamra M, Finidori J, Von Laue S, et al. Studies with a growth hormone antagonist and dual-fluorescent confocal microscopy demonstrate that the full-length human growth hormone receptor, but not the truncated isoform, is very rapidly internalized independent of Jak2-Stat5 signaling. J Biol Chem 1999;274:14791-8
    • (1999) J Biol Chem , vol.274 , pp. 14791-14798
    • Maamra, M.1    Finidori, J.2    Von Laue, S.3
  • 62
    • 0033305719 scopus 로고    scopus 로고
    • The growth hormone antagonist B2036 does not interact with the prolactin receptor
    • Goffin V, Bernichtein S, Carriere O, et al. The growth hormone antagonist B2036 does not interact with the prolactin receptor. Endocrinology 1999;140:3853-6
    • (1999) Endocrinology , vol.140 , pp. 3853-3856
    • Goffin, V.1    Bernichtein, S.2    Carriere, O.3
  • 63
    • 0027136111 scopus 로고
    • Affinity maturation of human growth hormone by monovalent phage display
    • Lowman HB, Wells JA. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol 1993;234:564-78
    • (1993) J Mol Biol , vol.234 , pp. 564-578
    • Lowman, H.B.1    Wells, J.A.2
  • 64
    • 0001139005 scopus 로고
    • Enzyme-polyethylene glycol adducts: Modified enzymes with unique properties
    • Davis FF, Abuchowski A, Van Es T, et al. Enzyme-polyethylene glycol adducts: modified enzymes with unique properties. Enzyme Eng 1978;4:169-73
    • (1978) Enzyme Eng , vol.4 , pp. 169-173
    • Davis, F.F.1    Abuchowski, A.2    Van Es, T.3
  • 65
    • 17844380498 scopus 로고    scopus 로고
    • Pegylation: A novel process for modifying pharmacokinetics
    • Harris JM, Martin NE, Modi M. Pegylation: a novel process for modifying pharmacokinetics. Clin Pharmacokinet 2001;40:539-51
    • (2001) Clin Pharmacokinet , vol.40 , pp. 539-551
    • Harris, J.M.1    Martin, N.E.2    Modi, M.3
  • 67
    • 0013362210 scopus 로고    scopus 로고
    • Single-dose safety and pharmacokinetics of B2036-PEG (Somavert) after subcutaneous administration in healthy volunteers [abstract]
    • Rodvold KA, Bennett WF, Zib KA. Single-dose safety and pharmacokinetics of B2036-PEG (Somavert) after subcutaneous administration in healthy volunteers [abstract]. J Clin Pharmacol 1997;37:869
    • (1997) J Clin Pharmacol , vol.37 , pp. 869
    • Rodvold, K.A.1    Bennett, W.F.2    Zib, K.A.3
  • 68
    • 1942521548 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of B2036-PEG, a novel growth hormone receptor antagonist, in acromegalic subjects
    • abstract P1-049
    • Rodvold KA, Van Der Lely AJ. Pharmacokinetics and pharmacodynamics of B2036-PEG, a novel growth hormone receptor antagonist, in acromegalic subjects [abstract P1-049]. Proceedings 81th Annual Meeting of the Endocrine Society; 1999
    • (1999) Proceedings 81th Annual Meeting of the Endocrine Society
    • Rodvold, K.A.1    Van Der Lely, A.J.2
  • 69
    • 0033305394 scopus 로고    scopus 로고
    • Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH
    • Thorner MO, Strasburger CJ, Wu Z, et al. Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH. J Clin Endocrinol Metab 1999;84:2098-103
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2098-2103
    • Thorner, M.O.1    Strasburger, C.J.2    Wu, Z.3
  • 70
    • 0034926532 scopus 로고    scopus 로고
    • Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-Peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men
    • Veldhuis JD, Bidlingmaier M, Anderson SM, et al. Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-Peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men. J Clin Endocrinol Metab 2001;86:3304-10
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3304-3310
    • Veldhuis, J.D.1    Bidlingmaier, M.2    Anderson, S.M.3
  • 71
    • 34147156302 scopus 로고    scopus 로고
    • Pegvisomant interference in GH assays results in underestimation of GH levels
    • Paisley AN, Hayden K, Ellis A, et al. Pegvisomant interference in GH assays results in underestimation of GH levels. Eur J Endocrinol 2007;156:315-9
    • (2007) Eur J Endocrinol , vol.156 , pp. 315-319
    • Paisley, A.N.1    Hayden, K.2    Ellis, A.3
  • 72
    • 33847392443 scopus 로고    scopus 로고
    • Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: Implications for cancer therapy
    • Yin D, Vreeland F, Schaaaf LJ, et al. Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. Clin Cancer Res 2007;13:1000-9
    • (2007) Clin Cancer Res , vol.13 , pp. 1000-1009
    • Yin, D.1    Vreeland, F.2    Schaaaf, L.J.3
  • 73
    • 0033692493 scopus 로고    scopus 로고
    • Intracerebroventricular administration of the rat growth hormone (GH) receptor antagonist G118R stimulates GH secretion: Evidence for the existence of short loop negative feedback of GH
    • Nass R, Toogood AA, Hellmann P, et al. Intracerebroventricular administration of the rat growth hormone (GH) receptor antagonist G118R stimulates GH secretion: evidence for the existence of short loop negative feedback of GH. J Neuroendocrinol 2000;12:1194-9
    • (2000) J Neuroendocrinol , vol.12 , pp. 1194-1199
    • Nass, R.1    Toogood, A.A.2    Hellmann, P.3
  • 74
    • 34548779889 scopus 로고    scopus 로고
    • Treatment of acromegaly with pegvisomant during pregnancy: Maternal and fetal effects
    • Brian SR, Bidlingmaier M, Wajnrajch MP, et al. Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects. J Clin Endocrinol Metab 2007;92:3374-7
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3374-3377
    • Brian, S.R.1    Bidlingmaier, M.2    Wajnrajch, M.P.3
  • 75
    • 0034690311 scopus 로고    scopus 로고
    • Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
    • Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med 2000;342:1171-7
    • (2000) N Engl J Med , vol.342 , pp. 1171-1177
    • Trainer, P.J.1    Drake, W.M.2    Katznelson, L.3
  • 76
    • 0035944825 scopus 로고    scopus 로고
    • Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
    • Van Der Lely AJ, Hutson RK, Trainer PJ, et al. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet 2001;358:1754-9
    • (2001) Lancet , vol.358 , pp. 1754-1759
    • Van Der Lely, A.J.1    Hutson, R.K.2    Trainer, P.J.3
  • 77
    • 33847700931 scopus 로고    scopus 로고
    • Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: Safety and efficacy evaluation from the German Pegvisomant Observational Study
    • Schreiber I, Buchfelder M, Droste M, et al. Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study. Eur J Endocrinol 2007;156:75-82
    • (2007) Eur J Endocrinol , vol.156 , pp. 75-82
    • Schreiber, I.1    Buchfelder, M.2    Droste, M.3
  • 78
    • 15944375488 scopus 로고    scopus 로고
    • Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-1 levels in patients with acromegaly
    • Jehle S, Reyes CM, Sundeen RE, et al. Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-1 levels in patients with acromegaly. J Clin Endocrinol Metab 2005;90:1588-93
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1588-1593
    • Jehle, S.1    Reyes, C.M.2    Sundeen, R.E.3
  • 79
    • 26244434860 scopus 로고    scopus 로고
    • Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist
    • Jørgensen JOL, Feldt-Rasmusen U, Frystyk J, et al. Cotreatment of acromegaly with a somatostatin analog and a growth hormone receptor antagonist. J Clin Endocrinol Metab 2005;90:5627-31
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5627-5631
    • Jørgensen, J.O.L.1    Feldt-Rasmusen, U.2    Frystyk, J.3
  • 80
    • 36849041110 scopus 로고    scopus 로고
    • Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly
    • Neggers JCM, Van Aken MO, Janssen JAM, et al. Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly. J Clin Endocrinol Metab 2007;92:4598-601
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4598-4601
    • Neggers, J.C.M.1    Van Aken, M.O.2    Janssen, J.A.M.3
  • 81
    • 43649083544 scopus 로고    scopus 로고
    • NCT 00383708. Available from: www.ClinicalTrials.gov
    • NCT 00383708. Available from: www.ClinicalTrials.gov
  • 82
    • 43649089315 scopus 로고    scopus 로고
    • NCT 0068029. Available from: www.ClinicalTrials.gov
    • NCT 0068029. Available from: www.ClinicalTrials.gov
  • 83
    • 43649089848 scopus 로고    scopus 로고
    • Treatment with pegvisomant alone compared to combination therapy with pegvisomant/octreotide LAR in acromegaly [abstract OR 53-3]
    • June 2-5; Toronto, Ontario, Canada
    • Harris PE, D'Souza G, Good AJ, et al. Treatment with pegvisomant alone compared to combination therapy with pegvisomant/octreotide LAR in acromegaly [abstract OR 53-3]. The Endocrine Society Annual Meeting; 2007 June 2-5; Toronto, Ontario, Canada
    • (2007) The Endocrine Society Annual Meeting
    • Harris, P.E.1    D'Souza, G.2    Good, A.J.3
  • 84
    • 18744389775 scopus 로고    scopus 로고
    • Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly
    • Feenstra J, De Herder WW, Ten Have Smth, et al. Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly. Lancet 2005;365:1644-46
    • (2005) Lancet , vol.365 , pp. 1644-1646
    • Feenstra, J.1    De Herder, W.W.2    Have Smth, T.3
  • 85
    • 0034919001 scopus 로고    scopus 로고
    • Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly
    • Trainer PJ, Drake WM, Perry LA, et al. Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. J Clin Endocrinol Metab 2001;86:2989-92
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2989-2992
    • Trainer, P.J.1    Drake, W.M.2    Perry, L.A.3
  • 86
    • 18444366740 scopus 로고    scopus 로고
    • Cardiovascular risk factors in acromegaly before and after normalization of serum IGF-I levels with the GH antagonist pegvisomant
    • Sesmilo G, Fairfield WP, Katznelson L, et al. Cardiovascular risk factors in acromegaly before and after normalization of serum IGF-I levels with the GH antagonist pegvisomant. J Clin Endocrinol Metab 2002;87:1692-999
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1692-1999
    • Sesmilo, G.1    Fairfield, W.P.2    Katznelson, L.3
  • 87
    • 33751528568 scopus 로고    scopus 로고
    • Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly
    • Paisley AN, O'Callaghan CJ, Lewandowski KC, et al. Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly. J Clin Endocrinol Metab 2006;91:4635-40
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4635-4640
    • Paisley, A.N.1    O'Callaghan, C.J.2    Lewandowski, K.C.3
  • 88
    • 33846964162 scopus 로고    scopus 로고
    • Treatment with growth hormone receptor antagonist in acromegaly: Effect on cardiac structure and performance
    • Pivonello R, Galderisi M, Auriemma RS, et al. Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance. J Clin Endocrinol Metab 2007;92:476-82
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 476-482
    • Pivonello, R.1    Galderisi, M.2    Auriemma, R.S.3
  • 89
    • 0036891721 scopus 로고    scopus 로고
    • Growth hormone receptor antagonist improves insulin resistance in acromegaly
    • Rose DR, Clemmons DR. Growth hormone receptor antagonist improves insulin resistance in acromegaly. Growth Horm IGF Res 2002;12:418-24
    • (2002) Growth Horm IGF Res , vol.12 , pp. 418-424
    • Rose, D.R.1    Clemmons, D.R.2
  • 90
    • 0036284407 scopus 로고    scopus 로고
    • A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal
    • Parkinson C, Drake WM, Roberts ME, et al. A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal. J Clin Endocrinol Metab 2002;87:1797-804
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1797-1804
    • Parkinson, C.1    Drake, W.M.2    Roberts, M.E.3
  • 91
    • 0346728594 scopus 로고    scopus 로고
    • Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant
    • Drake WM, Rowles SV, Roberts ME, et al. Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant. Eur J Endocrinol 2003;149:521-7
    • (2003) Eur J Endocrinol , vol.149 , pp. 521-527
    • Drake, W.M.1    Rowles, S.V.2    Roberts, M.E.3
  • 92
    • 26244464853 scopus 로고    scopus 로고
    • Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant
    • Barkan AL, Burman P, Clemmons DR, et al. Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant. J Clin Endocrinol Metab 2005;90:5684-91
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5684-5691
    • Barkan, A.L.1    Burman, P.2    Clemmons, D.R.3
  • 93
    • 34249853600 scopus 로고    scopus 로고
    • The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly
    • Lindberg-Larsen R, Moller N, Schmitz O, et al. The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly. J Clin Endocrinol Metab 2007;92:1724-8
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1724-1728
    • Lindberg-Larsen, R.1    Moller, N.2    Schmitz, O.3
  • 94
    • 0036046249 scopus 로고    scopus 로고
    • Effects of a growth hormone receptor antagonist on bone markers in acromegaly
    • Fairfield WP, Sesmilo G, Katznelson L, et al. Effects of a growth hormone receptor antagonist on bone markers in acromegaly. Clin Endocrinol (Oxford) 2002;57:385-90
    • (2002) Clin Endocrinol (Oxford) , vol.57 , pp. 385-390
    • Fairfield, W.P.1    Sesmilo, G.2    Katznelson, L.3
  • 95
    • 0347362889 scopus 로고    scopus 로고
    • Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal
    • Parkinson C, Kassem M, Heickendorff L, et al. Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. J Clin Endocrinol Metab 2003;88:5650-5
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5650-5655
    • Parkinson, C.1    Kassem, M.2    Heickendorff, L.3
  • 96
    • 33846040409 scopus 로고    scopus 로고
    • Gender, body weight, disease activity, and previous radiotherapy influence the response to pegvisomant
    • Parkinson C, Burma P, Messig M, Trainer PJ. Gender, body weight, disease activity, and previous radiotherapy influence the response to pegvisomant. J Clin Endocrinol Metab 2007;92:190-5
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 190-195
    • Parkinson, C.1    Burma, P.2    Messig, M.3    Trainer, P.J.4
  • 97
    • 35848944677 scopus 로고    scopus 로고
    • Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy
    • Frohman LA, Bonert V. Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy. Pituitary 2007;10:283-9
    • (2007) Pituitary , vol.10 , pp. 283-289
    • Frohman, L.A.1    Bonert, V.2
  • 98
    • 33644594740 scopus 로고    scopus 로고
    • Elevated transaminases during medical treatment of acromegaly: A review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis
    • Biering H, Saller B, Bauditz J, et al. Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis. Eur J Endocrinol 2006;154:213-20
    • (2006) Eur J Endocrinol , vol.154 , pp. 213-220
    • Biering, H.1    Saller, B.2    Bauditz, J.3


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