Running has a negative effect on bone metabolism and proinflammatory status in male aged rats

Experimental Gerontology

Volumn 43, Issue 6, 2008, Pages 578-583

  Sipos, Wolfgang ^a   Rauner, Martina ^b   Skalicky, Monika ^a   Viidik, Andrus ^c,d   Hofbauer, Günther ^b   Schett, Georg ^e   Redlich, Kurt ^f   Lang, Susanna ^f   Pietschmann, Peter ^b,f  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c SMZ Sophienspital   (Austria)

^d AARHUS UNIVERSITY   (Denmark)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bone metabolism; Bone structure; Cytokine; Osteoporosis; Proinflammation; RANKL

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; GAMMA INTERFERON; OSTEOCALCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE STRUCTURE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXERCISE; EXPERIMENTAL MODEL; INFLAMMATION; MALE; MORPHOMETRICS; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RUNNING; TRABECULAR BONE; TREADMILL EXERCISE; VOLUNTARY MOVEMENT; WALKING;

ACID PHOSPHATASE; AGING; ANIMALS; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; CATHEPSINS; CELL COUNT; COLLAGEN TYPE I; CYTOKINES; FLOW CYTOMETRY; ISOENZYMES; MALE; MODELS, ANIMAL; OSTEOCALCIN; OSTEOCLASTS; OSTEOPROTEGERIN; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RUNNING; T-LYMPHOCYTES;

ANIMALIA; RATTUS;

EID: 43649096989     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2008.03.008     Document Type: Article

References (25)

1. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottavini E., and De Benedictis G. Inflamm-aging. An evolutionary perspective on immunoscene. Ann. NY Acad. Sci. 908 (2000) 244-254
2. Franceschi C., Valensin S., Bonafe M., Paolosso G., Yashin A.I., Monti D., and De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 35 (2000) 879-896
3. Hansalik M., Skalicky M., and Viidik A. Impairment of water maze behaviour with ageing is counteracted by maze learning earlier in life but not by physical exercise, food restriction or housing conditions. Exp. Gerontol. 41 (2006) 169-174
4. Hind K., Truscott J.G., and Evans J.A. Low lumbar spine bone mineral density in both male and female endurance runners. Bone 39 (2006) 880-885
5. Kim S.K., Kwon J.Y., and Nam T.J. Involvement of ligand occupancy in insulin-like growth factor-I (IGF-I) induced cell growth in osteoblast like MC3T3-E1 cells. Biofactors 29 (2007) 187-202
6. Kovacs E.J. Aging, traumatic injury, and estrogen treatment. Exp. Gerontol. 40 (2005) 549-555
7. Loupal G., Url A., Skalicky M., and Viidik A. Physical exercise retards the development of chronic nephropathy in the aging rat as efficiently as food restriction does. Gerontology 51 (2005) 83-93
8. Narath E., Skalicky M., and Viidik A. Voluntary and forced exercise influence the survival and body composition of ageing male rats differently. Exp. Gerontol. 36 (2001) 1699-1711
9. Obermayer-Pietsch B. Genetics of osteoporosis. Wien. Med. Wochenschr. 156 (2006) 162-167
10. Parfitt M., Drezner M., Glorieux F., Kanis J., Malluche H., Meunier P., Ott S., and Recker R. Bone histomorphometry: standardization of nomenclature, symbols, and units. J. Bone Miner. Res. 2 (1987) 595-610
11. Patel M.B.R., Arden N.K., Masterson L.M., Phillips D.I.W., Swaminathan R., Syddall H.E., Byrne C.D., Wood P.J., Cooper C., and Holf R.I.G. Investigating the role of growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD). Bone 37 (2005) 833-841
12. Patsch J., Muschitz C., Resch H., and Pietschmann P. Of mice and men: pathophysiology of male osteoporosis. J. Mens Health Gend. 4 (2007) 87-93
13. Pietschmann P., Skalicky M., Kneissel M., Rauner M., Hofbauer G., Stupphann D., and Viidik A. Bone structure and metabolism in a rodent model of male senile osteoporosis. Exp. Gerontol. 42 (2007) 1099-1108
14. Rauner M., Sipos W., and Pietschmann P. Osteoimmunology. Int. Arch. Allergy Immunol. 143 (2007) 31-48
15. Rector R.S., Rogers R., Ruebel M., and Hinton P.S. Participation in road cycling vs running is associated with lower bone mineral density in men. Metabolism 57 (2008) 226-232
16. Reid I.R. Relationships between fat and bone. Osteoporosos Int. 19 (2008) 595-606
17. Seibel M.J. Bone turnover in nutrition related disorders. Wien. Med. Wochenschr. 157 (2007) 593-605
18. Sipos W., Willheim M., Hofbauer G., and Pietschmann P. Evaluation of the suitability of monoclonal antibodies applied for flow cytometric intracellular cytokine detection in porcine peripheral blood lymphocytes. J. Vet. Med. A 52 (2005) 55-60
19. Sipos W., Pietschmann P., and Rauner M. Strategies for novel therapeutic approaches targeting cytokines and signaling pathways of osteoclasto- and osteoblastogenesis in the fight against immune-mediated bone and joint diseases. Curr. Med. Chem. 15 (2008) 127-136
20. Skalicky M., Narath E., and Viidik A. Housing conditions influence the survival and body composition of ageing rats. Exp. Gerontol. 36 (2001) 159-170
21. Thomsen, J.S., Skalicky, M., Viidik, A., in press. Influence of physical exercise and food restriction on the biomechanical properties of the femur of ageing male rats. Gerontology.
22. Viidik A., and Skalicky M. Voluntary exercise and mild food restriction effectively retard the collagen biomarker of aging. Aging Clin. Exp. Res. 15 (2003) 475-481
23. Wang L., Banu J., McMahan C.A., and Kalu D.N. Male rodent model of age-related bone loss in men. Bone 29 (2001) 141-148
24. Willheim M., Thien R., Schrattbauer K., Bajna E., Holub M., Gruber R., Baier K., Pietschmann P., Reinisch W., Scheiner O., and Peterlik M. Regulatory effect of 1α,25-dihydroxyvitamin D3 on the cytokine production of human peripheral blood lymphocytes. J. Clin. Endocrinol. Metab. 84 (1999) 3739-3744
25. Ziegler S., Niessner A., Richter B., Wirth S., Billensteiner E., Woloszczuk W., Slany J., and Geyer G. Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor kappa B ligand. Metabolism 54 (2005) 935-938