Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice

Acta Neuropathologica

Volumn 115, Issue 6, 2008, Pages 663-674

  Sakuma, Kunihiro ^a   Akiho, Mai ^a   Nakashima, Hiroyuki ^a   Nakao, Ryuta ^b   Hirata, Miyuki ^b   Inashima, Shuichiro ^b   Yamaguchi, Akihiko ^c   Yasuhara, Masahiro ^b  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

Calcineurin; Hypertrophy; MEF2C; MEF2D; Skeletal muscle

Indexed keywords

CYCLOSPORIN A; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; MYOCYTE ENHANCER FACTOR 2D; MYOGENIN; PLACEBO; SCATTER FACTOR RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; FAST MUSCLE FIBER; GASTROCNEMIUS MUSCLE; IMMUNOHISTOCHEMISTRY; MALE; MECHANICAL STRESS; MICROSATELLITE MARKER; MONONUCLEAR CELL; MOUSE; MUSCLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOLEMMA; SLOW MUSCLE FIBER; SOLEUS MUSCLE; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; CYCLOSPORINE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HYPERTROPHY; INDOLES; MALE; MICE; MICE, INBRED ICR; MUSCLE FIBERS; MUSCLE, SKELETAL; MYOGENIC REGULATORY FACTORS; WEIGHT-BEARING;

EID: 43649087953     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-008-0371-5     Document Type: Article

References (36)

1. Abbott KL, Friday BB, Thaloor D, Murphy TJ, Pavlath GK (1998) Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells. Mol Biol Cell 9:2905-2916
2. Black BL, Olson EN (1998) Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol 14:167-196
3. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3:1014-1019
4. Chin ER, Olson EN, Richardson JA, Yang Q, Humphries C, Shelton JM, Wu H, Zhu W, Bassel-Duby R, Williams RS (1998) A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev 12:2499-2509
5. Coleman ME, DeMayo F, Yin KC, Lee HM, Geske R, Montgomery C, Schwartz RJ (1995) Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 270:12109-12116
6. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: A play in three Akts. Genes Dev 13:2905-2927
7. Delling U, Tureckova J, Lim HW, De Windt LJ, Rotwein P, Molkentin JD (2000) A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Mol Cell Biol 20:6600-6611
8. DeVol DL, Rotwein P, Sadow JL, Novakofski J, Bechtel PJ (1990) Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth. Am J Physiol 259:E89-E95
9. Dunn SE, Burns JL, Michel RN (1999) Calcineurin is required for skeletal muscle hypertrophy. J Biol Chem 274:21908-21912
10. Dunn SE, Chin ER, Michel RN (2000) Matching of calcineurin activity to upstream effectors is critical for skeletal muscle fiber growth. J Cell Biol 151:663-672
11. Dunn SE, Simard AR, Bassel-Duby R, Williams RS, Michel RN (2001) Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. J Biol Chem 276:45243-45254
12. Florini JR, Ewton DZ, Coolican SA (1996) Growth hormone and the insulin-like growth factor system in myogenesis. Endocrinol Rev 17:481-517
13. Friday BB, Horsley V, Pavlath GK (2000) Calcineurin activity is required for the initiation of skeletal muscle differentiation. J Cell Biol 149:657-665
14. Glass DJ (2003) Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol 5:87-90
15. Hinits Y, Hughes SM (2007) Mef2s are required for thick filament formation in nascent muscle fibres. Development 134:2511-2519
16. -/- mice leads to decreased muscle size in the adult. Dev Biol 232:115-126
17. Lai K-MV, Gonzalez M, Poueymirou WT, Kline WO, Na E, Zlotchenko E, Stitt TN, Economides AN, Yancopoulos GD, Glass DJ (2004) Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Mol Cell Biol 24:9295-9304
18. Lazaro JB, Bailey PJ, Lassar AB (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev 16:1792-1805
19. Michel RN, Dunn SE, Chin ER (2004) Calcineurin and skeletal muscle growth. Proc Nutr Soc 63:341-349
20. Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol 16:3814-3824
21. Mora S, Pessin JE (2000) The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter. J Biol Chem 275:16323-16328
22. Musaró A, McCullagh KJA, Naya FJ, Olson EN, Rosenthal N (1999) IGF-I induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature 400:581-585
23. Musaró A, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, Barton ER, Sweeney HL, Rosenthal N (2001) Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet 27:195-200
24. Naya FJ, Mercer B, Shelton J, Richardson JA, Williams RS, Olson EN (2000) Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. J Biol Chem 275:4545-4548
25. Oh M, Rybkin II, Copeland V, Czubryt MP, Shelton JM, Rooij EV, Richardson JA, Hill JA, De Windt LJ, Bassel-Duby R, Olson EN, Rothermel BA (2005) Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol 25:6629-6638
26. Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S (2002) A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci USA 99:9213-9218
27. Parsons SA, Wilkins BJ, Bueno OF, Molkentin JD (2003) Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol 23:4331-4343
28. Potthoff MJ, Arnold MA, McAnally J, Richardson JA, Bassel-Duby R, Olson EN (2007) Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol 27:8143-8151
29. Potthoff MJ, Wu H, Arnold MA, Shelton JM, Backs J, McAnally J, Richardson JA, Bassel-Duby R, Olson EN (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest 117:2459-2467
30. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 3:1009-1013
31. Sakuma K, Watanabe K, Totsuka T, Uramoto I, Sakamoto K Sano M (1998) Differential adaptations of insulin-like growth factor, basic fibroblast growth factor and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study. Acta Neuropath (Berl) 95:123-130
32. Sakuma K, Nishikawa J, Nakao R, Watanabe K, Totsuka T, Nakano H, Sano M, Yasuhara M (2003) Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2. Acta Neuropath (Berl) 105:271-280
33. Sakuma K, Nakao R, Aoi W, Inashima S, Fujikawa T, Hirata M, Sano M, Yasuhara M (2005) Cyclosporin A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration. Acta Neuropath (Berl) 110:269-280
34. Sakuma K, Nakao R, Yamasa Y, Yasuhara M (2006) Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervation. Biochim Biophys Acta Gen Subj 1760:980-987
35. Stupka N, Plant DR, Schertzer JD, Emerson TM, Bassel-Duby R, Olson EN, Lynch GS (2006) Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice. J Physiol 575:645-656
36. Talmadge RJ, Otis JS, Rittler MR, Garcia ND, Spencer SR, Lees SJ, Naya FJ (2004) Calcineurin activation influences muscle phenotype in a muscle-specific fashion. BMC Cell Biol 5:28